High-throughput Sequencer Dec 2011 – 758 sequencers

Apr 2012 – 823 sequencers

Biomedical Research

1 – © 2012 Internet2

Source: http://omicsmaps.com/, Dec. 5, 2011

Increasing at 25% per year

Image: Illumina

Ion Proton Sequencer

Democratization of Sequencing

2 – © 2012 Internet2

Handheld USB Sequencer

Image: Oxford Nanopore Technologies

Image: Life Technologies

Source: L. D. Stein Genome Biol. 11, 207 (2010)

Moving beyond Moore’s Law

3 – © 2012 Internet2

Research Centers Who’s Who

4 – © 2012 Internet2

University VP / CIO

MedicalSchool

CIO

AcademicMedicalCenter

CIO

CancerCenter

CIOGenomics

CenterCIO

• Who does research involving Big Data?

• Who does wide area networking?

• Who talks with whom?• Who is responsible for

security? • Who is collaborative?• Who is in charge?

ESnet Science DMZ for Biomedical Researchers

5 – © 2012 Internet2

Sensitive data– PHI– Limited data set– De-identified

Security– ACLs in DMZ switch– Server hardening– Firewall issues– Encryption– Best practices guide

Source: http://fasterdata.es.net/science-dmz/science-dmz-architecture/

• What do biomedical researchers need today? Tomorrow?• Who are the collaborative early adopters?• How can we disseminate best practices?

– Training the trainer workshops– Educational materials– Performance monitoring and troubleshooting– ESnet’s Science DMZ architecture– Security recommendations

• What is unique in the life sciences?– Security Issues– Transport protocols– International collaborations

Engaging Biomedical Researchers

6 – © 2012 Internet2