UNIVERSITY OF PERPETUAL HELP SYSTEM - ISABELA CAMPUSMinante Uno, Cauayan City, Isabela Introduction For this second rotation of RLE duty, the BSN IV Group 6 students were assigned forfour consecutive weeks at Echa gue District hospital in Delivery Room, Operation room and emergency area. Our shift was 7 ± 3 pm in OR, DR, ER. Unfortunately, we never handled a patient suffering from complications area of this case to present I discuss this because this is very rare to know. Hemolytic disease of a newborn is sometimes left unknown. We neve r had t he chance to understand this case because we feel that is it¶s not i mportant. The group has these objectives for our case. We want to familiarize ourselves about haemolytic disease of a newborn, be able to differentiate t ypes of blood , to enhance ourselves how fetal circulation happens, to understand deeply about Rh groups and ABO Groups . Most important being a nursing student, we must know how this disease will occur. About the different diagnostic procedures and wha t are the effective nursing interventions when handling this type of case. We also included here the different medical management both pharmacologic and non pharmacological.