Global SYMPLICITY RegistryLocations and Inclusion Criteriaa,b

SYMPLICITY RegistryMajor Adverse Events

SYMPLICITY RegistryChange in Office SBP

SYMPLICITY RegistryHigh Baseline BP Subset

SYMPLICITY RegistryDesign Implications for Clinical Practicea,b

Treatment Effectiveness in RDNResponse Assessment

SYMPLICITY RegistryPredictors of RDN Response

Number and Types of Comorbidities

RDN Response

Biomarkers of RDN Effectiveness Current and Future Directions

SYMPLICITY HTN-3Resultsa,b

SYMPLICITY HTN-3Subgroup Analyses

SYMPLICITY HTN-3Medication Changesa

SYMPLICITY HTN-3 Medication Types

SYMPLICITY HTN-3Medication Types (cont)a

SYMPLICITY HTN-3African-American Population

SYMPLICITY HTN-3African-American Population

(cont)a

SYMPLICITY HTN-3African-American Population

(cont)a

SYMPLICITY HTN-3 Procedural Effects – No. of Ablations

SYMPLICITY HTN-3Procedural Effects – Circumferentiality

Other RDN Procedural Factors

ConclusionsRDN Moving Forward

Abbreviations

References

References (cont)

References (cont)

References (cont)