Funding Opportunities at the NIH :

Minority Serving Institutions and small schools

Avrom Caplan, PhDAssociate University Dean for Research

The City University of New York

www.cuny.edu/research

National Institutes of Health

National Instituteon Alcohol Abuseand Alcoholism

National Instituteon Alcohol Abuseand Alcoholism

National Instituteof Arthritis andMusculoskeletaland Skin Diseases

National Instituteof Arthritis andMusculoskeletaland Skin Diseases

National CancerInstitute

National CancerInstitute

National Instituteon Drug Abuse

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Instituteof Environmental Health Sciences

National Instituteon Aging

National Instituteon Aging

National Instituteof Child Healthand HumanDevelopment

National Instituteof Child Healthand HumanDevelopment

National Institute onDeafness and OtherCommunicationDisorders

National Institute onDeafness and OtherCommunicationDisorders

National EyeInstitute

National EyeInstitute

National HumanGenome ResearchInstitute

National HumanGenome ResearchInstitute

National Instituteof Mental Health

National Instituteof Mental Health

National Instituteof NeurologicalDisorders andStroke

National Instituteof NeurologicalDisorders andStroke

National Instituteof GeneralMedical Sciences

National Instituteof GeneralMedical Sciences

National Instituteof Nursing Research

National Instituteof Nursing Research

National Libraryof Medicine

National Libraryof Medicine

Center for Scientific Review

Center for Scientific Review

National Centerfor Complementaryand AlternativeMedicine

National Centerfor Complementaryand AlternativeMedicine

National Instituteof Allergy andInfectious Diseases

National Instituteof Allergy andInfectious Diseases

FogartyInternationalCenter

FogartyInternationalCenter

National Centerfor ResearchResources

National Centerfor ResearchResources

Clinical Center

Clinical Center

National Center on Minority Health andHealth Disparities

National Center on Minority Health andHealth Disparities

National Institute of Biomedical Imagingand Bioengineering

National Institute of Biomedical Imagingand Bioengineering

Office of the DirectorOffice of the Director

Center for InformationTechnology

Center for InformationTechnology

National Heart,Lung, and BloodInstitute

National Heart,Lung, and BloodInstitute

National Instituteof Dental andCraniofacialResearch

National Instituteof Dental andCraniofacialResearch

National Instituteof Diabetes andDigestive andKidney Diseases

National Instituteof Diabetes andDigestive andKidney Diseases

MBRS – minority biomedical research

support• SCORE – faculty support for biomedical and behavioral research – 3 different mechanisms for support, with each funding 25-35 new applications annually.

• RISE – progam for student support – for all students at an MSI • IMSD – progam for student support • MARC – progam for honors student support – for URMS

MBRS – minority biomedical research support

Research Initiative for Scientific Enhancement (RISE)

• developmental program to enhance undergraduate research at an MSI• goal is to increase number of UR minority students advancing to PhD in biomedical and behavioral research. Also, the goal is to ensure that master’s students go onto PhD and for PhD students to graduate• one RISE grant per institution

• expected to include salary support for undergraduates and plans for curricula enhancement; rcr training etc; rennovation (limited)

MBRS – minority biomedical research support

Initiative for maximizing student development (IMSD)

• similar to RISE but don’t have to be MSI

•

• one IMSD grant per institution (can’t have RISE and IMSD)• expected to include salary support for undergraduates and plans for curricula enhancement; rcr training etc; rennovation (limited)

The program offers an opportunity to develop new or expand existing effective academic developmental programs, including student research internships, in order to prepare students from underrepresented groups for competitive research careers and leadership positions in the biomedical or behavioral sciences.

SCORE PROGRAM

http://www.nigms.nih.gov/Minority/MBRS/SCOREDescription.htm

• Review is by special emphasis panels rather than standing study sections.No specific payline

• 25 grant maximum per institution; only full time faculty can apply

• must include developmental objective of the grant will increase research competitiveness as part of biosketch including plans for transition to R-type funding.

• application dates are: Jan 25, May 25 and Sept 25

• Chief MBRS branch is Hinda Zlotnik – 301 594 3900; zlotnikh@mnigms.nih.gov

SCORE PROGRAM – SC1

SC1 – RO1-like; 12 page research strategy; up to 5 years; 125-250K/yr.Collaboration with RO1 funded investigators encouraged

Only 1 PI and 1 renewal application allowed (ie 10 years)

Postdocs are allowed on SC1 but not SC2 or SC3

No student stipends; tuition or journal subscriptions

http://grants.nih.gov/grants/guide/pa-files/PAR-08-026.html

SCORE PROGRAM – SC2 – for early investigators

SC2 – testing new idea; preliminary data; switching to a new field. 3 yr max; 50K-100K/yr w/300K max. No renewal. 6 page research strategy

You need a mentor for SC2 – mentor activities must be described

Only 1 PI; no preliminary data needed….

No postdocs; student stipends; tuition or journal subscriptions

http://grants.nih.gov/grants/guide/pa-files/PAR-08-027.html

SCORE PROGRAM – SC3

SC3 – seek to continue competitive research of limited scope encouraged to participate in collaborations w/RO1 funded scientists.

renewable (developmental – no Co-Pis).

4 yrs @ 50K- 75K

http://grants.nih.gov/grants/guide/pa-files/PAR-08-028.html

Academic Research Enhancement Award - AREA (R15)

Must have less than $6 million in support in 4 out of the last 7 years• Biomedical and Behavioral research

• expose undergraduate students to research• improve research environment at the college

• research grant not a training grant- describe student activities; student profiles –

put these in environment and budget justification sections• 3 yrs, $300,000 total; 12 page• due dates are Feb. 25, June 25 and Oct. 25• preliminary data not required but recommended• letter of institutional support is a benefit• multiple PIs; renewable• reviewed in regular study section – payline ~19%

The New Research Strategy (the old Research Plan)

Specific aims 1 pageResearch Strategy 12 pages for R01

- Significance, Innovation and Approach

How to write a 12 page grant

-Significance needs to describe what will be the result of the research assuming everything works – what is the NIH buying?-Half a page??

-Innovation must described what’s new?

-Approach – put background into the intro to each aim; needs to include preliminary data

Formatted Reviewer Critiques

NIH grants: Review Criteria

Significance

Does the project address an important problem or a critical barrier to progress in

the field? If the aims of the project are achieved, how will scientific knowledge,

technical capability, and/or clinical practice be improved? How will successful

completion of the aims change the concepts, methods, technologies, treatments,

services, or preventative interventions that drive this field?

NIH grants: Review Criteria

Innovation

Does the application challenge and seek to shift current research or clinical

practice paradigms by utilizing novel theoretical concepts, approaches or

methodologies, instrumentation, or interventions? Are the concepts,

approaches or methodologies, instrumentation, or interventions novel to

one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts,

approaches or methodologies, instrumentation, or interventions proposed?

NIH grants: Review CriteriaApproach

Are the overall strategy, methodology, and analyses well-reasoned and

appropriate to accomplish the specific aims of the project? Are potential

problems, alternative strategies, and benchmarks for success presented? If

the project is in the early stages of development, will the strategy establish

feasibility and will particularly risky aspects be managed?

If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?

NIH grants: Review Criteria Investigator(s)

Are the PD/PIs, collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience

and training? If established, have they demonstrated an ongoing record

of accomplishments that have advanced their field(s)? If the project is

collaborative or multi-PD/PI, do the investigators have complementary and

integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?

You can address this in your personal statement for the Biosketch

NIH biosketch

Personal statement. Briefly describe why your experience and qualifications make you particularly well-suited for your role (e.g., PD/PI, mentor) in the project that is the subject of the application.

NIH encourages applicants to limit the list of selected peer-reviewed publications or manuscripts in press to no more than 15. Do not include manuscripts submitted or in preparation. The individual may choose to include selected publications based on recent, importance to the field, and/or relevance to the proposed research

NIH biosketch

Nih now wants a PubMed central reference number if publication was financed by prior NIH support

NIH biosketch

Research Support. List both selected ongoing and completed research projects for the past three years (Federal or non-Federally-supported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs.

Do not confuse "Research Support" with "Other Support." Though they sound similar, these parts of the application are distinctly different. As part of the biosketch section of the application, "Research Support" highlights your accomplishments, and those of your colleagues, as scientists.

NIH grants: Review Criteria Environment.

Will the scientific environment in which the work will be done contribute to

the probability of success? Are the institutional support, equipment and

other physical resources available to the investigators adequate for the

project proposed? Will the project benefit from unique features of the

scientific environment, subject populations, or collaborative arrangements?

Scientific environment: your colleagues – what is the culture in which you work?- how interactive is your department; division- what is the level of funding?- physical environment

Unique features: John Jay ???

This information is used to assess the capability of the organizational resources available to perform the effort proposed.

• Identify the facilities to be used (laboratory, clinical, animal, computer, office, other). If appropriate, indicate their capacities, pertinent capabilities, relative proximity and extent of availability to the project. Describe only those resources that are directly applicable to the proposed work. Provide any information describing the Other Resources available to the project (e.g., machine shop, electronic shop) and the extent to which they would be available to the project.

Resources Page

This part is easy….

• Describe how the scientific environment in which the research will be done contributes to the probability of success (e.g., institutional support, physical resources, and intellectual rapport). In describing the scientific environment in which the work will be done, discuss ways in which the proposed studies will benefit from unique features of the scientific environment or subject populations or will employ useful collaborative arrangements.

• For Early Stage Investigators, describe institutional investment in the success of the investigator, e.g., resources for classes, travel, training; collegial support such as career enrichment programs, assistance and guidance in the supervision of trainees involved with the ESIs project, and availability of organized peer groups; logistical support such as administrative management and oversight and best practices training; and financial support such as protected time for research with salary support.

Resources Page

Resources Page

institutional support:- space and arrangement of labs.- how many other funded labs

physical resources:

- what core facilities are available to you at your college and at CUNY as a whole?

- include RCMI resources

intellectual rapport:- how many scientists working in

your field are in your department?- how do you interact

(seminars/lab mtgs)- how about across CUNY?

• SCORE instructions:Institutions with well developed environments for the conduct of research and/or research training and significant support from NIH RO1 or equivalent are generally not suitable applicants for the SCORE program.

• RO1 instructions:Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?

Resources Page

The SCORE and RO1 instructions seem mutually exclusive…?

Formatted Reviewer Critiques

Overall Evaluation/Impact*

•Based upon consideration of the 5 core review criteria (& any additional

pertinent review criteria), reviewers provide an overall impact statement

and score to reflect their assessment of the likelihood for the project to

exert a sustained, powerful influence on the research field(s) involved.

•An application need not be strong in all categories to be judged likely to

have a major scientific impact. (For example, a project may propose to carry out

important work that by its nature is not innovative, but is essential to move a field forward, or

improve clinical decisions or outcomes).

*It IS NOT the mean score of the the other 5 criteria

NIH grants: Review Criteria

NIH grants: Review Criteria

• Overall impact• Core review criteria

- Significance – assumes all aims achieved

- Investigator – that means you!- Innovation - so whats new?- Approach – finally, the science itself- Environment – that means your dept., college and CUNY

These apply to RO1, R21, RO3, SC1, SC2 and SC3