hepatitis d (delta) virus hbsag rna antigen. coinfection –severe acute disease –low risk of...
TRANSCRIPT
Hepatitis D (Delta) VirusHepatitis D (Delta) VirusHBsAg
RNA
antigen
• Coinfection–severe acute disease– low risk of chronic infection
• Superinfection–usually develop chronic HDV infection–high risk of severe chronic liver disease
Hepatitis D - Clinical
FeaturesHepatitis D - Clinical
Features
•Percutanous exposures–injecting drug use
•Permucosal exposures–sex contact
Hepatitis D Virus
Modes of TransmissionHepatitis D Virus
Modes of Transmission
HBV - HDV CoinfectionHBV - HDV CoinfectionTypical Serologic CourseTypical Serologic Course
Time after ExposureTime after Exposure
Tit
er
Tit
er anti-
HBs
Symptoms
ALT Elevated
Total anti-HDV
IgM anti-HDV
HDV RNA
HBsAg
HBV - HDV SuperinfectionHBV - HDV SuperinfectionTypical Serologic CourseTypical Serologic Course
Time after ExposureTime after Exposure
Tit
erT
ite
rJaundice
Symptoms
ALTTotal anti-HDV
IgM anti-HDV
HDV RNA
HBsAg
Geographic Distribution of HDV InfectionGeographic Distribution of HDV Infection
HDV PrevalenceHigh
Intermediate
Low
Very Low
No Data
Taiwan
Pacific Islands
• HBV-HDV Coinfection
Pre or postexposure prophylaxis to prevent HBV infection
• HBV-HDV SuperinfectionEducation to reduce risk behaviors among persons with chronic HBV infection
Hepatitis D - PreventionHepatitis D - Prevention