gross brain overview: part i gross brain overview: part i basic neuroscience james h. baños, ph.d
TRANSCRIPT
Gross Brain Overview: Part IGross Brain Overview: Part I
Basic NeuroscienceBasic Neuroscience
James H. Baños, Ph.D.James H. Baños, Ph.D.
OverviewOverview
Anatomical DirectionsAnatomical Directions Cranial FossaCranial Fossa MeningesMeninges Pathology of the Cranial Fossa & Pathology of the Cranial Fossa &
MeningesMeninges
Anatomical DirectionsAnatomical Directions
Dorsal fin
Anatomical DirectionsAnatomical Directions
Dorsal fin
Anatomical DirectionsAnatomical Directions
Dorsal fin
Anatomical DirectionsAnatomical Directions
Dorsal
Ventral
Anatomical DirectionsAnatomical Directions
Dorsal
Ventral
Rostral
Rostrum = Stage or speaking platform
Caudal
Caudus = tail
Anatomical DirectionsAnatomical Directions
Dorsal
Ventral
Rostral Caudal
Dorsal-ventral and rostral-caudal are with respect to the neuraxis
Anatomical DirectionsAnatomical Directions
But wait……we evolved
Anatomical DirectionsAnatomical Directions
But wait……we evolved…
Dorsal
VentralRostral
CaudalDorsal
Ventral
Ventral Dorsal
Rostral Caudal
Caudal
Anatomical DirectionsAnatomical Directions
RostralCaudal
Caudal
Anatomical DirectionsAnatomical Directions
Dorsal
Ventral
VentralDorsal
Anatomical DirectionsAnatomical Directions
Anterior-posterior and superior-inferior are in 3-D spaceAnd do not respect the neuraxis.
Anterior
Anterior
Posterior
Posterior
Superior
Inferior Superior
Inferior
Anatomical DirectionsAnatomical Directions
Medial-lateral can also respect either the midline, or some other reference point
Lateral
Medial
A
B
Anatomical DirectionsAnatomical Directions
Mesial = Medial
Just to keep it interesting:
Anatomical DirectionsAnatomical Directions
Proximal
Distal
Ipsilateral vs. ContralateralIpsilateral vs. Contralateral
Ipsilateral -- On the same side, with respect to Ipsilateral -- On the same side, with respect to a reference pointa reference point
Contralateral -- Opposite side, with respect to Contralateral -- Opposite side, with respect to a reference pointa reference point
Anatomical PlanesAnatomical Planes
Sagittal Plane
Horizontal/axial Plane
Transverse Section
Coronal Plane
Coronal PlaneCoronal Plane
Corona = crown….but think Statue of Liberty
Sagittal PlaneSagittal Plane
Sagittal MRI Mid-sagittal plane
Horizontal PlaneHorizontal Plane
AKA:AKA: Axial planeAxial plane CT planeCT plane
Cranial FossaCranial Fossa
Cranial FossaCranial Fossa
Distinct areas of the skull baseDistinct areas of the skull base Contain and support various parts of the brainContain and support various parts of the brain Contact point for the meningesContact point for the meninges
Cranial FossaCranial Fossa
Anterior cranial fossa -- frontal lobes
Middle cranial fossa -- Temporal lobes
Posterior cranial fossa -- Cerebellum and brain stem
Cranial fossa contain lumen, or holes forCranial fossa contain lumen, or holes forcranial nerves, arterial supply, and venous cranial nerves, arterial supply, and venous
drainagedrainage
MeningesMeninges
MeningesMeninges
Three layers covering the brainThree layers covering the brain Dura materDura mater ArachnoidArachnoid Pia materPia mater
Support, protectionSupport, protection Contain circulating CSF that supports the brainContain circulating CSF that supports the brain
MeningesMeninges
Dura MaterDura Mater
““Tough Mother”Tough Mother” Thick, leathery outer coveringThick, leathery outer covering Adheres to inner surface of skullAdheres to inner surface of skull Support, and forms sinus system (veinous Support, and forms sinus system (veinous
drainage)drainage) Pain sensitivePain sensitive Has own blood supply -- Has own blood supply -- Middle meningeal Middle meningeal
arteryartery
ArachnoidArachnoid
Spongy/fibrous layer between the dura and piaSpongy/fibrous layer between the dura and pia Collagenous connective tissueCollagenous connective tissue Keep brain suspended in meningesKeep brain suspended in meninges
Subarachnoid spaceSubarachnoid space Contains CSFContains CSF
Pia MaterPia Mater
Innermost layerInnermost layer Adheres almost indistinguishably to cortical Adheres almost indistinguishably to cortical
surface, including sulci and gyrisurface, including sulci and gyri Difficult to see grossly or removeDifficult to see grossly or remove
Dura MaterDura Mater
Dura MaterDura MaterMiddle meningeal artery
ArachnoidArachnoid
ArachnoidArachnoid
Pia and arachnoid together are sometimes Pia and arachnoid together are sometimes referred to as the referred to as the leptomeningesleptomeninges
CSF flows between the arachnoid and pia in CSF flows between the arachnoid and pia in the the subarachnoid spacesubarachnoid space
Dural ReflectionsDural Reflections
Dural ReflectionsDural Reflections
Also called Also called dural septadural septa In certain places, the dura doubles on itself and In certain places, the dura doubles on itself and
forms a division or partition between parts of forms a division or partition between parts of the brainthe brain Falx cerebriFalx cerebri Tentorium cerebelliTentorium cerebelli
Falx CerebriFalx Cerebri
Extends down the longitudinal fissure, Extends down the longitudinal fissure, between the cerebral hemispheresbetween the cerebral hemispheres
Forms the triangular-shaped superior sagittal Forms the triangular-shaped superior sagittal sinus superiorlysinus superiorly
Falx CerebriFalx Cerebri
Falx CerebriFalx Cerebri
Tentorium CerebelliTentorium Cerebelli
Extends inward between the cerebellum and Extends inward between the cerebellum and occipital lobesoccipital lobes
Forms a “soft top” for the posterior cranial Forms a “soft top” for the posterior cranial fossafossa
Brain stem passes through Brain stem passes through tentorial notchtentorial notch Forms the Forms the transverse sinustransverse sinus posteriorly posteriorly
Tentorium CerebelliTentorium Cerebelli
Tentorium CerebelliTentorium Cerebelli
Tentorium CerebelliTentorium Cerebelli
Pathology of the Pathology of the MeningesMeninges
MeningitisMeningitis
Infection/inflammation of the meningesInfection/inflammation of the meninges BacterialBacterial ViralViral
Can progress toCan progress to More widespread CNS infectionMore widespread CNS infection Hydrocephalus, if flow of CSF is blocked (e.g., Hydrocephalus, if flow of CSF is blocked (e.g.,
purulent accumulation)purulent accumulation)
BleedsBleeds
Epidural HematomaEpidural Hematoma Rupture of middle meningeal arteryRupture of middle meningeal artery Blood accumulates between dura and skullBlood accumulates between dura and skull
Mass effect compresses brainMass effect compresses brain Fed by Fed by arterialarterial perfusion…can grow quickly perfusion…can grow quickly
BleedsBleeds
Epidural HematomaEpidural Hematoma
Masseffect
Midlineshift
BleedsBleeds
Subdural HematomaSubdural Hematoma Rupture of bridging veins from surface of cortex to Rupture of bridging veins from surface of cortex to
veinous sinuses (e.g., superior sagittal sinus)veinous sinuses (e.g., superior sagittal sinus) Accumulates more slowly (veins)Accumulates more slowly (veins) Still results in mass effect and compression of the Still results in mass effect and compression of the
brainbrain Older people particularly susceptible. Why?Older people particularly susceptible. Why?
BleedsBleeds
Subdural Hematoma -- crescent shapedSubdural Hematoma -- crescent shaped
BleedsBleeds
Subdural HematomaSubdural Hematoma
BleedsBleeds
Subarachnoid HemorrhageSubarachnoid Hemorrhage Rupture of cerebral vein or arteryRupture of cerebral vein or artery Bleeding into the subarachnoid spaceBleeding into the subarachnoid space Blood hugs the surface of the brain (i.e., within the Blood hugs the surface of the brain (i.e., within the
subarachnoid space). No mass effectsubarachnoid space). No mass effect Can block flow of CSF and result in Can block flow of CSF and result in
hydrocephalus hydrocephalus
BleedsBleeds
Subarachnoid HemorrhageSubarachnoid Hemorrhage
Herniation SyndromesHerniation Syndromes
subfalcine cingulate herniationsubfalcine cingulate herniation Cingulate gyrus herniates below falx cerebriCingulate gyrus herniates below falx cerebri
Herniation SyndromesHerniation Syndromes
Uncal/Transtentorial HerniationUncal/Transtentorial Herniation Uncus (medial temporal lobe) herniates medially over the Uncus (medial temporal lobe) herniates medially over the
edge of the tentorium cerebelli into the brain stemedge of the tentorium cerebelli into the brain stem
Herniation SyndromesHerniation Syndromes
Tonsilar HerniationTonsilar Herniation Cerebellar tonsil herniates through the foramen magnumCerebellar tonsil herniates through the foramen magnum
Coming up next…Coming up next…
OrganizationOrganization Developmental/EvolutionaryDevelopmental/Evolutionary MorphologyMorphology
3-D Orientation to Internal 3-D Orientation to Internal StructuresStructures