hinri labs
TRANSCRIPT
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HINRI Labs © 2009
Healthcare Institute for Neuro-Recovery and Innovation
“Turning knowledge into practice to transform lives.”
Translational
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Translational Labs
A patient-centered approach to:
“Turning knowledge into practice to transform lives.”
HINRI Labs © 2009
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HINRI Translational Labs Mission
Build a nationally recognized nexus for academia, science, medicine, business, philanthropy, and public policy to advance patient-centered
research, rehabilitation, restoration, and recovery from neurological impairments due to
injury, disease, or congenital causes.
HINRI Labs © 2009
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HINRI Labs © 2008
HINRI Translational Labs Goals
• Turn knowledge into practice to transform lives by:– Creating the nation's leading translational laboratories for
spinal cord injury, brain trauma, and neurological disorders with collaboration centers in Atlanta, Palo Alto, and Boston
– Linking knowledge, ideas, and innovation from the scientific, medical, philanthropic, public policy, investment, and patient communities
• Create and support clinical trials to speed times between innovation and application: – Supporting translational and clinical research – Promoting promising new technologies and commercial
applications
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HINRI Translational Labs Goals (cont.)
• Develop patient-centric coordinated care models:– Collaborate with experts on clinical, physical, emotional,
lifestyle, financial, family, friends, community, and faith for optimum capabilities development
• Engage Venture Philanthropy, Foundations, & Payors: – Fostering a pre-competitive environment to evaluate and
distribute critical intellectual property from research – Establishing best practices and a model standard of care for
rehabilitation and restoration– Creating economic support and rationalization of care for
recovery HINRI Labs © 2008
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HINRI Labs © 2008
HINRI Translational Lab The Problem Statement
Institute of Medicine – “it takes 18 years for accepted research to become common practice”, because of:
• Inadequately focused research • Delays in research to trials• Delays in trials to specialist providers• Delays in specialist knowledge to common practice • Delays in treatment applications to help patients• Lack of patient-centered treatments – traditional focus is on
incomplete SCI rather than acute (1st 30 days) or complete SCI • Reimbursement and Treatment Limits
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HINRI Labs © 2008
HINRI Translational Lab The Solution
Rapid Dissemination and Translation of Ideas & Best Practices for:
• Research – coordinate and support new ideas• Rehabilitation – Test and develop new individualized
patient-centered physical and emotional approaches to rehabilitation
• Restoration – Promote and conduct clinical trial testing in partnership with researchers, early stage companies and trauma centers
• Recovery – Provide clinical, emotional, & lifestyle education for individual, family, and friends to optimize recovery and capabilities
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Translational Research
HINRI Labs © 2008
Atlanta*
Boston*Palo
Alto*HINRI LABS
Finding Patient Centered Solutions
RestorationRehabilitation
Recovery
* Academia, Science, Medicine, Business, Philanthropy, and
Public Policy
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Translational Rehabilitation
HINRI Labs HINRI Labs HINRI Labs
Activity-Based
Electrophysiology
Patients
Payors
Nutrition/Supplements
Mental, SpiritualEmotional Health
Locomat & Armin
Tissue Regeneration
Manual TherapyMedical
Monitoring
Patient Centered
Best Practices
Improved Functionality
Optimum Capabilities
Hyperbaric Chamber
Collaboration Traditional RehabNon-Traditional Rehab
Assistive Technology
Clinical Trials
Clinical Practice
Academia, Business
HINRI Labs © 2008
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Translational Restoration
HINRI Labs © 2008
Basic Research
“P of P” Research
Clinical Research
Clinical Practice
University Partners
HINRI Labs
Shepherd Center
Trauma Centers
“Proof of Principle” Research – Does the basic science & new ideas hold true for human patients?
HINRI Translational Lab’s patient-centered clinical trial platform will foster collaboration between
universities and clinical research centers.
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Translational Recovery
HINRI Labs © 2008
Medication
Therapy
Physical Health
NutritionSocialization
Readiness for Employment
Education
Spirituality
Leisure Activities
Family and Friends
Patient CenteredGoals
Normality
Functionality
Fulfillment
Independence
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HINRI Labs © 2008
Hinri LABS Areas of Focus
Permanent or irreversible
central nervous system disorders
• Phase 1 - “Complete” Spinal Cord Injury (SCI)
• Phase 2 - Traumatic Brain Injury (TBI) and Stroke
• Phase 3 - Neurological Disorders*
*Disease/Degeneration – Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Parkinson’s, and Alzheimer’s
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HINRI Labs – Action Plan
1A Complete SCI Measurement – Neural Plasticity, Functional
Recovery
Electrophysiology and Robotics
1B Complete SCI Translation – Bench to Bedside
Assistive Technology, Holistic Medicine, Stem Cell Research
2 Brain Injury Measurement and Translation
Imaging, Surgery, Pharmaceuticals, Stem
Cells, Emerging Therapies
3 Neuro-Disease
Neural Injury and Degeneration - Cell
death, nerve regeneration and reconnection
Basic Research
Phase Target Focus Method
HINRI Labs © 2008
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HINRI Labs Timeline 2009
JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC
Atlanta – 1A
($3 MM)
Atlanta – 1B
($5 MM)
Palo Alto – 1A*
($10 MM)
Boston – 1A
($2.5 MM)
Atlanta – 2
($7.5 MM)
Atlanta – 3
($5 MM)
Phase
HINRI Labs © 2008*10 MM to be raised for Dr. Gary Steinberg and Dr. Graham Creasey at Stanford
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US Military Wounded Veterans
Patients
Test & DevelopBest Practices
Rehabilitation
Business Model
Promote/Conduct Clinical Trials
Restoration
Collaborate onBest Practices
Rehabilitation
Patient Centered Clinical & Lifestyle
Recovery
Foundations & CharitiesCommon Mission
Collaborate onBest Practices
Rehabilitation
Government, VA, Private Insurance
Capital
Venture PhilanthropyCommon Goals
Coordinate & Support Research
Strategic PartnersCollaboration
Translational
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Strategic Partners
• Location – The Shepherd Center has agreed to provide space on the third floor in their main building
• University Partners - Emory, Stanford and Harvard/MIT
• Media – CNN (Dr. Sanjay Gupta)• Corporate - Google Health and Microsoft HealthVault• SHARE Initiative – a $6MM partnership between
Humana, Major League Baseball, Bernie Marcus and the McCormick Foundation to assist Wounded Veterans and their Families at Shepherd (100 participants to date)
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Venture Philanthropy
Corporate Partners• Dr. Louis Sullivan* – 3M; Bristol, Myers, Squibb; CIGNA• Bernie Marcus – SHARE Initiative, Home Depot ($300 MM)• Jeff Arnold – WebMD• Bill Ide – Former ABA President, East West Institute• Bob Bozeman – Google Health• Ron Bachman - Microsoft HealthVault• John Brandon – Apple • John Moore – Morgan Stanley (Former Head of Global HC)• Carter Burton – GE Healthcare Financial Services• Sanjay Gupta – CNN Medical Director• Steve Case – Former Vice-Chair CECP• Anthony Begando – Tenon Consulting
* Have agreed to collaborate
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Foundations & CharitiesInitial Prospect List
Foundation Partners:
• Woodruff• Hewlett• Bill/Melinda Gates • Omidyar Network • Google• Gordon Moore• Henry Kravitz
Advisory Panel:
•David Brailer – Health Evolution Partners•Kleiner Perkins - Brooke Buyers •Draper Fisher Jurvetson - Steve Jurvetson and Tim Draper•James Robinson III – RRE Ventures•Pete G. Peterson – Blackstone•Silicon Valley Bank – Carlyle Group•Bono – Elevation Partners
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Military Partners• Armed Forces Service Organization (AFSO)• United Service Organization (USO)• Wounded Warrior Project • Military Foundations (2) – Tenon Consulting Solutions
Advisory Panel• Hon. Max Cleland• Hon. John McCain (Orson Swindle)• Gen. Norman Schwarzkopf• Hon. Jeb Bush and/or Hon. Jay Rockefeller• Tom Hanks – www.welcomebackveterans.org • Robin Williams - Christopher and Dana Reeve Foundation• Congressional Service Academy Representatives• Former Head(s) of VA or VA Hospital System• Secretary of the Army and/or Joint Chiefs
US MilitaryInitial Prospect List
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HINRI Labs © 2008
CHT Partnership
A CHT “Capabilities” Project
– Ross Mason, Fellow CHT
The Center for Health Transformation (CHT) will partner with HINRI Translational Labs (Atlanta, Palo Alto, and Boston) to advise, support, and promote the creation of a national nexus, collaboration, and model of a patient-centered standard of care in research, rehabilitation, restoration, and recovery from “permanent” central nervous system disorders.