gender differences and substance abuse: eliminate
TRANSCRIPT
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#Rx Summit www.NationalRxDrugAbuseSummit.org
Gender Differences and Substance Abuse: Eliminate Discrimination,
Improve Treatment and Save LivesAndrea Barthwell, MD, DFASAM, Founder and Director
Two Dreams Treatment CentersShruti Kulkarni, JD, Policy Director,
Center for Lawful Access and Abuse DeterrenceBehshad Sheldon, Chair, Board of Directors,
Female Opioid-Addiction Research and Clinical Experts
Advocacy Track
Moderator: Michael Barnes, JD, Chairman, Center for Lawful Access and Abuse Deterrence, and Member, National Rx
Drug Abuse & Heroin Summit Advisory Board
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Disclosures
Shruti Kulkarni, JD, and Michael Barnes, JD, have disclosed no relevant, real, or apparent personal or professional financial relationships with proprietary entities that produce healthcare goods and services.
Andrea Barthwell, MD, DFASAM – Consulting fees: Braeburn Pharmaceuticals, Appletree Partners, Ideal Option, Treatment Management Company, LLC; Ownership Interests: Encounter Medical Group, Treatment Partners, EMG Global
Behshad Sheldon – Salary and Ownership Interest: Braeburn Pharmaceuticals
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Disclosures
All planners/managers hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months.
The following planners/managers have the following to disclose:- Kelly J. Clark, MD, MBA, FASAM, DFAPA –
Consulting fees: Braeburn, Indivior
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Learning Objectives
Describe how gender differences play an important role in addiction and other disease progression, effects of medications, and barriers to treatment.
Identify laws and other institutionalized sanctions that are levied against people with SUDs —especially against women with addiction.
Recommend practical solutions that can help improve treatment and reduce discrimination and societal costs.
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Gender Differences and Substance Abuse: Eliminate Discrimination,
Improve Treatment and Save LivesAndrea Barthwell, M.D., D.F.A.S.M.
Behshad SheldonShruti Kulkarni, J.D.
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https://www.vogue.com/article/opioid-crisis-womens-health-heroine-oscar-nominated-documentary-
addiction-recovery
It’s Time to Talk About the Opioid Crisis as a Women’s Health IssueMARCH 6, 2018 4:38 PMBY IVANA RIHTER
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Disclosures: Dr. Andrea Barthwell
Apple Tree Partners (Consultant) Braeburn Pharmaceuticals (Consultant) Encounter Medical Group, P.C. (Partner) Ideal Options (Consultant) Treatment Management Company LLC
(Consultant) Treatment Partners LLC (Owner) Two Dreams (Founder) U.S. DOJ (Consultant)
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Disclosures: Behshad Sheldon
Epiodyne (consultant) R-pharm-US (consultant) Camurus (consultant)
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Disclosures: Shruti Kulkarni
Shruti Kulkarni has no relevant, real or apparent, personal or professional, financial conflicts to disclose. CLAAD’s funders include members of the
pharmaceutical, addiction treatment, and laboratory industries, and are disclosed on its website, www.claad.org.
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Topics
Women’s Health Considerations Substances and Consequences Screening Tools Treatment Needs Regulatory, Legislative, and Policy
Considerations Call to Action
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Fundamental Beliefs
Drug use is a preventable behavior Addiction is a
treatable disease of the brain Recovery is possible
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To link to this article: http://dx.doi.org/10.1080/10550881003684640
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Women’s Health
572,000 admission to SA Tx vs. 182,000 diagnoses of breast CA (2006) $182 billion per year Historical perspective
- Social exclusions- 1973 Our Bodies, Our Selves- 1994 NIH Guidelines
Exclusions c/w fetal health, premature birth, LBW, language developmental delays
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Special Characteristics
Initiate later than men Lower educational attainment Lower employment rates Lower average age at admission More likely to have using partner More likely to have major psychological
diagnosis- Major depression- Predates substance use
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Telescoping
Well established with alcohol Progress faster than in men to alcoholism, to
consequences, from 1st use to dependence, from regular use to problematic use 50-100% higher rate of premature death More circulatory and hepatic disease Comparable incidence of ulcer, GI bleeds, fatty
liver, obesity, anemia, malnutrition
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Alcohol and Telescoping Theories
- Lower free body water leads to higher BAC at same rates of consumption
- Lower alcohol dehydrogenase with lower metabolism and higher absorption
Socio-cultural rituals and protective factors- Binge rates 28 to 34% from 1995 to 2007- Senior drinking over 5 per session point
difference dropped from 23 to 7 from 1975 to 2006
- Single sex settings
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Conditions Liver: mortality 2x greater for men over women but
cirrhosis develops at faster rates for women v. men Cirrhotic threshold at half the rates for women v.
men (7-13 v. 14-27 drinks per week) -Becker Cardiovascular disease: 35% of U.S. women with
disease, heavy drinking increases risk- Saremi- moderate drinking is protective but >
3/day raises TG, cardiomyopathy, HTN, and stroke
- Ikehara- 3500 men and 4900 women studied increased risk of coronary disease; in men 69 gm, in women 23-46 grams. 3x increased if > 46 grams/day
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AHA Recommendations
To protect against cardiac disease, drinking is not as effective as:- Decreasing cholesterol- Decreasing BP- Balancing diet- Regularly exercising- Controlling weight
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Endocrine
Alcohol increases cortisol, which increases HTN and metabolic disturbances, decreases immune function, and disturbs the HPA axis In 2005, > 60% women were overweight or
obese- 80% NHB women- 70% H women- Associated with cardiac disease, HTN, Type
II DM, and respiratory cancers
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Endocrine, continued
Schroder: > 3 drinks/day associated with abdominal obesity (Type II DM) DM: 9.5 million women with diagnosis, 2.5
million undiagnosed, 23 million pre-diabetic Women > men with diagnosis, especially NHB
women (106/1000 v. 69/1000 NHW women)- Abstinence and high consumption increases
risk
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Endocrine, continued
Osteoporosis: 8 million in U.S. (80% of cases) Felson et al- 7 oz./week increases risk of hip
fracture- Women (54% increase) v. men (26%)
Kanis- Review of 3 studies (6,000 men v. 11,000 women)- With moderate and large amounts consumed,
increase risk of fracture, osteoporotic fracture, and hip fracture
Diaz- decreased risk of vertebral deformity if alcohol consumed > 5 day/week in > 65 y/o
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National Osteoporosis Foundation Recommendation
Do not drink for benefit Weight bearing exercise to increase bone
density Prevention with family history
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Cancer
Lung- 219,000 per year- Bandera et al- research inconclusive- Pollack- if > 40 ounces/month see 2x incidence- Djousee- 2 drinks/day is associated with 2x
incidence lung CA Breast- 2.5 million women with diagnosis, > 40,000
die annually- Irrespective of what is consumed, alcohol
increases risk of CA- Allen et al- 1.28 million women studied, for every
10 gm increase/day, risk of CA increases 12%
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Cancer, continued
Breast, continued- Longnecker- with increasing age, risk
increases with increasing consumption (if over 30 y/o)
GU CA- endometrial CA is most common in reproductive tract; 554,000 - Studies inconclusive, but suggestive
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Other Cancers
Allen et. al Million Woman Study (1.28 million middle-aged women followed 7 years)
69,700 cancers during f/u- 10% rectum- 24% liver- 12% breast increased with every 10 gm
increase/day - 29% H and N, oral cavity, pharynx- 22% esophagus- 44% larynx
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Work Up
CAGE TWEAK T-ACE AUDIT Apply when woman has
- Vague c/o- Stressful life events- Partner who uses- Quasi-legitimate use as a medicine
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Social Consequences
Intimate partner violence HIV/AIDS STDs
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The more we know about the complexity of addiction, the more effectively we can treat it and advocate for those with the disease.
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IOM, Broadening the Base of Treatment for Alcohol Problems, Washington, D.C.: National Academy Press, 1990a.
“The overall goal of treatment is to reduce or eliminate the use of alcohol [and/or other drugs] as a contributing factor to physical, psychological, and social dysfunction and to arrest, retard, or reverse the progress of any associated problems.”
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Treatment is…
Identification Brief intervention Assessment Diagnosis Counseling Medical, psychiatric, psychological, and social
services Follow-up
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Treatment Gap
Did not feel need for treatment5,938,000
Received treatment1,400,000
Sought but did not get treatment88,000
Felt need but did not seek treatment274,000
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Current Knowledge
Some is better than none More is better than less Treatment is best when driven by
assessment, buttressed with case management, and completed with follow up care in the community
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Motivation to Enter/Sustain Tx
Need not be voluntary Sanctions/enticements can increase
entry/retention Similar outcomes no matter the cause
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Non-Medication Treatments
May be effective for some people May work only to a certain point Need to target the non-rational survival brain,
not just the cortex
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Medication Targets
Facilitate treatment- Restore homeostasis- Co-morbid conditions
Relapse prevention- Stress reduction- Cues/craving/withdrawal- Cognitive/decision pause (thought to action)- Block action of drugs
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Combination Treatments
Medications in combination with counseling and psychotherapies may be the best addiction treatment we have at this point- Treat the survival/pleasure system
abnormalities with medications to facilitate abstinence and prevent relapse
- Treat the cortical decision-making system with counseling and therapies
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The Disease is Addressed With…
Non-medical treatment Medications Peer support Professional guidance Exercice Diet Ritual
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Twelve Step Facilitation Brain Recovery
Supports abstinence- Tones down the drive of the pleasure-reward
pathway Retrains the brain
- Provides healthier structure and ritual- Offers specific suggestions on a new way of
living and behaving Retools the emotions
- Modulates emotions- Works through connections with others- Provides safe structure for expression
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TSF Brain Recovery, cont.
Offers a range of interventions- Simple (slogans) to complicated (in-depth Step
work) for different stages of brain healing and recovery
Builds responsibility and better judgment- Provides a blueprint for living sober (Steps)- Exercises the prefrontal cortex - Provides constant reminders of needed behavior
changes and reinforcement of changes Is (almost) always available
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Mature Recovery
Well-learned habits of avoiding dangers Ample social networks Solid intimate relationships Healthy recreation and relaxation Employment and career development Philosophy of life Key activities or interests Acceptance of the past
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Gender Differences
Most research until recently was gender neutral Missed opportunities for prevention, incorrect
diagnoses, misinformed treatments, sickness, and death- 8 of the 10 prescription drugs withdrawn from the
market from 1997 to 2001 posed greater health risks for women than for men
- In 2013, FDA recommended first sex-specific dose (zolpidem)
• Medication on market 20 years
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Gender Differences
Biology - Fat storage – antipsychotics, antidepressants,
and antianxiety - Digestion/gastric acid – antifungals
(ketoconazole), antibiotic (tetracycline)- Other sex-related factors – heart medications,
pain medication Estrogen
- Fluctuations- Liver - Kidney
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Barriers to Women Seeking Treatment
Greater risk of arrest and criminalization - 24 states & DC consider substance use during pregnancy
to be child abuse; 3 consider it grounds for civil commitment
- 23 states & DC require health care professionals to report suspected prenatal drug use
Lack of Access - Only 10 states prohibit publicly funded drug treatment
programs from discriminating against pregnant women- Only 19 states have treatment programs specifically
designed for pregnant women Lack of childcare
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Recent Setbacks and Progress
Setbacks - States continue introducing new legislation criminalizing
women with SUD (e.g., MT & MO) Progress
- KY – PATHways, a one-stop shop for pregnant women in recovery, offering counseling, MAT, prenatal care, and parenting classes.
- MD – Launching coalitions to help women in recovery by providing supportive housing that welcomes children
- NJ – Allocated funding for gender-specific addiction plans that include family-centered treatment and trauma-informed care
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Federal Initiatives FDA – Diverse Women in Clinical Trial Initiative
- Office of Women’s Health, in collaboration with the NIH Office on Research in Women’s Health, launched the initiative to raise awareness about the importance of participation of diverse groups of women in clinical research, and to share best practices about clinical research design, recruitment, and subpopulation analyses
Improving Treatment for Pregnant and Postpartum Women- Authorizes $100 M to provide substance use treatment for pregnant
and postpartum women through programs in which, during the course of receiving treatment, (1) the women reside in facilities provided by the programs; (2) the minor children of the women reside with the women in such facilities, if the women so request; and (3) certain services are available to or on behalf of the women
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SAMHSA Grant Proposals 13 states proposed programs that refer to pregnant or parenting
women as a priority or target population (AZ, AK, IN, KY, ME, MA, MN, MS, MT, NH, TN, TX, WV)
AZ: increase the likelihood of recovery success by expanding peer support services, recovery homes, and recovery supports to pregnant and parenting women
AK: expand availability of MAT for pregnant and parenting women WV: increase access to OUD treatment; supplement evidence-
based prevention, treatment, and recovery activities pertaining to opioids currently undertaken; and support a comprehensive response to the opioid epidemic statewide. Anticipates that program will serve 520 pregnant/postpartum women with prevention, early intervention, treatment, and recovery support services for SUD
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Policy Recommendations
Substance-related education and prevention Eliminate laws and other institutionalized forms of
discrimination Advance laws, policies, and programs that improve
access to treatment Advancing legislation to provide access to health
care in jails through private or public insurance Eliminating economic sanctions levied against
people whose SUDs are managed as a chronic disease
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Women’s Influence
Women are positioned to influence health care policies and practices Health care utilization Health care decision making FORCE: advocacy and activism
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Gender Differences and Substance Abuse: Eliminate Discrimination,
Improve Treatment and Save LivesAndrea Barthwell, MD, DFASAM, Founder and Director
Two Dreams Treatment CentersShruti Kulkarni, JD, Policy Director,
Center for Lawful Access and Abuse DeterrenceBehshad Sheldon, Chair, Board of Directors,
Female Opioid-Addiction Research and Clinical Experts
Advocacy Track
Moderator: Michael Barnes, JD, Chairman, Center for Lawful Access and Abuse Deterrence, and Member, National Rx
Drug Abuse & Heroin Summit Advisory Board
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