Contributors.PrefacePART 1 Introduction to Clinical Medicine 1 The Practice of Medicine.The Editors 2 Global Issues in Medicine.Jim Yong Kim / Paul Farmer 3 Decision-Making in Clinical Medicine.Daniel B. Mark 4 Screening and Prevention of Diseases.Gary J. Martin 5 Principles of Clinical Pharmacology.Dan M. Roden 6 Women's Health.Andrea Dunaif 7 Medical Disorders during Pregnancy.Robert L. Barbieri / John T. Repke 8 Medical Evaluation of the Surgical Patient.Wei C. Lau / Kim A. Eagle 9 Geriatric Medicine.Lisa B. Caruso / Rebecca A. Silliman 10 Complementary and Alternative Medicine.Stephen E. Straus 11 Palliative and End-of-Life Care.Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel e1 The Safety and Quality of Health Care.David W. Bates e2 Economic Considerations in the Practice of Medicine. David Meltzer e3 Racial and Ethnic Disparities in Health Care. Joseph R. Betancourt / David Blumenthal e4 Ethical Issues in Clinical Medicine.Bernard Lo PART 2 Cardinal Manifestations and Presentation of Diseases SECTION 1 PAIN12 Pain: Pathophysiology and Management.Howard L. Fields / Joseph B. Martin 13 Chest Discomfort.Thomas H. Lee 14 Abdominal Pain.William Silen 15 Headache.Peter J. Goadsby / Neil H. Raskin 16 Back and Neck Pain.John W. Engstrom SECTION 2 ALTERATIONS IN BODY TEMPERATURE

17 Fever and Hyperthermia.Charles A. Dinarello / Reuven Porat 18 Fever and Rash.Elaine T. Kaye / Kenneth M. Kaye e5 Atlas of Rashes Associated with Fever.Elaine T. Kaye / Kenneth M. Kaye 19 Fever of Unknown Origin.Jeffery A. Gelfand / Michael V. Callahan 20 Hypothermia and Frostbite.Daniel F. Danzl SECTION 3 NERVOUS SYSTEM DYSFUNCTION21 Syncope.Mark D. Carlson 22 Dizziness and Vertigo.Robert B. Daroff 23 Weakness and Paralysis.Michael J. Aminoff 24 Gait and Balance Disorders.Lewis Sudarsky 25 Numbness, Tingling, and Sensory Loss.Michael J. Aminoff / Arthur K.Asbury 26 Confusion and Delirium.S. Andrew Josephson / Bruce L. Miller e6 Memory Loss.Thomas D. Bird / Bruce L. Miller 27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders.M.-Marsel Mesulam 28 Sleep Disorders.Charles A. Czeisler / John W. Winkleman / Gary S. Richardson SECTION 4 DISORDERS OF EYES, EARS, NOSE, AND THROAT29 Disorders of the Eye.Jonathan C. Horton 30 Disorders of Smell, Taste, and Hearing.Anil K. Lalwani 31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections. Michael A. Rubin / Ralph Gonzales / Merle A. Sande 32 Oral Manifestations of Disease.Samuel C. Durso e7 Atlas of Oral Manifestations of Disease.Samuel C. Durso / Janet A. Yellowitz SECTION 5 ALTERATIONS IN CIRCULATORY AND RESPIRATORY FUNCTION33 Dyspnea and Pulmonary Edema.Richard M. Schwartzstein 34 Cough and Hemoptysis.Steven E. Weinberger / David A. Lipson

35 Hypoxia and Cyanosis.Eugene Braunwald 36 Edema Eugene Braunwald / Joseph Loscalzo e8 Approach to the Patient with a Heart Murmur. Patrick O'Gara / Eugene Braunwald 37 Palpitations.Joseph Loscalzo SECTION 6 ALTERATIONS IN GASTROINTESTINAL FUNCTION38 Dysphagia.Raj K. Goyal 39 Nausea, Vomiting, and Indigestion.William L. Hasler 40 Diarrhea and Constipation.Michael Camilleri / Joseph A. Murray 41 Weight Loss.Carol M. Reife 42 Gastrointestinal Bleeding.Loren Laine 43 Jaundice.Daniel S. Pratt / Marshall M. Kaplan 44 Abdominal Swelling and Ascites.Robert M. Glickman / Roshini Rajapaksa SECTION 7 ALTERATIONS IN RENAL AND URINARY TRACT FUNCTION45 Azotemia and Urinary Abnormalities.Bradley M. Denker / Barry M. Brenner e9 Atlas of Urinary Sediments and Renal Biopsies.Agnes B. Fogo / Eric G. Neilsen 46 Fluid and Electrolyte Disturbances.Gary G. Singer / Barry M. Brenner 47 Hypercalcemia and Hypocalcemia.Sundeep Khosla 48 Acidosis and Alkalosis.Thomas B. DuBose, Jr. SECTION 8 ALTERATIONS IN SEXUAL FUNCTION AND REPRODUCTION49 Sexual Dysfunction.Kevin T. McVary 50 Hirsutism and Virilization.David A. Ehrmann 51 Menstrual Disorders and Pelvic Pain.Janet E. Hall SECTION 9 ALTERATIONS IN THE SKIN52 Approach to the Patient with a Skin Disorder. Thomas J. Lawley / Kim B. Yancey 53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders Calvin O. McCall / Thomas J. Lawley

54 Skin Manifestations of Internal Disease.Jean L. Bolognia / Irwin M. Braverman 55 Immunologically Mediated Skin Diseases.Kim B. Yancey / Thomas J. Lawley 56 Cutaneous Drug Reactions.Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub 57 Photosensitivity and Other Reactions to Light. David R. Bickers e10 Atlas of Skin Manifestations of Internal Disease. Thomas J. Lawley / Stephen Templeton SECTION 10 HEMATOLOGIC ALTERATIONS58 Anemia and Polycythemia.John W. Adamson / Dan L. Longo 59 Bleeding and Thrombosis.Barbara A. Konkle 60 Enlargement of Lymph Nodes and Spleen.Patrick H. Henry / Dan L. Longo 61 Disorders of Granulocytes and Monocytes.Steven M. Holland and John I. Gallin e11 Atlas of Peripheral Blood Smears.Dan L. Longo PART 3 Genetics and Disease 62 Principles of Human Genetics.J. Larry Jameson / Peter Kopp 63 Chromosome Disorders.Terry Hassold / Stuart Schwartz 64 The Practice of Genetics in Clinical Medicine.Susan Miesfeldt / J. Larry Jameson 65 Gene Therapy in Clinical Medicine.Katherine A. High PART 4 Regenerative Medicine 66 Stem Cell Biology.Minoru S. H. Ko 67 Applications of Stem Cell Biology in Clinical Medicine. Jack A. Kessler 68 Hematopoietic Stem Cells.David T. Scadden / Dan L. Longo 69 Tissue Engineering.Jennifer Anderson /Joseph P. Vacanti PART 5 Nutrition 70 Nutritional Requirements and Dietary Assessment. Johanna Dwyer 71 Vitamin and Trace Mineral Deficiency and Excess. Robert M. Russell / Paolo M. Suter 72 Malnutrition and Nutritional Assessment.Douglas C. Heimburger

73 Enteral and Parenteral Nutrition Therapy.Bruce R. Bistrian / David F. Driscoll 74 Biology of Obesity.Jeffrey S. Flier / Eleftheria Maratos-Flier 75 Evaluation and Management of Obesity.Robert F. Kushner 76 Eating Disorders.B. Timothy Walsh PART 6 Oncology and Hematology SECTION 1 NEOPLASTIC DISORDERS77 Approach to the Patient with Cancer.Dan L. Longo 78 Prevention and Early Detection of Cancer. Otis W. Brawley / Barnett S. Kramer 79 Cancer Genetics. Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein 80 Cancer Cell Biology and Angiogenesis. Robert G. Fenton / Dan L. Longo 81 Principles of Cancer Treatment. Edward A. Sausville / Dan L. Longo 82 Infections in Patients with Cancer. Robert Finberg 83 Cancer of the Skin. Arthur J. Sober / Hensin Tsao / Carl V. Washington 84 Head and Neck Cancer. Everett E. Vokes 85 Neoplasms of the Lung.John D. Minna / Joan H. Schiller 86 Breast Cancer. Marc E. Lippman 87 Gastrointestinal Tract Center. Robert J. Mayer 88 Tumors of the Liver and Biliary Tree. Brian I. Carr 89 Pancreatic Cancer. Yu Jo Chua / David Cunningham 90 Bladder and Renal Cell Carcinomas.Howard I. Scher / Robert J. Motzer 91 Benign and Malignant Diseases of the Prostate. Howard I. Scher 92 Testicular Cancer.Robert J. Motzer / George J. Bosl 93 Gynecologic Malignancies.Robert C. Young 94 Soft Tissue and Bone Sarcomas and Bone Metastases. Shreyaskumar R. Patel / Robert S. Benjamin

95 Carcinoma of Unknown Primary.Gauri R. Varadhachary /James L. Abbruzzese 96 Paraneoplastic Syndromes: Endocrinologic/Hematologic. J. Larry Jameson / Bruce E. Johnson 97 Paraneoplastic Neurologic Syndromes. Joseph Dalmau / Myrna R. Rosenfeld e12 Thymoma. Dan L. Longo e13 Late Consequences of Cancer and Its Treatment.Michael C. Perry / Dan L. Longo SECTION 2 HEMATOPOIETIC DISORDERS98 Iron Deficiency and Other Hypoproliferative Anemias. John W. Adamson 99 Disorders of Hemoglobin. Edward J. Benz 100 Megaloblastic Anemia. A. Victor Hoffbrand 101 Hemolytic Anemias and Anemias due to Acute Blood Loss. Lucio Luzzatto 102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes. Neal S. Young 103 Polycythemia Vera and Other Myeloproliferatve Diseases Jerry L. Spivek104 Acute and Chronic Myeloid Leukemia.Meir Wetzler /John C. Byrd / Clara D. Bloomfield 105 Malignancies of Lymphoid Cells.Dan L. Longo 106 Plasma Cell Disorders.Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson 107 Transfusion Biology and Therapy.Jeffery S. Dzieczkowski / Kenneth C. Anderson 108 Hematopoietic Cell Transplantation.Frederick R. Applebaum DISORDERS OF HEMOSTASIS109 Disorders of Platelets and Vessel Wall.Barbara A. Konkle 110 Coagulation Disorders.Valder Arruda / Katherine High 111 Thrombosis Venous.F.R. Rosendaal / H.R. Büller 112 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs.Jeffery L. Weitz PART 7 Infectious Diseases SECTION 1 BASIC CONSIDERATIONS IN INFECTIOUS DISEASES113 Introduction to Infectious Diseases: Host-Pathogen Interactions.Lawrence C. Madoff / Dennis L. Kasper

114 Molecular Mechanisms of Microbial Pathogenesis.Gerald B. Pier 115 Approach to the Acutely Ill Infected Febrile Patient.Tamar F. Barlam / Dennis L. Kasper 116 Immunization Principles and Vaccine Use.Gerald T. Keusch / Kenneth J. Bart / Mark Miller 117 Health Advice for International Travel.J.S. Keystone / P.. Kozarsky e14 Laboratory Diagnosis of Infectious Diseases. Alexander J. McAdam / Andrew B. Onderdonk SECTION 2 CLINICAL SYNDROMES: COMMUNITY-ACQUIRED INFECTIONS118 Infective Endocarditis.Adolf W. Karchmer 119 Infections of the Skin, Muscle, and Soft Tissues.Dennis L. Stevens 120 Osteomyelitis.Jeffrey Parsonnet 121 Intraabdominal Infections and Abscesses.Miriam J. Baron / Dennis L. Kasper 122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning. Joan R. Butterton / Stephen B. Calderwood 123 Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis. Dale N. Gerding / Stuart Johnson SECTION 3124 Sexually Transmitted Infections: Overview and Clinical Approach. King K. Holmes e15 Infectious Complications of Bites and Burns. Lawrence C. Madoff / Florencia Pereyra SECTION 3 CLINICAL SYNDROMES: NOSOCOMIAL INFECTIONS125 Health Care-Associated Infections.Robert A. Weinstein 126 Infections in Transplant Recipients.Robert Finberg /Joyce Fingeroth SECTION 4 APPROACH TO THERAPY FOR BACTERIAL DISEASES127 Treatment and Prophylaxis of Bacterial Infections. Gordon L. Archer / Ronald E. Polk SECTION 5 DISEASES CAUSED BY GRAM-POSITIVE BACTERIA128 Pneumococcal Infections.Daniel M. Musher 129 Staphylococcal Infections.Franklin D. Lowy 130 Strepococcal and Enterococcal Infections.Michael R. Wessels 131 Diphtheria and Other Infections Caused by Corynebacteria and Related Species. William R. Bishai / Jack R. Murphy

132 Infections Caused by Listeria monocytogenes. Elizabeth L. Hohmann / Daniel A. Portnoy 133 Tetanus.Elias Abrutyn 134 Botulism.Elias Abrutyn 135 Gas Gangrene and Other Clostridial Infections. Dennis L. Kasper /Lawrence C. Madoff SECTION 6 DISEASES CAUSED BY GRAM-NEGATIVE BACTERIA136 Meningococcal Infections.Lee M. Wetzler 137 Gonococcal Infections.Sanjay Ram / Peter A. Rice 138 Moraxella Infections.Daniel M. Musher 139 Haemophilus Infections.Timothy F. Murphy 140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria. Tamar F. Barlam / Dennis L. Kasper 141 Legionella Infection.Miguel Sabria / Victor L. Yu 142 Pertussis and Other Bordetella Infections.Scott A. Halperin 143 Diseases Caused by Gram-Negative Enteric Bacilli. Thomas A. Russo / James R. Johnson 144 Helicobacter Pylori Infections.John C. Atherton / Martin J. Blaser 145 Infections Due to Pseudomonas Species and Related Organisms. Reuben Ramphal 146 Salmonellosis.David A. Pegues / Samuel I. Miller 147 Shingellosis.Philippe Sansonetti / Jean Bergounioux 148 Infections Due to Campylobacter and Related Species.Martin J. Blaser 149 Cholera and Other Vibrioses.Matthew K. Waldor / Gerald T. Keusch 150 Brucellosis.Michael J. Corbel / Nicholas J. Beeching 151 Tularemia.Richard F. Jacobs / Gordon E. Schutze 152 Plague and Other Yersnia Infections.David T. Dennis / Grant L. Campbell 153 Bartonella Infections, Including Cat-Scratch Disease. David H. Spach / Emily Darby

154 Donovanosis.Gavin Hart SECTION 7 MISCELLANEOUS BACTERIAL INFECTIONS155 Nocardiosis.Gregory A. Filice 156 Actinomycosis.Thomas A. Russo 157 Infections Due to Mixed Anaerobic Organisms. Dennis L. Kasper / Ronit Cohen-Poradosu SECTION 8 MYCOBACTERIAL DISEASES158 Tuberculosis.Mario C. Raviglione / Richard J. O'Brien 159 Leprosy (Hansen's Disease).Robert H. Gelber 160 Nontuberculous Mycobacteria.C. Fordham von Reyn 161 Antimycobacterial Agents.Richard J. Wallace / David E. Griffith SECTION 9 SPIROCHETAL DISEASE162 Syphilis.Sheila A. Lukehart 163 Endemic Treponematoses.Sheila A. Lukehart 164 Leptospirosis.Peter Speelman / Rudy Harkskeerl 165 Relapsing Fever.David T. Dennis 166 Lyme Borreliosis.Allen C. Steere SECTION 10 DISEASES CAUSED BY RICKETTSIA, MYCOPLASMA, AND CHLAMYDIA167 Rickettsial Diseases.David H. Walker / Didier Raoult / J. Stephen Dumler / Thomas Marrie 168 Infections Due to Mycoplasmas.William M. McCormack 169 Chlamydial Infections.Walter E. Stamm SECTION 11 VIRAL DISEASES: GENERAL CONSIDERATIONS170 Medical Virology.Fred Wang and Elliott Kieff 171 Antiviral Chemotherapy, Excluding Antiretroviral Drugs.Lindsey R. Baden / Raphael Dolin SECTION 12 INFECTIONS DUE TO DNA VIRUSES172 Herpes Simplex Viruses.Lawrence Corey

173 Varicella-Zoster Virus Infections.Richard J. Whitley 174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis.Jeffery I. Cohen 175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8. Martin S. Hirsch 176 Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus. Fred Wang 177 Parvovirus Infections.Kevin E. Brown 178 Human Papillomavirus Infections.Richard C. Reichman SECTION 13 INFECTIONS DUE TO DNA AND RNA RESPIRATORY VIRUSES179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS). Raphael Dolin 180 Influenza.Raphael Dolin SECTION 14 INFECTIONS DUE TO HUMAN IMMUNODEFICIENCY VIRUS AND OTHER HUMAN RETROVIRUSES181 The Human Retroviruses.Dan L. Longo /Anthony S. Fauci 182 Human Immunodeficiency Virus Disease: AIDS and Related Disorders. Anthony S. Fauci / H. Clifford Lane SECTION 15 INFECTIONS DUE TO RNA VIRUSES183 Viral Gastroenteritis.Umesh D. Parashar / Roger I. Glass 184 Enterovirus and Reoviruses Infections.Jeffery I. Cohen 185 Measles (Rubeola).Anne Gershon 186 Rubella (German Measles).Anne Gershon 187 Mumps.Anne Gershon 188 Rabies and Other Rhabdovirus Infections.Alan C. Jackson / Eric C. Johannsen 189 Infections Caused by Arthropod and Rodent-Borne Viruses. Clarence J. Peters 190 Ebola and Marburg Viruses.Clarence J. Peters SECTION 16 FUNGAL AND ALGAL INFECTIONS191 Diagnosis and Treatment of Fungal Infections. John E. Edwards 192 Histoplasmosis.Chadi A. Hage / L. Joseph Wheat

193 Coccidioidomycosis.Neil M. Ampel 194 Blastomycosis.Stanley W. Chapman 195 Cryptococcosis.Arturo Casadevall 196 Candidiasois.John E. Edwards 197 Aspergillosis.David W. Denning 198 Mucormycosis.Alan M. Sugar 199 Miscellaneous Mycoses and Algal Infections.Stanley W. Chapman / Donna C. Sullivan 200 Pneumocystis Infection.A. Geroge Smulian /Peter D. Walzer SECTION 17 PROTOZOAL AND HELMINTHIC INFECTIONS: GENERAL CONSIDERATIONSe16 Laboratory Diagnosis of Parasitic Infections. Sharon L. Reed / Charles E. Davis 201 Agents Used to Treat Parasitic Infections.Thomas A. Moore e17 Pharmacology of Agents Used to Treat Parasitic Infections. Thomas A. Moore SECTION 18 PROTOZOAL INFECTIONS202 Ambiasis and Infection with Free-Living Amebas.Sharon L. Reed 203 Malaria.Nicholas J. White / Joel G. Breman 204 Babesiosis.Jeffery Gelfand e18 Atlas of Blood Smears of Malaria and Babesiosis. Nicholas J. White / Joel G. Breman 205 Leishmaniasis.Barbara L. Herwaldt 206 Trypanosomiasis.Louis V. Kirchhoff 207 Toxoplasma Infections.Lloyd H. Kasper 208 Protozoal Intestinal Infections and Trichomoniasis. Peter F. Weller SECTION 19 HELMINTHIC INFECTIONS209 Trichinella and Other Tissue Nematodes.Peter F. Weller 210 Intestinal Nematodes.Peter F. Weller /Thomas B. Nutman

211 Filarial and Related Infections.Peter F. Weller / Thomas B. Nutman 212 Schistosomiasis and Other Trematode Infections. Adel A.F. Mahmoud 213 Cestodes.A. Clinton White, Jr. / Peter F. Weller PART 8 Bioterrorism and Clinical Medicine Z214 Microbioterrorism.H. Clifford Lane / Anthony S. Fauci 215 Chemical Bioterrorism.Charles G. Hurst / Jonathan Newmark / James A. Romano 216 Radiation Bioterrorism.Zelig A. Tochner / Eli Glatstein PART 9 Disorders of Cardiovascular System SECTION 1 INTRODUCTION TO CARDIOVASCULAR DISORDERS217 Basic Biology of the Cardiovascular System.Joseph Loscalzo / Peter Libby / Eugene Braunwald 218 Epidemiology of Cardiovascular Disease.Thomas A. Gaziano / J. Michael Gaziano 219 Approach to the Patient with Possible Cardiovascular Disease. Eugene Braunwald SECTION 2 DIAGNOSIS OF CARDIOVASCULAR DISORDERS220 Physical Examination of the Cardiovascular System. Robert A. O'Rourke /Eugene Braunwald 221 Electrocardiography.Ary L. Goldberger e19 Atlas of Electrocardiography.Ary L. Goldberger 222 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging. Rick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik e20 Atlas of Noninvasive Cardiac Imaging.Rick Nishimura 223 Diagnostic Cardiac Catheterization and Angiography. Donald S. Baim SECTION 3 DISORDERS OF RHYTHM224 Principles of Electrophysiology.Gordon F. Tomaselli 225 The BradyarrhythmiasGordon F. Tomaselli 226 The Tachyarrhythmias.Francis Marchlinksi e21 Atlas of Cardiac Arrhythmias.Ary L. Goldberger SECTION 4 DISORDERS OF THE HEART

227 Heart Failure and Cor Pulmonale.Douglas L. Mann 228 Cardiac Transplantation and Prolonged Assisted Circulation. Sharon A. Hunt 229 Congenital Heart Disease in the Adult.John S. Child 230 Valvular Heart Disease.Patrick O'Gara / Eugene Braunwald 231 Cardiomyopathy and Myocarditis.Joshua Wayne / Eugene Braunwald 232 Pericardial Disease.Eugene Braunwald 233 Tumors and Trauma of the Heart.Eric H. Awrty / Wilson S. Colucci 234 Cardiac Manifestations of Systemic Disease.Eric H. Awrty / Wilson S. Colucci SECTION 5 VASCULAR DISEASE235 The Pathogenesis, Prevention, and Treatment of Atherosclerosis. Peter Libby e22 Atlas of Atherosclerosis. Peter Libby 236 The Metabolic Syndrome.Robert H. Eckel 237 Ischemic Heart Disease. Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo 238 Unstable Angina and Non-ST-Elevation Myocardial Infarction. Christopher P. Cannon / Eugene Braunwald 239 ST-Segment Elevation Myocardial Infarction.Elliott M. Antman / Eugene Braunwald 240 Percutaneous Coronary Intervention.Donald S. Baim e23 Atlas of Percutaneous Revascularization. Donald S. Baim 241 Hypertensive Vascular Disease.Ted A. Kotchen 242 Diseases of the Aorta.Mark A. Creager / Joseph Loscalzo 243 Vascular Diseases of the Extremities.Mark A. Creager / Joseph Loscalzo 244 Pulmonary Hypertension.Stuart Rich PART 10 Disorders of the Respiratory System SECTION 1 DIAGNOSIS OF RESPIRATORY DISORDERS245 Approach to the Patient with Disease of the Respiratory System. David A. Lipson / Steven E. Weinberger

246 Disturbances of Respiratory Function.Steven E. Weinberger /Ilene M. Rosen 247 Diagnostic Procedures in Respiratory Diseases. Scott Manaker / Steven E. Weinberger e24 Atlas of Chest Imaging.Patricia Kritek / John J. Reilly, Jr. SECTION 2 DISEASES OF THE RESPIRATORY SYSTEM248 Asthma.Peter J. Barnes 249 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia. Joel N. Kline / Gary W. Hunninghake 250 Environmental Lung Disease.Frank E. Speizer / John R. Balmes 251 Pneumonia.Lionel A. Mandell / Richard Wunderink 252 Bronchiectasis and Lung Abscess.Gregory Tino / Steven E. Weinberger 253 Cystic Fibrosis.Richard C. Boucher 254 Chronic Obstructive Pulmonary Disease.John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro 255 Interstitial Lung Diseases.Talmadge E. King, Jr. 256 Deep Venous Thrombosis and Pulmonary Thromboembolism. Samuel Z. Goldhaber 257 Disorders of the Pleura and Mediastinum.Richard W. Light 258 Disorders of Ventilation.Eliot A. Phillipson 259 Sleep Apnea.Neil J. Douglas 260 Lung Transplantation.Elbert P. Trulock PART 11 Critical Care Medicine SECTION 1 RESPIRATORY CRITICAL CARE261 Principles of Critical Care Medicine.John P. Kress / Jesse B. Hall 262 Acute Respiratory Distress Syndrome.Bruce D. Levy / Steve D. Shapiro 263 Mechanical Ventilatory Support.Edward P. Ingenito SECTION 2 SHOCK AND CARDIAC ARREST264 Approach to the Patient with Shock.Ronald V. Maier 265 Severe Sepsis and Septic Shock.Robert S. Munford

266 Cardiogenic Shock and Pulmonary Edema.Judith S. Hochman / David H. Ingbar 267 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death.Robert J. Myerberg / Agustin Castellanos SECTION 3 NEUROLOGIC CRITICAL CARE268 Coma.Allan H. Ropper 269 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage. J. Claude Hemphill / Wade S. Smith SECTION 4 ONCOLOGIC EMERGENCIES270 Oncologic Emergencies.Rasim Gucalp / Janice Dutcher PART 12 Disorders of the Kidney and Urinary Tract 271 Cellular and Molecular Biology of the Kidney. Alfred L. George / Eric G. Neilson 272 Adaptation of the Kidney to Renal Injury.Raymond C. Harris / Eric G. Neilson 273 Acute Renal Failure.Kathleen D. Liu / Glenn M. Chertow 274 Chronic Kidney Disease.Joanne M. Bargman / Karl Skorecki 275 Dialysis in the Treatment of Renal Failure.Kathleen D. Liu / Glenn M. Chertow 276 Transplantation in the Treatment of Renal Failure. Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh 277 Glomerular Diseases.Julia B. Lewis / Eric G. Neilson 278 Polycystic Kidney Disease and Other Inherited Tubular Disorders. David J. Salant / Parul S. Patel 279 Tubulointerstitial Diseases of the Kidney.Alan S. L. Yu / Barry M. Brenner 280 Vascular Injury to the Kidney.Kamal F. Badr / Barry M. Brenner 281 Nephrolithiasis.John R. Asplin / Fredric L. Coe / Murray J. Favus 282 Urinary Tract Infections, Pyelonephritis, and Prostatitis. Walter E. Stamm 283 Urinary Tract Obstruction.Julian L. Seifter / Barry M. Brenner PART 13 Disorders of the Gastrointestinal System SECTION 1 DISORDERS OF THE ALIMENTARY TRACT284 Approach to the Patient with Gastrointestinal Disease. William L. Hasler / Chung Owyang 285 Gastrointestinal Endoscopy.Louis Michel Wong Kee Song / Mark Topazian

e25 Video Atlas of Gastrointestinal Endoscopy. Mark Topazian 286 Diseases of the Esophagus.Raj. K. Goyal 287 Peptic Ulcer Disease and Related Disorders.John Del Valle 288 Disorders of Absorption.Henry J. Binder 289 Inflammatory Bowel Disease.Sonia Friedman / Richard S. Blumberg 290 Irritable Bowel Syndrome.Chung Owyang 291 Diverticular Disease and Common Anorectal Disorders. Susan L. Gearhart 292 Mesenteric Vascular Insufficiency.Susan L. Gearhart 293 Acute Intestinal Obstruction.Susan L. Gearhart / William Silen 294 Acute Appendicitis and Peritonitis.Susan L. Gearhart / William Silen SECTION 2 LIVER AND BILIARY TRACT DISEASE295 Approach to the Patient with Liver Disease.Marc Ghany /Jay H. Hoofnagle 296 Evaluation of Liver Function.Daniel S. Pratt / Marshall M. Kaplan 297 The Hyperbilirubinemias.Allan W. Wolkoff 298 Acute Viral Hepatitis.Jules L. Dienstag 299 Toxic and Drug-Induced Hepatitis.Jules L. Dienstag 300 Chronic Hepatitis.Jules L. Dienstag 301 Alcoholic Liver Disease.Mark E. Malliard / Michael F. Sorrell 302 Cirrhosis and Its Complications.Bruce R. Bacon e26 Atlas of Liver Biopsies.Jules L. Dienstag 303 Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver. Bruce R. Bacon 304 Liver Transplantation.Jules L. Dienstag /Raymond T. Chung 305 Diseases of the Gallbladder and Bile Ducts.Norton J. Greenberger / Gustav Paumgartner SECTION 3 DISORDERS OF THE PANCREAS

306 Approach to the Patient with Pancreatic Disease. Phillip P. Toskes / Norton J. Greenberger 307 Acute and Chronic Pancreatitis.Norton J. Greenberger / Phillip P. Toskes PART 14 Disorders of the Immune System, Connective Tissue, and Joints SECTION 1 THE IMMUNE SYSTEM IN HEALTH AND DISEASE308 Introduction to the Immune System.Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci 309 The Major Histocompatability Complex.Gerald T. Nepom 310 Primary Immune Deficiency Diseases.Max D. Cooper / Harry W. Schroeder, Jr. e27 Primary Immunodeficiencies Associated with or Secondary to Other Diseases. Max D. Cooper SECTION 2 DISORDERS OF IMMUNE-MEDIATED INJURY311 Allergies, Anaphylaxis, and Systemic Mastocytosis.K. Frank Austen 312 Autoimmunity and Autoimmune Diseases.Peter E. Lipsky / Betty Diamond 313 Systemic Lupus Erythematosus.Bevra Hannahs Hahn 314 Rheumatoid Arthritis.Peter E. Lipsky 315 Acute Rheumatoid Fever.Jonathan R. Carapetis 316 Systemic Sclerosis (Scleroderma) and Related Disorders. John Varga 317 Sjögren's Syndrome.Haralampos M. Moutsopoulos 318 The Spondyloarthritides.Joel D. Taurog 319 The Vasculitis Syndromes.Carol A. Langford / Anthony S. Fauci e28 Atlas of Clinical Imaging of the Vasculitic Diseases. Carol A. Langford / Anthony S. Fauci 320 Behçet's Syndrome.Haralampos M. Moutsopoulos 321 Relapsing Polychondritis.Carol A. Langford /Bruce C. Gilliland 322 Sarcoidosis.Robert P. Baughman /Elyse E. Lower 323 Familial Mediterranean Fever and Other Hereditary Recurrent Fevers. Daniel L. Kastner 324 Amyloidosis.David C. Seldin / Martha Skinner SECTION 3 DISORDERS OF THE JOINTS AND ADJACENT TISSUES

325 Approach to Articular and Musculoskeletal Disorders. John J. Cush / Peter E. Lipsky 326 Osteoarthritis.David T. Felson 327 Gout and Other Crystal Arthropathies.H. Ralph Schumacher / Lan X. Chen 328 Infectious Arthritis.Lawrence C. Madoff 329 Fibromyalgia.Carol A. Langford /Bruce C. Gilliland 330 Arthritis Associated with Systemic Disease and Other Arthritides. Carol A. Langford / Bruce C. Gilliland 331 Periarticular Disorders of the Extremities.Carol A. Langford / Bruce C. Gilliland PART 15 Endocrinology and Metabolism SECTION 1 ENDOCRINOLOGY332 Principles of Endocrinology.J. Larry Jameson 333 Disorders of the Anterior Pituitary and Hypothalamus. Shlomo Melmed / J. Larry Jameson 334 Disorders of the Neurohypophysis.Gary L. Robertson 335 Disorders of the Thyroid Gland.J. Larry Jameson / Anthony P. Weetman 336 Disorders of the Adrenal Cortex.Gordon H. Williams / Robert G. Dluhy 337 Pheochromocytoma.Hartmut P.H. Neumann 338 Diabetes Mellitus.Alvin C. Powers 339 Hypoglycemia.Phillip E. Cryer 340 Disorders of the Testes and the Male Reproductive System. Shalender Bhasin / J. Larry Jameson 341 Disorders of the Ovary and Female Reproductive Tract. Janet E. Hall 342 The Menopause Transition and Postmenopausal Hormone Therapy. JoAnn E. Manson /Shari S. Bassuk 343 Disorders of Sex Development.John C. Achermann / J. Larry Jameson 344 Endocrine Tumors of the Gastrointestinal Tract and Pancreas. Robert T. Jensen 345 Disorders Affecting Multiple Endocrine Neoplasia Syndromes. Camillo Jimenez / Robert Gagel SECTION 2 DISORDERS OF BONE AND MINERAL METABOLISM

346 Bone and Mineral Metabolism in Health and Disease. F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg 347 Diseases of the Parathyroid Gland and Other Hyper-and Hypocalcemia Disorders. John T. Potts, Jr. 348 Osteoporosis.Robert Lindsay / Felicia Cosman 349 Paget Disease and Other Dysplasias of Bone.Murray J. Favus /Tamara J. Vokes SECTION 3 DISORDERS OF INTERMEDIARY METABOLISM350 Disorders of Lipoprotein Metabolism.Daniel J. Rader / Helen H. Hobbs 351 Hemochromatosis.Lawrie W.Powell 352 The Porphyrias.Robert J. Desnik / Kenneth H. Astrin 353 Disorders of Purine and Pyrimidine Metabolism. Robert L. Wortmann 354 Wilson Disease.George J. Brewer 355 Lysosomal Storage Disease.Robert J. Hopkin / Gregory A. Grabowski 356 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism. Yuan-Tsong Chen 357 Heritable Disorders of Connective Tissue.Darwin J. Prockop / Malwina Czarny-Ratajczak 358 Inherited Disoders of Amino Acid Metabolism in Adults. Nicola Longo 359 Inherited Defects of Membrane Transport.Nicola Longo e29 Atlas of Clinical Manifestations of Metabolic Diseases. J. Larry Jameson PART 16 Neurologic Disorders SECTION 1 DIAGNOSIS OF NEUROLOGIC DISORDERS360 Mechanisms of Neurologic Disorders.Stephen Hauser / M. Flint Beal 361 Approach to the Patient with Neurologic Disease. Daniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser 362 Neuroimaging in Neurologic Disorders.William P. Dillon e30 Atlas of Neuroimaging.Andre Furtado / William P. Dillon e31 Electrodiagnostic Studies of Nervous System Disorders: EEG and EMG.Michael J. Aminoff e32 Technique of Lumbar Puncture.Elizabeth Robbins / Stephen L. Hauser SECTION 2 DISEASES OF THE CENTRAL NERVOUS SYSTEM

363 Seizures and Epilepsy.Daniel H. Lowenstein 364 Cerebrovascular Diseases.Wade S. Smith / Joey English / S. Claiborne Johnston 365 Dementia.Thomas D. Bird / Bruce L. Miller 366 Parkinson's Disease and Other Extrapyramidal Disorders. Mahlon R. DeLong / Jorge L. Juncos 367 Hyperkinetic Movement Disorders.C. Warren Olanow 368 Ataxic Disorders.Roger N. Rosenberg 369 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases. Robert H. Brown, Jr. 370 Disorders of the Autonomic Nervous System.Phillip A. Low / John W. Engstrom 371 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders. M. Flint Beal / Stephen L. Hauser 372 Diseases of the Spinal Cord.Stephen L. Hauser / Allan H. Ropper 373 Concussion and Other Head Injuries.Allan H. Ropper 374 Primary and Metastatic Tumors of the Nervous System. Stephen M. Sagar / Mark A. Israel 375 Multiple Sclerosis and Other Demyelinating Diseases. Stephen L. Hauser / Douglas S. Goodin 376 Meningitis, Encephalitis, Brain Abscess, and Empyema. Karen L. Roos / Kenneth L. Tyler 377 Chronic and Recurrent Meningitis.Walter J. Koroshetz / Morton N. Swartz 378 Prion Diseases.Stanley B. Prusiner / Bruce Miller SECTION 3 NERVE AND MUSCLE DISORDERS379 Peripheral Neuropathy.Vinay Chaudhry 380 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies. Steven L. Hauser / Arthur K. Asbury 381 Mysathenia Gravis and Other Diseases of the Neuromuscular Junction. Daniel B. Drachman 382 An Approach to Muscular Dystrophy and Other Muscle Diseases. Robert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell 383 Polymyositis, Dermatomyositis, and Inclusion Body Myositis. Marinos C. Dalakas e33 Special Issues in Inpatient Neurologic Consultation. S. Andrew Josephson / Martin A. Samuels SECTION 4 CHRONIC FATIGUE SYNDROME

384 Chronic Fatigue Syndrome.Stephen E. Straus SECTION 5 PSYCHIATRIC DISORDERS385 Biology of Psychiatric Disorders.Steve Hyman / Eric Kandel 386 Mental Disoders.Victor I. Reus SECTION 6 ALCOHOLISM AND DRUG DEPENDENCY387 Alcohol and Alcoholism.Marc A. Schuckit 388 Opioid Drug Abuse and Dependence.Mark A. Schuckit 389 Cocaine and Other Commonly Abused Drugs.Jack H. Medelson / Nancy K. Mello 390 Nicotine Addiction.David M. Burns PART 17 Poisoning, Drug Overdose, and Envenomation e34 Heavy Metal Poisoning. Howard Hu e35 Poisoning and Drug Overdosage.Christopher H. Linden / Michael J. Burns / Mark B. Mycyk 391 Disorders Caused by Reptile Bites and Marine Animal Exposures. Paul Auerbach / Robert Norris e36 Ectoparasite Infestations and Arthropod Bites and Stings. Richard J. Pollack / James H. Maguire SUMMARIES OF CHAPTERS e1 TO e36.APPENDIXLaboratory Values of Clinical Importance.Alexander Kratz / Michael A. Pesce / Daniel J. Fink INDEX.