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Grassroots Grassroots Biosecurity Biosecurity Initiatives: Initiatives: A New Tool for Synthetic Biology Policy A New Tool for Synthetic Biology Policy Stephen M. Maurer Goldman School of Public Policy University of California at Berkeley [email protected] Biological Weapons Convention 2008 Meeting of States Parties December 3, 2008

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Grassroots Grassroots BiosecurityBiosecurity Initiatives: Initiatives: A New Tool for Synthetic Biology PolicyA New Tool for Synthetic Biology Policy

Stephen M. MaurerGoldman School of Public PolicyUniversity of California at [email protected]

Biological Weapons Convention2008 Meeting of States PartiesDecember 3, 2008

Why Would We Want a Community-Level Initiative?An Historically Plausible Idea.

Physics Today (Feb. 1976)

A Contemporary Example: Enforcing Minimum Screening Standards

The Problem: Global MarketsPowerful Commercial Tools.Beyond Regulation and

Treaties?

The Solution: Global Markets?!Not “Stakeholders” and

“Dialogue.”Price Signals

and Standards.New Scientist (Nov. 12, 2005)

Our Experiment: Synthetic BiologyBerkeley, Munich and Afterward.

A Conventional Policy Analysis

How Does Synthetic Biology Add to the BW Risk?Resurrecting Controlled/Extinct PathogensTraditional Engineered ThreatsAdvanced/Emerging Threats

“Technical Solutions for Biosecurityin Synthetic Biology” (April 2, 2008)http://www.ia-sb.eu/wp-content/uploads/2008/09/iasb_report_biosecurity_syntheticbiology.pdf

Designing Community-Level Responses (I)

Resurrecting Controlled/Extinct Pathogens

Goal: Uniform, Strong Screening Standards

Designing Community-Level Responses (I)

Analysis:No Company (Country) Loses Business.

Good News: Incentives to Defect are Weak.

But: Lack of Focal Point, Incentives to Defect.

Establishing and Stabilizing a Standard.

Designing Community-Level Responses (I)

Tactics:Code of Conduct

Seal of Approval

(Grant restrictions, Consumer pledge?)

Open Blackwatch

The BCW Can Help.

Designing Community-Level Responses (II)

Traditional Engineered Threats:Goal:

Improved Screening Technology.Analysis:

Better Use of Existing Screening Effort.Tactics:

Sharing Virulence Data (ViREP)SafeguardOpen Blackwatch (again)?

Designing Community-Level Responses (III)

Advanced/Emerging Threats:Goal:

Learn, Develop, and Apply Principles.Analysis:

Biosecurity is an Empirical DisciplineTactics:

PortalInformation Sharing: Article and Database

http://gsppi.berkeley.edu/EoC/uc-berkeley-synthetic-biology-security-program

The Lessons So Far…

A New and Sometimes Powerful Lever

Academic and Commercial Communities Have Global Reach.

Solutions Cross National BordersHarmonization is Automatic

Academic and Commercial Communities are NimbleA Fast Way to Get Things Done

Academic and Commercial Communities are Flexible

Biosecurity is an Experimental DisciplineWe Must Be Able to Try and Fail and Try Again

The Lessons So Far, ctd…

Diplomacy vs. Markets – A False ChoiceIs It Enough?

Nature (Sept. 25, 2008)

Next Steps

Implementing the Munich AgendaNext Talk: Code of Conduct

An Opportunity for this meetingAdvanced ProjectsLet’s [email protected]

Grassroots Grassroots BiosecurityBiosecurity Initiatives: Initiatives: A New Tool for Synthetic Biology PolicyA New Tool for Synthetic Biology Policy

Stephen M. MaurerGoldman School of Public PolicyUniversity of California at [email protected]

Biological Weapons Convention2008 Meeting of States PartiesDecember 3, 2008