grignard reaction key features: handling of air/ moisture sensitive chemicals, formation of c-c...
TRANSCRIPT
![Page 1: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/1.jpg)
Grignard Reaction CH3
O
RMgX
OH
R
CH3
Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond.
n-Butyl lithium
Key features: Strong base such as KOtBu, NaH, n-BuLi handled.
Boron trifluoride etherate
Key features: Moisture sensitive catalyst BF3:Et2O handled .
OH
RX
ORn-BuLi
O
OR NaBH4
BF3 Et2O
OH
Reaction Handled
![Page 2: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/2.jpg)
B(OH)2 X Pd catalyst
Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond.
Suzuki Coupling
Key features: Handling of air sensitive reagents, Aromatic C-C bond formation.
Negishi Coupling ZnX X Pd catalyst
Gomberg Reaction
Key features: Handling of diazonium salt. Aromatic C-C bond formation.
N2 X H OH
Reaction Handled
![Page 3: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/3.jpg)
Ritter Reaction
OH CO2OH
COOH
Key features: Displacement of tertiary alcohol group with amido group.
Vilsmeier-Haack Reaction
Key features: POCl3 handling. Typical formylation reaction.
Kolbe Carboxylation
Key features: Handling of high pressure reaction.
Ph
PhOH RCN
Acid
Ph NH
R
Ph O
N
POCl3
DMFN
H
O
R
R'
R
R'
Reaction Handled
![Page 4: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/4.jpg)
Birch Reduction Na, NH3
Key features: Handling of pyrophoric metals. Aromatic reduction.
Baeyer-Villiger Oxidation
Key features: Handling of reactive chemical, like peracid, Peroxide, etc.
Borane Reduction
OR
O
BH3 Me2S OH
Key features: Pyrophoric BDMS handled.
R
O
CH3COOOH O R
O
Reaction Handled
![Page 5: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/5.jpg)
NH2
O
NaOBr NH2Hofmann Rearrangement
Key features: Hypobromite handled. Synthesis of amine from ketone.
Reformatsky Reaction
Key features: Handling of sensitive organometallic reagent
Skraup Synthesis
Key features: Oxidation using H2SO4 and Nitrobenzene.
O
BrOEt
OZn
OEtHO
O
NH2
HO OH
OH H2SO4
PhNO2
N
Reaction Handled
![Page 6: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/6.jpg)
Chiral Separation
CH3
O
Chiral catalyst CH3
OH
CH3
O
Chiral metal catalyst
H2
CH3
OH
Key features: Separation of racemic pure compound.
Asymmetric Hydrogenation
Key features: Synthesis of optically pure compound.
Asymmetric Reduction
Key features: Handeled pyrophoric reagents. High ee achieved.
H3C
NHEt
L-Tartaric Acid
H3C
NHEt
Reaction Handled
![Page 7: Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as](https://reader036.vdocument.in/reader036/viewer/2022082414/56649e845503460f94b86a9f/html5/thumbnails/7.jpg)
Transesterification
S X S SO2NH2
n-BuLi, SO2 gas
NH3
O
NNN
O NN
N
Key features: Acid/ base catalyzed transesterification.
Click Chemistry
Key features: One-pot triazole chemistry.
Thiophene Chemistry
Key features: Handeled n-BuLi, sulfur dioxide gas.
R''O R
O
R'OH R'O R
O
R''OH
Reaction Handled