greener chemical products and processes standard

GREENER CHEMICAL PRODUCTS AND PROCESSES STANDARD

GC Chemical Characteristics Task Group

presentation to

Joint Committee on Greener Chemical Products and ProcessesAmerican Chemical SocietyGreen Chemistry Institute

Washington DC

October 20, 2009

• Developed list of chemical characteristics– Categories – Subcategories – Criteria, potential route of exposure– Examples of tests to inform the criteria– Matrix of information needed based on intended application,

(e.g., closed process, industrial operations, dispersive use)

• Developed list of filter criteria• Applied filter to chemical criteria to determine if

appropriate for this standard at this time

STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSESGC CHEMICAL CHARACTERISTICS TASK GROUP

Approach


Chemical Characteristic Filter Criteria

1. Is there an established definition? Definable?

2. Is there a validated test? Measurable?

or

3. Is there a generally accepted methodology, calculation, model?

4. Is the test/method commonly done?


3-Tiered Approach

3. Potential Future ConsiderationsCharacteristics that may be added to this Standard at some future time (e.g., size – nanomaterials; genomics

2. State-of-the-Science StatementEvolving characteristics – do not yet fulfill our Filter Criteria (e.g., 14-Day Worm, Endocrine Disrupters)

1. Chemical Characteristics

Characteristics that fulfill 3 of our 4 Filter Criteria

No mention in this Standard

Include text statement in thisStandard

List as a Chemical Characteristic for evaluation in this Standard


Chemical Characteristic Categories & Subcategories

A. Physical Safety

B. Human Health

C. Ecological Impact(includes long-term impacts used

in life cycle analyses)

FireReactivitySpecial

AcuteChronic

AirWaterSoil

Subcategories


Chemical Characteristic Categories, Subcategories & Criteria

A. Physical Safety

Fire

Reactivity

Special

Flammability

Explosivity

Corrosive (metal)OxidizerWater-ReactiveRadioactive

Subcategories Criteria


B. Human Health

Acute Inhalation

Dermal

Oral

* Only applies to small number of chemicals

Chemical Characteristic Categories, Subcategories, Criteria & Tests

Subcategories Criteria Example Tests

IDLHSTEL/CeilingLC50 (inhalation)Odor threshold *

LD50Skin IrritationEye Irritation

LD50 (oral)ARfD


B. Human Health

Chronic Subchronic Toxicity Repeat dose (28- or 90-day)

Reproductive If triggered by repeatDevelopmental Effects dose or QSAR

Carcinogenicity If on IARC or NTP list or if triggered by repeat dose

Neurotoxicity If triggered by repeat dose

Sensitization (I, D)

Chronic Inhalation RfC, TLV

Chronic oral RfD (oral)

Mutagenicity Bacterial reverse mutation assay, in vitro cytogenetics




C. Ecological Impact

Air Persistence

Bioaccumulation

Exposure/Fate

Toxicity

Long-term Effects

Persistence (Air) Half-Life

N/A – No Air Test(s) Available

Fugacity with Volatilization (VP)

N/A – No Air Test(s) Available

AcidificationGlobal Warming PotentialOzone-Depleting PotentialPhotochemical Smog





Water Persistence

Bioaccumulation

Exposure/Fate

Toxicity

Long-term Effects

EPA Persistence (Water) Half-Life, orBiodegradability & Hydrolysis Half-Lives

Log Kow, or BCF, or BAF

Fugacity with Water Solubility

Fish LC50Daphnae LC50Green Algae EC50

EutrophicationTheoretical Oxygen Demand, or Biological Oxygen Demand, or Chemical Oxygen Demand





Soil Persistence

Bioaccumulation

Exposure/Fate

Long-term Effects

Persistence (Soil) Half-Life

N/A – No Soil Test(s) Available

Fugacity with Koc

Groundwater Mobility Factor



• Standard needs to be practical, usable, and provide relevant information

• Group has developed a recommended list of chemical characteristics that:– Have established definitions, – Are measurable using validated tests or are

calculable using standard, accepted methods, and – Have tests that are done commonly.– Provide relevant information from a supplier to his

customer.


SUMMARY

greener chemical products and processes standard

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