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Adenomyomatosis of the Gallbladder Ifeanyi Malu,BSc.,MA., RDMS expected Mrs. Shelia Chong, MBA, RDMS June, 2015

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Page 1: Gallbladder

Adenomyomatosis of the Gallbladder

Ifeanyi Malu,BSc.,MA., RDMS expectedMrs. Shelia Chong, MBA, RDMS

June, 2015

Page 2: Gallbladder

Normal Anatomy

GB parts• Neck• Body• Fundus-Body and neck directed toward porta hepatis-Fundus slants inferiorly to the right

--http://fitsweb.uchc.edu/student/selectives/Luzietti/Gallbladder_anatomy.htm

Page 3: Gallbladder

Normal Sonographic Anatomy

• The normal gallbladder wall appears as thin walled and anechoic

• Pear shaped saccular structure

-Ultrasoundpaedia.com

Page 4: Gallbladder

Sagittal Gallbladder

GB Sag Decub Adenomyomatosis of GB

• Diffuse gallbladder wall thickening including numerous intramural echogenic foci.

• “Comet-tail” reverberation artifact extends intraluminally from the near wall of the gallbladder.

-Ultrasoundpaedia.com

Page 5: Gallbladder

Adenomyomatosis of GBTransverse view

• Diffuse thickening of gallbladder wall

• Demonstrates circular band around the fundal region of the gallbladder wall

-Kilmas B., & Zegal (2015).

Page 6: Gallbladder

Normal Physiology

• Bile is stored in the GB until needed for digestion• The gallbladder is about 7.5–10 cm (3–4 inches) long and

about a 2.5 cm (1 inch) wide.• The gallbladder is made up of layers of tissue: -mucosa -muscular layer -perimuscular layer -serosa

-www.cancer.ca/en/cancer

Page 7: Gallbladder

Overview

• Adenomyomatosis of the Gallbladder is a common hyperplastic cholecystosis of the gallbladder wall

• Not malignant• May involve the gallbladder in a focal,

segmental, or diffuse form

-Dogra, V., & Karani, J. (2013).-Ryu et al. (n.d.).

Page 8: Gallbladder

Segmental Adenomyomatosis

• Segmental type is when the lesion is annular and separating the two compartments of the gallbladder

-Ozgonul, A., Bitiren, M., Guldur, M. E., Sogut, O., & Yilmaz, L. E. (2010).

Page 9: Gallbladder

Diffuse Adenomyomatosis

• Diffuse type is termed if it causes thickness in the gallbladder wall

-Ozgonul, A., Bitiren, M., Guldur, M. E., Sogut, O., & Yilmaz, L. E. (2010).

Page 10: Gallbladder

Fundus Adenomyomatosis

• Fundal type is defined if the lesion is localized on the “base of the gallbladder through the lumen in a hemispheric shape.”

• May appear as a discrete mass, known as an adenomyoma

-Ozgonul, A., Bitiren, M., Guldur, M. E., Sogut, O., & Yilmaz, L. E. (2010).

Page 11: Gallbladder

Transverse gallbladder fundus highly with echogenic foci within the mass

Sirigu,D. (2015).

Page 12: Gallbladder

Normal Relevant Vascular Anatomy

http://blogs.nvcc.edu/rkeith/2012/02/10/holy-gallstones-batman/

Page 13: Gallbladder

Normal Relevant Vascular Sonographic Anatomy

• Color Doppler demonstrates a twinkle artifact arising from one of the hyperechoic foci within the mass

-Sirigu, D. (n.d.).

Page 14: Gallbladder

Relevant Diagnostic Imaging Test

• Ultrasound• MRI• CT• NM• MRCP (or oral cholecystography)• Plain X-Ray

Page 15: Gallbladder

Relative Sensitivities of CT,MRI,& MRCP in the Diagnosis

-Hiroki, H., Tomoaki, I., & Hironobu ,S. et al.(2003).

Page 16: Gallbladder

Ultrasound Modality• Mural thickening (diffuse, focal, annular)

– segmental/annular form is especially difficult to distinguish from gallbladder carcinoma

• Comet-tail artifact• Considered to be the diagnostic findings on ultrasound

examination includes intramural cystic formation (anechoic diverticula) with echogenic foci and/or reverberation artifacts together with full or partial thickening of the gallbladder wall

-Ryu, Y. (n.d.).-Ghersin, Soudack, &Gaitini (2003

Page 17: Gallbladder

Sonogram in a patient with adenomyomatosis.

Adenomyomatosis GB Ultrasound Preferred

• Ultrasonography (US) is the favorite radiologic examination

• On US, diffuse or segmental gallbladder wall thickening is evident

-Dogra, V., & Karani, J. (2013).

Page 18: Gallbladder

Sonographic Appearance

• Sonographic appearance of GADM includes the following findings:

-focal or diffuse thickening of the gallbladder wall, -small anechoic cystic spaces within the affected portion of the wall, representing Rokitansky-Aschoff sinuses, and -intramural echogenic foci with or without associated acoustic shadows or reverberation artifacts.

Ghersin, Soudack, &Gaitini (2003).

Page 19: Gallbladder

Sag view of GADM

Hyperechoic • Longitudinal sonogram of

gallbladder shows a hyperechoic focus in the anterior wall with reverberation artifact, which is characteristic of hyperplastic cholecystosis.

-Dogra, V., & Karani, J. (2013).

Comet-tail Artifact

Page 20: Gallbladder

CT Modality

• Abnormal gallbladder wall thickening and enhancement

• Rokitansky-Aschoff sinuses of sufficient size can be visualized

• Reveal a thickened gallbladder wall with the rosary sign

Ryu, Y. (n.d.).

Page 21: Gallbladder

CT Images

CT modality• CT abdomen coronal Several

stones of various size are noted in the gallbladder. The gallbladder is not well extended and shows some mural enhancement. In the fundus and also more proximally at the infundibulum some dilated intramural diverticula are seen, so-called rosary sign.

-Ryu, Y. (n.d.).

CT

Page 22: Gallbladder

MRCP (or oral cholecystography)

• Does not rely on contrast opacification of the lumen of the gallbladder. MRCP is also able to show:

• mural thickening• focal sessile mass• pearl necklace sign • hourglass configuration in annular types

-Ryu, Y. (n.d.).

Page 23: Gallbladder

MRCP

MRCP• Numerous T2 hyperintense

intramural gallbladder foci are isointense to bile on T2 weighted sequences

-Kilmas B., & Zegal(2015)

MRCP Image

Page 24: Gallbladder

Oral cholecystogram

• Oral cholecystogram shows focal fundal thickening in a patient with focal fundal adenomyomatosis

• Better seen after partial contraction of the GB

-emedicine.medscape.com-Hagan-Ansert, S. (2012).

Page 25: Gallbladder

Pain in the right upper abdomen Ultrasound Images of Adenomyomatosis of the gallbladder with a thickened wall longitudinal

Color doppler shows twinkling artefacts caused by cholesterol crystals in the wall

.

-ultrasoundcases.info

Page 26: Gallbladder

Ultrasound Images:Color Doppler

ultrasoundcases.info

Page 27: Gallbladder

Ultrasound Images: Transverse view

ultrasoundcases.info

Page 28: Gallbladder

MRI

• Demonstrates Pearl necklace sign • Diffuse-type adenomyomatosis typically

shows early mucosal enhancement and subsequent serosal enhancement.

• Localized adenomyomatosis exhibits homogeneous enhancement

Ryu, Y. (n.d.).

Page 29: Gallbladder

MRI

MRI• Gallbladder wall thickening

with numerous T2 hyperintense intramural foci which are isointense to bile on T2 weighted sequences

Kilmas B., & Zegal(2015)

MRI IMAGE

Page 30: Gallbladder

Nuclear Medicine

• FDG-PET– metabolic characterization with PET has been

suggested as a useful adjunct in problematic cases

Ryu, Y. (n.d.).

Page 31: Gallbladder

Images Modalities

• US cannot differentiate between the segmental type of adenomyomatosis and gallbladder carcinoma

• On US, diffuse or segmental gallbladder wall thickening is evident

• Radiography is not the preferred choice• CT is useful in excluding gallbladder carcinoma.• However,ultrasonography (US) is the preferred

radiologic examination Dogra & Karani (2013)

Page 32: Gallbladder

Sonography Indications

• Acute RUQ pain• Non-visualization of GB on OCG• Excessive burping or nausea

-Chong,S. (2015)

Page 33: Gallbladder

GB Sonographic Technique

• NPO (at least 6-8 hours before the exam)• 3.5MHZ transducer used for average patient• 5.0 MHZ, 7.5MHZ or 10MHZ for very thin

patient• Must be imaged in both longitudinal and

transverse

-Chong, S. (2015).

Page 34: Gallbladder

Sonographic Scan Protocol

• Entire GB• GB, Neck• GB, Body• GB,Fundus• CBD( with color

Doppler)

-Chong, S. (2015).

Page 35: Gallbladder

Sonography Indications

• May be asymptomatic• RUQ abdominal pain• Nausea• Vomiting

-Chong,S. (2015).

Page 36: Gallbladder

Pathology Description

• Pathologically, defined as epithelial proliferation and hypertrophy of the muscularis of the gallbladder, with “outpouching of the mucosa into the thickened muscular layer.”

• Rokitansky-Aschoff sinus within the thickened muscular layer of the gallbladder

-

-Hiroki, H., Tomoaki, I., & Hironobu ,S. et al.(2003).

Page 37: Gallbladder

Epidemiology

• Common in women• Patients over 40 years has higher incidence

-Chong, S. (2015).

Page 38: Gallbladder

Etiology

• Unknown

-Kilmas B., & Zegal ,H.(2015).

Page 39: Gallbladder

Abnormal Physiology

• Gallbladder adenomyomatosis (GADM) is a “common acquired benign hyperplastic disease of the gallbladder mucosa” .

• Sonographically, it is characterized by diffuse or focal thickening of the gallbladder wall associated with small intramural cystic spaces, known as Rokitansky-Aschoff sinuses.

-Ghersin, Soudack, &Gaitini (2003)

Page 40: Gallbladder

Abnormal Clinical Findings

• May be asymptomatic• RUQ pain• Nausea• Vomiting

-Chong, S (2015).

Page 41: Gallbladder

Abnormal Sonographic Findings

• May be diffuse thickening of the wall• Present as a circular band around a section of

the wall-around the fundal area• Segmental and focal adenomyomatosis may

be difficult to differentiate from gallbladder carcinoma

-Sirigu,D.(n.d.).

Page 42: Gallbladder

Abnormal Sonographic Findings

• Does not move with position changes• Associated with comet tail artifact• Papillomas may occur singly or in groups

-Hagan-Ansert,S. (2015).

Page 43: Gallbladder

Treatment & Monitoring

Treatment• Elective surgery is often

performed in patients with right upper quadrant pain

Monitoring• Ultrasound

Page 44: Gallbladder

Differential diagnosis

• Gallbladder carcinoma• Phrygian cap• Gallbladder polyp (cholesterol polyp)• Cholelithiasis• Adenoma

-Ryu et al. (n.d.).

Page 45: Gallbladder

Prognosis

• Cholecystectomy may be performed as a result of one or more of the following:

-patient symptomatic with RUQ pain -focal appearances may be difficult to distinguish from malignancy

-http://radiopaedia.org/articles/adenomyomatosis-of-the-gallbladder

Page 46: Gallbladder

References• Adusumilli,S.,& Siegelman, E.S.(2005). MRI of the bile ducts, gallbladder,

and pancreas. In: Siegelman ES., ed. Body MRI. Philadelphia: Elsevier Inc.; 2005: 63-127

• Chong, S. (March, 2015). Gallbladder Lecture Handout. Sanford-Brown Institute, Garden City NY

• Dogra, V., & Karani, J. (2013). Adenomyomatosis Imaging. Electronically retrieved from http://emedicine.medscape.com/article/363728-overview#a1

• Ghersin,E., Soudack,M., & Gaitini,D. (2003). Twinkling Artifact in Gallbladder Adenomyomatosis. Retrieved from http://www.jultrasoundmed.org/content/22/2/229.full.pdf+html?sid=a5031d87-4b49-45f8-88a0-6ac8ea2040c2

Page 47: Gallbladder

References

• Hagen-Ansert, S.L. (2012). Textbook of Diagnostic Sonography: 2-Volume Set, 7e. Elsevier, Mosby

• Hiroki, H., Tomoaki, I., & Hironobu ,S. et al.T(2003). The pearl necklace sign: an imaging sign of adenomyomatosis of the gallbladder at MR cholangiopancreatography. Radiology.2003; 227: 80-88

• Kilmas B., & Zegal ,H.(2015). Adenomyomatosis. Electronically retrieved from http://sonoworld.com/CaseDetails/Adenomyomatosis.aspx?ModuleCategoryId=631

• Ozgonul, A., Bitiren, M., Guldur, M. E., Sogut, O., & Yilmaz, L. E. (2010). Fundal Variant Adenomyomatosis of the Gallbladder: Report of Three Cases and Review of the Literature. Journal of Clinical Medicine Research, 2(3), 150–153. doi:10.4021/jocmr2010.05.338w

• Ryu, Y., et al. (n.d.). Adenomyomatosis of the Gallbladder. Available at http://radiopaedia.org/articles/adenomyomatosis-of-the-gallbladder

Page 48: Gallbladder

References• Sirigu, D. (2015). Adenomyomatosis (adenomyomatous hyperplasia) of the

gallbladder. Available at http://sonoworld.com/CaseDetails/Adenomyomatosis_(adenomyomatous_hyperplasia)_of_the_gallbladder.aspx?CaseId=485