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Global antimicrobial resistance surveillance system (GLASS) Workshop on Innovave Approaches to Establishing and Strengthening Regional Integrated and Laboratory Networks for Disease Control, Prevenon and Clinical Care in Africa Africa CDC, Addis Ababa, 27 th - 29 th March 2017 Christoph H. Larsen ([email protected])

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Page 1: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

Global antimicrobial resistance surveillance

system (GLASS)

Workshop on Innovative Approaches to Establishing and Strengthening Regional Integrated and Laboratory Networks for Disease Control, Prevention and Clinical Care in AfricaAfrica CDC, Addis Ababa, 27th - 29th March 2017

Christoph H. Larsen ([email protected])

Page 2: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

2

GLASS – Global Report 2014: Lessons learned

GLASS – Purpose and implementation strategy

GLASS – Data collected, data flow

GLASS – Next steps

Challenges

Outline

Page 3: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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2014 – Global Report on AMR

2015 – Development of global standards, tools

21st March 2016 – GLASS call for enrolment (ongoing)

01st April 2017 – Data call opens

Timeline

Page 4: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

4

?

Global Report 2014: Lessons Learned

Page 5: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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Global Report 2014: Lessons Learned

Page 6: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

6

Regional Netw

ork

Reg

ion

al N

etw

ork

Global Report 2014: Lessons Learned

Page 7: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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Lack of common standards and coordination

Country data not shared with national bodies

Global Report 2014: Lessons Learned

Page 8: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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Lack of common standards and coordination

Country data not shared with national bodies

Isolate-based strategy

Global Report 2014: Lessons Learned

Page 9: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Purpose

Foster national AMR surveillance systems with globally agreed standards

Present quality data as actionable information for informed decision-making

Page 10: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Implementation Strategy

Initially focus on selected pathogen | antibacterial combinations in humans

Collect clinical, laboratory, epidemiological data

Page 11: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Data Collected Annually

Key performance indicators of national AMR surveillance system

Patient core epidemiological data, i.e. age, gender

Aggregated AMR data of selected pathogens

Newly suspected or detected types of AMR

Page 12: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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Sample-based strategy

GLASS – Data Collected Annually

Page 13: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Data Collected Annually

8 selected pathogens:Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus,S. pneumoniae, Salmonella spp, Shigella spp,N. gonorrhoeae

4 sample types:blood, urine, stool, urethral / cervical swabs

Standard pathogen | antimicrobial combinations,plus: country-specific modifications

Page 14: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Data Flow

Page 15: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Data Flow

= ± +

EQA

LIMSAccredita

tion

(e.g. SLIPTA

/SLMTA)

HMIS

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GLASS – Data Flow

Page 17: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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Regional Network

Regio

nal N

etwo

rk

GLASS – Data Flow

Page 18: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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21st March 2016 – GLASS call for enrolment (ongoing)

1st April 2017 – GLASS call for data

2018/2019 – Links to: AMU, EML, HIV, TB, malaria

2019 – One Health: animal and environmental domains

Next Steps

Page 19: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

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GLASS – Challenges

Availability and quality of laboratory results

Change of paradigm from isolates to cases

AMR data management at laboratory and national levels

Page 20: Global antimicrobial resistance surveillance system (GLASS) · GLASS – Data Collected Annually 8 selected pathogens: Acinetobacter spp, E. coli, K. pneunomiae, S. aureaus, S. pneumoniae,

Merci

GLASS SecretariatTechnical teamCHOWDHARY, TejinderEREMIN, SergeyESCHER, MartinaGRISKEVICIENE, JolantaLARSEN, Christoph H.MANGLANI, SapnaPESSOA DA SILVA, Carmem Lucia (Lead)TORNIMBENE, Barbara

Administrative supportFIAWOO-MARKHAM, Mawuto

አመሰግናለሁTh

ank

you

اوي متشكر

Obrigado