gigantism
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Gigantism
Table 4Kevin Knox, Kaley Miller, Hailey Ray, Ashley Spaulding
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Symptoms
•Pretty big people (usually two standard deviations above normal height should be)
•Delayed puberty•Double vision or difficulty
with side vision
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•Headaches•Increased sweating•Irregular periods
(females)•Large hands and feet
with large fingers and toes
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•Release of breast milk•Thickening of facial
features•Weakness•Bulging forehead
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Causes•***Excess of growth
hormone ***(Acromegaly)
•Most commonly: Noncancerous(adenoma) tumor of the pituitary gland
•Carney complex
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•Medications that reduce growth hormone release such as somatostain analogs
•Dopamine aganoists but they are the least effective
Possible solutions
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Radiation therapy can be used to bring the growth hormone level back to normal but it take 5 to 10 years to take full effect and often effects other pituitary hormones
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•Removal of tumor on pituitary through endonasal surgery (through nose)
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Exams and Tests
•CT or MRI scans•Failure to suppress serum growth
hormone (GH) levels after an oral glucose challenge (maximum 75g)
•High prolactin levels•Increased insulin growth factor-I (IGF-I)
levels
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Miscellaneous
•Female to male ratio of 1:2 (twice as common in males)
•Commonly occurs with Acromegaly •App