fungal chitosan in medical textiles

8/10/2019 Fungal Chitosan in Medical Textiles

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FUNGAL CHITOSAN IN

MEDICAL TEXTILESBy

NISHI PANDEY-17 SUHASINI GANESH-30

PARAS KWATRA-18 SUKANYA G.NINAWE-31

POMI DANDAPAT-21 USHA NANDHINI.C-35


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MEDICAL TEXTILES

Medical textiles are the textile products and constructiofor medical applications.

Materials used include monofilament and multifilamenwoven, knitted, and nonwoven fabrics, and composite

There are mainly four classifications in medical textiles:

Health care and Hygiene medical textiles.

Non-implantable medical textiles.

Implantable medical textiles.

Extra corporeal devices.


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FIBRES IN MEDICAL TEXTILES

Commonly used natural fibres are cotton, silk and rege

cellulosic fibres (viscose rayon). Commonly used syntheinclude polyester, polyamide, polytetrafluoroethylene polypropylene, carbon, glass, and so on.

Biodegradable fibres include cotton, viscose rayon, popolyurethane, collagen, and alginate.

Non-biodegradable fibres include polyester (e.g. Dacr

polypropylene, PTFE, carbon etc.A variety of natural polymers such as collagen, alginatchitosan, etc have been found to be essential materialwound dressings.


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CHITIN

Chitin, poly (-(1-4)-N-acetyl-D-glucosamine), is a natural polmajor importance is the most abundant polymer after cellulo

Chitinoccurs in nature as ordered crystalline microfibrils formcomponentsin the exoskeleton of marine invertebrates arththe cell walls of fungi and yeast.

Depending on its source, chitin occurs as two allomorphs, naand forms. A third allomorph -chitin has also been describ


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CHITOSAN

Whenthe degree of deacetylation of chitin reaches about 5

becomes soluble in aqueous acidic media and is called chit

Chitosan is a linear polysaccharide consisting of -(1-4)-2-am-glucopyranose units.

Chitin are a renewable and inexpensive source of chitosan.


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PREPARATION AND PROPERTIES

Chitosan is commonly prepared by deacetylating a-ch50 % aqueous alkali at 100-160 C for a few hours.

Chitin and chitosan (CTS) are highly basic polysacchar

Their unique properties include polyoxysalt formation, afilms, chelate metal ions and optical structural charact

Chitosan, the deacetylated product of chitin, is solubleacids such as acetic acid, formic acid, etc.

The most accepted one is the interaction of the positi

CTS with the negatively charged residues at the cell sumany fungi and bacteria, which causes extensive cell salterations and alters cell wall permeability.

As a result, CTS inhibits the normal metabolism of micro and finally leads to the death of these cells.


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ADVANTAGES

BIOCOMPATABILITY

BIODEGRADABILITY

SAFE MATERIAL

ANTI-MICROBIAL ACTIVITY

ANALGETIC ACTIVITY

WOUND HEALING ACTIVITY

ANTI-TUMOR ACTIVITY


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PRODUCTION OF FUNGAL CHITO

SELECTION OF MICROBIAL SPECIES

GROWTH MEDIUM

SOLID STATE FERMENTATION

RECOVERY AND EXTRACTION

PURIFICATION AND DEACETYLATION

EVALUATION

APPLICATION


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13.3

17.4

14.2

18.5

0

2

4

6

8

10

12

14

16

18

20

21.4 22.0 23.2 24.2

Biomass(g/L)

Chitosan % Yield

Chitosan yield fromAspergillus niger

1785 at incubation period of 96h

&120h) For the stain of chitosan

niger 1785 strain we havculture media incubateand 120 hours.

CULTURE MEDIA-1 For 96 hours ,the biomass i

& the % yield for chitosan 21.4%.

For 120 hours, the biomassyield for chitosan is 22.0%

CULTUREMEDIA-2 For 96 hours the biomass in

the % yield for chitosan pro23.2%.

For 120 hours the biomass yield for chitosan is 24.2%


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GLOBAL CHITOSAN MARKET SHARE,BYPRODUCT SEGMENT(2013-2014)


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Global marketing of chitosan(metric tonnes


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BIOMEDICAL APPLICATIONS OF CHIT

Physical form

Applications

Solution Bacteriostatic agents

Homeostatic agents

Cosmetics

Gel Delivery vehicle

Spermicide

Powder Surgical glove powder

Enzyme immobilization

Film /membrane Dialysis membrane

Contact lensWound dressing

Sponge Mucosal haemostatic dressing

Wound dressing

Fibres Improvement of dyeability

Miscellaneous

Anticholesteremic materials

Antigastritis agents

Anticoagulants


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CHITOSAN AS FIBRES IN MEDICALTEXTILES

Woven, non-woven fabrics, and knitted fabrics derivedchitosan fibers are amenable for use as wound-face pragents, wound-healing protective agents, and as woufilling agents.

It can be made into strong fibers that may be used as material and as a wound dressing when chopped fibe

incorporated into non-woven matrix. Non-woven fabrics has excellent characteristics as an a

Also a suitable material for absorbable, flexible suture fcontact with bile, urine and pancreatic juices.


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Medical textile products in perc

Percentage

Surgical Dressing

Surgical sutures

Contact lens

Artificial implants

Disposables

Sanitary napkinsChitosan can be uproducts contribut80% of total produ

medical textiles.


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REFERENCES

A.J Rigby, S.C. Anand, A.R. Horrocks, J. Text.Inst. 88(1997) 83-93.

T.L. Vigo, Textile processing and properties: Preparation, Dyeing, Performance, Elsevier, London, 1994.

M. Levin, S.B. Sello, Functional finishes (Part A), Marcel Dekker, Ne

C.G. Daughton, T. Ternes, Environ. Health Perspect. 107 (1999) 90

T.L. Vigo, Advantages in antibacterial polymers and materials, inand bioactive polymers, Gabelein, C., (Eds) Plenum Press, New Y225-237.

Alternate to collagen: Synthesis of artificial collagen gels based opolymerisable collagen-mimetic peptides. Murugesan Muthu, SaTony Cass, MagdiYacoub.

Imperial College, London, England, United Kingdom 61.2.SafavieJuncker D. Microfluidics made of yarns and knots: from fundameto simple networks and operations. Lab Chip.2011;11:261824.


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fungal chitosan in medical textiles

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