Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes

Featured Article:

Christie Y. Jeon, Sc.D., Mary N. Haan, Dr.PH., Caroline Cheng, M.S., Erin R. Clayton, Ph.D., M.P.H., Elizabeth R. Mayeda, M.P.H., Joshua W. Miller, Ph.D.,

Allison E. Aiello, Ph.D., M.S.

Diabetes Care Volume 36: 520-525

March, 2012

Study Objectives

 •Although chronic infections are associated with increased levels of inflammatory cytokines and CVD, there is limited evidence on how infections affect risk of diabetes. •Examined the association between serological evidence of chronic viral and bacterial infections and incident diabetes in a prospective cohort of Latino elderly

Jeon C et al. Diabetes Care 2012;36:520-525

Study Design

• Analyzed data on 782 individuals aged >60 years and diabetes-free in 1998–1999

 • Blood was tested for antibodies to herpes simplex virus 1, varicella

virus, cytomegalovirus, Helicobacter pylori, and Toxoplasma gondii

 • Population followed until June 2008 • Estimated relative incidence rate of diabetes by serostatus, with

adjustment for age, sex, education, cardiovascular disease, smoking, and cholesterol levels

Jeon C et al. Diabetes Care 2012;36:520-525

Jeon C et al. Diabetes Care 2012;36:520-525

Jeon C et al. Diabetes Care 2012;36:520-525

Jeon C et al. Diabetes Care 2012;36:520-525

Conclusions

 •H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study •Findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes

Jeon C et al. Diabetes Care 2012;36:520-525