granulomatous lesions of nose
TRANSCRIPT
![Page 1: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/1.jpg)
Granulomatous lesions of noseBALASUBRAMANIAN THIAGARAJAN
OTOLARYNGOLOGY ONLINE
![Page 2: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/2.jpg)
IntroductionFeatures of granula of nose:
1. Presence of granuloma which contains – macrophages, epithelioid cells, and multinucleated giant cells
2. Presence of vasculitis which may be primary or secondary
3. Majority of these conditions have systemic manifestations
OTOLARYNGOLOGY ONLINE
![Page 3: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/3.jpg)
Classification of granulomatous lesions of nose1. Infective
2. Inflammatory
3. Neoplastic
OTOLARYNGOLOGY ONLINE
![Page 4: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/4.jpg)
Infective causes Bacterial
Tuberculosis – Mycobacterium tuberculosis
Leprosy – Mycobacterium Leprae
Rhinoscleorma – Klebsiella Rhinoscleromatis
Syphilis – Treponema Pallidum
Actinomycosis – Actinomyces israeli
OTOLARYNGOLOGY ONLINE
![Page 5: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/5.jpg)
Infective causes Fungal & protozoalAspergillus – Fumigatous, Flavus and Niger
Zygomycosis – Conidiobolus coronatus, Rhizopus oryae
Dermatacietes – Curvularia, Alternaria and Bipolaris
Rhinosporidiosis – Rhinosporidium seeberi
Blastomycosis – Blastomyces dermatitidis and Cryptococcus neoformans
Histoplasmosis – Histoplasma Capsulatum
Sporotrichosis – Sporotrichum schenkii
Coccidioidimycosis – Coccidioidi immitis
Leishmaniasis (protozoal) – Leishmania donovani
OTOLARYNGOLOGY ONLINE
![Page 6: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/6.jpg)
InflammatoryWegner’s granulomatosis
Sarcoidosis
Churg-strauss syndrome
Cholestrol granuloma
Eosinophilic granuloma
OTOLARYNGOLOGY ONLINE
![Page 7: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/7.jpg)
Neoplastic
T-cell lymphoma (Lethal midline granuloma)
OTOLARYNGOLOGY ONLINE
![Page 8: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/8.jpg)
SarcoidosisSystemic condition of unknown etiology
Can involve any part of the human body. Commonly involves nodes, lungs, upper airway, eyes, liver and small bones of hand and feet
Commonly affects young adults between third and fifth decades
Nasal manifestations are part of multisystem involvement
Female preponderance 2:1
OTOLARYNGOLOGY ONLINE
![Page 9: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/9.jpg)
EtiologyUnknown
Infective agents suspected
Exposure to Beryllium, zirconium, pine pollen and peanut dust have been implicated
Type 4 delayed hypersensitivity reactions depressed in these patients
Cell mediated immunity is normal
Gamma globulin levels are increased
The entire process seems to be initiated by antigen presenting cells of alveoli
Failure of suppressor regulatory mechanism is responsible for persistence of granuloma
OTOLARYNGOLOGY ONLINE
![Page 10: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/10.jpg)
OTOLARYNGOLOGY ONLINE
![Page 11: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/11.jpg)
Clinical Features - SarcoidosisNasal stuffiness / obstruction
Crusting
Blood stained nasal discharge
Purulent discharge
Facial pain
Mucoid discharge
Anosmia (rare)
OTOLARYNGOLOGY ONLINE
![Page 12: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/12.jpg)
Nasal findings - sarcoidosisGranular in appearance – “Strawberry skin”
Erythematous mucosa with tiny pale granulomas
Nasal mucosa is friable causing nasal congestion, bleeding
Mucosal crusting are also evident
Perforation of nasal septum (anterior portion). If septoplasty is ventured in these patients there could be associated collapse of the bridge of nose
Nasal bones may be involved causing expansion of the dorsum of the nose and thickening of skin in that area. (Responds well to medical management).
OTOLARYNGOLOGY ONLINE
![Page 13: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/13.jpg)
Histology - SarcoidosisNon caseating granuloma
Presence of epithelioid cell tubercles
Fibrinoid necrosis could be seen at the center which gets converted into hyaline fibrous tissue on healing
Schaumann bodies (crystalline/calcified inclusion bodies) are seen
OTOLARYNGOLOGY ONLINE
![Page 14: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/14.jpg)
Persistent granuloma - causes
Increased production of calcitriol by monocytes
Continued antigenic stimulation
Failure of suppressor mechanism
Abnormalities in the regulation of cytokine network
OTOLARYNGOLOGY ONLINE
![Page 15: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/15.jpg)
Other systems - sarcoidosisLung infiltrates
Peripheral node involvement
Skin involvement
Liver
Eye
Spleen
Heart
Kidneys
Larynx
Joints
Uterus
Lacrimal glands
OTOLARYNGOLOGY ONLINE
![Page 16: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/16.jpg)
Sarcoidosis – Diagnostic testsKveim test – Skin test Risk of virus / Prion transfer
Elevated angiotensin converting enzyme
X-ray chest – pulmonary infiltrates
Biopsy of nasal mucosa will help only if found abnormal
X-ray nasal bones – rarefaction / osteolysis if they are involved
OTOLARYNGOLOGY ONLINE
![Page 17: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/17.jpg)
Sarcoidosis - ManagementSpontaneous remission – probable
Oral steroids / methotrexate / hydroxycholoquine
Nasal steroid spray
Nasal saline douching to remove crusts
Surgery is contraindicated
OTOLARYNGOLOGY ONLINE
![Page 18: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/18.jpg)
Wegner’s granulomaGranulomatous inflammation of respiratory tract and kidneys
Necrotizing vasculitis involving small – medium sized vessels
Triad of airway, lung and renal disease common
Can occur in any age
OTOLARYNGOLOGY ONLINE
![Page 19: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/19.jpg)
Wegner’s granuloma - EtiologyUnknown
Inflammatory – hypersensitivity reaction with immune response to unknown stimuli (bacteria)
Deposition of immune complexes could cause vasculitis
cANCA elevated in Wagner's
OTOLARYNGOLOGY ONLINE
![Page 20: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/20.jpg)
Wegner’s granuloma-clinical featuresSymptoms disproportionate to clinical findings
Malaise, pyrexia and sense of ill well
This disease is lethal. Pts usually die within 6 months due to renal failure
Nasal block
Epistaxis
Nasal septal destruction, collapse of bridge of nose
Facial pain
Nasal surgeries cause destruction of nasal septum and nasal bridge collapse
Cough, hemoptysis and pleural pain
Glomerulonephritis – renal casts and RBC in urine (mid urine sampling)
OTOLARYNGOLOGY ONLINE
![Page 21: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/21.jpg)
Wegner’s granuloma – Ocular symptomsConjunctivitis
Dacryocystitis
Episcleritis
Corneal ulceration
Proptosis due to orbital granuloma
Blindness
OTOLARYNGOLOGY ONLINE
![Page 22: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/22.jpg)
Wegner’s granuloma – oral symptomsHyperplastic granular lesion involving gingiva of interdental area
Loosening of tooth
Cavities fail to heal
Extensive ulcerative stomatitis
OTOLARYNGOLOGY ONLINE
![Page 23: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/23.jpg)
Wegner’s granuloma – otologial symptomsAOM
Otitis media with effusion
Facial nerve paralysis
Middle ear filled with necrotizing granulation tissue
Conductive / sensorineural hearing loss
OTOLARYNGOLOGY ONLINE
![Page 24: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/24.jpg)
Wegner’s granuloma-Miscellaneous symptomsSkin ulceration over distal arms and legs
Polymyalgia / polyarthritis
Nervous system involvement
OTOLARYNGOLOGY ONLINE
![Page 25: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/25.jpg)
Wegner’s granuloma - DiagnosiscANCA test positive
ESR elevated
Elevated CRP level
Serum urea, creatinine and serum angiotensin converting enzyme levels to be assessed
Biopsy
CT imaging – nasal mucosal thickening. Pt with h/o previous nasal surgery showing bone destruction and new bone formation is virtually diagnostic
OTOLARYNGOLOGY ONLINE
![Page 26: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/26.jpg)
Wegner’s granuloma - histologyVasculitis is mandatory
Fibrinoid vascular necrosis is common
Presence of giant cell granuloma
OTOLARYNGOLOGY ONLINE
![Page 27: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/27.jpg)
Wegner’s granuloma - TreatmentSteroids
Cytotoxic drugs – cyclophosphamide, azathioprime, mycophenolate mofetil
Treatment to be initiated before renal damage sets in
OTOLARYNGOLOGY ONLINE
![Page 28: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/28.jpg)
Churg Strauss syndromeSystemic vasculitis, bronchial asthma
Eosinophilic rich granuloma
Small and medium sized vasculitis
Nasal polyposis, nasal crusting, septal perforation
Can be managed with oral steroids
OTOLARYNGOLOGY ONLINE
![Page 29: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/29.jpg)
Eosinophilic granuloma
Involves clonal proliferation of Langerhans cells associated with heterogenous inflammatory infiltrate of eosinophils, histiocytes, lymphocytes, plasma cells and neutrophils. This condition may also be considered as a manifestation of histiocytosis x.
OTOLARYNGOLOGY ONLINE
![Page 30: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/30.jpg)
Eosionophilic granuloma - featuresAll organs may be affected
Predominantly involves bones (temporal, frontal and parietal bones)
Males are commonly affected, twice as common as females
Commonly affects individuals in the first three decades of life
Painful swelling over involved bone followed by cervical adenopathy
Mandibular lesions tooth ache, gum ulceration and loosening of teeth
Involvement of temporal bone will simulate acute mastoiditis
OTOLARYNGOLOGY ONLINE
![Page 31: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/31.jpg)
Eosinophilic granuloma - imaging
Punched out bony lesions in the jaw with radiolucent areas around teeth
Skull lesions show beveled margins due to angular destruction of bone
OTOLARYNGOLOGY ONLINE
![Page 32: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/32.jpg)
Eosinophilic granuloma - ManagementLocalized disease can be managed by curettage and irradiation if need be.
Solitary disease is more common
Regimen of etoposide & steroids for 12 months has proved promising
Recent regimen also include alpha interferon and bone marrow transplantation
OTOLARYNGOLOGY ONLINE
![Page 33: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/33.jpg)
Cholesterol granulomaThis condition results from hemorrhage / trauma
Granulomatous reaction is directed against cholesterol crystals
Shows male preponderance, without any age preponderance
This lesion is known to affect frontal / maxillary sinus causing swelling and cosmetic deformity
Proptosis could also be evident
Lesion produces a cyst like expansion of the affected bone. The sinus cavity appears opaque and does not show contrast enhancement
Histology shows giant cell granuloma
Surgery and curettage of the lesion helps
OTOLARYNGOLOGY ONLINE
![Page 34: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/34.jpg)
Lethal midline granuloma
Also known as “T cell lymphoma” stewartgranuloma
Extensive destruction of mid face
Can involve patients of any age group
Male preponderance has been observed
EB virus infections have been implicated
OTOLARYNGOLOGY ONLINE
![Page 35: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/35.jpg)
Midline granuloma – clinical featuresProdromal stage – May last for many years. Nasal obstruction and rhinorrhea are the classic features
Period of activity – Necrosis develops around nasal cavity. Purulent discharge + crusting+ tissue loss+ There is progressive destruction of nasal framework, palate, upper lip, orbit and skull base. Pyrexia may be present due to super added infection
Terminal stage – Bleeding, gross disfigurement and ultimately death
OTOLARYNGOLOGY ONLINE
![Page 36: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/36.jpg)
Midline granuloma - DiagnosisIt is a challenge because atypical cells are dispersed in necrotic areas
Biopsy material should be taken from under the slough / crust
Immunohistochemistry is a clincher
Absence of granulomas / giant cells is a feature
There is always associated thrombosis and necrosis
OTOLARYNGOLOGY ONLINE
![Page 37: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/37.jpg)
Midline granuloma - ManagementInitially low dose radiotherapy was preferred
Now a days full course of radiotherapy is administered covering the entire area
Development of disseminated lymphoma is a problem
Chemotherapy is indicated only for high grade lesions
OTOLARYNGOLOGY ONLINE
![Page 38: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/38.jpg)
Nasal tuberculosisRare
Always associated with primary PT
Features include – ulcers, polypoidal lesions and nodules
Ulcers if present are typically seen in the anterior portion of nasal septum and inferior turbinate
Lupus vulgaris – is an indolent infection involving the skin and mucosal lining of nasal cavity
Nose picking commonly causes this condition
OTOLARYNGOLOGY ONLINE
![Page 39: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/39.jpg)
TB Nose – Clinical featuresNasal discharge / obstruction
Presence of non foul smelling crusts
Epistaxis
Presence of ulceration can cause mild fetor
Ulceration of nasal mucosa is followed by fibrosis, and contraction of nares
Extensive involvement of turbinates can lead to secondary atrophic rhinitis
Apple jelly nodules – Early lesion. Reddish brown nodule at the mucocutaneous junction
Cartilagenous portion of nasal septum undergoes destruction
OTOLARYNGOLOGY ONLINE
![Page 40: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/40.jpg)
Lupus - FeaturesCan cause extensive scarring of vestibule and may extend up to the skin of face. These lesions are nodular in nature.
Features of lupus nodules:
Blanching on pressure
Bacterial examination
Biopsy
When pressure is applied to adjoining nasal mucosa using glass slide, pinkish nodules will stand out because the adjacent areas undergo blanching
Biopsy of the lesion is always diagnostic
OTOLARYNGOLOGY ONLINE
![Page 41: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/41.jpg)
Nasal tuberculosis - Histopathology
Presence of tuberculous granuloma
In the center of the lesion collection of RE cells +
Giant cells are seen throughout the tubercle
Coagulation necrosis is a feature
OTOLARYNGOLOGY ONLINE
![Page 42: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/42.jpg)
Nasal tuberculosis - complicationsDacryocystitis
Lupus of the face
Atrophic rhinitis
Development of epithelioma - very rare
OTOLARYNGOLOGY ONLINE
![Page 43: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/43.jpg)
Nasal leprosyTuberculoid leprosy – skin lesions may extend up to nasal vestibule. Nasal mucosa is not involved. Cutaneous anesthesia is a feature.
Lepromatous leprosy – Highly infectious discharge from nasal cavity. Nasal crust formation, serosanguinous nasal discharge. Presence of nodular thickening of nasal mucosa is the earliest feature. These nodules are commonly seen in the anterior end of inferior turbinate. Nasal obstruction is classically out of proportion to mucosal oedema visualized. Collapse of the anterior bridge of the nose with destruction of anterior nasal spine is a feature. Both bony and cartilagenous portions of nasal septum are destroyed. Radiological evidence of destruction of anterior nasal spine is virtually diagnostic of lepromatous leprosy.
Borderline leprosy – poor immunological tolerance. Skin around nose and eyes are involved. Nasal mucosa is free of disease
OTOLARYNGOLOGY ONLINE
![Page 44: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/44.jpg)
Nasal syphilisPrimary syphilis - commonly seen in the vestibule of the nose. Usually appears as hard, non painful ulcerated papule. Always associated with enlarged rubbery non tender lymphadenopathy. Spontaneous resolution is seen in 6 weeks. Smears from the lesion are positive. VDRL +
Secondary syphilis – infective stage. Catarrhal rhinitis, crusting, fissuring of nasal vestibule, and enlarged non tender lymph nodes.
Tertiary syphilis – Bony portion of nasal septum involved. Septal perforation involving bony portion of nasal septum is seen
OTOLARYNGOLOGY ONLINE
![Page 45: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/45.jpg)
Nasal syphilis - symptomsPain & headache – worse during night
Swelling / obstruction of nose
Diminished olfaction
Perforation of bony nasal septum with collapse of bridge of nose
Secondary atrophic rhinitis
Lesion is usually unilateral
Tenderness over the bridge of the nose is a characteristic sign
Swollen nasal mucosa that does not shrink with decongestants
OTOLARYNGOLOGY ONLINE
![Page 46: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/46.jpg)
Congenital syphilisAlso known as snuffles
Usually begins classically during 3rd week of life
Begins as serous rhinitis, which later becomes purulent
Excoriation of upper lip and vestibule of nose
OTOLARYNGOLOGY ONLINE
![Page 47: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/47.jpg)
RhinoscleromaProgressive granulomatous lesion begins at the nose and extends up to nasopharynx
Larynx, trachea and lower airway can rarely be involved
Can occur at any age, and can affect all age groups
Causative organism – Klebsiella rhinoscleromatis
Granulomatous infiltrates in the submucosa is a feature. Accumulated inflammatory cells include: Plasma cells, lymphocytes, eosinophils and scattered large foam cells (Mikulicz cells). These foam cells have a central nucleus and a vacuolated cytoplasm containing bacillli
OTOLARYNGOLOGY ONLINE
![Page 48: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/48.jpg)
Rhinoscleroma – Clinical featuresAtrophic stage – Changes appear in the nasal mucous membrane. This stage clinically resembles atrophic rhinitis
Granulation / nodular stage – Nodules are non ulcerative in nature. These nodes are initially bluish red and rubbery. Later these nodes become a little paler and harder
Cicatrizising stage – Adhesions and scarring is a feature of this stage. Stenosis distort normal nasal anatomy. Shape of the nose changes and is classically name the Tapir’s nose. Lymphatic spread is uncommon because of extensive scarring. This disease may involve nasopharynx, maxillary sinus and lower airways too.
OTOLARYNGOLOGY ONLINE
![Page 49: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/49.jpg)
Rhinoscleroma - Investigations
Levin test – complement fixation test based on reaction of patient’s serum with suspensions of K. rhinoscleromatis
High titres of antibodies to K. rhinoscleromatis has been demonstrated in these individuals
Tissue biopsy is diagnostic
OTOLARYNGOLOGY ONLINE
![Page 50: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/50.jpg)
Rhinosporidiosis
It is a chronic granulomatous disease characterised by production of nasal polypiand other manifestations of hyperplastic nasal mucosa. Etiologic agent has been hypothesized to be Rhinosporidium seeberi. It has also been described as a strawberry like mulberry mass.
OTOLARYNGOLOGY ONLINE
![Page 51: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/51.jpg)
Rhinosporidiosis - History1892 – Malbran observed the organism in nasal polyp
1900 – Seeber described the organism
1903 – O’kineley described the histology of the lesion
1905 – Minchin & Fantham restudied O’Kineley’s slide and named the organism as Rhinosporidium Kineley
1913 – Zschokke reported a similar lesion in horses and named the organism Rhinosporidium equi
1923 – Ashworth described for the first time life cycle of rhinosporidium seeberi
1924 – Forsyth described a skin lesion for the first time
1953 – Demellow described mode of transmission of the disease
OTOLARYNGOLOGY ONLINE
![Page 52: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/52.jpg)
Rhinosporidiosis – Special characteristics
More than 90% of these patients have been reported from India and Srilanka
Madurai, Thirunelveli, Ramnad and Kanyakumari districts of Tamilnadu are considered to be endemic zones
Disease transmission is probably due to taking bath in common ponds where cattle also bathe
OTOLARYNGOLOGY ONLINE
![Page 53: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/53.jpg)
Rhinosporidiosis – Theories of spread
Demellow’s theory of direct transmission
Autoinoculation theory of Karunarathne (responsible for satellite lesions)
Hematogenous spread (spread to distant sites)
Lymphatic spread (rare)
OTOLARYNGOLOGY ONLINE
![Page 54: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/54.jpg)
Karunarathne’s theory
Rhinosporidium seeberi existed in dimorphic state.
It existed in saprophyte form in soil and water.
Inside tissues it took yeast form
According to karunarathne, this dimorphic existance helped organism to survive hostile environmental conditions
OTOLARYNGOLOGY ONLINE
![Page 55: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/55.jpg)
Rhinosporidiosis – Reasons for endemicity
Physical characteristics of water in the ponds
Presence of synergistic aquatic organism
Genetic predisposition of affected patients
Host immunity status
OTOLARYNGOLOGY ONLINE
![Page 56: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/56.jpg)
Life cycle (Ashworth)Spore is the basic infecting unit
It is about 7 microns in size
It is also known as spherule
It has clear cytoplasm filled with 15-20 vacuoles containing food matter
It is enclosed in a chitinous membrane
These spores are commonly found in connective tissue spaces and is very rarely intracellular
OTOLARYNGOLOGY ONLINE
![Page 57: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/57.jpg)
Life cycle Ashworth (contd)Spores begin to increase in size
At 50-60 microns size granules begin to appear
Nucleus prepare for cell division
Mitosis begins – 4,8,16, 32 and 64 nuclei are formed
At 7th division size becomes 100 microns
Fully mature sporangium – 150 microns
Mature spores are found in the centre and immature ones at the periphery
OTOLARYNGOLOGY ONLINE
![Page 58: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/58.jpg)
Life cycle - Recent
Juvenile sporangium also known as trophozoite – size ranging from 6-100 microns
It has a single nucleus at 7 micron stage and multiple nuclei at 100 microns stage
Lipid granules begin to appear within the cytoplasm
Intermediate sporangium – 100-150 microns. Has bilamellar cell wall, outer chitinous and inner cellulose. Only immature spores are seen within the cytoplasm. No mature spores are seen
OTOLARYNGOLOGY ONLINE
![Page 59: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/59.jpg)
Mature sporangiumSize – 100 – 400 microns
Cell wall is thin and bilamellar with one weak spot known as operculum
Inside cytoplasm mature and immature spores are seen
Spores are embedded in mucoid matrix
Mature spores are covered with mucoid material resembling a comet (comet of Beattee)
Mature spores give rise to electron dense granules which are the ultimate infecting unit
OTOLARYNGOLOGY ONLINE
![Page 60: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/60.jpg)
Clinical classification
Nasal
Nasopharyngeal
Mixed
Bizarre (ocular / genital)
Malignant rhinosporidiosis (cutaneous)
OTOLARYNGOLOGY ONLINE
![Page 61: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/61.jpg)
Common sites affected
Nose – 78%
Nasopharynx – 68%
Tonsil – 3%
Eye – 1%
Skin – very rare
OTOLARYNGOLOGY ONLINE
![Page 62: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/62.jpg)
Nasal rhinosporidiosis - FeaturesLesions are polypoidal reddish and granular
Lesions may be multiple, pedunculated and friable
Surface studded with whitish dots (sporangia)
Nasal lesions highly vascular and bleeds on touch
Entire mass could be clothed with mucous secretion
Lesion is restricted to nasal mucous membrane and does not cross the mucocutaneous junction
OTOLARYNGOLOGY ONLINE
![Page 63: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/63.jpg)
Rhinosporidiosis - HistologyPapillomatous hyperplasia of mucous membrane with rugae formation
Epithelium over sporangia thinned out and giant cells could be seen in this area
Accumulation of mucous + in crypts
Increased vascularity due to angiogenesis factor
Spores stain with sudan black and Bromphenolblue
OTOLARYNGOLOGY ONLINE
![Page 64: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/64.jpg)
Nasal rhinosporidiosis - Features
Chronicity
Recurrence
Dissemination
OTOLARYNGOLOGY ONLINE
![Page 65: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/65.jpg)
Chronicity - ReasonsAntigen sequestration
Antigenic variation
Immune suppression
Immune distraction
Immune deviation
Binding of host immunoglobulins
OTOLARYNGOLOGY ONLINE
![Page 66: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/66.jpg)
Treatment
Surgery
Dapsone 100 mg/day – 6 months
OTOLARYNGOLOGY ONLINE
![Page 67: Granulomatous lesions of nose](https://reader031.vdocument.in/reader031/viewer/2022032114/55a6692e1a28abf17e8b45a8/html5/thumbnails/67.jpg)
OTOLARYNGOLOGY ONLINE