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GI Viruses

Non-enteropathogenic

enteroviruses

reovirus

some adenoviruses

Opportunistic Viruses

HIV

Pathogenic GI Viruses

D and V Viruses Family Genome Structure

rotaviruses Reoviridae segmented ds RNA Naked

enteric adenoviruses

types 40, 41Adenoviridae

ds DNA segmented

linearNaked

calici viruses (norovirus,

sapovirusCaliciviridae ss +RNA linear

Naked, cup like

projections

astroviruses Astroviridae ss +RNA linear Naked, starlike

Enteric corona viruses Coronaviridae

Toroviruses Coronaviridae

Enteroviruses Family Genome Structure

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Poliovirus

Coxsackie A

Coxsackie B

ECHO viruses

Enteroviruses #68-71

Viruses that peak in the

winter

Corona, Influenza,

RSV, Rotavirus,

Astrovirus,

Bocavirus

Family

Picornaviridae,

genus Enterovirus

Naked, smallss + RNA

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Broad. Ranges from none

for 99% of ppl to URI

toaseptic meningitis to

paralytic poliomyelitis

(assymetric flaccid

paralysis, or bulbar poliowith loss of muscles of

respiration)

Infects lymphocytesin pharynx-

to intestines- to feces. Stops

here for most ppl, but some get

viremia and spread of virus to

liver and heart--> secondary

viremia with high levels of virus

able to cross BBB

-Herpangina (vesicular

pharyngitis).

-Hand, Foot, and Mouth

Disease.

-Aseptic Meningitis

-Heart defects in

newborns.

all of these use fecal-oral route

-Acute Infectious

myocarditis

-Pericarditis

similar to coxsackie, but

less severe, aseptic

meningitis

acute Hemorrhagive

conjunctivitis

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Prevention/Treatment Other

Rotateq vaccineis good

for prevention or at least

reduction in severity of

infection. Doses are given

during time infant has no

Ab's

Types A,B,C. A has

Four serotypes and

is most common in

US. C is mostcommon in Asia

Outbreaksworldwide of D and

V, including

Norwalk OH and

Sapporo Japan

Prevention/Treatment Other

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Poliovirus vaccine,

trivalent(three serotypes,

need immunity to all

three). Live or killed

(each has pros and

consIgA vs IgG, antigenic

load)

Enteric, cytopathic,

human orphan, 32

serotypes