A Metaphor for the Graduates

continued on page 5

It always amazes me to look over the

thesis topic of the graduating MD-PhD

students, to see how diverse a group it

is, and how their work resonates with

what is the finest and most exciting

stuff in biomedical science. I guess that

is said partly out of a sense of pride,

because a lot of the papers published

by this particular group of graduating

students are in fact among the finest

work of the last few years. In

the tremendous diversity of topics, some com-

mon themes emerge, especially in the areas

of development and regulatory control.

For instance, we have Victoria Wang’s

studies of how the transcription factor,

Oct-1 controls so many diverse aspects

of organ development, or David

Miyamoto’s work on how kinesins

function in the cell cycle. Or Sunny

Haparvat’s studies of how the devel-

opment of the retina is controlled

by thyroid hormone, starting to put

a developmental perspective on the

widely known importance of thy-

roid hormone to brain develop-

ment. Some students might have

considered collaborating, since Tom

Deuel and Vassilios Bezzerides were

both studying the elongation of axons

in the developing brain, and Eric

Osborn’s studies of actin dynamics in endothelial cells would prob-

ably have given important information to both of them, and maybe

Eric and Jason Commander had some interesting conversations,

given Jason’s interest in the function of endothelial cells in the

inflammatory response.

The theme of regulatory control connects Emanuela Binello’s

studies of immune regulation and cardiac rejection, and Jay

Chyung’s studies of regulation of the

proteins that cause Alzheimer’s disease,

as well as Wes Ulm’s analysis of viral

restriction and the retroviral proteins

that cause this phenomenon. Arlo

Miller also defined how the melanoma

proteins are regulated by the microph-

thalmai protein, David Berry focused

on how glycosaminoglycans regulate so

many diverse aspects of cellular func-

tion, and Yonatan Grad took a bioinfor-

matics approach to hunt through entire

genomes to identify sequences that reg-

2A YEAR OF BONDING

4BREAD AND CIRCUS

5MENTORING DINNER SERIES

6PROGRAM NOTES

9FOR THE RECORD

Contents

BY DR. CHRIS A. WALSH

The MD-PhD Class of 2006 with Dr. Chris Walsh (far left) at the program’s annual spring dinner held on June 6, 2006. Frontrow (left) Emanuela Binello, Jay Chyung, David Miyamoto, Victoria Wang, Eric Osborn, Jacob Ulm; Back row (left) DavidBerry, Thomas Deuel, Vassilios Bezzerides, Yonatan Grad, Jason Camander. Not pictured: Sanjiv Harpavat and Arlo Miller.

IN THIS EDITION,

we celebrate the end of a

busy and productive acade-

mic year in which enrollment

includes 148 MD-PhD students

in various stages of training

working towards completion

of their dual degrees at Harvard

and/or MIT. While we welcomed

12 new students last July (see

page 2), we congratulated 13

graduates leaving the program

this June with the 20th anni-

versary celebratory dinner with

special remarks by Dr. Chris

Walsh and Dr. Vassilios

Bezzerides speaking on

behalf of his class.

— Linda Burnley, editor

MD-PhDProgramHARVARD MEDICAL SCHOOL

n e w s l e t t e rspring/summer 2006 ■ vol. 17 ■ no. 1

Director’s remarks to the graduates at the AnnualSpring Dinner held on June 6, 2006

Relationships in Science as in Life

2 HARVARD MD-PHD PROGRAM n e w s l e t t e r

Aseemingly disparate group of aspiring scientists and clini-cians, this year’s MD-PhD class brings with it a variety ofinterests, both academic and extracurricular. From the

moment our summer course began, there was excitement allaround. We quickly came together through Sunday night VanderbiltHall potlucks, daytrips around Boston, and late night treks for icecream. In the coming years, we expect this bond to grow strongerand to be a source of support within our group. Despite our variedobsession with the Red Sox or Yankees, 9 pm bedtimes versus mid-night Minipreps, and love for warm weather compared to the frigidchills of Boston, our group shares a strong common interest in thepursuit of free food and, of course, a little bit of research if time per-mits.

Below are short descriptions of each of the members of the first-year class. These blurbs highlight the diverse backgrounds of thegroup, and the tremendous contribution that such diversity is sureto make in our future development as physician-scientists.

Katrina Abuabara, a native of Northern California, stayed true toher roots and graduated from Stanford University in 2001 with a BAin human biology and a MA in sociology. She then migrated southto Mexico City, where she worked on reproductive health epidemi-ology in Latin America. She has since focused on disease modelingand decision analysis at UCSF and the Harvard School of PublicHealth, and is currently interested in infectious disease and interna-tional health policy. Even after two years in Boston, she still isn’t con-vinced that winter is a time to be indoors, and you may just find herbundled in down, biking along the Charles or jogging in Brookline.

Joseph Franses was born inWest Lafayette, Indiana, andattended Purdue University,where he earned bachelorsdegrees in chemistry and chemi-cal engineering in 2005. Aftercollege, he married his highschool and college sweetheart,Nicole Waples, before coming toHMS. In his spare time he enjoysplaying on the dominant HSTintramural basketball team,reading, trying to not forget howto play the piano, and findingmore things that need to be fixedin his new condo. Joseph’s pastresearch interests included inter-facial chemistry and engineer-ing, organometallic chemistry,and biochemical engineering;his current research interests

include cardiovascular drug delivery, biomaterials, and vascularbiology. He hopes to, in chronological order: own a dog, have somekids, and become a cardiologist and researcher. Joseph is very hon-ored to be part of such a fantastic group of colleagues.

Vijay Ganesh was born and raised in upstate New York. As he head-ed to Harvard to pursue a degree in biology, his prescient mothertold him that his good fortunes would follow him to Boston.Unfortunately, this has come to mean that in the six years since heleft his hometown, the N.Y. Yankees and N.Y. Giants have failed towin a single championship, while the historically inept Red Sox andPatriots have experienced unprecedented luck. Perhaps as a testa-ment to his emotional fortitude, Vijay decided to remain in Bostonfor his MD-PhD. He is excited to continue his research training inneuroscience. Though he knows that a career as a physician-scien-tist is difficult to craft, what he has witnessed in Boston and abroadtells him that anything is possible. This delusion keeps him moti-vated, and his first-rate classmates in HST keep him happy—bothin class, and on the tennis, basketball, and squash courts.

Marie Hollenhorst is from Saratoga, California. She attendedStanford University, where she studied biology and did research onthe molecular mechanism of T cell anergy. After graduating, shemade the strange choice to trade Palo Alto’s palm-tree-lined streetsfor the gray skies of Boston. Luckily, in Boston she found a group offriendly and smart MD/PhD students who proved to be just crazyenough to merit spending 7-8 years with. In the future, Marie hopesto combine her passions for chemistry, biology, and medicine into asuccessful career that will still allow her to have time for her favoriteactivity: sleeping!

Honor Hsin graduated from Harvard College in 2005 with a degreein biochemical sciences. She currently aspires to pursue her interestsin molecular neuroscience and forensic psychiatry at MIT and

First-Year MD-PhDs Now Ready for Next Step

IN THEIR OWN WORDS

A Year of Bonding

Erin Loeliger and Marie Hollenhorst at the first Joslin/MD-PhD Program poster symposium in August 2005.

EditorLinda Burnley

Assistant EditorJanelle McCluskey

DesignerKathleen Sayre

This newsletter is published twice a year since it was first published in 1990.

©COPYRIGHT 2006

BY THE PRESIDENT AND FELLOWS OF

HARVARD COLLEGE

www.hms.harvard.edu/md_phd

MD-PhDPROGRAMn e w s l e t t e r

PHOTO CREDITS: LINDA BURNLEY, MOSHE JAKUBOWSKI, LIZA GREEN

3

Harvard, respectively. In her spare time sheenjoys running in the gym before class andreading books and articles on foreign affairsand defense policy.

Erin Loeliger was raised on the fair shores ofMaryland’s Chesapeake Bay and attendedthe University of Maryland BaltimoreCounty, graduating with a major in bio-chemistry and a minor in philosophy for anice balanced academic diet. During hertime at UMBC, Erin worked in a structuralbiochemistry lab studying viral proteins ofHIV. Her current research interests includevirology and stem cell biology. She spendsher free time pursuing her back-up career ofballroom dancing, pondering the meaningof life and other unanswerable questionsand trying to learn how to cook withoutburning her kitchen down. Erin feelsimmeasurably lucky to be a member of sucha fabulous class.

Athar Malik, a native of southeast Michigan,graduated from the Johns HopkinsUniversity in 2005 with a degree in biomed-ical engineering. Athar’s undergraduateexperiences investigating cartilage tissueengineering excited him about the therapeu-tic potential of stem cells and tissue engi-neering. However, he recently became evenmore excited by the field of neuroscience andis now planning on working in a cellular andmolecular neuroscience laboratory.Motivated principally by his faith as anAhmadi Muslim, Athar hopes to improveunderstanding of normal and pathologicprocesses in the human body through his

career as a physician-scientist. As an avidathlete, Athar regularly makes time to playpickup games of basketball and squash withhis colleagues.

Peter Miller is a “southern” lad from Atlanta,GA, but has been in Boston for the past fiveyears. As a 2005 graduate of MIT with a dualB.S. in chemical engineering and biology, heis most interested in cancer research,although he has also worked in biochemicalengineering and immunology in the past.Outside of class he enjoys sports, “straightchillin’ and illin’” with colleagues, and log-ging onto MyCourses. Other than that, Peterlooks forward to many, many, many years ofeducation and hopes to run a lab, practicepediatric oncology, and cure cancer by theage of thirty four.

Sidharth Puram is perhaps the only onewho considers Boston a spring break desti-nation. Born and raised in Minnesota, heviews Boston as a pleasant escape from theoccasional minus-30-degree wind chills ofhis home. As a former MIT student studyingbiology and neuroscience, he worked in thelab of Dr. Bob Langer on DNA delivery usingpolymer microspheres. However, in theupcoming years he hopes to “ditch the engi-neering,” and pick up some good old-fash-ioned biology, a.k.a. droning the days awaywith Western Blots. In his copious amountsof free time, Sid enjoys scuba diving, playingsquash, and participating in photo shootswith his HST colleagues. Although a neuro-science focused research career is his mostlikely aspiration, he feels confident that if all

else fails, he can fall back on a career of pro-fessional “car on frozen lake” driving andsnow football. You’ll know you’ve found himwhen you see the guy without a jacket in thedead of the Boston winter.

Xavier Rios-Villanueva used to live inPuerto Rico, where he did his undergradstudies in industrial biotechnology. Heenjoys explaining to people the “special”relationship between Puerto Rico and theUS, and how he is not really an internation-al student. In addition, he wishes to becomea better salsa dancer and spends a consider-able amount of his free time learning aboutthe Japanese culture and language via anime.Currently he is interested in applying sys-tems biology approaches to stem cells andhuman metabolism and, as a pastime, won-ders why people decided to build cities inplaces where winter lasts six months.

Takahiro Soda is a son of one of thoseJapanese “salarymen” who thought he wasbeing sent to the USA for 2 or 3 years andwould soon return to Japan and live an aver-age life. However, his family ended up stay-ing here for a long time. As a result, Takahirograduated from UCLA with a degree in neu-roscience. He has taken part in research onHuntington’s disease and is interested in psy-chiatric illnesses. When Takahiro is not inclass, he is sleeping, playing soccer, or eating,sometimes all at the same time. His drive inlife is to consume mass quantities of goodfood. He somehow plans to achieve this endthrough a career involving research and careof psychiatric illness.

HARVARD MD-PHD PROGRAM n e w s l e t t e r

From left to right: Katrina Abuabara, Vijay Ganesh, Athar Malik, Marie Hollenhorst, XavierRios, Erin Loeliger, Peter Miller, Honor Hsin, Joseph Franses, Taka Soda, and Sid Puram.

4

Since September, the first and second yearMD-PhD classes have gathered weeklyfor the free exchange of ideas, and, of

course, free food. Our goal was to create aforum for informalpeer adv is ing andsocial interaction; theresult was much cama-raderie and a fascinat-ing series of studentand guest presenta-tions. The topics variedwidely with our diverseinterests, encompass-ing everything fromthe conventional to theunconventional, andthen the even less con-ventional.

Cr a i g M e r m e lbegan the series with an ethical debate on theright of a pharmacist to refuse emergency

contraception. Ben Rapoport later managedto overcome his micrographia long enough topresent an analysis of crossword strategy usingan overhead projector. In October, first yearstudent Peter Miller stepped up to thelunchtable with a truly novel topic: medicine.Using the second years as an overzealous con-sult service for the first year class, we collec-tively cracked the case “A Five Day Old GirlWith Leukocytosis.”

Ben Rapoport set a new standard of enter-tainment with his presentation “ExoticMedical Images: Raw Food Diets,” a review ofstrange but true vignettes from the photo-graphic archives of the New England Journalthat will make you think twice before orderingsushi again.

Sol Schulman continued the foray intopseudo-science with a talk on “ExecutivePrivilege: A Matter Of Life And Death,” sur-veying the dark medical secrets of the US pres-idents. After hearing circumstantial evidencethat our potent leader George ‘The PotomacStallion’ Washington may not have been sopotent, that president Harding likely sufferedfrom mumps orchitis, and that FDR was into

digital clubbing, we successfully completed aquiz matching president with pathology.

Dr. Thomas Stossel, Professor of Medicineat Harvard Medical School and the Brighamand Women’s Hospital, engaged us in a livelytalk and subsequent discussion on the rela-tionship between publicly and privately fund-ed research. A strong believer in the benefits offostering a close relationship between acade-mia and industry, Dr. Stossel highlightedrecent government regulation of such interac-tion and how we would be impacted as futurephysician-scientists.

The weekly lunches also provide a meansby which to implement more formal advising.Distinguished guests have included Dr. Walsh,Dr. Blacklow, Dr. Rupnick, and Dr. Dienstag,collectively covering topics ranging from laband graduate program selection to summerclinical clerkship opportunities.

The ancient Romans knew the only trueway to placate an oppressed working class, andsome things never change. Our busy ways pullour classes in many directions, but we contin-ue to look forward each week to our very ownbread and circus.

We are happyto introduce the

inaugural MD-PhD

Newsletter cartoon

by Ben Rapoport,

MD-PhD student now

entering his third

year in the program.

Ben began drawing

cartoons for elemen-

tary school spelling

assignments and

eventually went on

to draw editorial

cartoons for the

Harvard Crimson.

Bread and CircusSome things never change

The author, Sol Schulman

HARVARD MD-PHD PROGRAM n e w s l e t t e r

HARVARD MD-PHD PROGRAM n e w s l e t t e r

MENTORS AND ROLE MODELS are important, as we’ve

been told all our lives. For many of us, that’s how we got

here (and why we wanted to) in the first place. However,

as we make our way through the MD-PhD Program, it may seem

hard to locate role models who are able to maintain a clinical practice

while successfully pursuing academic research. So, we worked with

Dr. David Hafler and our program director, Dr. Chris Walsh, to begin

a series of dinners this past June to help address this issue.

The plan was, we could have a small group of MD-PhD students in

their lab years of their MD-PhD visit the homes of faculty who would

open their living rooms and their lives to the students, invite a few fac-

ulty friends, and chat with us over Thai food about how to make this

career path work. No powerpoint, no chalk talks—just straightforward

advice about the things you think about, but are never quite sure who

to ask—how do you move from your residency into a lab of your

own? How do you make time to have kids? How does tenure work?

How can you do all this and be happy and fulfilled?

So far, we’ve had four dinners. We began in June, 2005, with

Dr. Chris Walsh and his wife Dr. Ming Hui Chen and their lovely

daughters who invited Dr. Maria Rupnick to join us for Thai food and

a discussion of the proposed changes to the medical curriculum at

HMS. A few months later, Dr. Hafler and his wife Dr. Janet Hafler, and

their son Brian, who is a member of the MD-PhD Program, and their

younger son Jason, hosted a dinner in September, inviting us and Dr.

Laurie Glimcher, Dr. David Fisher and Dr. Michael Brenner out to West

Newton to enjoy a lovely fall day and conversation. We had a Chinese

New Year-themed dinner with Dr. Cynthia Morton in January, which

led to a great set of discussions about tenure, applying to residency and

the realities of the two academic-track parent families.

In April we were hosted by the Provost of Harvard University, Dr.

Steven Hyman and his wife Dr. Barbara Bierer, VP for Research at

BWH. It was a great opportunity to chat and get advice from a couple

who both hold key administrative positions. We’re also scheduling

dinners with Dr. David Altshuler and Dr. Joel Hirschhorn—if you

have any suggestions for dinners or if you’d like to help out, please

let me know!

So, what do you want to be when you grow up?

So, what do you want to be when you grow up?

BY SARAH E. HENRICKSON

ulate all different kinds of genes regardless of their

function.

And so it seems everything these days in science is

about relationships. How one thing regulates or relates

to another. As though the outer boundary lines of bio-

medical science are becoming sketched in—after all,

we know how many base pairs of DNA there are in our

genome, how many genes there are (approximately),

and there are fewer and fewer proteins out there with-

out names or ascribable functions. Genome sequenc-

ing projects are done with the big players humans and

mice and are now down to sequencing the nine-toed

hedgehog and the armadillo—no kidding—or to fig-

uring out how to sequence your genome or mine, and

not just Craig Ventor’s DNA or the DNA of Craig

Ventor’s pet dog. This maturity has led some people to

suggest that certain fields—like developmental genet-

ics—are becoming mature, and that tomorrow’s

Nature and Cell papers will have to come from some-

where else. Increasingly this somewhere else involves

working with a finite group of parts and focusing on

how they relate, because even with a finite number of

elements, we know that their relationships will still be

almost infinite.

And I guess that’s a metaphor for where we are

tonight. Because even though we are a finite group of

people, our relationships are potentially infinite and

much more interesting: relationships to families, to

friends, to our science, and to the science that is done

by our colleagues. That is where the real interest lies,

the “Cell papers of our life-times” not inside ourselves

as one piece, but how we relate. This is something I

find I have always done a very bad job of remembering

myself, and that I have been thinking of this week as I

was at my old school—the University of Chicago—

helping to celebrate the career of one of my former

teachers, and catching up with some old fellow stu-

dents. So with that, congratulations, good luck, and

may you have successful relationships.

Dr. Walsh is the HMS Bullard Professor of Neurology;

Chief of Genetics and Professor of Pediatrics at Children’s

Hospital; Howard Hughes Investigator at BIDMC; and

the Director of the MD-PhD Program since 2003.

METAPHOR FOR GRADUATES

5

c o n t i n u e d f r o m p a g e 1

PROGRAM

Program Submits 5-Year Competitive Renewal to NIHThe Harvard MD-PhD Program submitted its five-year competitive

renewal of its training grant to the NIH last January.

The grant was composed of 1,531 pages containing a comprehensive

report on the program’s progress over the past five years, including sup-

porting data for the $17.1M budget

request. Carefully detailed data tables

and analysis of the program’s adminis-

tration, finances, faculty, alumni, cur-

rent students and applicant pools sup-

ported the program’s request.

The program faculty and staff

worked for over two months to com-

plete the project. While the number of

MSTP trainee positions in the current

grant is 44, the program director, Dr. Chris A. Walsh, felt strongly that the

grant justified a budget increase to 50 trainee slots. Review of the grant

was held at the NIH on June 20, 2006 and a council decision is anticipat-

ed in October. The funding requested for the next five-year period is

anticipated to begin on July 1, 2007.

The finished grant before it was shipped to the NIH.

6HARVARD MD-PHD PROGRAM n e w s l e t t e r

The Days of Molecular Medicine Conferencethis past May in Stockholm, Sweden focused on Chronic

Inflammation. Marlys Fassett and Sarah Henrickson (below)

both fourth years in the program, traveled across the Atlantic

to hear great lectures, including those from HMS professors

Laurie Glimcher and Diane Mathis, and chat with colleagues over

posters from across the world. The conference showcased fantas-

tic science, from basic mechanisms of NFkB and innate immuni

ty to the clinical trials for thera-

pies for rheumatoid arthritis and

other autoimmune disorders. A

panel on the regulatory challenges

in the US and Europe for new

drugs generated spirited discus-

sion, as did the banquet at the

Vasa Museum, home to a 17th

century Swedish ship that made it

less than half an hour out of the

harbor on its maiden voyage

before sinking, only to be resur-

rected in the 1950s from

Stockholm Harbor. A wonderful

trip! Next year, the DMM confer-

ence will be at MGH and will

focus on Emerging Technology

and Human Disease.

Dr. Alan M. Michelson, MD-PhD class of 1986, and member of

the program’s faculty committees for the past 10 years, has accepted

a position as Associate Director for Basic Research at the National

Heart, Lung and Blood Institute. In this capacity, Dr. Michelson will

work with the NHLBI Director, Dr. Elizabeth Nabel, on extramural

basic science policy and the development of new research initiatives.

Dr. Michelson will also continue his own laboratory research as a

Senior Investigator in the NHLBI Division of Intramural Research.

Dr. Chris Walsh recognized Dr. Michelson’s role in the Program—

citing his outstanding contributions as chair of the Committee of

Advisors and member of the Executive Committee and

Subcommittee on Admissions—with a plaque presented to him at

the program’s dinner in honor of the graduates on June 6, 2006.

Parenthetically, Dr. Michelson was one of 8 graduates of the pro-

gram honored at the program’s first annual graduation dinner 20

years ago in 1986.

In the fall of 2004, the Executive Council of the AAMC approved a

proposal to establish a new MD-PhD Section of the GraduateResearch Education and Training (GREAT) Group. Membership

in this body includes the faculty who serve as the institutional lead-

ers of MD-PhD programs (MSTP and others) at medical schools.

The mission of the MD-PhD Section is to advance the education,

training and career development of physician-scientists, with an

emphasis on training in the MD-PhD programs of LCME accredited

medical schools. Both Dr. Chris Walsh and Ms. Linda Burnley are

members of the new MD-PhD Section with Linda serving as a

founding member of the MD-PhD Section’s Executive Committee as

well as co-chair of the data analysis committee.

MD-PhD Alumnus Dr. Robert L. Satcher, Jr. (MIT ’93), (HMS ’94)

gave the Robert H. Ebert Lecture “From Harvard to NASA: An Alumni

Perspective on Space, Medicine, and Astronauts” on April 28, 2006 as

part of the Alliance Revisitation Weekend events. Dr. Satcher was select-

ed by NASA in May 2004 and completed Astronaut Candidate Training

this past February as part of preparation for future

flight assignments as a mission specialist. Prior

to NASA training, he was Assistant Professor at

the Feinberg School of Medicine, Northwestern

University, in Orthopaedic Surgery where he also

held appointments as an Attending Physician at

Children’s Memorial Hospital in Chicago special-

izing in musculoskeletal oncology and an adjunct

appointment in the biomedical engineering

department at Northwestern University.

✓

✓

✓Noted

Annual MD-PhD Programand Joslin Diabetes Poster SymposiumLast August, Dr. Joel Hirschhorn,

assistant professor of pediatrics

and genetics, associate director of

graduate education, collaborated

with Dr. Diane J. Mathis, profes-

sor of medicine at Joslin Diabetes

Center, to co-sponsor the first

annual MD-PhD Poster Symposium for the first and second year

students to present research done during their summer labs. Other

MD-PhD and summer undergraduate students on campus were

invited to attend, as were investigators at the Joslin, who described

research opportunities in their labs. There was a great turnout and a

very enthusiastic response to this initial event. We look forward to

the 2nd annual poster session to be held on August 3, 2006.

notes

Annual RetreatThe program’s 23rd annual weekend student/fac-

ulty retreat was held last October, 2005 at

Waterville Valley, NH. Over 100 participants

attended the retreat in which Gary Nabel, MD,

PhD (left) delivered the 6th Annual Eva Neer

Memorial Lecture: “When Bad Viruses Kill Good

Cells: From Mechanisms to Prevention.” Dr.

Nabel, a 1982 graduate of the MD-PhD

Program, is Director of the Vaccine Research

Center in the National Institute of allergy and Infectious Diseases at

NIH. He is well known as a molecular virologist and immunologist

for his work in the fields of HIV, Ebola virus, and cancer research.

Several senior students (Anna Farago, John Hanna, Christina Mills,

Cullen Taniguchi, Ram Srinivasan, Junne Kamihara, Phillip Erwin,

Ashutosh Jadhav) gave oral presentations of their thesis research. A

joint poster session highlighted research results from 25 different

labs followed by a special guest lecture by Elizabeth G. Nabel, MD,

Director of National Heart, Lung, and Blood Institute on “Genomic

Medicine and Cardiovascular Disease.” Retreat sponsors included by

Merck Research Laboratories, Chiron BioPharmaceuticals, Pfizer,

Inc, Abbott Laboratories, Genzyme Corporation, the NIH-MSTP

grant, and Harvard Medical School.

The program is now planning the next retreat to be held

October 13-15, 2006 at Waterville Valley. Cancer research pioneer

Dr. M. Judah Folkman, Julia Dyckman Andrus Professor of

Pediatric Surgery, has accepted our invitation to give the Eva Neer

Memorial Lecture. Save the date!

HARVARD MD-PHD PROGRAM n e w s l e t t e r7

Awards and Honors

Amma Agymang, Phillip Erwin, and Carlos Ponce each receivedindividual Ruth L. Kirschstein National Research Services Awards sponsored by the National Institutues of Health following submissionof individual fellowship applications.

Hannah Chang was awarded the Ashford Fellowship as MD-PhDgraduate student in the Biophysics Program.

Marlys Fassett and Sarah Henrickson were awarded travel fellowships to present abstracts at the Days of Molecular MedicineConference "Inflammation in Chronic Disease" sponsored byMassachusetts General Hospital, Karolinska Institutet and NatureMedicine May 24-27, 2006, Stockholm, Sweden.

Sarah Henrickson received Outstanding Poster Award last fall at theCBR Institute for Biomedical Research Annual Retreat. Sarah also wasselected to present a plenary lecture at HMS Medical Education Daylast fall; promoted to “Instructor-G” status as teaching assistant.

Todd Herrington now finishing his thesis in the lab of John Assadwas named as a recipient of the Stuart H.Q. and Victoria QuanFellowship, an intra-Harvard fellowship for neuroscience graduate students.

The first recipient of this Harvard Stem Cell Institute’s MedicalScientist Training Fellowship is Ashutosh Jadhav, whose thesis work has been carried out in the lab of Professor Constance Cepkowhere he has been studying the development of the mammalian retina. The title of his thesis is “Regulation of vertebrate retinal development by the Notch signaling pathway.”

Ryan Lanning was awarded the Department of Defense Breast CancerResearch Program 2005 Predoctoral Traineeship Award. He was alsonamed an Athinoula A. Martinos Research Scholar for biomedicalimaging in 2005.

Arindel Maharaj was named an Albert J. Ryan Fellow in November,2005 and was awarded a European Commission travel award to attendthe Euroconference on Angiogenesis in France in May 2006.

Christina Mills received the Keystone Symposia scholarship ($1000 to help defray travel and lodging expenses associated with attendance)for the Advances in Influenza Research: From Birds to Bench toBedside conference held March 28 - April 2, 2006.

Benjamin Rapoport has been awarded the Hugh Hampton YoungMemorial Fellowship, a competitive graduate fellowship at MIT.

Sashank Reddy won a CUE teaching award last fall. The award recognized his work as a TF for Chem285 taught at Harvard.

Benjamin Sommers won the annual Academy Health DissertationAward. The Dissertation Award honors an outstanding scientific contri-bution from a doctoral thesis in health services research and the candi-date showing exceptional promise as a health services researcher. Thisyear's dissertation award will be featured in a special session at theAnnual Research Meeting on Tuesday, June 25, 2006.

8 HARVARD MD-PHD PROGRAM n e w s l e t t e r

Newest Class for 2006-07The MD-PhD Program received 477 applications (63% men;

37% women) from undergraduates applying for admission

and funding from the MSTP grant. About 17% were invited

for competitive interviews for MSTP funding offers. The new

MSTP class includes: Mr. Jonathan Abraham (Harvard), Ms.

Milena Andzelm (Harvard), Ms. Erin Chen (U-Chicago), Mr.

Mark Lee (Yale), Ms. Devarati Mitra (Stanford), Mr. Yin Ren

(MIT), Mr. Cameron Sadegh (MIT); and Ms. Yawei Yang

(UCLA); and 2 deferrals from 2005 applicant pool: Ms. Sarah

Hill (Harvard) and Ms. Karolina Maciag (Harvard); Mr.

David Konieczkowski (Princeton) deferred until 2007.

In August, Ms. Amy Saltzman (Princeton), also a deferral

from 2005, will join the program in the social sciences track

along with Mr. Stephen Huffaker (U-Wisconsin), a recipient

of the new NIH-Graduate Partners Program. The program

also welcomed Ms. Aurore Halkovich and Mr. Xavier Moisset,

visiting French MD-PhD students sponsored by INSERM,

who are participating in the summer course.

PROGRAM notes

Spring Dinner on June 6 honored the MD-PhD Class of 2006 and brought together, pictured from top:• Drs. Alan Michelson, Yonatan Grad, and

Ms. Linda Burnley• Dr. Vassilous Bezzerides, center, gave remarks

on behalf of his graduating class. Shown with him are his parents, Bandel and ElizabethBezzerides, and his wife, Ann Mitsakos.

• Graduate Thomas Deuel shown here with his mother Dr. Ruthmary K. Deuel.

• Getting together at the Spring Dinner.Above: Students gatherat the annual summerbarbeque in 2005 onHMS Quad.

Left: Jason Comanderat the Match Day onMarch 23, 2006.

Gallery

C O N T I N U E D F R O M PA G E 7

9

For the RecordNew PublicationsGrossman D, Ellertson C, Abuabara K, Blanchard K, Rivas FT. Do Product Labeling and Practice

Guidelines Deter Contraceptive Use? Am J Public Health. 2006 Jan 31

Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ,

Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of

human lung cancer. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30.

Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson

C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and con-

trol of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39.

Sarbassov dos D, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. Prolonged

Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB. Mol Cell. 2006 Apr 21;22(2):159-68.

Bailey SN, Ali SM, Carpenter AE, Higgins CO, Sabatini DM. Microarrays of lentiviruses for gene

function screens in immortalized and primary cells. Nat Methods. 2006 Feb;3(2):117-22.

Sarbassov dos D, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol.

2005 Dec;17(6):596-603. Epub 2005 Oct 13. Review.

Ali SM, Sabatini DM. Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphory-

lates its hydrophobic motif site. J Biol Chem. 2005 Apr 4.

Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW,

Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb

as a cell cycle regulator. Dev Cell. 2005 Mar;8(3):435-42.

Dulay MT, Baca QJ, Zare RN. Enhanced proteolytic activity of covalently bound enzymes in pho-

topolymerized sol gel. Anal Chem. 2005 Jul 15;77(14):4604-10.

O'Hara FP, Beck E, Barr LK, Wong LL, Kessler DS, Riddle RD. Zebrafish Lmx1b.1 and Lmx1b.2 are

required for maintenance of the isthmic organizer. Development. 2005 Jul;132(14):3163-73.

Bernstein-Hanley I, Balsara ZR, Ulmer W, Coers J, Starnbach MN, Dietrich WF. Genetic analysis of

susceptibility to Chlamydia trachomatis in mouse. Genes Immun. 2006 Jan 5.

Sifri CD, Begun J, Ausubel FM. The worm has turned—microbial virulence modeled in

Caenorhabditis elegans. Trends Microbiol. 2005 Mar;13(3):119-27. Review.

Berry D, Ren J, Kwan CP, Sietsma DK, Sasisekharan R, Finklestein SP. Dimeric fibroblast growth fac-

tor-2 enhances functional recovery after focal cerebral ischemia. Restor Neurol Neurosci. 2005;23(3-

4):251-6.

Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J,

Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin EF 3rd, Liotta L,

Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE.Adipocyte-derived collagen VI affects

early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma

microenvironment. J Clin Invest. 2005 May;115(5):1163-76.

Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclin

D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb;25(3):1081-8.

Chang HH, Oh PY, Ingber DE, Huang S. Multistable and multistep dynamics in neutrophil differen-

tiation. BMC Cell Biol. 2006 Feb 28;7(1):11

Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC. Functional imaging with cellular resolution reveals

precise micro-architecture in visual cortex. Nature. 2005 Feb 10;433(7026):597-603.

Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles. Langmuir. 2005 Dec 20;21(26):12124-9.

Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles. J Am Chem Soc.

2005 Sep 28;127(38):13213-9.

Vining MS, Bradley PL, Comeaux CA, Andrew DJ. Organ positioning in Drosophila requires com-

plex tissue-tissue interactions. Dev Biol. 2005 Nov 1;287(1):19-34. Epub 2005 Sep 19.

Deuel TA, Liu JS, Corbo JC, Yoo SY, Rorke-Adams LB, Walsh CA. Genetic interactions between dou-

blecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006 Jan

5;49(1):41-53.

Erwin PA, Mitchell DA, Sartoretto J, Marletta MA, Michel T. Subcellular targeting and differential S-

nitrosylation of endothelial nitric-oxide synthase. J Biol Chem. 2006 Jan 6;281(1):151-7.

Erwin PA, Lin AJ, Golan DE, Michel T. Receptor-regulated dynamic S-nitrosylation of endothelial

nitric-oxide synthase in vascular endothelial cells. J Biol Chem. 2005 May 20;280(20):19888-94.

Mitchell DA, Erwin PA, Michel T, Marletta MA. S-Nitrosation and regulation of inducible nitric

oxide synthase. Biochemistry. 2005 Mar 29;44(12):4636-47.

HARVARD MD-PHD PROGRAM n e w s l e t t e r

PhDs CompletedAndrew J. Aguirre, Health Sciences and Technology, BBS-Genetics (DMS) at Harvard University. [Ronald A. Depinho,M.D.] Genetic Determinants of Pancreatic Ductal Adenocarcinoma (9/05).

Siraj M. Ali, Health Sciences and Technology, Biophysics (GSAS) at Harvard University. [David Sabatini, M.D., Ph.D.] ATale of Two mTor Complexes (6/05).

Zarine R. Balsara, Health Sciences and Technology, Immunology (DMS) at Harvard University. [Michael N. Starnbach,Ph.D.] The interaction of Chlamydia trachomatis with mammalian host cells (5/06).

Jakob Begun, Health Sciences and Technology, BBS Microbiology and Molecular Genetics (DMS) at Harvard University.[Frederick M. Ausubel, Ph.D.] Investigating the host-pathogen interaction using a Staphylococcus-Caenorhabditis ele-gans model system (5/05).

Irene A. Chen, Health Sciences and Technology, Biophysics (GSAS) at Harvard University. [Jack W. Szostak, Ph.D.]Building a Protocell: Physical Aspects and Emergent Behaviors (9/05).

Savita V. Dandapani, Castle, BBS-Cell and Developmental Biology (DMS) at Harvard University. [Martin R. Pollak, M.D.]Role of alpha-actinin-4 in the kidney (7/06).

John P. Dekker, Cannon, Neuroscience (DMS) at Harvard University. [Gary I. Yellen, Ph.D.] Molecular Analysis of Gatingin Voltage - Dependent Ion Channels (5/06).

Phillip A. Erwin, Cannon, BBS-Cell and Developmental Biology (DMS) at Harvard University. [Thomas Michel, M.D.,Ph.D.] Dynamic S-Nitrosylation of Endothelial Nitric Oxide Synthase in Vascular Endothelial Cells (9/05).

Anna F. Farago, Castle, BBS-Microbiology and Molecular Genetics (DMS) at Harvard University. [Susan Dymecki, M.D.,Ph.D.] Uncovering Molecular and Spatial Predictors of Brainstem Identity (6/06).

John R. Greenland, HST, Virology (DMS) at Harvard University. [Norman Letvin, M.D.] Vaccine antigen expression andimmune responses (6/06).

Robert S. Griffin, Health Sciences and Technology, Neuroscience (DMS) at Harvard University. [Clifford Woolf, Ph.D.]Gene expression associated with neuropathic pain (9/05).

Robert S. Hagan, Health Sciences and Technology, Biology at MIT. [Peter Sorger, Ph.D.] Regulation of the SpindleCheckpoint by Mad2 Binding Proteins (7/05).

David H. Jung, Castle, BBS-Genetics (DMS) at Harvard University. [Frederick W. Alt, Ph.D.] Cis-acting elements con-trolling antigen receptor gene assembly (6/05).

Junne Kamihara, Health Sciences and Technology, Biology at MIT. [David E. Houseman, Ph.D.] Studies at theHemochromatosis (HFE) Locus: Gene conversions, Haplotypes, and an Association Analysis (12/05).

Rita Khodosh, Health Sciences and Technology, Biology at MIT. [Paul A. Garrity, Ph.D.] Beach1 Functionally AntagonizesRab11 During Development and in Regulating Synaptic Morphology (7/05).

Christina E. Mills, Health Sciences and Technology, Infectious Disease at Harvard School of Public Health. [MarcLipsitch, D.Phil] Transmission and Control of Pandemic Influenza (3/06).

Bradley J. Molyneaux, Cannon, Neuroscience (DMS) at Harvard University. [Jeffrey D. Macklis, M.D.] MolecularDevelopment of Corticospinal Motor Neurons (9/05).

Carlos F. Paz, Cannon, BBS-Cell and Developmental Biology (DMS) at Harvard University [Charles J. Wietz, M.D.,Ph.D.] Circadian Clock Function in the Mammalian Retina (10/05).

Robert S. Ohgami, Health Sciences and Technology, BBS- Cell and Developmental Biology (DMS) at Harvard University.[Mark D. Fleming, M.D., D. Phil] Identification and characterization of the Steap family of metalloreductases (5/06).

James Rhee, Health Sciences and Technology, BBS-Genetics (DMS) at Harvard University [Bruce M. Spiegelman,Ph.D.] Partnership of HNF4a with the transcriptional coactivator PGC-1a in the regulation of hepatic glucose and lipidhomeostasis (9/05).

Douglas Rubinson, Health Sciences and Technology, Biology at MIT. [Frank B. Gertler, Ph.D.] Knocked Down andKnocked Out: A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout uncovers functions inmouse development (5/05).

Safa A. Sadeghpour, Health Sciences and Technology, Brain & Cognitive Sciences at MIT. [Guosong Liu, M.D., Ph.D.]NMDA Normalization in Hippocampal Neurons: Activity-Dependent, Temporal, and Spatial Properties (8/05).

Patrick Safo, Cannon, Neuroscience (DMS) at Harvard University. [Wade G. Regehr, Ph.D.] The Role ofEndocannabinoids in Synaptic Plasticity as the Granule Cell to Purkinje Cell Synapse (6/06).

Jay A. Shendure, Peabody, BBS-Genetics (DMS) at Harvard University [George M. Church, Ph.D.] Multiplex GenomeSequencing and Analysis (8/05).

Bryan K-H. Sun, Holmes, BBS-Genetics (DMS) at Harvard University. [Jeannie T. Lee, M.D., Ph.D.] Mechanisms of Tsix-mediated repression of Xist (4/06).

David Y. Takeda, Health Sciences and Technology, Pathology (DMS) at Harvard University. [Anindya Dutta, Ph.D.]Regulation of Mammalian Replication Initiators During the Cell Cycle (6/05).

Cullen M. Taniguchi, Castle, BBS-Cell and Developmental Biology (DMS) at Harvard University [C. Ronald Kahn, M.D.,D.Sc.] The Dissection of Insulin Signaling Isoforms In Vivo: Molecular Mechanisms of Hepatic Insulin Action (11/05).

Vesselin T. Tomov, Health Sciences and Technology, BBS-Genetics (DMS) at Harvard University. [Brian Seed, Ph.D.]Codon-Optimized and Reporter-Packaging Strains of HIV-1 (6/06).

Griffin M. Weber, Health Sciences and Technology, Engineering & Applied Sciences (GSAS) at Harvard University. [LucilaOhno-Machado, M.D., Ph.D.] Data representation and algorithms for biomedical informatics applications (5/05).

Ernest N. Yeh, Health Sciences and Technology, Electrical Engineering and Computer Science at MIT. [Daniel K.Sodickson, M.D., Ph.D.] Advanced Image Reconstruction in Parallel Magnetic Resonance Imaging: Constraints andSolutions (5/05).

Glenn C-W. Yiu, Health Sciences and Technology, Neuroscience (DMS) at Harvard University. [Zhigang He, Ph.D.,B.M.] Signaling Mechanisms Limiting Axon Regeneration in the Adult Central Nervous System (5/06).

GSAS = Graduate School of Arts and Sciences BBS = Biological and Biomedical Sciences DMS = Division of Medical Sciences

10 HARVARD MD-PHD PROGRAM n e w s l e t t e r

Farago AF, Awatramani RB, Dymecki SM. Assembly of the brainstem cochlear nuclear complex is revealed

by intersectional and subtractive genetic fate maps. Neuron. 2006 Apr 20;50(2):205-18.

Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki

SM. Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.

Neuron. 2005 Dec 22;48(6):933-47.

Farh KK, Grimson A, Jan C, Lewis BP, Johnston WK, Lim LP, Burge CB, Bartel DP.The widespread

impact of mammalian MicroRNAs on mRNA repression and evolution. Science. 2005 Dec

16;310(5755):1817-21.

Tompers DM, Foreman RK, Wang Q, Kumanova M, Labosky PA. Foxd3 is required in the trophoblast

progenitor cell lineage of the mouse embryo. Dev Biol. 2005 Sep 1;285(1):126-37.

Sheen VL, Jansen A, Chen MH, Parrini E, Morgan T, Ravenscroft R, Ganesh V, Underwood T, Wiley J,

Leventer R, Vaid RR, Ruiz DE, Hutchins GM, Menasha J, Willner J, Geng Y, Gripp KW, Nicholson L,

Berry-Kravis E, Bodell A, Apse K, Hill RS, Dubeau F, Andermann F, Barkovich J, Andermann E,

Shugart YY, Thomas P, Viri M, Veggiotti P, Robertson S, Guerrini R, Walsh CA. Filamin A mutations

cause periventricular heterotopia with Ehlers-Danlos syndrome. Neurology. 2005 Jan 25;64(2):254-62.

van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks

FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of

lipid antigen presentation. Nature. 2005 Oct 6;437(7060):906-10.

Castigli E, Wilson SA, Garibyan L, Rachid R, Bonilla F, Schneider L, Geha RS.TACI is mutant in com-

mon variable immunodeficiency and IgA deficiency. Nat Genet. 2005 Aug;37(8):829-34.

Shamri R, Grabovsky V, Gauguet JM, Feigelson S, Manevich E, Kolanus W, Robinson MK, Staunton

DE, von Andrian UH, Alon R. Lymphocyte arrest requires instantaneous induction of an extended

LFA-1 conformation mediated by endothelium-bound chemokines. Nat Immunol. 2005

May;6(5):497-506.

Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S,

von Andrian UH.The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-

expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.

Blood. 2005 Aug 15;106(4):1314-22.

Uchimura K, Gauguet JM, Singer MS, Tsay D, Kannagi R, Muramatsu T, von Andrian UH, Rosen SD.

A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in

high endothelial venules. Nat Immunol. 2005 Nov;6(11):1105-13.

Greenland JR, Liu H, Berry D, Anderson DG, Kim WK, Irvine DJ, Langer R, Letvin NL. Beta-amino

ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Mol

Ther. 2005 Jul;12(1):164-70.

Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH.

Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol.

2006 Feb 6.

Mapelli M, Filipp FV, Rancati G, Massimiliano L, Nezi L, Stier G, Hagan RS, Confalonieri S, Piatti S,

Sattler M, Musacchio A. Determinants of conformational dimerization of Mad2 and its inhibition by

p31(comet). EMBO J. 2006 Mar 9; [Epub ahead of print]

Hagan RS, Sorger PK. Cell biology: the more MAD, the merrier. Nature. 2005 Mar 31;434(7033):575-7.

Schmidt M, Hanna J, Elsasser S, Finley D. Proteasome-associated proteins: regulation of a proteolytic

machine. Biol Chem. 2005 Aug;386(8):725-37.

Harpavat S, Cepko CL. RCAS-RNAi: a loss-of-function method for the developing chick retina. BMC

Dev Biol. 2006 Jan 22;6:2.

Sen J, Harpavat S, Peters MA, Cepko CL. Retinoic acid regulates the expression of dorsoventral topo-

graphic guidance molecules in the chick retina. Development. 2005 Dec;132(23):5147-59.

Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J,

Zhang X, Shyr Y, Kinney MC. Differential gene expression in anaplastic lymphoma kinase-positive

and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum Pathol. 2005

May;36(5):494-504.

Henrickson SE, EM Hartmann, G. Ott and A. Rosenwald. “Gene Expression Profiling in Malignant

Lymphomas.” In Microarray Technology and Cancer Gene Profiling ed. Simone Mocellin (2005).

Jadhav AP, Mason HA, Cepko CL. Notch 1 inhibits photoreceptor production in the developing

mammalian retina. Development. 2006 Mar;133(5):913-23.

Jung D, Giallourakis C, Mostoslavsky R, Alt FW. Mechanism and Control of V(D)J Recombination at

the Immunoglobulin Heavy Chain Locus. Annu Rev Immunol. 2006 Jan 16

Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltrans-

ferase. J Biol Chem. 2005 Jun 3;280(22):21313-20.

Mahajan VS, Leskov IB, Chen JZ.Homeostasis of T cell diversity. Cell Mol Immunol. 2005

Feb;2(1):1-10. Review.

Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systemic drug competition in drug-eluting

stent tissue deposition properties. J Control Release. 2005 Dec 5;109(1-3):236-43.

Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial drug distribu-

tion for drug-eluting stents. Circulation. 2005 Apr 5;111(13):1619-26.

Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA. Vascular endothelial growth factor local-

ization in the adult. Am J Pathol. 2006 Feb;168(2):639-48.

Loureiro RM, Maharaj AS, Dankort D, Muller WJ, D'Amore PA. ErbB2 overexpression in mammary

cells upregulates VEGF through the core promoter. Biochem Biophys Res Commun. 2005 Jan

14;326(2):455-65.

Engelman JA, Janne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE,

Cantley LC. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell

lung cancer cell lines. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3788-93.

Miller AJ, Levy C, Davis IJ, Razin E, Fisher DE. Sumoylation of MITF and its related family members

TFE3 and TFEB. J Biol Chem. 2005 Jan 7;280(1):146-55.

Mills CE, Robins JM, Bergstrom CT, Lipsitch M. Pandemic Influenza: Risk of Multiple Introductions

and the Need to Prepare for Them. PLoS Biol. 2006 Feb 21;3(6):e135

Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification

of corticospinal motor neurons. Neuron. 2005 Sep 15;47(6):817-31.

Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon

JP, Zavacki AM, Zeold A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC.

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and

PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul;7(7):698-705.

Ohgami RS, Campagna DR, Antiochos B, Wood EB, Sharp JJ, Barker JE, Fleming MD. nm1054: a

spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood. 2005 Nov

15;106(10):3625-31.

Ohgami RS, Campagna DR, McDonald A, Fleming MD. The Steap proteins are metalloreductases.

Blood. 2006 Apr 11.

Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker

JE, Fleming MD. Identification of a ferrireductase required for efficient transferrin-dependent iron

uptake in erythroid cells. Nat Genet. 2005 Nov;37(11):1264-9.

Ohliger MA, Greenman RL, Giaquinto R, McKenzie CA, Wiggins G, Sodickson DK. Concentric coil

arrays for parallel MRI. Magn Reson Med. 2005 Nov;54(5):1248-60.

Willig-Onwuachi JD, Yeh EN, Grant AK, Ohliger MA, McKenzie CA, Sodickson DK. Phase-con-

strained parallel MR image reconstruction. J Magn Reson. 2005 Oct;176(2):187-98.

Yeh EN, Stuber M, McKenzie CA, Botnar RM, Leiner T, Ohliger MA, Grant AK, Willig-Onwuachi

JD, Sodickson DK. Inherently self-calibrating non-Cartesian parallel imaging. Magn Reson Med.

2005 Jul;54(1):1-8.

Yeh EN, McKenzie CA, Ohliger MA, Sodickson DK. Parallel magnetic resonance imaging with adap-

tive radius in k-space (PARS): constrained image reconstruction using k-space locality in radiofre-

quency coil encoded data. Magn Reson Med. 2005 Jun;53(6):1383-92.

Sodickson DK, Hardy CJ, Zhu Y, Giaquinto RO, Gross P, Kenwood G, Niendorf T, Lejay H,

McKenzie CA, Ohliger MA, Grant AK, Rofsky NM. Rapid volumetric MRI using parallel imaging

with order-of-magnitude accelerations and a 32-element RF coil array: feasibility and implications.

Acad Radiol. 2005 May;12(5):626-35.

Osborn EA, Rabodzey A, Dewey CF Jr, Hartwig JH. Endothelial actin cytoskeleton remodeling during

mechanostimulation with fluid shear stress. Am J Physiol Cell Physiol. 2006 Feb;290(2):C444-52.

Parmar KM, Larman HB, Dai G, Zhang Y, Wang ET, Moorthy SN, Kratz JR, Lin Z, Jain MK,

Gimbrone MA Jr, Garcia-Cardena G. Integration of flow-dependent endothelial phenotypes by

Kruppel-like factor 2. J Clin Invest. 2006 Jan;116(1):49-58.

Parmar KM, Nambudiri V, Dai G, Larman HB, Gimbrone MA Jr, Garcia-Cardena G. Statins exert

endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005 Jul

22;280(29):26714-9.

Philippakis AA, He FS, Bulyk ML. Modulefinder: a tool for computational discovery of cis regulatory

modules. Pac Symp Biocomput. 2005;:519-30

Born RT, Pack CC, Ponce CR, Yi S. Temporal evolution of 2-dimensional direction signals used to

guide eye movements. J Neurophysiol. 2006 Jan;95(1):284-300.

For the Record

11

Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the

order of substrate degradation. Cell. 2006 Jan 13;124(1):89-103

Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. Nutritional regula-

tion of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005 Aug 26;122(4):505-15.

Song B, Diaz-Griffero F, Park do H, Rogers T, Stremlau M, Sodroski J. TRIM5alpha association with

cytoplasmic bodies is not required for antiretroviral activity. Virology. 2005 Dec 20;343(2):201-11.

Dillon CP, Sandy P, Nencioni A, Kissler S, Rubinson DA, Van Parijs L. Rnai as an experimental and

therapeutic tool to study and regulate physiological and disease processes. Annu Rev Physiol.

2005;67:147-73.

Sanders GD, Bayoumi AM, Sundaram V, Bilir SP, Neukermans CP, Rydzak CE, Douglass LR, Lazzeroni

LC, Holodniy M, Owens DK. Cost-effectiveness of screening for HIV in the era of highly active anti-

retroviral therapy. N Engl J Med. 2005 Feb 10;352(6):570-85.

Ryu J, Liu L, Wong TP, Wu DC, Burette A, Weinberg R, Wang YT, Sheng M. A critical role for myosin IIb

in dendritic spine morphology and synaptic function. Neuron. 2006 Jan 19;49(2):175-82.

Safo PK, Regehr WG. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005 Nov

23;48(4):647-59.

Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J, Sheng M, Blackstone C.

Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and

mitoptosis during programmed cell death. Curr Biol. 2005 Dec 6;15(23):2112-8.

Jaworski J, Spangler S, Seeburg DP, Hoogenraad CC, Sheng M. Control of dendritic arborization by the

phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci. 2005 Dec

7;25(49):11300-12.

Seiguer E, Smith JJ. Perception and process at the Food and Drug Administration: obligations and

trade-offs in rules and guidances. Food Drug Law J. 2005;60(1):17-32.

Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of Secreted Oligomers of Amyloid

{beta}-Protein on Hippocampal Synaptic Plasticity: A Potent Role for Trimers. J Physiol. 2006 Feb 9;

[Epub ahead of print]

Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe

KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and

avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov;33(Pt 5):1087-90.

Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R,

Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt

synaptic plasticity in vivo. Nat Med. 2005 Apr 17.

Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, Agnaf OE, Hartley DM, Selkoe DJ.

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of

natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 9;25(10):2455-62.

Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of

the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan;8(1):79-84.

Shapiro KA, Moo LR, Caramazza A. Cortical signatures of noun and verb production. Proc Natl Acad

Sci U S A. 2006 Jan 31;103(5):1644-9.

Shapiro KA, Mottaghy FM, Schiller NO, Poeppel TD, Fluss MO, Muller HW, Caramazza A, Krause BJ.

Dissociating neural correlates for nouns and verbs. Neuroimage. 2005 Feb 15;24(4):1058-67.

Zhang K, Zhu J, Shendure J, Porreca GJ, Aach JD, Mitra RD, Church GM. Long-range polony haplotyp-

ing of individual human chromosome molecules. Nat Genet. 2006 Mar;38(3):382-7.

Shendure J*, Porreca GJ*, Reppas NB, Lin X, McCutcheon JP, Rosenbaum AM, Wang MD, Zhang K,

Mitra RD, Church GM. Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome. Science.

2005 Aug.

Zhu Z, Shendure J, Church GM. Discovering functional transcription-factor combinations in the

human cell cycle. Genome Res. 2005 Jun;15(6):848-55.

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Wang YC, Stevens AL, Han J. Million-fold preconcentration of proteins and peptides by nanofluidic fil-

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TOSTESON MEDICAL EDUCATION CENTER

260 LONGWOOD AVENUE, ROOM 168

BOSTON, MASSACHUSETTS 02115-5720

mdphd@hms.harvard.edu

www.hms.harvard.edu/md_phd

TEL 617-432-0991

FAX 617-432-2791

H A R V A R D M E D I C A L S C H O O L

MD-PhDPROGRAMn e w s l e t t e r

Class of 2006 Internship/Residency and Postgraduate Appointments

David A. Berry, Principal, Flagship Ventures -Cambridge, MA.

Vassilios J. Bezzerides, Pediatrics, Children’sHospital - Boston, MA.

Emanuela Binello, Surgery Preliminary, Mt. SinaiHospital - New York, NY; Neurological Surgery,Mt. Sinai School of Medicine - New York, NY.

Jay H. Chyung, Consultant - HCNR, BostonConsulting Group - Boston, MA.

Jason I. Comander, Preliminary Medicine,Brigham & Women’s Hospital - Boston, MA;Ophthalmology, Massachusetts Eye & EarInfirmary - Boston, MA.

Thomas A.S. Deuel, Preliminary Medicine, Yale-New Haven Hospital - New Haven, CT; Neurology,Partners Neurology (Massachusetts General/Brigham & Women’s Hospitals) - Boston, MA.

Yonatan H. Grad, Internal Medicine, Brigham &Womens’ Hospital - Boston, MA.

Sanjiv Harpavat, Pediatrics, Baylor College ofMedicine - Houston, TX.

Arlo J. Miller, Transitional, Virginia Mason MedicalCenter - Seattle, WA; Dermatology, Mayo GraduateSchool of Medicine - Rochester, MN.

David T. Miyamoto, Preliminary Medicine -Brigham & Women’s Hospital - Boston, MA;Radiation Oncology, Harvard/ Brigham &Women’s/Massachusetts General Hospitals -Boston, MA.

Eric A. Osborn, Internal Medicine, Beth IsraelDeaconess Medical Center - Boston, MA.

Jacob W. Ulm, Pediatrics, UCLA Medical Center -Los Angeles, CA.

Victoria E. Wang, Preliminary Medicine-, StanfordUniversity Programs - Stanford, CA; RadiationOncology, Harvard/ Brigham &Women’s/Massachusetts General Hospitals -Boston, MA..

For the Record

v i s i t o u r w e b s i t e a t w w w. h m s . h a r v a rd . e d u / m d _ p h d

PresortedFirst-Class Mail

U.S. Postage PAIDPermit 250

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Summer Course starts July 5

MSTP National Meeting July 7-10

Summer BBQ July 27

Poster Symposium Aug 3

24th Annual Retreat Oct 13-15

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