Hand Hygiene

One Integrated Approach to Protect Your System.

CAL STAT PLUS® ANTISEPTIC HANDRUB WITH ENHANCED EMOLLIENTS

SUPERIOR CLINICAL PERFORMANCE THAT ENCOURAGES COMPLIANCE

EXCELLENTMOISTURIZATION

CHG COMPATIBLE MRSA & VRE

References: Fendler EJ, Ali Y, Hammond BS, Lyons MK, Kelly MB, Vowell NA. The impact of alcohol hand sanitizer use on infection rates in an extended care facility. American Journal of Infection Control 2002;30:226-33. Cal Stat Plus Antiseptic Handrub with Enhanced Emollients Healthcare Personnel Handwash Data #310-301-1181.

CalStat Plus Handrub Ethanol Gel Product thickened with carbomer* 4% CHG Product

Clinical Antimicrobial Efficacy Healthcare Personnel Handwash Study

Application 1 Application 2

Ave

rage

Log

Red

uctio

n fr

om B

asel

ine

5 -

4.5 -

4 -

3.5 -

3 -

2.5 -

2 -

1.5 -

1 -

0.5 -

0 -

4.12

3.93

2.43

4.41

2.15

3.62

The Tentative Final Monograph for Health-Care Antiseptic Drug Products; Proposed Rule (TFM) published in the Federal Register June 17, 1994 is the FDA’s principal regulation that sets the clinical performance standards for antiseptic hand hygiene products in the healthcare industry.

MEETING & EXCEEDING CLINICAL STANDARDS

As Healthcare professionals - you are routinely exposed to a range of pathogenic microorganisms every day.

You should expect superior clinical performance from the hand hygiene products you use daily. Commercially available products are not equivalent in antimicrobial performance to products that are specifically formulated and clinically tested to meet the Food and Drug Administration’s (FDA) clinical efficacy standards.

HAND HYGIENE DESIGNED FOR HEALTHCARE

Superior in log reduction to a marketed 4% chlorhexidine gluconate (CHG) healthcare personnel handwash product.

Antiseptic handwash products

that contain CHG provide residual

activity after washing by leaving an

antimicrobial residual on the skin.

Alcohol handrubs must be

compatible with the CHG residual

where CHG is the primary antiseptic

wash product used. Compatibility

is demonstrated if there is no

decrease in residual CHG activity

after applying a hand hygiene

product.

PATIENTS MATTERFAST AND EFFECTIVE ANTIMICROBIAL PERFORMANCE

Reference: Efficacy of Cal Stat Plus Antiseptic Handrub with Enhanced Emollients Versus Pathogenic Microorganisms Using a Time Kill Study #310-302-1181.

*Community-Acquired Methicillin Resistant Staphylococcus aureus USA 300 was obtained from Michigan Department of Community Health (MDCH).

Test Organism

Average Log10 Reduction at: Percent Kill at:

15 sec 30

60 sec

15 sec

30 sec

60 sec

Acinetobacter baumannii 19606 7.23 7.23 7.23 >99.99999 >99.99999 >99.99999

Acinetobacter iwolfii 15309 5.47 5.47 5.47 >99.999 >99.999 >99.999

Citrobacter freundii 8090 7.10 7.10 7.10 >99.99999 >99.99999 >99.99999

Enterobacter aerogenes 35028 7.01 7.01 7.01 >99.99999 >99.99999 >99.99999

Enterobacter cloacae 10699 7.08 7.08 7.08 >99.99999 >99.99999 >99.99999

Enterobacter gergoviae 33028 7.10 7.10 7.10 >99.99999 >99.99999 >99.99999

Enterococcus faecalis 29212 7.02 7.02 7.02 >99.99999 >99.99999 >99.99999

Enterococcus faecium (VRE) 51559 6.72 6.72 6.72 >99.9999 >99.9999 >99.9999

Percent Reduction Against MRSA

100 -90 -80 -70 -60 -50 -40 -30 -20 -10 -0 -

15 seconds

Per

cent

Red

uctio

n

30 seconds 60 seconds

In a time kill study, Cal Stat Plus Handrub significantly reduced the bacterial counts of transient pathogenic organisms including MRSA, VRE and Community Acquired MRSA

Percent Reduction Against VRE

15 seconds

Per

cent

Red

uctio

n

30 seconds 60 seconds

100 -90 -80 -70 -60 -50 -40 -30 -20 -10 -0 -

MRSA & VRE

Reference: Compatibility of Cal Stat Plus Antiseptic Handrub with Enhanced Emollients with Chlorhexidine Gluconate (CHG) Residual # 310-303-1181

Compatibility of CHG Residual with Cal Stat Plus

CHG CHG + Cal Stat Plus

Log

Red

ucti

on

6.00 -

5.00 -

4.00 -

3.00 -

2.00 -

1.00 -

0.00 -

5 Minutes3 Hours

Staphylococcus aureus ATCC 6538

Carbomer Incompatibility

Carbomer, a polymer commonly used to thicken alcohol handrubs, can inactivate the CHG residual on skin. Cal Stat Plus handrub utilizes a patented polymer technology that is compatible with CHG

6.00 -

5.00 -

4.00 -

3.00 -

2.00 -

1.00 -

0.00 -

Compatibility of Marketed Alcohol Products with a CHG Residual

CHG Residual

CHG Residualand Product A

(containing carbomer)

CHG Residualand Product B

(containing carbomer)

Ave

rag

e Lo

g R

educ

tio

n 4.23

0.640.72

Staphylococcus aureus ATCC 6538

n=12

1Greten,Z., Klein, D., Kaiser, N., Dell’ Aringa, B., Karanja, P.Inactivation of Residual CHG Activity by Thickened Alcohol Solutions,APIC 2004 Annuual Conference, Phoenix, AZ, June 2004.

In a simulated skin model study, Cal Stat Plus handrub did not reduce the antimicrobial CHG residual on the skin.

Hypoallergenic

Clinical testing with a Repeat Insult Patch Test showed no skin sensitization. Results from 201 adult volunteers tested indicated that there was no dermatologic evidence of sensitization after repeated applications of Cal Stat Plus handrub

*EN 1500:1997. Chemical disinfectants and antiseptics-Hygienic handrub-Test method and requirements Kramer A, Rudolph P, Kampf G, Pittet D. Limited efficacy of alcohol-based hand gels. Lancet 2002; 359:1489-90.

SHOULD NOT BE AN OUTCOME OF COMPLIANCE.DAMAGED HANDS

Enhanced Emollients A 63% isopropyl alcohol handrub, Cal Stat has a patented polymer technology

that is the clinically proven solution for maintaining skin health while providing superior antimicrobial efficacy.

Before After

Cha

nges

in S

kin

Hyd

ratio

n fr

om

Bas

elin

e S

KIC

ON

uni

t

Graph 2: Changes in Skin Hydration 1 Hour Post 2 Applications

Cal Stat PlusHandrub

Provon® Moisturizing Hand and Body Lotion

Huntington® Brand Accent Plus® Amino Lotion

Vaseline® Intensive

Care® Lotion

Untreated

250 -

200 -

150 -

100 -

50 -

0 -

-50 -

WITH PERFORMANCEGraph 1: Changes in Skin Hydration at 1 and 2 Hours Post One Application

Cal Stat Plus Handrub Endure 320 Purell 2 in 1 Untreated

Reference: Skin Moisturization Study with an Alcohol Hand Rub HTR Study: 04-123124-112

60 -

50 -

40 -

30 -

20 -

10 -

0 -

-10 -

-20 -

1 hour 2 hour 1 hour 2 hour

1 hour 2 hour

1 hour 2 hour

Cha

nges

in S

kin

Hyd

ratio

n fr

om B

asel

ine

SK

ICO

N u

nit

CONNECTING COMPLIANCE

Reference: Forearm Controlled Application Test for Estimating the Relative Efficacy of Moisturizing Lotions HTR Study 04-124004-112Provon is a registered trademark of GOJO Industries, Inc.Huntington and Accent Plus are registered trademarks of Ecolab, Inc.Vaseline Intensive Care is a registered trademark of Unilever Supply Chain, Inc.

Hydration for up to 2 hours after 1 application

Moisturizes as well as lotion

STERIS Corporation5960 Heisley RoadMentor, OH 44060-1834 • USA440-354-2600 • 800-548-4873www.steris.com

Solutions designed to service you best when they are connected. Facing unforeseen challenges together with a single vision.

That is the power of...

PRODUCT PART NUMBER PACKAGE SIZE

1181-03 4 oz 72 per case

1181-49 2 oz 96 per case

1181-87 1 liter 12 per case

1181-RP 15 oz* 18 per case*with pumpette

For more information, please contact your STERIS account manager.

Document # M3116EN.2007-03, Rev. BGPSI Printed 3/2015, XXX©2015 by STERIS Corporation. All rights reserved. Printed in USA.

Ordering Information

Just one more tool in STERIS’s arsenal to stop the spread of germs.