2022 2022WWW.CAYMANCHEM.COM WWW.CAYMANCHEM.COMCAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897

Kinase InhibitorsThe signal transduction pathways responsible for virtually every cell function in the body are built on a network of kinases. Because kinases are so acutely involved in the regulation of biological processes, the field of drug discovery endeavors to validate novel kinase targets for therapeutic intervention as well as to develop and improve target selectivity of modulatory small molecules. Use the signal transduction cascades inside this brochure to explore Cayman’s broad selection of inhibitors targeting specific nodes of the major kinase signaling pathways.

NF-кB

PARP Bcl-2 Bad

RAD514-3-3

c-Kit c-Met EGFR

PDPK1/PDK1

mTOR

DNA-PK

Wee1

S6KIKK

GSK3

PIP₃ DAGCa2+PTEN

PLC

PKC

JAK FAK

RSK MNK

HER2 FGFR IGF-1R CSF1R/Fms FLT3 ALK DDR1 EphB3

internalization and adaptor binding

MAP3Ks

MAP2Ks

MAPKs

proliferation glycolysis

apoptosis

translation

cell cycle

DNA damageDNA repair

Src

MEKK2/3

MEK5

Raf

MEK1/2

ERK1/2ERK5

PI3K

PKB/Aktp38JNK

ATM c-Abl

Aurora Plk CDK

AMPK

Chk1/2

KINASE SIGNALINGPATHWAYS

Kinase Network Map adapted from the Harvard Medical School LINCS Center

Kinases

Click on any of the kinases in the pathway to browsespecific inhibitors or visitwww.caymanchem.com/kinases to explore Cayman's entire catalog of more than 1,300 kinase inhibitors.

Second messengers

Hsp90

Ras

STAT

TSC

p53

Cdc25

MDM2

Related proteins Kinase Signaling Pathways Diagram Inside!

120301149813139

1001042211494

1208722143200561486117135

19420153441330814881

10009209

1311119157218131303221136

167331312313122

1001024610011251

1666713313172761729015115

1962633347222581827128927

2119321503167091798616613

1483317505177081364117329

1670711598176691209411609

104601000672710010399

1306718075

149321470818095

1001101118130

16986152797092032877

10010591

16499148701540618412

10010236

1538313310133111396481590

1738518193180991555317701

21482175421594618096

10010466

1159916999130341629270970

1697813643133461099714185

1149119178203512149017859

1917613602150151073513601

1977819374185161837117670

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Item No.Item No.Product Name

Product Name

Product Name

Product Name

Product Name Product Name

Product Name

Product Name

Product Name

Product Name

Product Name

Product Name Product Name Product Name

Product Name Product Name

Product Name Product Name

Product Name

Product Name

Product NameProduct NameBosutinibDasatinibImatinib (mesylate)NilotinibPonatinib

(R)-CrizotinibGolvatinibINCB 28060SU11274Tivantinib

CC-115Ku-0060648 NU 7026NU 7441PI-103

AZD 4547BGJ398JNJ-42756493PD 173074TAS 120

1-AzakenpaulloneBIOCHIR99021SB-216763TWS119

BMS 345541 (hydrochloride)IKK-16 (hydrochloride)IKK2 Inhibitor VIIMD 0354TPCA-1

BLZ-945EdicotinibKi20227PexidartinibPLX5622

FLT3 Inhibitor IIIGilteritinib PacritinibQuizartinibUNC2025

AG-1024BMS 754807LinsitinibNVP-AEW541 (hydrochloride)Picropodophyllotoxin

BaricitinibCP 690,550FilgotinibLestaurtinibRuxolitinib

DoramapimodPD 169316SB 202190SB 203580VX-745

BX-795BX-912GSK2334470KT 5720UCN-01

BYL719CAL-101LY294002TGR-1202Wortmannin

A-443654Akt Inhibitor VIIIAZD 5363GDC-0068ML-9

Calphostin CGö 6976Gö 6983LY333531 (hydrochloride)Staurosporine

BI-2536BI-6727GSK461364ON-01910 (sodium salt)TAK-960

BentamapimodJNK Inhibitor VJNK Inhibitor VIIIJNK Inhibitor XVISP 600125

AZD 6244BIX02189PD 0325901TrametinibU-0126

AZD 8055PP242RapamycinTorin 1Torin 2

AZD 7762CCT241533 (hydrochloride)LY2603618LY2606368PF-477736

AMG 900MLN8237PF-03814735Phthalazionone pyrazoleZM 447439

AP26113CeritinibCH5424802PF-06463922TAE684

Abl Family & Bcr-Abl

c-Met

DNA-PK

1554421107191661829819173

Item No. Product NameFR180204GDC-0994SCH 772984Ulixertinib (hydrochloride)XMD8-92

ERK FGFR Family

GSK3 IKKs

CSF1R/Fms

1149216237104831316611493

Item No. Product NameAfatinibAZD 9291ErlotinibGefitinibLapatinib

EGFR/ErbB/HER Family

FLT3

IGF-1R

JAK Family

p38 MAPK

PDPK1/PDK1 PI3K PKB/Akt

PKC

2108914244131981149713338

Item No. Product NameCGP 77675 (hydrate)PP1 (Src Inhibitor)PP2SaracatinibSU6656

SrcPlks

JNK MEK

mTOR

1470710009197

162731514928459

Item No. Product NameDinaciclibFlavopiridol (hydrochloride)PD 0322991 (hydrochloride)Ro 3306Senexin B

CDKs Chk1/2

AuroraALK (Anaplastic Lymphoma Kinase)Simplify Screening and Hit-SeekingKinase Screening Library (96-Well)Item No. 10505

Comprehensive Kinase Screening LibraryItem No. 28940

· Consists of two plates with ~160 selective and non-selective kinase inhibitors

· Includes inhibitors of lipid, receptor and non-receptor tyrosine, serine/threonine, and dual specificity kinases

· Targets include the ROCK, ALK, GSK3, PKC, PDGFR, VEGFR, Src, MAPK, CDK, and PI3K families, among many others

· Contains more than 850 kinase inhibitors, providing greater coverage of individual kinases, kinase isoforms and mutants, and kinase families

KINASE RESOURCE CENTER Browse more than 1,300 kinase inhibitors

Find tools and resources for inhibitor selectionwww.caymanchem.com/kinases

2022 2022WWW.CAYMANCHEM.COM WWW.CAYMANCHEM.COMCAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897 CAYMAN CHEMICAL · 1180 EAST ELLSWORTH ROAD · ANN ARBOR, MI 48108 · USA · (800) 364-9897

NF-кB

PARP Bcl-2 Bad

RAD514-3-3

c-Kit c-Met EGFR

PDPK1/PDK1

mTOR

DNA-PK

Wee1

S6KIKK

GSK3

PIP₃ DAGCa2+PTEN

PLC

PKC

JAK FAK

RSK MNK

HER2 FGFR IGF-1R CSF1R/Fms FLT3 ALK DDR1 EphB3

internalization and adaptor binding

MAP3Ks

MAP2Ks

MAPKs

proliferation glycolysis

apoptosis

translation

cell cycle

DNA damageDNA repair

Src

MEKK2/3

MEK5

Raf

MEK1/2

ERK1/2ERK5

PI3K

PKB/Aktp38JNK

ATM c-Abl

Aurora Plk CDK

AMPK

Chk1/2

KINASE SIGNALINGPATHWAYS

Kinase Network Map adapted from the Harvard Medical School LINCS Center

Kinases

Click on any of the kinases in the pathway to browsespecific inhibitors or visitwww.caymanchem.com/kinases to explore Cayman's entire catalog of more than 1,300 kinase inhibitors.

Second messengers

Hsp90

Ras

STAT

TSC

p53

Cdc25

MDM2

Related proteins