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L A SM O N O S US A N T O

POSGRADUATE BIOMEDICAL SCIENCE

UNIVERSITY SUMATERA UTARA

FACULTY OF MEDICINE

  LUCOCORTICOSTEROIDS:

MECHANISM ACTION

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glucocorticoids,

corticosteroidsGlucocorticosteroids

steroids

Introduction

most effective anti-inflammatorytherapy for asthma

yet are relatively ineffectivein chronic obstructive

pulmonary disease

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Glucocorticoids suppress inflammation viaseveral molecular mechanisms

suppress the multiple inflammatory genes

reversing histone acetylation of activatedinflammatory genes

binding of ligand-bound glucocorticoid receptors (GR) toco-activator molecules

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recruitment ofhistonedeacetylase-2 tothe activatedinflammatory genetranscriptioncomplex

(transrepression)

higher concentrations ofglucocorticoids GRhomodimers interact withDNA recognition sites toactivate transcription

increased histoneacetylation ofanti-inflammatory

genes andtranscription ofseveral geneslinked toglucocorticoidside effects(trans-activation).

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CONCLUSION

Glucocorticoids most effective therapy forcontrolling asthma and suppress airwayinflammation

Antiinflammatory effects of corticosteroidsare due to transactivation of anti-inflammatory genes

The recognition different molecular mechanismsof glucocorticoid resistance has identified newtherapeutic

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Peter J. Barnes   British Journal of Pharmacology (2011) 163 29–43

References:

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