Genetics Lesson 1

Genetics Lesson 1DefinitionsAlleleGeneHomozygousHeterozygousDominantRecessiveCo-dominantDiploidHaploidKaryotypeChromosomeHomologousLocusGenotypePhenotype

Genetic Cross DiagramsMale or FemaleWhat are the chances of having a baby boy?Show the genotypic and phenotypic frequenciesGenetic Cross DiagramsHuntingtons Disease

A normal male reproduces with a female suffererWhat is the F1 filial generation?Provide the genotypic and phenotypic ratiosMonohybrid Inheritance inheritance of a single genePure breeding = HOMOZYGOUS throughout

Pea Flowers red, white and pinkPure bred red with Pure bred whiteF1 generation results =F2 generation results when crossed with pure bred redCystic FibrosisCross a Carrier female with a normal maleWhat are the chances of having a male carrier?

http://www.newscientist.com/article/dn10013-cystic-fibrosis-gene-protects-against-tuberculosis.html Why does Cystic Fibrosis still exist?Why are white people more likely to suffer from Cystic Fibrosis?

Describe and Explain

Sickle cell AnaemiaCo-dominanceCross a couple both with the sickle cell trait (heterozygotes)

Why would the sickle cell haemoglobin have a different structure to a normal haemoglobin?Does this set of chromosomes come from a male or female?

X and Y chromosomes

What kind of sex chromosomes are there in this persons sex cells?

XY

1 2 3 4 5

6 7 8 9 10

11 12 13 14 15

16 17 18 19 20

21 22 23

13DiseasesThe gene for Haemophilia is recessive but if you are a carrier you can have slight problems in clotting.The Queen is a carrier (Hh)What is her genotype?If she mates with another carrier what are the ratio of genotypes and phenotypes produced. Sex Determination and Sex LinkageSex Determination2 monthsSRY sex determining region of YWolffian DuctMullerian Duct

Duchenne Muscular DystrophyMutation in the dystrophin geneWeaknessIssues with walking and mobilityFibrosis of tendonsDuchenne Muscular DystrophySex LinkageI am red colour blind.If I were to mate with a normal sighted person (not a carrier)What are the chances of my children being colour blind?What are the chances of my Grandchildren being colour blind if they mate with a colour blind person?Show the genotype and phenotype ratios for each answer

Co DominanceCat CoatBrownGingerTortoiseshell

Page 124 Question 3Siamese catsTyrosinase Why are all kittens born the same colour then develop these markings?

AllelesPleiotropy

Polygenic Inheritance

Multiple AllelesBlood Groups

RBC Compatibility

Blood Groups ABO and Rhesus Groups

Rhesus = Antigen D on the surface of Red Blood Cell

How can the Rhesus type cause an issue during childbirth?ABO InheritanceA mother who is blood group A and a father who is blood group B have two childrenOne is group O and the other ABWhat are the genotypes of the parents, use a genetic diagram to answer your questionA woman of group A has a baby with group O. She does not know who the father is. A boyfriend had group B, her husband group AB. Who was the father?

Multiple alleles and Dominance hierarchyCoat ColourAgouti C AChincilla C ChHimalayan C HAlbion C aPedigree Charts page 120