global rare fungal infection registryfungi.ro/wp-content/uploads/2013/01/fungiscope_2011.pdf ·...

Global Rare Fungal Infection Registry since 2003

Report October 2011

Working group of the

Under the auspices of

Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck and Pfizer

Study Co-ordinators ................................................................................... 3

Introduction .............................................................................................. 6

Current Results .......................................................................................... 9

Achievements and Goals ........................................................................... 16

Presentations 2010 and 2011 ................................................................. 16

Publications .......................................................................................... 18

Awards ................................................................................................ 18

2011 and 2012 Goals ............................................................................. 19

Long-term Goals ................................................................................... 19

Contact Information ................................................................................. 20

Participating Institutions ........................................................................... 21

Report October 2011 of 33

Study Co-ordinators

Clinical ID Microbiology Molecular Biology Pharmacology Pathology

Austria

Elisabeth Presterl, MD Allgemeines Krankenhaus -Universitätskliniken Wien Währinger Gürtel 18-20 1090 Wien T +43-1-40400-4440 F +43-1-4400-4418 elisabeth.presterl@meduni wien.ac.at

Cornelia Lass-Flörl, MD Institute of Hygiene, Microbiology and Social Medicine Universität Innsbruck Fritz-Pregl-Str. 3 6020 Innsbruck T +43-512-9003-70725 F +43-512-9003-73700 [email protected]

Walter Buzina, MD Institut für Hygiene Medizinische Universität Universitätsplatz 4 8010 Graz T +43-316-380-7719 F +43-316-380-9648

[email protected]

Ulrich Strasser. MD Institut für Pathologie Medizinische Universität Innsbruck Müllerstr. 44 A-6020 Innsbruck T +43-512-9003-71304 F +43-512-582-088 [email protected]

Brazil

Marcio Nucci, MD Hospital Universitário Universidade Federal do Rio de Janeiro Av. Brigadeiro Trompovsky S/N 21941-590 Rio de Janeiro T +55-21-2562-2463 F +55-21-2562-2460 [email protected]

Czech Republic

Zdeněk Ráčil, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420-53223-2830/3642 F +420-53223-3603 [email protected]

Iva Kocmanova, MD Dept. of Microbiology University Hospital Brno, Jihlavska 20 62500 Brno T +420 53223 2974 [email protected]

Martina Lengerova, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 3642 [email protected]

Mojmir Moulis, MD Dept. of Pathology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 1111 [email protected]

Ludmila Malaskova, MD Dept. of Biochemistery University Hospital Brno Jihlavska 20 62500 Brno T. +420 53223 3073 [email protected]

mailto:elisabeth.presterl@meduni%0Bwien.ac.at�

mailto:elisabeth.presterl@meduni%0Bwien.ac.at�

mailto:[email protected]�











Germany

Oliver A. Cornely, MD, FIDSA, FACP Klinikum der Universität Klinik I für Innere Medizin 50924 Köln T +49-221-478-6494 F +49-221-478-3611 [email protected]

Guido Fischer, MS, PhD Landesgesundheitsamt Baden-Württemberg Referat 96 - Arbeitsmedizin, umweltbezogener Gesundheitsschutz Nordbahnhofstraße 135 70191 Stuttgart T +49-711-904-39620 F +49-711-904-37105 [email protected]

Ralf Bialek, MD MVZ Labor Dr. Krause Steenbeker Weg 25 24106 Kiel T +49-431-388-252 [email protected]

Carsten Müller, MD Klinikum der Universität Institut für Pharmakologie 50924 Köln T +49-221-478-5066 F +49 221 478 7184 [email protected]

Axel Hamprecht, MD Klinikum der Universität Institut f. Mikrobiologie, Immunologie u. Hygiene Goldenfelsstr. 19-2 D-50935 Köln T +49-221-478 32023 F +49-(0)221-478-32134

[email protected]

India

Anupma Jyoti Kindo, MD Dept. of Microbiology Sri Ramachandra Medical College/Research Institute No.1, Ramachandra Nagar Porur, Chennai, 600 116 T +91-944-523-9196 F +91 44 2476 5608

[email protected]








Israel

Morad Wattad, MD Rabin Medical Center Infectious Diseases Unit 39 Jabotinski St. 49100 Petah Tikva T +972-3-937-7377 F +972-3-937-6365 [email protected]

Italy

Livio Pagano, MD Dipartimento di Ematologia Universita Cattolica del Sacro Cuore (Roma) Largo Francesco Vito 1 00168 Roma T +39-6-355-03953 F +39-630-51343 [email protected]

Maurizio Sanguinetti, MD Istituto di Microbiologia (Roma) Università Cattolica del Sacro Cuore Largo Francesco Vito 1 00168 Roma T +39-06-3015-4964 F +39-06-3051-152 [email protected]

Annamaria Tortorano, MD Dip. Sanità Pubblica-Microbiologia-Virologia Milano Università di Milano Via Pascal, 36/38 20133 Milano T +39-2-503-15145 F +39-2-503-15146 [email protected]

Andrea Novelli, MD Dipartimento di Farmacologia Università degli Studi di Firenze Viale Pieraccini, 6 50139 Firenze T +39-055-4271-286 F +39-055-4271-280 [email protected]

Gianluigi Vago, MD Department of Clinical Sciences Luigi Sacco Hospital University of Milan Via Pascal, 36/38 20133 Milano T +39 0285994869 F +39 0285994800 [email protected]

Turkey

Sevtap Arikan, MD Mycology Laboratory (Ankara) Hacettepe University 06100 Ankara F +90 (312) 3115250 [email protected]









Introduction The incidence of invasive fungal infections (IFI) is increasing in all parts of the world.

The etiology for this ongoing epidemiological development is not completely

understood. However, major contributing factors are the increasing number of

transplantation procedures undertaken around the world (estimated at 500,000 per

year), a widening of the indications for intensive chemotherapy, and the growing

number of other clinical conditions requiring immunosuppressive treatment.

Therapeutic standards have been developed for the most frequent IFI, i.e.

candidiasis, aspergillosis and cryptococcosis. But, the so called “rare fungi” are also a

reason for the increased number of IFIs. Thus clinicians are now facing infections

due to a variety of different fungi without any reliable treatment recommendations

and therapeutic decision making is not evidence based. Prevalence of “rare fungi” is

virtually unknown and there is an additional knowledge gap in pathogen biology,

since isolates have not been collected systematically.

In order to overcome the lack of knowledge on epidemiology, clinical course, biology

and pathomechanism and finally to develop an evidence based diagnostic-

therapeutic integrated approach of IFI caused by “rare fungi”, A Global Rare Fungal

Infection Registry – Fungiscope™ has been created.

Fungiscope™ uses a web-based electronic case form accessible via

www.fungiscope.net. For inclusion into the registry patients require cultural,

histopathological, serological or molecular evidence of IFI and the associated clinical

symptoms and signs. The clinical data on underlying disorder and IFI will be

collected and stored in an internet-based database. Additionally, the pathogen

strains and samples of infected tissue are collected, examined and stored in a bio-

bank – the Fungithek. The clinical and biological data are subsequently evaluated

and analysed. Figure 1 presents the data / sample flow and overall project structure.

The clinical database and the bio-bank are connected and accessable to the public

via a web-based search engine - FungiQuest (figure 2).

In the following report we introduce the most current results and achievements. We

also discuss future goals and ongoing developments of the project.


Figure 1: Project structure


Figure 2: FungiQuest database search engine


Current Results Until now, 257 evaluable cases have been documented. The most frequently

registered pathogens were Zygomycetes (n=97; 38%), yeasts (n=41; 16%),

Fusarium spp. (n=41; 16%), and Dematiaceae (n=31; 12%) followed by

Scedosporium spp. (n=15; 6%) and Penicillinum spp. / Paecilomyces spp. (n=9;

3.5%) (figure 3). The majority of patients were Caucasian followed by Asian and

North/South American Indian origins (figure 4). The contribution of cases by

country is shown in figure 5.

Sites of infection differ among pathogens, see figure 6. In patients with invasive

zygomycosis, the lungs were the most commonly involved organs with an

incidence of approximately 50%. Other involved sites were the paranasal sinuses,

the gastrointestinal tract, the central nervous system and deep soft tissues with

an equal distribution of approximately 10%. Fusarium spp. infections frequently

presented as disseminated infections (35%). Commonly involved organs were the

lungs, deep soft tissues and eyes. Infections with Dematiaceae mostly involved

the paranasal sinuses, deep soft tissues, lungs and eyes (range from 14% -

20%). By contrast, yeasts were mostly diagnosed from blood cultures

(approximately 45%) and presented as disseminated infections.

The evaluation of risk factors for the development of IFI revealed differences

between individual pathogens shown in figure 7. The most common risk factors

for developing an infection with Zygomycetes and Fusarium spp. were

chemotherapy or haematopoetic stem cell transplantation (HSCT) (approximately

60%) followed by stay at an intensive care unit and diabetes mellitus, with a

much lower frequency of approximately 20%. Hospitalization in an intensive care

unit and chemotherapy or HSCT remained the most common risk factors for a

yeasts infection, however, they were present with a frequency of only 30%.

Further risk factors were chronic renal or pulmonal diseases and diabetes mellitus.

By contrast, in patients with Dematiaceae infection, the most common risk factor

was diabetes mellitus (approximately 40%) followed by chemotherapy or HSCT

and chronic renal disease, both equaling approximately 15%.


Mortality, attributable mortality and IFI outcome differed among individual

pathogens and are shown in figure 8. The highest overall mortality was observed

in patients with zygomycosis infection, followed by patients with Fusarium spp.

and yeast infections. By contrast, the lowest overall mortality was revealed in

patients with Dematiaceae, equaling only 9%. The attributable mortality

correlated with overall mortality. The highest rates of complete and partial

remissions were observed in patients with IFI caused by Dematiaceae. Patients

with a yeats infection displayed the lowest rate of response to treatment.

In conclusion, the clinical relevance of invasive fungal infections by rare fungi is

increasing. In a short time, actual cases from several countries world-wide could

be documented and showed a broad spectrum of pathogens. Further investigators

and coordinators are encouraged to contribute to the success of Fungiscope™.

Figure 3: Distribution of 257 pathogens by major groups


Figure 4: Ethnicities


Figure 5: Case contributions by country


Figure 6: Risk factors for major groups


Figure 7: Sites of infection for major groups


Figure 8: Outcomes for major groups


Achievements and Goals Presentations 2010 and 2011

April 10-13, 2010 20th European Congress of Clinical Microbiology

and Infectious Diseases (ECCMID), Vienna, Austria

May 7-8, 2010 Paul-Ehrlich-Gesellschaft für Chemotherapie e.V.,

Spring Meeting of the “Sektion Antimykotische

Chemotherapie”, Bonn, Germany

June 18-19, 2010 MSD Workshop „Infektionen in der Hämatologie“,

Munich, Germany

June 23-26, 2010 10th Congress of Infectious Diseases and Tropical

Medicine, Cologne, Germany

September 9-11, 2010 44th Congress of the German Society for Mycology

(DMykG e.V.), Vienna, Austria

September 12-15, 2010 50th Interscience Conference on Antimicrobial

Agents and Chemotherapy (ICAAC), MA, Boston,

USA

October 1-5, 2010 Annual Congress of the German Society for

Hematology and Oncology (DGHO), Berlin,

Germany

March 31-April 2, 2011 Annual Congress of the German Society for

Infectious Diseases (DGI), Leipzig, Germany

May 7-10, 2011 21st ECCMID/27th ICC, Joint Congress of the

European Society of Clinical Microbiology and

Infectious Diseases and the International Society of

Chemotherapy20th, Milan, Italy

September 1-3, 2011 45th Congress of the German Society for Mycology

(DMykG e.V.), Kiel, Germany


October 2-5, 2011 5th Trends in Medical Mycology (TIMM), Valencia,

Spain

September 17-21, 2011 51th Interscience Conference on Antimicrobial

Agents and Chemotherapy (ICAAC), Chicago, USA

September 30-October 4, 2011 Annual Congress of the German Society for

Hematology and Oncology (DGHO), Basel,

Switzerland


Publications

December 2009 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V.

Rickerts, C. Lass-Flörl, C. Beisel, R. Herbrecht, Y.

Roth, G. Silling, A.J. Ullmann, K. Borchert, G.

Egerer, J. Maertens, G. Maschmeyer, A. Simon, M.

Wattad, G. Fischer, J.J. Vehreschild, O.A. Cornely

Forty-one Recent Cases of Invasive Zygomycosis

from a Global Clinical Registry

J Antimicrob Chemother. 2010 Feb;65(2):296-302

July 2008 Rüping M.J.G.T., Albermann N., Ebinger F.,

Burckhard I., Beisel C., Müller C., Vehreschild J.J.,

Kochanek M., Fätkenheuer G., Bangard C., Ullmann

A.J., Herr W., Kolbe K., Hallek M., Cornely O.A.

Posaconazole concentrations in the central nervous

system.

J Antimicrob Chemother 2008 Dec;62 (6):1468-70

Awards

Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology (DMykG e.V.) awarded to Dr. M.J.G.T. Vehreschild for her work on Fungiscope


2011 and 2012 Goals

Completion of molecular genetic analyses by Prof. Sybren de Hoog from the

CBS Fungal Biodiversity Center

Initiation of an epidemiological online survey to monitor trends

Publication of a subset analysis on rare yeasts, including resistance patterns

Publication of a comparison between sequencing and morphological results

for the first 100 Fungiscope isolates

Publication of a joint analysis on Fusarium spp. in cooperation with the

Brazilian Fusarium spp. Group, chaired by Prof. Nucci.

Extending the FungiQuest™ platform (online since April 2010):

o Faster inclusion of new cases

o Inclusion of FungiThek / isolate information

o Improved search-engine

Long-term Goals Susceptibility testing of all isolates

Comprehensive collection of clinical cases and corresponding isolates from

all continents

Open access structure offering data and isolates to research groups

Basic research

Microbiological studies

Diagnostic studies

Clinical trials


Contact Information

Chair:

Oliver A. Cornely, MD, FIDSA, FACP [email protected]

Coordinating Physicians:

Maria J.G.T. Vehreschild (née Rüping), MD [email protected]

Technical advisor, site operator clinicalsurveys.net:

Jörg J. Vehreschild, MD [email protected]

Uniklinik Köln

Infectious Diseases – Clinical Trials Unit II

BH E15 R64

Kerpener Strasse 62

50937 Köln

Germany

T +49-221-478-6494

F +49-221-478-3611 www.fungiscope.net




http://www.fungiscope.net/�


Participating Institutions Argentina

Infectologia, Fundaleu, Departamento Medico, Buenos Aires, Argentina Maria Cecilia Dignani

Instituto Nacional de Enfermedades Infecciosas "Dr. C. G. Malbrán", Buenos Aires, Argentina

Susana Cordoba

Centro de Referencia de Micología Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina Marisa Biasoli

Australia

Department of Microbiology & Infectious Diseases, Royal Perth Hospital, Perth, Australia

Christopher Heath

Austria

Abt. f. Anästhesie und Intensivmedizin, Wilhelminenspital Wien, Wien, Austria Peter Wimmer

Anästhesiologie und Intensivmedizin, Landesklinikum Thermenregion Baden, Baden, Austria

Franz Schwameis

Infektionen und Tropenmedizin, Universitätsklinik I für Innere Medizin, Medizinische Universität Wien, Wien, Austria

Christina Kratzer, Elisabeth Presterl

Institut für Anästhesie und Intensivmedizin, Landeskrankenhaus Steyr, Steyr, Austria

Achim von Goedecke

Institut für Hygiene, klinische Bakteriologie und Mykologie, Medizinische Universität Graz, Graz, Austria Walter Buzina

Institut für Hygiene, Mikrobiologie und Sozialmedizin, Medizinische Universität Innsbruck, Innsbruck, Austria

Cornelia Lass-Flörl, Isabella Schalk, Anna Huppert

Institut für Pathologie, Medizinische Universität Innsbruck, Innsbruck, Austria Ulrich Strasser

Kinder- Herzzentrum Linz, AKh Linz, Linz, Austria Werner Moosbauer

Klinik für Anästhesiologie, Wagner-Jauregg Nervenklinik, Linz, Austria Udo Illievich


Klinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Austria Sebastian Ott

Krankenhaushygiene, Landeskrankenhaus Klagenfurt, Klagenfurt, Austria Ulrich Zerlauth

Section of Infectious Diseases, Department of Medicine, Medical University of Graz, Austria Martin Hoenigl

Universitätsinstitut für Medizinische Mikrobiologie, Hygiene und Infektiologie - SALK Labor GmbH, Salzberger Universitätsklinikum, Salzberg, Austria

Markus Hell

Universitätsklinik für Dermatologie, Medizinische Universität Wien, Wien, Austria

Katharina Pfistershammer

Belgium

University Hospital Gasthuisberg , Leuven, Belgium

Johan Maertens, Isabel Spriet, Katrien Lagrou

Brazil

Hematology and Mycology Laboratory, Hospital Universitário Clementino Fraga, UFRJ, Rio de Janeiro, Brazil Marcio Nucci

Infection Control Dept., Santa Casa Complexo Hospitalar, Universidade Federal do Rio Grande do Sul, Brazil

Alessandro Pasqualotto

Laboratory of Mycology, Hospital das Clinicas, Federal University of Paraná, Curitiba, Brazil

Flávio de Queiroz Telles

Serviço de Oncohematologia / TMO, Hospital Univ. Prof. Edgard Santos - UFBA, Salvador, Bahia, Brazil

Marco Aurélio Salvino, Monica Botura

Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil Denise Pereira

Canada

Department of Medicine, Peter Lougheed Center, Calgary, Canada Andrew Johnson

Departments of Medicine & Microbiology and Immunology, McGill University, Montreal, Canada Don Sheppard

Microbiology and Infectious Diseases, SMBD - Jewish General Hospital, Montreal, Canada Mark Miller

Service de Maladies Infectieuses, Département de Pédiatrie, McGill University, Montreal, Canada

Philipe Ovetchkine


Chile

Facultad de Medicina, Universidad de Valparaíso, Chile Thomas Weitzel

Unidad de Infectología, Clínica Alemana, Santiago de Chile, Chile Luis Thompson

China

Changhai Hospital, Department of Hematology, Shanghai P.R., China Yang, Jian-Min

Institute of Hematology, Peking University People's Hospital, Beijing, China Feng-Rong Wang

Department of Hematology, Guangdong General Hospital, Guangdong, China Xin Du

Zhejiang University, School of Medicine, The First Affiliated Hospital, Bone Marrow Transplant Center, Hangzhou Zeijiang, China Huang, He

Columbia

Conjunto Residencial Montevideo, Medellin, Columbia Angela Restrepo, Angela Tobón

Cuba

Instituto de Hematologia e Inmunologia, Habana, Cuba Alberto Arencibia Núñez

Czech Republic

Dept. of Internal Medicine, Hematooncology, Faculty Hospital Brno, Brno, Czech Republic Zdenek Racil

Denmark

Dept. of Hematology, Copenhagen University Hospital, Copenhagen, Denmark

Jannik Helweg-Larsen, Emil Hermansen

France

Hospital Saint-Louis, Paris, France Emmanuel Raffoux, Patricia Ribaud

Hematology and Oncology, University Hospital of Strasbourg Hautepierre Hospital, Strasbourg, France

Raoul Herbrecht


Germany

Abteilung für Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, Heidelberg, Germany

Johann Wilhelm Schier

Abteilung für Innere Medizin, Hämatologie u.Onkologie, Klinikum Frankfurt, Germany Michael Kiehl

Abteilung für Kinder- und Jugendmedizin, Marienhospital Witten, Witten, Germany

Bahman Gharavi

Department of Infectious Diseases and Tropical Medicine, Ludwig-Maximilians-Universität München, Muenchen, Germany

Thomas Loescher

Dermatologie, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany Gesina Hansel

Division of Clinical Infectious Diseases, Medical Clinic, Research Center Borstel, Borstel, Germany

Christoph Lange

Gastroenterologie & Infektiologie DGI, St. Josef Hospital, Klinikum der Ruhr-Universität Bochum, Bochum, Germany

Renate Schlottmann

Georg-August-Universität, Goettingen, Germany Silke Neumann

Hämatologie / Internist. Onkologie, Uniklinik Erlangen, Erlangen, Germany Wolf Rösler

Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam, Germany

Angelika Gerhardt, Georg Maschmeyer

Hämatologie und Onkologie, Medizinische Klinik I, Kliniken Sindelfingen, Sindelfingen, Germany

Stefan Neuburger

Hämatologie und Onkologie, Universitätsklinikum Freiburg, Freiburg, Germany

Hrtmut Bertz, Werner C. Neubauer

Hämatologie/Onkologie/Immunologie/Rheumatologie, Klinikum Schwäbisch Gmünd / Stauferklinik, Mutlangen, Germany Holger Hebart

HNO-Klinik, Universitätsklinikum Düsseldorf, Duesseldorf, Germany Kathrin Scheckenbach

II. Medizinische Klinik, Einheit für Stammzelltransplantation, Klinikum Augsburg, Augsburg

Christoph Schmid

III. Medizinische Klinik und Poliklinik, Johannes Gutenberg Universität Mainz, Mainz, Germany

Andrew Ullmann

Infektiologikum Frankfurt, Frankfurt, Deutschland Gaby Knecht


Institut für Infektiologie, Asklepios Klinik St. Georg, Hamburg, Germany M. Sabranski

Institut für Medizinische Mikrobiologie und Hygiene, Universität Lübeck, Luebeck, Germany Jan Rupp

Institut für Medizinische Mikrobiologie, Universitätskliniken Göttingen, Göttingen, Deutschland Uwe Groß

Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Germany Claudia Wickenhauser

Institut für Tropenmedizin, Universitätsklinikum Düsseldorf, Düsseldorf, Germany Stefan Reuter

Kinderkardiologie und Pädiatrische Intensivmedizin, Klinikum der Universität München-Großhadern, München, Germany Markus Loeff

Klinik f. Hämato-Onkologie, Klinikum Harlaching, Städtisches Klinikum München GmbH, München, Germany Xavier Schiel

Klinik für Anaesthesiologie und Operative Intensivmedizin, Klinikum Konstanz, Konstanz, Germany

Wolfgang Krüger

Klinik für Dermatologie, University of Tübingen, Tübingen, Germany Sybille Schmidt, Martin Schaller

Klinik für Hals-, Nasen- und Ohrenheilkunde, Klinikum der Universität München-Großhadern, München, Germany

Robert Guerkov

Klinik für Hämatologie und Onkologie, Vivantes Krankenhaus, Berlin, Germany

Jörg Beyer, Markus Müller

Klinik für Hämatologie, Onkologie & Palliativmedizin, Städt. Kliniken Bielefeld gem.GmbH, Bielefeld, Germany Martin Görner

Klinik für Hämatologie, Onkologie und Klin. Immunologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany

Thomas Schröder

Klinik für Hämatologie/Internistische Onkologie und Stammzelltransplantation, Kliniken Essen Süd, Essen, Germany

Mohammed Wattad

Klinik für Infektiologie und Tropenmedizin, LMU, München, Germany Thomas Loescher

Klinik für Innere Medizin IV, Onkologie und Hämatologie, Martin-Luther-University Halle-Wittenberg, Halle, Germany

Maximilian Christopeit, Hans-Heinrich Wolf

Klinik für Knochenmarktransplantation, Universitätsklinikum Essen, Essen, Rudolf


Germany Trenschel

Klinik für Neonatologie, Universität zu Bonn, Bonn, Germany Cornelia Graef

Klinik für Nephrologie, Universitätsklinikum Essen, Essen, Germany Oliver Witzke

Klinik für Neurochirurgie, Charité-Universitätsmedizin Berlin, Berlin, Germany Olaf Süss

Klinik für Neurologie, Helios-Klinikum Berlin-Buch, Berlin, Germany Franz-Josef Dieste

Klinik für Pneumologie, Hannover Medical School, Hannover, Germany Matthias Pletz

Klinik I für Innere Medizin, Uniklinik Köln, Köln, Germany

Oliver Cornely, Maria Vehreschild, Jörg Janne Vehreschild, Fedja Farowski

Klinik und Poliklinik für Innere Medizin C, Hämatologie und Onkologie - Transplantationszentrum Universitätsklinikum der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany

William Krüger

Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie und Onkologie, Universitätsklinikum Rostock, Rostock, Germany

Kersten Borchert, Lena Diestel, Michael Schmitt

Klinik und Poliklinik für Orthopädie, Uniklinik Köln, Köln, Germany Rolf Sobottke

Klinik und Poliklinik für Kinderheilkunde, Universitätsklinikum Münster, Münster, Germany Jörg Ritter

Klinikum der Johann Wolfgang Goethe-Universität, Mainz, Germany Sabine Mousset

Klinikum Dortmund Nord, Abteilung Pneumologie/Infektiologie, Germany Stefanie Später

Klinikum Mannheim , Mannheim, Germany Anne Dietz

Klinikum Neuperlach, Müuenchen, Germany Meinolf Karthaus

Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, Uniklinik Erlangen, Erlangen, Germany

Stefan Kallert, Stefan Krause

Medizinische Klinik 5 – Hämatologie und Internistische Onkologie, University of Witten/Herdecke, Köln, Germany

Stefan Sauerland

Medizinische Klinik A, KMT-Zentrum, Uniklinik Münster, Münster, Germany Gerda Silling, Andreas Groll


Medizinische Klinik I, Klinikum Bremen-Mitte, Bremen, Germany Henrike Thomssen

Medizinische Klinik III, Klinikum der Universität München-Großhadern, München, Germany

Helmut Ostermann, Lisa Peterson

Medizinische Klinik und Poliklinik I, Uniklinik Dresden, Dresden, Germany Ulrich Schuler

Medizinische Klinik und Poliklinik II, Charité-Universitätsmedizin Berlin, Berlin, Germany Markus Ruhnke

Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany

Werner Heinz, Jürgen Löffler, Hartwig Klinker, Bhanu Sinha

Medizinische Klinik und Poliklinik II, Universitätsklinikum Schleswig-Holstein, Kiel, Germany Heinz-A. Horst

Medizinische Klinik und Poliklinik V, Universitätsklinikum Heidelberg, Heidelberg, Germany Gerlinde Egerer

Medizinische Poliklinik, Klinikum der Universität München-Großhadern, Müuenchen, Germany

Johannes Bogner

MVZ Labor Dr. Krause und Kollegen, Kiel, Germany Ralf Bialek

Mykologisches Labor, Krankenhaus Dresden-Friedrichstadt, Dresden, Germany

Irina Vennewald

Onkologikum Frankfurt, Frankfurt, Germany Angelika Böhme

Pädiatrische Hämatologie und Onkologie Infektiologie, Zentrum der Kinderheilkunde, Universität zu Bonn, Bonn, Germany Arne Simon

Rheumatologische Ambulanz, Sana Rheumazentrum Rheinland-Pfalz AG, Bad Kreuznach, Deutschland Eckhard Weber

Uniklinik Frankfurt, Frankfurt, Germany Volker Rickerts

Uniklinik Ulm, Ulm, Germany Georg Härter

Universitätsklinikum Freiburg, Freiburg, Germany Helmut Lang

Zentrum für Infektiologie und Reisemedizin, Universitätsklinikum Freiburg, Freiburg, Germany Dirk Wagner

Greece


1st Department of Propaedeutic Medicine, Athens University, Athens, Greece Anna Skiada

Cystic Fibrosis Department, Aghia Sophia Children´s Hospital, Athens, Greece

Stavros Doudounakis

Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory, Athens University, Athens, Greece

George L. Petrikkos

Laboratory for Clinical Microbiology, Attikon University General Hospital, Athens, Greece

Joseph Meletiadis

India

Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India

Arunaloke Chakrabarti

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh, India Ritesh Agarwal

Dept. of Microbiology, Centre for Basic Sciences, Kasturba Medical College, Manipal University, Manipal, India

Prakash Yegneswaran

Indonesia

Department of Internal Medicine University of Indonesia, Faculty of Medicine University of Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia

Erni J Nelwan

Ireland

Dept. of Bacteriology, Belfast City Hospital, Belfast, Ireland John E. Moore

Trinity College, Dublin Saint James Hospital, Dublin, Ireland Thomas Rogers

Israel

Department of Otolaryngology – Head & Neck Surgery, Edith Wolfson Medical Center, Holon, Israel Yehudah Roth

Hadassah University Medical Center, Jerusalem, Israel Maya Korem

Infectious Diseases Unit, Rabin Medical Center, Petah Tikva, Israel Morad Wattad

Sheba Medical Center Israel, Tel Aviv, Israel Nathan Keller

Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Ronen Ben-Ami

Italy

Department of Biomedical Science and Human Oncology — Hygiene Maria Teresa


Section, University of Bari, Bari, Italy Montagna

Dipartimento di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy Livio Pagano

Dipartimento di Farmacologia, Università degli Studi di Firenze, Firenze, Italy Andrea Novelli

Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino, Genova, Italy

Andrea Bacigalupo

Hematology Unit, San Camillo-Forlanini Hospital, Rome, Italy Mariagrazia Garzia

Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Rome, Italy Maurizio Sanguinetti

Laboratorio di Micologia Medica, Sezione Sanità Pubblica, University of Milan, Milan, Italy

Annamaria Tortorano

Oncoematologia Pediatrica, Policlinico G.B. Rossi, Verona, ItalyClinica di Oncoematologia Pediatrica, Azienda Ospedaliera Padova, Padova, Italy Simone Cesaro

Pathology Unit, Luigi Sacco Hospital, University of Milan, Milan, Italy Gianluigi Vago

Japan

Division of Control and Treatment of Infectious Diseases, Chiba University Hospital, Chiba, Japan

Akira Watanabe, Katsuhiko Kamei

Nagasaki University Hospital, Nagasaki, Japan Shigeru Kohno

Seirei Hamamatsu General Hospital, Shizuoka, Japan Shinichiro Morioka

Korea

Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, Korea

Joon Seong Park

Hematology-Oncology Clinic, Hematopoietic Stem Cell Transplantation Center, Center for Specific Organs Cancer, Research Institute and Hospital, National Cancer Center, Korea

HyeonSeok Eom

Kuwait

Microbiology Department, Health Sciences Center, Kuwait, Kuwait Eiman Mokaddas

Lebanon


American University of Beirut Medical Center, Beirut, Lebanon Souha kanj-Sharara

Lithuania

Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania Marius Miglinas

Mexico

Hospital Civil de Guadalajara, Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico,

Eduardo Rodriguez-Noriega

Hospital General de Culiacán, Sinaloa, Mexico Ramón Rivas Llamas

Netherlands

Canisius-Wilhelmina Hospital , Nijmegen, Netherlands Jacques Meis

University Medical Center Groningen, Groningen, the Netherlands Jan P. Arends

Peru

Hematology/ BMT Department, Rebagliati National Hospital, Lima, Peru Eduardo Fernandez-Vertiz

Portugal

Coimbra University Hospital, Coimbra, Portugal Tome, Rui

Romania

Department of Mycology-Mycotoxicology, Universitatea Petre Andrei, Iasi, Romania Mihai Mares

Russia

Department of Clinical Mycology, Allergology and Immunology, St. Petersburg Medical Academy of Postgraduate Education, St. Petersburg, Russia

Klimko, Nikolay

Singapore

Infectious Diseases Care, 03-01 Mount Elizabeth Medical Centre, 228510 Singapore Kurup, Asok

National University Health System, University Medicine Center, Division of Infectious Diseases, NUHS Tower Block, Level 10, 119228 Singapore

Louis Yin Ann, Chai


National University Health System, University Children\'s Medical Institute, Department of Pediatrics, 119228 Singapore, Singapore Chan, Si Min

Slovakia

National Cancer Institute, Bratislava, Slovakia Lubos Drgona

South Africa

Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Robert Dunn

Nelson R. Mandela School of Medicine, Pretoria, South Africa Teke Apalata

Spain

Hospital de la Princesa, Madrid, Spain Rafael de la Cámara

Servicio de Enfermedades Infecciosas, Hospital Universitario Virgen del Rocío, Sevilla, Spain

Martin-Pena Almudena

Sweden

Clinical Micrbiological Laboratory, Sunderby Hospital, Luleå, Luleå, Sweden Peter Cettner

Switzerland

Abt. für Spitalhygiene und Spitalepidemiologie, Universitätsspital Basel, Basel, Switzerland

Andreas Widmer

Division of Infectious Dieseases & Hospital Epidemiology, Universitätsspital Basel, Basel, Switzerland U. Flueckiger

Medizin I Abteilung für Hämatologie, Universitätsspital Basel, Basel, Switzerland Alois Gratwohl

Institut für Infektionskrankheiten, Bern, Switzerland Stefan Zimmerli

Universitätsklinik für Pneumologie, Inselspital, Universitätsspital Bern, Bern, Switzerland Sebastian Ott

Taiwan

Far Eastern Memorial Hospital, Taipei, Taiwan Chiaying Liu

Tai-Chen Stem Cell Therapy Center, National Taiwan University, Taipeh, Taiwan Jih-Luh Tang

Division of Infectious Diseases, Department of Internal Medicine, Center For Infection Control, National Taiwan University Hospital, Taipei, Taiwan Yee-Chun Chen


Thailand

Division of Infectious Diseases and Tropical Medicine, Khon Kaen University, Khon Kaen, Thailand

Ploenchan Chetchotisakd

Turkey

Akdeniz University Medical Faculty, Department of Clinical Microbiology, Antalya, Turkey Dilara Ogunc

Department of Medicine, Section of Infectious Diseases, Hacettepe University Medical School, Ankara, Turkey

Murat Akova, Sevtap Arikan, Omrun Uzun

Beyoglu Eye Training and Research Hospital, Istanbul, Turkey Serhat Imamoglu

United Kingdom

Department of Infection, St George's University of London, London, United Kingdom Jon Lambourne

NPHS Microbiology ABM (Swansea and Bridgend), Wales, United Kingdom Nidhika Berry

USA

Department of Infectious Diseases, Section of Transplant Infectious Diseases, Medicine Institute and Transplant Center, Cleveland Clinic Lerner College of Medicine of Case Western University, Cleveland, Ohio, USA

Sherif Beniameen Mossad

Department of Pathology, University of Colorado, Denver, USA Diane Hutchinson

University of Alabama at Birmingham, Birmingham, USA John Baddley

University of Texas Southwestern Medical Center at Dallas, Dallas, USA Sanjay Revankar

Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA Linda Boyken

MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana, USA

Patricia Connolly

Division of Medical Microbiology, Department of Pathology The Johns Hopkins University School of Medicine, Baltimore, MD, USA Sean Zhang

global rare fungal infection registryfungi.ro/wp-content/uploads/2013/01/fungiscope_2011.pdf ·...

Documents