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Genetically ModifiedOrganisms

Conie Angulo

Ali M. MeghadadiWriting 39C/ 33374

June 4, 2014

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Problem

Lack of Organs

122,439 people that need an organsOnly 14,000 donors

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Genetically Constructed

Organs(Anthony Atala, Wake Forrest Baptist medical center)

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History Genetic Code

Stem Cell Research Tissue Engineering

Genetically

Constructed Organs

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Tissue Engineering

1. Obtain the

Cells2. Grow them

outside of the

body

3. Print the

scaffold

4. Scaffolds =

printed organBerger

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Problems

Early Works

Scientist estimate clinical trials in 10 to 15

years

More money and time is being spent

Technological barriers (unviable organs)

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Xenotransplantations

Practice oftransplanting,

infusing living

cells, tissues or

organs from one

species to another

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Successes

Transplanted cells have been used fordiabetes, Alzheimers and Parkinson's

disease

Helped show improvement in life threating

diseases

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Controversy

Moral and ethical

Views

Health Risks

Rejection Rates

Animal Activist

Protesters outside a lab in San Diego, 2002 (Berger)

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Future of medicine

Selective breeding

Immunosuppressant

and containment

Pigs are slaughtered

everyday Only possible

solution to the lack

of organs

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Works Cited

"Animal Organs in Humans: Unresolved Risks." U.S National Library of Medicine. U.S. National

Library of Medicine, 28 Oct. 2013. Web. 19 May 2014.

.

Atala Anthony: Printing a Human kidney Perf. Atul Gawande. TED Talk, 2011. Video.

Brunt, Keith R., Richard D. Weisel, and Li Ren-Ke. "Stem Cells And Regenerative Medicine --

Future Perspectives." Canadian Journal Of Physiology & Pharmacology90.3 (2012): 327-335.Academic Search Complete. Web. 1 May 2014.

"Diaries of Despair Protest ."Xenotransplantation (Animal to Human Transplants). Uncaged, n.d.

Web. 27 May 2014. .

Hani, Homayoun, et al. "Caprine Pncreatic Islet Xenotransplantation Into Diabetic

Immunosuppressed BALB/C Mice."Xenotransplantation21.2 (2014): 174-182.Academic Search

Complete. Web. 13 May 2014.

Heneine, W. (n.d.). [Web Based Recording]. How big is the risk? Organ farm Retrieved fromhttp://www.pbs.org/wgbh/pages/frontline/shows/organfarm/interviews/heneine.html

Piguet P, Poindron P (eds): Genetically Modified Organisms and Genetic Engineering in Research

and Therapy. BioValley Monogr. Basel, Karger, 2012, vol 3, pp 132

"Uniting People and Information to Help Save Lives." OPTN: Organ Procurement and

Transplantation Network. Health Resources and Services Administration, U.S. Department of

Health & Human Services, 1 May 2014. Web. 1 May 2014. http://optn.transplant.hrsa.gov.

Xenotransplantation Technology.Revivicor's Technology - Xenotransplantation Technology.Revivicor Incorporation, n.d. Web. 19 May 2014. .

http://optn.transplant.hrsa.gov/http://optn.transplant.hrsa.gov/http://optn.transplant.hrsa.gov/http://optn.transplant.hrsa.gov/