Nikolaos Fragakis

Assistant Professor, FESC

3rd University Cardiology Department

Hippokration Hospital, Thessaloniki

BRUGADA SYNDROME

Phenotypic Manifestations & Drugs Effect

Patterns of Brugada ECG.

New ECG criteria

Brugada ECG and right precordial early

repolarization seen in athlete’s heart

Brugada ECG

Athlete’s ECG

STJ/ST80 > 1

STJ/ST80 < 1

Abnormalities of the Br ECG

BRUGADA Phenocopies

ECG pattern characteristic of BrS that may arise from

multiple causes (metabolic disorders, electrocution,

ischemia, etc) and disappear upon resolution of the injury

negative pharmacological challenge test

Negative genetic test

Unknown prognosis

Comparison of various type 1

Brugada phenocopies

Acute IMI with

RV involvementTypical BR1

congenital

hypokalemic

periodic paralysis

hyperkalemia,

hyponatremia &

acidosis

Acute PE

Comparison of various type 1

Brugada phenocopies

Terminology of the Brugada Syndrome

and its Associated Manifestations

International Registry of Brugada

Phenocopies

(www.brugadaphenocopy.com)

Diagnostic drugs in Brugada

syndrome

Potential antiarrhythmic drugs in Brugada syndrome

Diagnostic drugs in Brugada syndrome

PACE 2007;30:823–825