1. Hemophilia A Inherited blood disease where your blood doesnt clot normally.

2. Cause

Lack of clotting factors

Hemophilia A (most common type)

• Lack of clotting factor VIII

Passed on with X chromosome

1 3. Symptoms

Spontaneous bleeding

• Large or deep bruises

• Joint pain and swelling - internal bleeding

• Random bleeding or bruising

• Blood in urine

• Nosebleeds

• Tightness in joints

2 4. Symptoms

Emergency Signs

• Sudden pain, swelling, and warmth of joints and muscles

• Long and painful headaches

• Constant vomiting

• Fatigue

• Neck Pain

• Double Vision

3 5. Characteristics

Continuous bleeding after:

• Injury

• Surgery

• Tooth extraction

4 6. Characteristics

More serious complications-

• Bleeding into:

• • Joints

• • Muscles

• • Brain

• • Other internal organs

5 7. Characteristics

Lifelong Disease

8. Who Is Affected?

Women may be carriers

• Passed down to children

• • Males have 50% chance of getting disease

• • Females have 50% chance of carrying disease

Hemophilia is mostly in men

• Men only have one X-chromosome

All age groups

• Mostly children

6 9. How It Normally Works Blood vessels are cut or damaged Clotting factor recruits collagen http://www.3dchem.com/molecules.asp?ID=195 8 7 Blood reacts to clotting factors Platelets form plug at the injury site Bleeding stops!! 11 10 9 How Disease Affects Homeostasis No clotting factor to recruit collagen No clotting factor for blood to react to Platelets dont form a plug Bleeding Does Not Stop! 12 10. Diagnosis

Family history of hemophilia

• Fetus testing

Blood testing from a child or adult

Diagnostic Testing

Carrier Testing

13 11. Treatment

Replacement of the missing clotting factor

Desmopressin

• Injected into vein

• Can be given as nasal medication

• • Helps body release factor VIII

14 12. Prevention

Cant be prevented

• Genetic disorder

Genetic Counseling

• Figures out the chance of your child getting hemophilia

Regular exercise

• Prevents bleeding

15 13. Bibliography - Contents

http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_what.html

http://www.mayoclinic.com/health/hemophilia/DS00218/DSECTION=causes

http://ghr.nlm.nih.gov/condition/hemophilia

http://www.mayoclinic.com/health/hemophilia/DS00218/DSECTION=symptoms

http://www.inheritedhealth.com/condition/Hemophilia/179#symptomsandcharacteristics

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001565/

http://www.mayoclinic.com/health/hemophilia/DS00218/DSECTION=treatments-and-drugs

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html

14. Bibliography - Pictures

1-http://biomed.brown.edu/Courses/BI108/2006-108websites/group01Heparin-coatedOxygenators/pages/Heparin_pharmacokinetics.htm

2 -http://en.nkfu.com/what-is-hemophilia-signs-and-treatment/

3 -http://www.tmj.ro/article.php?art=58506380129851

4 -http://www.unm.edu/~mpachman/Blood/displaz.htm

5 -http://www.psd202.org/PEHS/departments/science/tmurphy/sixth_hour_web/Hemophilia/symptons_and_characteristics.html

6 -http://presscoverage.us/soapbox/the-redefinition-of-perfect/

7 -http://www.health911.com/cuts-&-wounds

8 -http://www.3dchem.com/molecules.asp?ID=195

9 -http://www.healthjockey.com/2008/02/11/vacuming-blood-clots-proves-to-be-effective-heart-attack-treatment/

10 -http://sciencephoto.com/images/download_lo_res.html?id=802600116

11 -http://www.fotosearch.com/illustration/blood-drop.html

12 -http://www.flickr.com/photos/csessums/4966652884/

13 -http://www.thereforyou.com/about-hemophilia/overview/who-gets-hemophilia.html

14 -http://products.hospira.com/search/productDetails?listNumber=DESMOPRESSIN_ACETATE&page=Drugs&sort=ndc&order=asc

15 -http://www.thereforyou.com/about-hemophilia/gist-of-genetics/genetics-counseling.html