hemozel suppositories … · *corresponding author: prof. dr. kenza mansoor, department of...

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HemoZel Suppositories

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Page 1: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

HemoZelSuppositories

Page 2: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

What is HemoZel Suppositories?

A natural product endorsed by a clinical study,

that helps to improve the symptoms of internal

Hemorrhoids, with an effective formula which

provides rapid and prolonged relief for anorectal

discomfort.

Suppositories are known to effectively promote

the absorption of ingredients and release in the

body.

Page 3: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Benefits of HemoZel Suppositories

Soothes itching, stinging and helps relieve pain.

Reduces inflammation.

Promotes healing, tissue regeneration andprevents bleeding.

It also favors other conditions such as analfissures or cracks.

Acts as an antiseptic, avoiding possibleinfections.

Page 4: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

What are Internal Hemorrhoids?

Internal Hemorrhoids are inflamed blood vessels that

are located inside the rectum, affecting 75% of the adult

population at some time in their life, although it also

appears in children.

Such condition is generally presented by the frequent

effort to make small and hard bowel movements and the

result of heavy lifting. Other associated conditions may

be obesity, pregnancy and sitting or standing for

excessively long periods.

Page 5: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Ingredients:

• Hamamelis Virginiana

• Menthol

Page 6: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

HamamelisVirginiana

It is a natural shrub that grows in humid or

boggy forests with warm temperatures,

originally from Virginia, United States. Also

known as Witch Hazel.

Due to its astringent action, it promotes

healing and acts as an anti-inflammatory and

anti-hemorrhagic.

It is also accredited with venotonic,

vasoprotectives, moisturizing, diuretic,

antioxidant, antiseptic and bactericidal

virtues.

Page 7: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Menthol

It is a saturated secondary alcohol, found in the oils of some

mint species, native to the Mediterranean.

Menthol stands out for its analgesic, anti-irritant and

refreshing properties, reducing pain and providing a feeling

of well-being.

Page 8: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Clinical study

In Herbresearch2, Tussenhausen-Mattsies, Germany and the University of

Petra, Amman, Jordan, a clinical study was conducted on the efficiency of

the ingredients Hamamelis Virginiana and Menthol for the treatment of

Hemorrhoids.

Page 9: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Clinical study

The study preparation consisted of Suppositories composed of

400mg Dry leaf extract of Hamamelis Virginiana L., extraction

solvent 30% Ethanol m/m and 25 mg of Menthol in a matrix of hard

fat. Suppositories were applied twice a day.

It was performed in patients between 33-58 years old, that

presented chronic Hemorrhoids, measuring during the

symptomatology trial such as rectal bleeding, constipation, mass

sensation, burning, itching, edema, and anal discomfort.

After 8 days of treatment, a 98.8% reduction in the symptoms was

observed with respect to the initial value, without adverse reactions.

Page 10: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Clinical Study Reference

Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy1,

Faculty of Pharmacy & Medical Sciences,

Herbresearch2, Tussenhausen-Mattsies, Germany; University of Petra,

Amman, Jordan.

Hamamelis Virginiana L. leaf extract Suppositories in the treatment

of Hemorrhoids: non-interventional trial and stability study

K. MANSOOR1,*, F. QADAN2, M. SCHMIDT2

Received October 30, 2017; accepted December 4, 2017

*Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical

Medicinal Chemistry and Pharmacognosy,

Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan

[email protected]

Pharmazie 73: 237–240 (2018) doi: 10.1691/ph.2018.7942

Page 11: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Manufacturer

The Manufacturer specializes in the complete production of

Suppositories of various shapes and sizes, for more than 40

years. Products and services range from the acquisition of

basic materials to packaging and laboratory analysis.

It also has the following certifications:

- Good Manufacturing Practices (GMP).

- Pharmaceutical License.

- UAE Plant Registration.

- SFDA Plant Registration.

Page 12: HemoZel Suppositories … · *Corresponding author: Prof. Dr. Kenza Mansoor, Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy & Medical Sciences,

Victoria World Wide Business

Connections Group, LLC.

Dr. Tevsijk Group, LLC.

5801 NW 151ST St, Suite 203,

Miami Lakes, FL 33014, USA

Phone: (1) 305-895-7077 / Fax: (1) 305-895-7088

[email protected]

www.vwwbc.com