h3abionet newsletter july 2016 issue 16 nm edits · 2019. 3. 13. · page | 1 h3abionet monthly...

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Page | 1 H3ABioNet Monthly Newsletter Issue 16 : July 2016 This newsletter describes the H3ABioNet activities from January to June 2016. The first half of this year has seen the successful completion of a number of training workshops and the Education and Training working is busy working on the organization of several new workshops which will take place over the second half of the year. This issue includes an article describing the experiences of a trainer from one of the workshops which H3ABioNet provided support for. In other exciting training news, our first Introduction to Bioinformatics Course has started and is being broadcast to 19 classrooms around Africa. We will keep you updated on its progress! The other working groups are also working hard towards achieving their milestones and some of their activities are described below in their working group reports. The research working group established a Research proposals sub- committee to provide support for grant proposals through peer review. I hope the students and researchers will take advantage of this initiative to improve funding and other proposals before they get submitted. The working group has also successfully run a monthly webinar series which has seen some excellent research talks presented by both junior and senior scientists. At H3ABioNet Central we submitted the H3ABioNet annual report to the NIH, which include requested budgets for year 5, our final year of the grant! We are now preparing for the next phase, and templates have been sent out to existing and potential new nodes to complete if they are interested in participating in the new proposal for an H3Africa Informatics Network. I invite you now to continue reading to find out more about our activities over the last few months. Prof. Nicky Mulder

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Page 1: H3ABioNet Newsletter July 2016 Issue 16 NM edits · 2019. 3. 13. · Page | 1 H3ABioNet Monthly Newsletter Issue 16 : July 2016 now preparing for the next phase, and templates have

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sletterIssue16:July2016

ThisnewsletterdescribestheH3ABioNetactivitiesfromJanuarytoJune2016.The

firsthalfof this yearhas seen thesuccessful completionofanumberof training

workshops and the Education and Training working is busy working on the

organizationofseveralnewworkshopswhichwilltakeplaceoverthesecondhalf

of the year. This issue includes an article describing the experiences of a trainer

from one of the workshops which H3ABioNet provided support for. In other

exciting trainingnews,our first IntroductiontoBioinformaticsCoursehasstarted

andisbeingbroadcastto19classroomsaroundAfrica.Wewillkeepyouupdated

onitsprogress!

The other working groups are also working hard towards achieving their

milestonesandsomeoftheiractivitiesaredescribedbelowintheirworkinggroup

reports. The research working group established a Research proposals sub-

committeetoprovidesupportforgrantproposalsthroughpeerreview.Ihopethe

studentsandresearcherswilltakeadvantageofthis initiativeto improvefunding

and other proposals before they get submitted. The working group has also

successfullyrunamonthlywebinarserieswhichhasseensomeexcellentresearch

talkspresentedbybothjuniorandseniorscientists.

At H3ABioNet Central we submitted the H3ABioNet annual report to the NIH,

which include requestedbudgets for year 5, our final year of the grant!We are

nowpreparing for thenext phase,and templates havebeen sentout toexisting

andpotentialnewnodestocompleteiftheyareinterestedinparticipatinginthe

newproposalforanH3AfricaInformaticsNetwork.

Iinviteyounowtocontinuereadingtofindoutmoreaboutouractivitiesoverthelastfewmonths.

Prof.NickyMulder

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Anumberof trainingworkshopshavebeenplannedand runduring the firsthalfof

2016 with various levels of involvement from H3ABioNet. The first was a Whole

Genome and RNA Sequencing workshop hosted by the University of Khartoum,

Sudan inMarch 2016. The training was conducted as a pre-conference workshop

during the University of Khartoum’s Postgraduate Conference. The workshop was

held over five days and covered the practical analysis of whole-exome and RNA

sequencing data. Although H3ABioNet did not directly fund the workshop, several

H3ABioNet students were given travel fellowships to attend. You may read more

aboutthisworkshopinafeaturearticleincludedinthisnewsletter.

Aworkshop, focused on the Bioinformatics Analysis and Annotation of Variants in

NGSdata,washeldasasatelliteworkshoptothePharmacogenomicsandPrecision

MedicineConference,inApril2016atUniversityofCapeTown(UCT).Theworkshop

wasaimedatgenetics,genomicsandbioinformaticsresearchersinterestedintheuse

of genomic data for personalizing treatment. It included a combination of lectures

andhands-on practical exercises covering topics such asNGS theory (anoverview)

andannotationofvariants,includingfunctionalanalysisandimplications.H3ABioNet

provided travel fellowships to 6 African students to attend the workshop and

contributedtoteachingandsettingupofinfrastructurefortheworkshop.

TheH3AfricaNicolproject,incollaborationwiththeJ.CraigVenterInstitute,USA,ran

a practical workshop on microbiome analysis at UCT in April 2016. H3ABioNet

provided technicalandadministrativesupportandcontributed to theteaching.The

workshopprovidedabackgroundtomicrobiomestudiesandcoveredtopicssuchas

sample preparation, sequencing, run interpretation, pipeline processing for

taxonomic classification and post-processing analysis. The workshop was designed

for participantswho already have basic bioinformatics skills andwhomay already

havebeeninvolvedinmicrobiomework.

TheH3ABioNetEducationandTrainingworkinggroup(E&TWG),inconjunctionwith

theH3ABioNetInfrastructureworkinggroup,heldadatasupportworkshoppriorto

the8thH3Africaconsortiummeeting inSenegal inMay2016.H3ABioNet flewin17

H3AfricaDataSupportworkinggroupmemberstoattend.Thisinteractiveworkshop

provided an overview of data management, analysis and submission for H3Africa

projects. ItalsoprovidedanopportunityforDataSupportWorkingGroupmembers

who represent the H3Africa projects, to engage with H3ABioNet and discuss their

needs.

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Tocomplementourformaltrainingendeavours,anumberofinternshavealsobeen

placedinordertogainsomeone-on-onetrainingatourpartnernodesinH3ABioNet.

Mr Shaun Aron from the University of the Witwatersrand H3ABioNet node was

awarded an internship at Harvard, wherehe spent 3monthsworkingwith various

experts inpopulationgenetics. The latest internships includeMsAzzaAhmed,who

hasbeenawardedaninternshipatourUniversityofIllinoisH3ABioNetnode,where

she will learn about high performance computing for whole exome and RNA

sequence data. Trust Odia and Falola Oluwadamilare from Covenant University in

Nigeria have been placed at the Institute Pasteur node in Tunisia to work on

modellingofhost-pathogeninteractions.

The E&T WG is also excited to announce that the online Introduction to

Bioinformaticscoursewassuccessfullylaunchedonthe13thJuly2016andiscurrently

underway. An immense amount of planning and preparation has gone into

developingthecourseandweareexcitedtohaveover350participantsregisteredfor

thecourseacross19classroomsin11Africancountries!Wehavejustcompletedthe

firsttwo-weekmoduleforthecourse(DatabasesandResources)andhavereceived

somegreatpositivefeedbackfromtheclassroomsthusfar.Besuretocheckoutthe

course webpage that contains information on all the classrooms as well as the

recordedcoursematerial(lecturerecordings,slidedecksandpracticalassignments)

astheybecomeavailable.http://training.h3abionet.org/IBT_2016/?page_id=130.

IBTwebsitehomepage.Lecturevideos,slidesandassignmentsareopenaccess

ShaunAronandNickyMulder

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TheInfrastructureworkinggroup(ISWG)hasbeenbusyinthefirstsixmonthsof

2016.

• WehelpedrunaverysuccessfulDataSupportWorkshop,inconjunctionwiththeE&TWG,atthe8thH3AfricaConsortiumMeetinginDakar,Senegal.Thisbroughttogetherresearchgroups,representativesofthebiorepositories,andotherkeystakeholderstodiscussandplanhowdata,generatedbytheresearchgroups,willbeprocessedandmoved.Afterhearingfromparticipantsontheirgoals,wehadsessionson:laboratoryinformationmanagementsystems;dataharmonisation;overviewofkeypipelinesandanalysis;dataprocessing,storage,transferandsecurityoptions;anddrawingupadatamanagementplan.

• TheH3AfricaParticipantsRecruitmentDatabasewentintooperation.AttherequestofthefunderswedevelopedadatabasesystemtoallowH3Africaprojectstoreportonprogressinrecruitmentofparticipantsandcollectionofdata.ImplementedusingREDCap,thesystemwasdevelopedinashortperiodoftimeandhasreceivedgoodfeedbackfromall.Manypeoplewereinvolvedinthis,butparticularcreditgoestoMamanaMbiyavanga.

• TheCloudComputingTaskforceheldseveralon-linemeetings,andstartedacollaborationwithVictorJongeneel’sgroupattheUniversityofIllinoistoworkonprojectsofcommoninterest.WeareplanningaCloudHackathonforAugust2016todevelopportablecomputationalpipelinesofrelevanceforH3Africaandtodevelopskillsonthecontinent.

• ManymembersoftheISWGhavebeenverybusywiththeH3AfricaCustomChipdesignproject.Using300genomesgeneratedbyH3Africaprojectsaswellasotherdatasets,H3ABioNetisworkingwithpartnerstodevelopacustomchipfortheGWASprojectsbeingdoneinH3Africa.Thishasrequiredhugecross-continentaldatatransfers(over100TB)andlotsofcomputation.

• Wearestillbusywithanumberoflongtermprojects,including:rolloutofNetmapandGlobusOnlineendpointsformanagingandmonitoringdatatransfers;deployingandupgradingeBiokits;andupdatingsystemsadministrationdocumentation.

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Afteraperiodofrelativelylittlework,theDataManagementTaskforceisstartingto

gearupfortheexpecteddelugeofdatafromtheH3AfricaProjects.Thiswillbea

majorareaofworkforthenext6months.RolloutoftheGlobusOnlineandnetmap

endpointswillcontinue,too.

DataSupportworkshopat8thH3AfricaconsortiummeetinginDakar,Senegal

SureshMaslamoneyScottHazelhurst

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Since January 2016, a bioinformatics themehas been chosen for each researchseminar run by the Research Working Group (RSWG). For each session, twospeakers working in the field are invited to give a 20-minute presentation,followed by 10-15 minutes for interactions with participants, questions andanswers. Topics covered so far are: GWAS and Population Genetics;Metagenomics; Big Data; NGS; and planning ones career within the field ofbioinformatics.

TheH3ABioNetResearchProposalsSub-committeewasestablished.ThechairoftheRSWGcompliedadraftforgeneralproposalguidelines,whichwascirculatedamongthemembersoftheworkinggroupaswellasotherinterestedmembersofthe H3ABioNet network. Somemembers of this sub-committee expressed theirwillingnesstoreviewnodes'proposalsaswellasgraduatestudents'proposals.

AsecondMozillaStudyGroupwaslaunchedinKhartoum,SudaninMarch2016asafollowupfor theNGStrainingworkshopthattookplacethere.AzzaAhmed isleadingthestudygroup,whichmeetseveryMonday.Duringeachmeeting, twomembers of the group, on a rotation basis, present and summarize a chapterwithinaselectedbioinformaticsbookorarticle.This isfollowedbydiscussionofthe presented material. We are aiming to launch other study groups at thedifferentH3ABioNetnodes.

H3ABioNetisorganizingajointhackathonwiththeIBMResearchAfricateam.Themain objective of this hackathon is to analyse transcriptional data sets from arangeofMalaria parasite isolatesexposed toartemisinin inculture,whichhavebeen generated by University Notre Dame (US). This data needs to be pre-processed andprepared for anopen challenge thatwill be launched under theDREAMChallengesinitiativewithinthenext2years.ThehackathonwillbeheldinJohannesburg, South Africa from 5th to 10th September 2016. For furtherinformation, kindly refer to the hackathon call available at this link:http://h3abionet.org/h3abionet-ibm-research-africa-hackathon-malaria-drug-resistance-2016

SocialmediachannelsliketwitterandFacebookhavealsobeenusedtoadvertise

for the H3ABioNet Researchworking group seminars to promote the seminars

andattractmoreattendees.

AmelGhouilaFaisalFadlelmola

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Overview

Thisperiod (January– July2016)camerighton theheelsof the fourthconsortium

Annual general meeting in November 2015, and so began with lots of promise.

StrategyfortheYear4activitieswaspresentedatthegeneralmeetingandwastobe

quicklyadoptedandimplemented.Highonthelistwere:establishmentofthelong-

overduenodeliaisonscheme,theHelpdeskmanagementcommittee,newtoolsfor

outreach among these slide decks, flyers, brochures, the group article, and an

improvedwebsite-allgearedtowardsengagingawidersetofaudiences.

Progresssofar

Ofthelistedactivitiesabove,wehavemadesomeprogressonthefollowing:

• Membertermsofreference(TOR)-thesehavebeenupdatedandrevised.

• Work group reconstitution - we have registered dwindling meetingparticipation from members. We are currently revisiting working groupcomposition,callingfornewvolunteers,re-examiningcompileddeliverablesandlayingoutnewstrategysforfutureoperations.

• Helpdesk management committee - advanced work plans are in place forthisactivity.

• Outreach-wearegearingtostartonthisinearnest.

• Helpdeskarticle-hasbeenstartedonbut isyet tobe finalized,so there isstill roomforadditional contribution andauthorship. Please get in touch ifinterested.

Challengesandwayforward

• The dwindling activity participation mentioned above has greatly slowed

down the pace of our group activities. In view of this we are re-branding,

expandingmembershiptoincludevariouscategories,andarefocusingmore

ontheoutreachaspectsofourcompileddeliverables.Forthisweshallneed

adiversesetof skill setsandwesee lotsofopportunities forcontribution.

We are also contemplating the launch of amonthly group journal club to

draw more people. We are calling for renewed commitments from all

volunteers, as success depends on collective participation in our coming

groupactivities.

JonathanKayondoPandamSalifu

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During the initialH3ABioNetGeneralAssembly in2012, theNodeManagersdecided

that thenetwork should developand implementaNodeAssessmentExercise (NAE).

TheprimarygoalfortheNAEwastogiveindividualNodestheopportunitytoprove,in

an objective fashion, that they had reached the level of technical competence that

couldbeexpectedfromgroupsthatwouldprovidedataanalysis servicestoH3Africa

researchprojects. It isoneof themajor goalsof theH3ABioNetnetwork to develop

technical skills and infrastructure on the African Continent to a level where African

scientistsnolongerdependoncolleaguesinEurope,AsiaorNorthAmericatoanalyse

thegenomicdatageneratedbytheirresearchprojects.

ANodeAssessmentTaskForce(NATF)wasassembledaftertheGeneralAssembly,and

taskedwith developing a framework for the organisation of the NAE aswell as the

materials for two specific exercises driven by the needs of the H3Africa research

projects:thecallingofgenomicvariantsfromhigh-throughputgenomesequencedata,

and the processing of chip-based genotyping data followed by genome-wide

associationstudies(GWAS).TheNATFproducedanAssessmentProtocoloutliningthe

procedures used to administer the NAE, including an independent evaluation by

expertsexternal toH3ABioNet. Italsoproduced thematerials for the first twoNAE:

standardoperatingprocedures(SOP)fortheanalysis,trainingdatasetstohelpnodes

prepare for taking the NAE, and personalized test datasets used during the actual

assessment.TheUniversityofCapeTownNodetooktheleadershipfortheGWASNAE,

while the University of Illinois worked on the variant calling NAE. All the necessary

materialswerereadybyend2013.

During the 2013 General Assembly, several nodes expressed the desire to have

additional NAE available to them, to test analysis skills that may be more widely

shared.Asaresult,theNATFproducedtwomoreNAE,fortheanalysisofmicrobiomes

fromthehigh-throughputsequencingof16SrDNAamplicons,andforgeneexpression

analysis from RNA-seq datasets. The necessary materials were prepared in a

collaborationbetween theUCT and Illinois nodes, andhavebeen available fromthe

fallof2014.

The first H3ABioNet node to actually take the plunge was the Wits node in

Johannesburg,whosubmittedtotheNAEinthesummerof2014.TheWitsnodetook

advantageofanH3ABioNetGWAScourseandofthepresenceofanintern fromthe

BotswanaNodetoassembleananalysisteamandashadowteam,whoindependently

analysed the test data.The report theysubmittedwas reviewedvery positively, and

theywereaccreditedwithflyingcolours.Ittookoverayearbeforethenexttwonodes

declaredthemselvesreadyinthefallof2015:theUCTnodeforthevariantcallingNAE,

and theCUBREnode inNigeria for theGWASNAE.Again, bothnodes did verywell,

andwereaccreditedasaresult. It isveryencouragingtoseethatallnodesthattook

theNAEperformedextremelywellintheviewofourexternalexperts.

Itshouldbenoted,however,thatH3ABioNetincludes32differentnodes,andthatso

faronly threehave takenoneof theNAE,andnonehave takenmore thanone.The

H3ABioNetleadershiphasmadeitapriorityforallparticipatingnodestoconcentrate

ontrainingtheirstaff,throughcoursesandinternships,togetreadyandtaketheNAE

beforetheendofthecurrentgrant in2017.Wesincerelyhopethatmorenodeswill

provetheircommitmenttoactuallydeveloptheirtechnicalcapacityandtoparticipate

intheNAEwithinthenextyear. VictorJogeneel

ProgressintheH3ABioNetnodeassessmentexercise

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InMarch 2016 I travelled to Sudan to help run aweeklongwhole exomeandRNAsequencing data analysis course at the University of Khartoum. The course wasattendedby25students,mostlyfromtheUniversityofKhartoumwithawiderangeof backgrounds, including researchers from medicine, veterinary and chemistrydepartments.

ThegroupinfrontoftheUniversityLibrary

CourseDesign

Iwastaskedwithcoveringthewholeexomesequencing(WES)process.Istartedwithan introduction to sequencing technologies, different sequencing approaches, andthechallengesposedbyeachapproach.OverthenextfewdaysIcoveredalignment,variantcallingandannotation,thebioinformaticprocessesrequiredtoturn therawsequencing data into a list of variants and how to analyse and interpret thesevariants.Themorningsconsistedoftalksprovidingabackgroundtotheconceptsandtools,whichwerethenappliedinthepracticalsessionafterlunch.

Thefirstpracticalsessiontookstudentsfromtherawdata(BAMfile)throughtoalistof variants (vcf file), covering quality control and applying different filters. In thesecondsessionstudentstookarealdiagnosticcase,usingthepatient'sphenotypetodesign a gene panel, annotate variants and apply filters and bioinformatic tools toidentifythecausativevariants.

Thecourseranverysmoothly

The course and practical sessions ran very smoothlywith students very interactiveandopen,askinglotsofquestionsanddemonstratingunderstandingofthematerialpresented. Under the leadership of Prof. Faisal Fadlelmola the University hasdeveloped a very good computer infrastructure, ideally suited to running such acourse,with20workstationsrunningBioLinuxandacluster,allofwhichare inverysafehandswithAzzaAhmed,thegroup’ssystemadministrator.

Iwould also like to thankRehabAhmedandAzza (again!) for their help answeringquestionsandtroubleshootingthroughoutthepracticals.

WholeexomeandRNAseq

analysiscourse,Khartoum

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Thecomputersuiteiswellsetupforrunningsuchacourse

Coursephotoinclassroom

ExperienceofSudan

I didn’t know what to expect from Khartoum, however I was very pleasantlysurprised.EveryoneImetwasveryfriendlyandhospitable,apointdemonstratedbynearlyhalf thecourseactingasexpertguides forusonatourofKhartoumthedayafterthecoursehadfinished.OneofthestudentskindlypresenteduswithapaintingofanAlzeer,atraditionalpottostorewaterintheAlhoush(thecommunalcourtyardofafamilyhome)shehadpaintedherself.

I felt very safe travelling around the city and despite the city not being a touristhotspot the hotel was very comfortable and we ate very well at a range ofrestaurants!One restaurant even treatedus toaperformance fromoneof finalists(?)fromSudanesePopIdol!

SomethingswereasIexpected-itwashot!Mostdayswereabove40oC(apparently

reaching47oConeday!)withtheoddsandstorm.LuckilythePCroomhadfansandAC! It was interesting to see the PC’s being wrapped up each evening and howdespitethistheywerestillcoveredbysandanddustthefollowingmorning!

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The(?)finalistfrompopidolperformingatarestuarant

TheUniversitylibraryatnight

Thanks

I would like to thank H3ABioNet and the Mozilla Foundation for funding withoutwhich the course would not have been possible and Jelena and Risha for theintroductionsandencouragement!

I’dalsoliketothankFaisalformakingusfeelsowelcomeandhostingusthroughouttheweekandtheUniversityofKhartoumwhowereveryhelpful,makingtheVisaandimmigrationprocessesverysmooth.

ThisarticlecomprisesexcerptsfromanarticlebyAledJones

Originalarticleavailableathttp://trendinafrica.org/wp-content/uploads/2016/04/Sudan-school.pdf

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Recently,SusanSzuchwroteanewspiecefortheNationalCenterforSupercomputing

Applications (NCSA) newspage, in which she described the H3Africa African chip

design project and the invovlement of the NCSA Blue Waters team in making it

possible“todiscovergenomicvariantsinover300deeplysequencedhumansamples

tohelpconstructagenotypingchipspecificforAfricanpopulations”.Asmanyofyou

areaware,theH3AfricaGenomeAnalysisWorkingGrouppartneredwithH3ABioNet

andtheWellcomeTrustSangerInstitutetodesignandconstructthischip,whichwill

be used as a tool for rapid and inexpensive genotyping of individuals in order to

identifygenomicbasesofdisease,specificallyinAfricanpopulations.Duetothelarge

amountsofdata,thisprojectrequiredaveryfastcomputer-wherebettertogothan

NCSA’sBlueWater;thefastestsupercomputeronauniversitycampus.

SzuchnotestheeffortoftheBlueWatersteamasbeinginstrumentaltothesuccess

of the project, in which Professor NicolaMulder’s team at the University of Cape

Town (UCT), in partnership with Dr Manj Sandhu’s team at the Wellcome Trust

Sanger Institute, developed the computational workflow for extracting genomic

variants, and in which the High Performance Biological Computing node (HPCBio)

helpedinitiatetheworkflowonBlueWaters.

Inthearticle,SzuchquotedDr.LiudmilaMainzer,seniorresearchscientistwithNSCA

andtheHPCBiogroup, insayingthat"withouttheir[BlueWaters’] involvementand

professionalism, this work would have been very difficult to complete. For our

project, the Blue Waters team was as important as the compute, storage and

networkingresources."

Thearticlealsodescribeshowtheprojectwasamutuallybeneficialoneandthatthe

NSCA Blue Waters team discovered new tools for data transfer through

troubleshooting problems in conjunction with the H3ABioNet team of

bioinformaticians.Theimportanceofthisprojectintermsofsocialimpactandreach

wasalsonoted.

KimGurwitz

Theoriginalfullarticle,writtenbySusanSzuch,isavailableat

http://www.ncsa.illinois.edu/news/story/supercomputer_changing_genetic_medic

ine_in_africa

SupercomputerchangingGeneticmedicine

inAfrica

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Congratulations to Gerrit Botha and Liudmila Sergeevna Mainzer who recently

provided oral presentations on the bioinformatics data processing of the H3Africa

GenotypingChipandVariantcallingapproachesontheBlueWatersSupercomputer

at the 4th Annual NCSA Blue Waters Symposium

(https://bluewaters.ncsa.illinois.edu/bw-sym-2016)

Gerrit Botha also received theprize for themostdata transfersconductedonBlue

Waters.

Congratulations to two Consortium students (Olivier Sheik Amamuddy and Phillip

Magambo), who completed one-year Bioinformatics MSc programmes in the

ResearchUnit in BioinformaticsatRhodesUniversity in 2015andstarted their PhD

degreesatRUBithisyear.OlivierisfromMauritiusandamemberofProfYasminaJ.

Fakim’sgroupaspartofH3ABioNet,andPhillipisfromUgandaandamemberofProf

EnockMatovu’sgroupaspartofTrypanoGEN.

Congratulations toRUBimembers PhillipMagamboandDavidBrownwhoreceived

best poster and best oral presentation, respectively, at the national SASBMB

conferenceinJuly2016withintheBioinformaticsandOmicstrack.PhillipMagambo

presented his MSc work on a drug discovery project against Human African

Trypanosomiasis (sleeping sickness). David Brown presented his work on “Human

GenomeMutation Analysis Portal –HUMA”which is beingdesigned as part of the

H3ABioNetprojecttohosthumanmutationinformationandanalysenonsynonymous

mutationsattheproteinlevel.

CongratulationstoJaquilineMugofromcentralnode,whowasawardedascholarship

tovisitourSABmemberMarkMcCarthy’s lab inOxfordandtoEmileChimusa,who

has taken up a Senior Lectureship in the Division of Human Genetics at UCT.

CongratulationstoNicolaMulder,whoco-authoredaSciencepaperwiththeGlobal

Alliance for Genomics and Health:

http://www.ncbi.nlm.nih.gov/pubmed/27284183

RUBimembers,RowanHatherley,DavidBrown,MichaelGlenisterandOzlemTastan

Bishop,havecompleted the firstphaseof thehomologymodellingpipeline,PRIMO

(PRotein Interactive Modelling pipeline), and it is available for the use of the

Consortiummembersathttps://primo.rubi.ru.ac.za/.PRIMOisforproteinmonomer

modelling,andallowsuserstomodel ligandsandions incomplexwiththeirprotein

targets.Itsuser-friendlyinterfacemakesiteasytouseandifnecessarytochangethe

modellingparameters.

Anyannouncementsforthenexteditionofthenewslettermaybesendto

[email protected]@uct.ac.za

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August22ndtoAugust26th2016;H3ABioNetCloudcomputinghackathon,Unviersity

ofPretoria,SouthAfrica(http://www.h3abionet.org/17-h3abionet-

courses/h3abionet-courses-upcoming/266-h3abionet-cloud-computing-hackathon)

September5thtoSeptember10th2016;H3ABioNet/IBMResearchAfricaHackathon

onMalariaDrugResistanceforaDREAMchallenge,Johannesburg,SouthAfrica

(http://www.h3abionet.org/h3abionet-ibm-research-africa-hackathon-malaria-drug-

resistance-2016)

September20thtoSeptember23rd2016;Joint2016conferenceoftheSouthAfrican

SocietiesforBioinformaticsandSouthAfricanGeneticsSociety,DurbanSouthAfrica.

**Earlyregistrationdeadline15thofAugust2016(http://www.sasbi-sags.co.za/)

October3rdtoOctober14th2016:INDAHands-onNGS-Statisticscourse,Dakar,

Senegal.**ApplicationscloseonAugustthe15th2016

(http://www.h3abionet.org/component/content/article/17-h3abionet-

courses/h3abionet-courses-upcoming/269-inda-hands-on-ngs-statistics-course)

October27thtoOctober31st2016:NinthH3Africaconsortiummeeting,Mauritius(http://h3africa.org/events/9-news/284-9th-meeting-of-the-h3africa-consortium-2)

November6thtoNovember10th2016;NinthAnnualRECOMB/ISCBConferenceonRegulatory&SystemsGenomics,withDREAMChallenges&CytoscapeWorkshop,Phoenix,Arizona,USA(https://www.iscb.org/recomb-regsysgen2016)

November21sttoNovember23rd2016;ThefourthInternationalSocietyforComputationalBiologyLatinAmericaBioinformaticsConference(ISCB-LA),jointlyorganizedwithA2B2C,willtakeplaceinBuenosAires,Argentina(https://www.iscb.org/iscb-latinamerica2016)

ImportantdatesforPIs:

November1-4th:H3ABioNetSAB(1-2nd)andAnnualGeneralMeeting(3-4th),Cape

Town,SouthAfrica.

31stAugustisthedeadlineforthesumissionofyourfinalclaimsforyear4.

Anyupcomingeventsforthenexteditionofthenewslettermaybesendto

[email protected]@uct.ac.za

H3ABioNetMonthlyNew

sletterIssue16:July2016

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H3ABioNetWorkingGroupMeetingScheduleuntilendAugust

2016

SummaryofH3ABioNetupcomingworkinggroupmeetings:

WorkingGroup Time DateMonth(2016)

Cloudcomputingtaskforcemeeting UTC=14:00 Thursday,11 August

RWSG UTC=11:00 Friday,12 August

H3ABioNetseminarseries UTC=13:00 Thursday,18 August

ISWG UTC=13:00 Friday,19 August

USWG UTC=9:00 Friday,26 August

E&TWG UTC=11:00 Tuesday,30 August

AcronymsusedforthevariousH3ABioNetworkinggroups:

E&TWG Educationandtrainingworkinggroup

RSWG Researchworkinggroup

ISWG Infrastructureworkinggroup

USWG Usersupportworkinggroup

NAWG Nodeaccreditationworkinggroup

TimezoneconversiontabletoUTCforallofH3ABioNetworkinggroupmeetings:

UTCTimeOffsetTimeZoneName

Regions/CountriesintheTimezoneoffset

-5hours CDT Chicago,USA

0hours GMT BurkinaFaso,Ghana,Mali,Morocco,Senegal

+1hour WATCameroon,Chad,Gabon,Namibia,Nigeria,Niger,Tunisia

+2hours CATBotswana,Egypt,Malawi,SouthAfrica,Sudan,Zambia

+3hours EAT Ethiopia,Kenya,Tanzania,Uganda

ThiseditionofthenewsletterwascompiledandeditedbyKimGurwitz.Forany

corrections,[email protected]