genostar 2009 genostar bioinformatics solutions connecting, completing and exploring biochemical and...
TRANSCRIPT
Genostar 2009
Genostar Bioinformatics Solutions
Connecting, completing and exploring biochemical
and genomic data with Metabolic Pathway Builder
ChemAxon's User Group Meeting, June 3-4th
Genostar 2009
Genostar: about us
Located in the heart of the French Alps, near Grenoble
Grenoble area• Top center for research in France, outside Paris
21,000 researchers200+ laboratories
Strong life sciences research• French National Institute for Research in Computer Science and
Control (INRIA)• Atomic Energy Research Center (CEA)• Institute for Structural Biology• European Molecular Biology Laboratory (EMBL)
Genostar 2009
Genostar: about us
Genostar provides bioinformatics software, databases and analysis services for microbial research
Applications• Vaccine discovery and development• Drug discovery• Diagnostics• Agro-foods• Environment
Genostar 2009
Our offer: software, data and services
Products Metabolic Pathway Builder suite
Perform genomic, proteic, and metabolic research with a comprehensive software suite
GenoAnnot / ProteoAnnot Perform comparative genomic and proteic sequence annotation and reannotation
PathwayExplorer Perform comparative genomic and differential metabolic analyses
MicroB Database Integrate, rigorously cross-checked genomic, proteic, biochemical and metabolic data
on about 800 organisms
KDB Explorer Explore, visualize and highlight the metabolic and non-metabolic pathways specific to your organism
PathwayExplorer GenoMirror Local mirror to interactively explore KEGG data while maintaining research confidentiality
Services We provide a full range of bioinformatics analysis services
Genostar 2009
PathwayExplorer module
Draws on heterogeneous data into a powerful entity-relationship model
genomic (GenomeReviews, EMBL, Genbank),
proteic (Swiss-Prot),
classification (Enzyme, GO, NCBI taxonomy…)
biochemical (KEGG ligand),
metabolic (KEGG pathways),
expression data
Comparative genomics and metabolomics• Integrates proprietary and public methods: EC prediction,
pattern inference, homologies and syntons computations…• Interactive and specialized viewers
Marvin, Jchem BaseInteractively explore and visualize metabolic pathways
Compare your own data with our reference database
Genostar 2009
PathwayExplorer and ChemAxon (1/4)
Run Chemaxon structural searche.g: search compounds that contain
benzoate substructure
Manage and display chemical compounds
with Marvin
Explore compoundsextracted from KEGG
ligand database
Genostar 2009
PathwayExplorer and ChemAxon (2/4)
Find and display biochemical reactions that involve a
benzoate derived compound
Genostar 2009
PathwayExplorer and ChemAxon (3/4)
Colorize reactions that involve benzoate derived compounds
Colorize catalyzed reactions Listeria Innocua Bacillus Subtilis
Genostar 2009
PathwayExplorer and ChemAxon (4/4) Select a pathway in the KEGG map… … and explore its genomic organization
Listeria innocua Bacillus subtilis
Compare syntenic regions• 1 operon in Bacillus• 2 operons in Listeria
Genostar 2009
Perspectives
Extend Metabolic Pathway Builder capacities further in the direction of cheminformaticsIncrease connections to external biochemical and chemical databases
(ChEBI and UniPathway, PubChem)
Integrate 3D facilities
(PDB, PubChem, MarvinSpace)
Implement structural analysis, predict molecular properties
(Calculator Plugins - Chemical Terms)
Extend partnerships to increase our capacity in drug discovery and molecular design
Genostar 2009
PartnersContact
Pierre-Emmanuel [email protected]
+33 476 97 10 74
Sophie Huet [email protected]
+33 476 97 10 78
Adrienne [email protected]
Thank you