gregory m. gibbons, md, pgy-3 department of emergency medicine...
TRANSCRIPT
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The StomachThe Stomach
Making Life Betterthrough Research, Education & Healthcare TM
Gregory M. Gibbons, MD, PGY-3 Department of Emergency Medicine
Tampa General Hospital University of South Florida
Monday, November 10, 2008
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Objectives
1. Review anatomy and physiology of the stomach
2. Identify common Emergency Department pathologies
3. Review treatment and disposition guidelines.
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Function
• The stomach is a highly acidic environment due to gastric acid production and secretion which produces a luminal pH range usually between 1 and 2 depending food intake, time of the day, drug use, and other factors.
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Function
• Combined with digestive enzymes, it is able to break down large molecules to smaller ones so that they can eventually be absorbed from the large intestine.
• Pepsinogen is secreted by chief cells and turns into pepsin under low pH conditions and is a necessity in protein digestion.
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Function
• The human stomach can produce and secrete about 2.2 to 3 liters of gastric acid per day with basal secretion levels being typically highest in the evening.
• The stomach can expand to hold between 2-4 liters of food.
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Function
• Absorption of vitamin B12 from the small intestine is dependent on conjugation by intrinsic factor which is produced by parietal cells of the stomach.
• Other functions include absorbing some ions, water, and some lipid soluble compounds such as alcohol, aspirin, and caffeine.
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Anatomy
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Anatomy
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Anatomy
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Anatomy
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Anatomy
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Anatomy
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Case #1
• 35 year old male presents to the ED with complaints of epigastric pain x 12 hours. – No PMH– No PSH– No Meds
• Recently on 3 day drinking binge because the Rays are in the World Series.
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Gastritis
• Can be classified as:
– Acute
– Chronic
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Acute Gastritis
• Erosive– Medications– Alcohol– Cocaine– Stress– Radiation– Bile reflux– Ischemia
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Acute Gastritis
• Bacterial– Helicobacter pylori
– Helicobacter heilmanii
– Tuberculosis
– Syphilis
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Acute Gastritis
• Phlegmonous gastritis– Streptococcus– Staphlococcus– Proteus– Clostridium– E.Coli
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Acute Gastritis
• Viral– Cytomegalovirus (CMV)
• Fungal– Candida albicans– Histoplasmosis
• Parasitic – Anisakidosis
• Esosinophilic– Allergies
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Acute Gastritis
• Bile
• Ischemia
• Trauma
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Acute Gastritis
• Administer medical therapy as needed, depending on the cause and the pathological findings.
• No specific therapy exists for acute gastritis, except for cases caused by H pylori.
• Administer fluids and electrolytes as required, particularly if the patient is vomiting.
• Discontinue the use of drugs known to cause gastritis (eg, NSAIDs, alcohol).
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Chronic Gastritis
• H pylori–associated chronic gastritis• Infectious granulomatous gastritis• Gastritis in patients who are
immunosuppressed• Autoimmune gastritis • Chronic reactive chemical gastropathy• Chronic noninfectious granulomatous
gastritis
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Chronic Gastritis
• Lymphocytic gastritis
• Eosinophilic gastritis
• Radiation gastritis
• Ischemic gastritis
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H. Pylori Eradication
• Twice-a-day PPI – PPI - Lansoprazole (Prevacid) 30 mg PO bid,
omeprazole (Prilosec) 20 mg PO bid
– Clarithromycin (Biaxin) 500 mg PO bid
– Amoxicillin 1000 mg PO bid or metronidazole 500 mg PO bid
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Case #2
• 35 year old male presents to the ED with complaints of epigastric pain x 2 days. – No PMH– No PSH– No allergies.
• Has been taking Advil for right knee pain secondary to running.
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Peptic Ulcer Disease
• Peptic ulcers are defects in the gastric or duodenal mucosa that extend through the muscularis mucosa.
• H pylori infection and NSAID use are the most common etiologic factors
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Peptic Ulcer Disease
• Other less common causes are hypersecretory states– Zollinger-Ellison syndrome– G-cell hyperplasia– Mastocytosis– Basophilic leukemias
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Pathophysiology
• Under normal conditions, a physiologic balance exists between peptic acid secretion and gastroduodenal mucosal defense.
• Mucosal injury and, thus, peptic ulcer occur when the balance between the aggressive factors and the defensive mechanisms is disrupted.
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Pathophysiology
• Aggressive factors, such as NSAIDs, H pylori, alcohol, bile salts, acid, and pepsin, can alter the mucosal defense by allowing diffusion of hydrogen ions and subsequent epithelial cell injury.
• The defensive mechanisms include tight intercellular junctions, mucus, mucosal blood flow, cellular restitution, and epithelial renewal.
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Frequency
• One-year point prevalence is 1.8%.
• Lifetime prevalence is approximately 10%.
• PUD affects approximately 4.5 million people annually.
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Morbidity / Mortality
• Medical office visits and hospitalizations for PUD have decreased in the last few decades.
• The mortality rate has decreased modestly in the last few decades and is approximately 1 death per 100,000 cases.
• The hospitalization rate is approximately 30 patients per 100,000 cases.
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Sex
• Prevalence has shifted from predominance in males to similar occurrences for both sexes.
• Lifetime prevalence is approximately 11- 14% for men and 8-11% for women.
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Age
• Age trends for ulcer occurrence reveal declining rates in younger men, particularly for duodenal ulcer, and increasing rates in older women.
• Trends reflect complex changes in risk factors for PUD, including the prevalence of H pylori infection and the use of NSAIDs in older populations.
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History
• Epigastric pain (the most common symptom):– Gnawing or burning sensation – Occurs 2-3 hours after meals – Relieved by food or antacids – Patient awakens with pain at night. – May radiate to the back
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History
• Nausea • Vomiting, which might be related to partial
or complete gastric outlet obstruction • Dyspepsia, including belching, bloating,
distention, and fatty food intolerance • Heartburn • Chest discomfort
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History
• Anorexia, weight loss • Hematemesis or melena resulting from
gastrointestinal bleeding • Dyspeptic symptoms that might suggest
PUD are not specific because only 20- 25% of patients with symptoms suggestive of peptic ulceration are found on investigation to have a peptic ulcer.
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Physical
• In uncomplicated PUD, clinical findings are few and nonspecific. – Epigastric tenderness – Guaiac-positive stool resulting from occult
blood loss – Melena resulting from acute or subacute
gastrointestinal bleeding – Succussion splash resulting from partial or
complete gastric outlet obstruction
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Causes
• H pylori infection • Nonsteroidal anti-inflammatory drugs • Severe physiologic stress
- Burns - CNS trauma - Surgery - Severe medical illness
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Causes
• Hypersecretory states:– Gastrinoma (Zollinger-Ellison syndrome)– Multiple endocrine neoplasia (MEN-I) – Antral G cell hyperplasia– Systemic mastocytosis– Basophilic leukemias
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Lab Studies
• In most patients with uncomplicated PUD, routine laboratory tests usually are not helpful.
• If the diagnosis of PUD is unclear or complicated and PUD is suspected, obtaining CBC, liver function tests (LFTs), amylase, and lipase might be useful.
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Imaging Studies
• Upper gastrointestinal series– Double-contrast
radiography might approach the diagnostic accuracy of upper GI endoscopy. However, it has been replaced largely by diagnostic endoscopy, when available.
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Other Tests
• Detection of H pylori infection is essential in all patients with peptic ulcers.
• Endoscopic or invasive tests include a rapid urease test, histopathology, and culture.
• Nonendoscopic or noninvasive tests include serum H pylori antibody detection, fecal antigen tests, and urea breath tests.
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Special Studies
• A fasting serum gastrin level should be obtained in certain cases to screen for Zollinger-Ellison syndrome.
• A secretin stimulation test may be used if the diagnosis of Zollinger-Ellison syndrome cannot be made with the gastrin level alone.
• Measurement of acid secretion is not useful in the routine evaluation of PUD.
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Upper GI endoscopy
• Preferred diagnostic test in the evaluation of patients with suspected PUD
• Highly sensitive for the diagnosis of gastric and duodenal ulcers
• Allows for biopsies and cytologic brushings in the setting of a gastric ulcer to differentiate a benign ulcer from a malignant lesion
• Allows for detection of H pylori infection with antral biopsies for a rapid urease test and/or histopathology in patients with PUD
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Medical Treatment
• Given the current understanding of the pathogenesis of PUD, most patients with PUD are treated successfully with cure of H pylori infection and/or avoidance of NSAIDs, along with the appropriate use of anti-secretory therapy.
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Surgical Treatment
• With the success of medical therapy, surgery has a very limited role in the management of PUD. • Refractory, symptomatic peptic ulcers,
though rare with the cure of H pylori infection and the appropriate use of antisecretory therapy, are a potential complication of PUD.
• Perforation usually is managed emergently with surgical repair.
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Surgical Treatment
• Obstruction can complicate PUD, particularly if PUD is refractory to aggressive antisecretory therapy, H pylori eradication, or avoidance of NSAIDs.
• Penetration, particularly if not walled off or if a gastrocolic fistula develops, is a potential complication of PUD.
• Bleeding can complicate PUD, particularly in patients with massive hemorrhage and hemodynamic instability.
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Surgical Care
• The appropriate surgical procedure depends on the location and nature of the ulcer. – Simple oversewing of the ulcer with treatment of the
underlying H pylori infection or cessation of NSAIDs for bleeding PUD.
– Additional surgical options for refractory or complicated PUD include vagotomy and pyloroplasty, vagotomy and antrectomy with gastroduodenal reconstruction (Billroth I) or gastrojejunal reconstruction (Billroth II), or a highly selective vagotomy.
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Case #3
• Mother presents with her first-born, white, 3 week old male. He has nonbilious projectile vomiting after each feeding. – Unremarkable perinatal period– Breast fed– Not gaining weight
• Mother states “I feel a lump in his belly that feels like an olive.”
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Pyloric Stenosis
• Pyloric stenosis, also known as infantile hypertrophic pyloric stenosis (IHPS), is the most common cause of intestinal obstruction in infancy.
• IHPS occurs secondary to hypertrophy and hyperplasia of the muscular layers of the pylorus, causing a functional gastric outlet obstruction.
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Pyloric Stenosis
• The causes of IHPS are multifactorial. Both environmental factors and hereditary factors are believed to be contributory.
• Possible etiologic factors include deficiency of nitric oxide synthase containing neurons, abnormal myenteric plexus innervation, infantile hypergastrinemia, and exposure to macrolide antibiotics.
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Pyloric Stenosis
• The incidence of IHPS is 2-4 per 1000 live births.
• Death from IHPS is rare and unexpected. The reported mortality rate is very low and usually results from delays in diagnosis with eventual dehydration and shock.
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Pyloric Stenosis
• IHPS is more common in whites than Hispanics, African Americans, or Asians.
• IHPS has a male-to-female predominance of 4:1, with 30% of patients with IHPS being first-born males.
• The usual age of presentation is approximately 3 weeks of life (1-18 wk).
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History
• Classically, the infant will have nonbilious vomiting or regurgitation, which may become projectile (up to 70%), after which the infant is still hungry.
• Emesis may be intermittent or occur after each feeding.
• The emesis may become brown or coffee color due to blood secondary to gastritis or a Mallory- Weiss tear at the gastroesophageal junction
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History
• The infant will begin to show signs of dehydration and malnutrition such as poor weight gain, weight loss, decreased urinary output, lethargy, and shock.
• The infant may develop jaundice, which is corrected upon correction of the disease.
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Physical
• In up to 60-80% of the infants with infantile hypertrophic pyloric stenosis, a firm, nontender, and mobile hard pylorus that is 1-2 cm in diameter, described as an "olive," may be present in the right upper quadrant at the lateral edge of the rectus abdominus muscle.
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Physical
• Clinicians may also observe gastric peristalsis just prior to emesis as the peristaltic waves try to overcome the obstruction.
• Signs of dehydration include depressed fontanelles, dry mucous membranes, decreased tearing, poor skin turgor, and lethargy.
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Labs
• Electrolytes, pH, BUN, and creatinine levels– Hypochloremic, hypokalemic metabolic
alkalosis is the classic electrolyte and acid- base imbalance of pyloric stenosis
• Elevated unconjugated bilirubin level may be present.
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Imaging
• If the clinical presentation is typical and an olive is felt, the diagnosis is confirmed and further imaging is not warranted.
• Ultrasonography is the imaging modality of choice when evaluating a child for IHPS. It is both highly sensitive (90-99%) and specific (97-100%) in the hands of a qualified sonographer.
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US of Pyloric Stenosis
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Correction
• The Ramstedt pyloromyotomy is the procedure of choice– The underlying antro-pyloric
mass is split leaving the mucosal layer intact.
• Nonsurgical treatment for IHPS with atropine sulfate, both intravenous and oral, has shown encouraging results.– 21 days– May be an option for non-surgical candidates
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Prognosis
• Surgery is curative with minimal mortality.
• The prognosis is very good, with complete recovery and catch-up growth if detected in a timely fashion.
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Case #4
• 75 year old male presents to the ED with complaints of epigastric pain, intermittent nausea and vomiting and weight loss.– Smoked everyday of his life– Ate a diet of only smoked meats– Refused treatment for H. pylori– Avoided fruits and vegetables
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Gastric Cancer
• Gastric cancer is the second most common cause of cancer-related death in the world.– Gastric cancer is the seventh leading cause
of cancer deaths in the US.• More than 22,000 new cases are
diagnosed each year
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Gastric Cancer
• In the United States, Asian and Pacific Islander males and females have the highest incidence of stomach cancer, followed by black, Hispanic, white, American Indian, and Inuit populations.
• Gastric cancer affects slightly more men than women.
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Gastric Cancer
• Most patients are elderly at diagnosis. The median age for gastric cancer in the United States is 70 years for males and 74 years for females.
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History
• Most symptoms of gastric cancer reflect advanced disease. Patients may complain of indigestion, nausea or vomiting, dysphasia, postprandial fullness, loss of appetite, melena, hematemesis, and weight loss.
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History
• Early disease has no associated symptoms; however, some patients with incidental complaints are diagnosed with early gastric cancer.
• Most symptoms of gastric cancer reflect advanced disease.
• Late complications include pathologic peritoneal and pleural effusions; obstruction of the gastric outlet, gastroesophageal junction, or small bowel;
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Causes
• Diet - A diet rich in pickled vegetables, salted fish, excessive dietary salt, and smoked meats correlates with an increased incidence of gastric cancer.
- A diet that includes fruits and vegetables rich in vitamin C may have a protective effect.
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Causes
• Smoking – Smoking is associated with an increased
incidence of stomach cancer in a dose- dependent manner, both for number of cigarettes and duration of smoking.
– A meta-analysis of 40 studies estimated that the risk was increased by approximately 1.5- to 1.6-fold and was higher in men.
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Causes
• Helicobacter pylori infection– Chronic bacterial infection with H pylori is the
strongest risk factor for stomach cancer.– History of prolonged gastritis have a 6-fold
increase in their risk of developing gastric cancer
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Causes
• Previous gastric surgery– The rationale is that surgery alters the
normal pH of the stomach, which may in turn lead to metaplastic and dysplastic changes in luminal cells.
– Retrospective studies demonstrate that a small percentage of patients who undergo gastric polyp removal have evidence of invasive carcinoma within the polyp.
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Causes
• Some 10% of stomach cancer cases are familial in origin.
• Ebstein-Barr virus: The Epstein-Barr virus may be associated with an unusual form of stomach cancer (<1%), lymphoepithelioma-like carcinoma.
• Pernicious anemia associated with advanced atrophic gastritis and intrinsic factor deficiency is a risk factor for gastric carcinoma.
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Causes
• Gastric ulcers – Gastric cancer may develop in the remaining
portion of the stomach following a partial gastrectomy for gastric ulcer.
– Benign gastric ulcers may themselves develop into malignancy.
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Causes
• Obesity: Obesity increases the risk of gastric cancer.
• Radiation exposure: Atomic bomb survivors exposed to radiation have had an increased risk of stomach cancer.
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Labs
• The goal of obtaining laboratory studies is to assist in determining optimal therapy.
• A complete blood cell count can identify anemia, which may be caused by bleeding, liver dysfunction, or poor nutrition. Approximately 30% of patients have anemia.
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Labs
• Electrolyte panels and liver function tests also are essential to better characterize the patient's clinical state.
• Carcinoembryonic antigen (CEA) is increased in 45-50% of cases.
• Cancer antigen (CA) 19-9 is elevated in about 20% of cases
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Imaging
• Esophagogastroduodenoscopy has a diagnostic accuracy of 95%.
• Chest radiograph is done to evaluate for metastatic lesions.
• CT scan or MRI of the chest, abdomen, and pelvis assess the local disease process as well as evaluate potential areas of spread (ie, enlarged lymph nodes, possible liver metastases).
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Histology
• Adenocarcinoma of the stomach constitutes 90-95% of all gastric malignancies.
• The second most common gastric malignancies are lymphomas.– Gastrointestinal stromal tumors (2%),
Carcinoids (1%), adenoacanthomas (1%), and squamous cell carcinomas (1%)
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Treatment
• Most surgeons in the United States perform a total gastrectomy.
• A randomized trial comparing subtotal with total gastrectomy for distal gastric cancer revealed similar morbidity, mortality, and 5-year survival rates
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Outcome
• The 5-year survival rate for a curative surgical resection ranges from:– 60-90% for patients with stage I– 30-50% for patients with stage II disease– 10-25% for patients with stage III disease– <5% for patients with Stage IV
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Case #5
• 2 year old male presents with mother who states “My kid swallowed a fork”.
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Foreign Bodies
• Parents of children who have swallowed a coin that has passed the gastroesophageal junction should be assured that the foreign body will probably pass through the GI tract unimpeded and without consequence.
• Other objects that are likely to pass without incident include small toys, buttons, and marbles.
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Foreign Bodies
• Alkaline disk batteries or objects with sharp edges or points mandate more vigilant management.– Batteries that have passed the lower
esophageal sphincter (LES) should be monitored with serial radiographs taken at 12-hour intervals.
– Their passage may be aided with cathartics, gastrointestinal lavage, or enemas.
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Foreign Body
• Objects with sharp edges or points present a special problem because of the possibility for erosion or perforation.– These include pins, needles, tacks, razor
blades, pieces of glass, or open safety pins.• Esophageal impaction demands surgical removal• Many of these objects also pass through the GI
tract without incident once they are past the gastroesophageal junction
– Obtain a daily radiograph and monitor closely for signs of peritonitis or GI bleeding.
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Foreign Body
• Body packers are at risk of death if the packets of the illicit substance rupture.
• Such patients should be hospitalized and whole bowel irrigation (ie, Go-LYTLEY) considered. – Consultation with a specialist from a poison
control center is recommended.
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Questions?