hmm 4401– cancer...risk factors and causes • genetics (philadelphia chromosome): breast cancer...
TRANSCRIPT
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HMM 4401–Cancer
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Cancer
• A group of diseases characterised by unregulated cell growth: (i) invade locally; (ii) produce distant sattelites (metastases)
• The ”cancer epidemic”: if all tobacco-relatedcancers were removed from statistics, therewould have been a decline in age-adjustedcancer incidence among women (but not men)
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Carcinogenesis
• Initiation: a carcinogen (chemical, virus, radiation, sunlight) changes the cell’s geneticmaterial to make the cell cancerous
• A promotor (a genetic flaw or another agent) may make the cell more susceptible to carcinogens
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Risk factors and causes• Genetics (Philadelphia chromosome): Breast cancer
and ovarian cancer (BRA1,BRA2 (some women have 80-90% risk of breast cancer), colon cancer, Down’ssyndrome
• Smoke (lung, mouth, larynx, bladder)• Radiation: X-rays and other ionizing radiation, non-
ionizing radiation? (sunlight, mobile phones?)• Diet (fibre, smoked food)• Place of living (Japan, USA)• Infections
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Colonoscopic view of bleeding colon cancer
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Basal cell carcinoma, most common form of cancer
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Terms
• Carcinoma, adenocarcinoma• Sarcoma• Hematogenic and lymphatic metastases• Hepatoma• Seminoma• Hypernephroma• Lymphoma• Leukemia
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Diagnosis• Screening• Biopsy: fine needle and lump• Cytology (Papanicolaou, other)• Examination of any opening: oral, bronchial,
esophageal, gastric, rectal, colonic, vaginal, urethral• Examination of stool and urine• X-ray• CT• MRI
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Screening• Screening: a test to detect the possibility of cancer• Aim: early diagnosis• Sensitivity: The probability that a patient with cancer
will have a positive test• Specificity: The probability that a patient without
cancer has a negative• Predictive value positive: the probability that a patient
with a positive test has cancer
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Treatment• Surgery for solid tumours (not diffuse cancers such
as leukemia, lymphomas, etc)
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Treatment• Surgery• Radiation; curing: lymphomas, seinomas, others;
palliation for painful metastates• X-rays (electromagnetic radiation), proton beam
radiation• Side effects: nausea, skin burns, tissue damage
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Treatment• Surgery• Radiation• Chemotherapy (cytostatics etc.). Note side effects:
nausea, vomiting, fatigue, hair-loss• Combination therapy• Investigational therapy: high dose radiation combined
with later infusion of stem cells• Adjuvant therapy
• Great improvements in therapy: some lymphomas, some childhood cancers, seminoma,
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Tumour markers/antigens
• PSA – prostata specific antigen• CEA - Carcinoembryonic antigen (colon,
breast, pancreas, smoking, etc)• Alpha-fetoprotein (liver cancer, testis, ovary)• Others
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Herceptin®• Human Epidermal growth factor Receptor 2 (HER2)
gene results in HER2 protein overexpression• HER2 overexpression occurs in approximately 25%
of breast cancer patients• HER2 protein overexpression correlates with several
negative prognostic variables, including estrogenreceptor-negative (note: tamoxiphen)
• Herceptin¨ (Trastuzumab) monoclonal antibody • Mechanism: cytotoxic, cytostatic
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Herceptin®• HER2 protein overexpression correlates with several
negative prognostic variables, including estrogenreceptor-negative
• Herceptin¨ (Trastuzumab) monoclonal antibody • Mechanism: cytotoxic, cytostatic• Side effects: fever, chills, nausea, vomiting,
cardiomyopathy, anaphylaxis• Costs NOK 250,000 per patient
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Breast cancer
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Breast anatomy, normal and abnormal
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Breast cancer• Symptoms/occurence: lump, 1/10,• Risk factor: age, genetics (BCA1-2), nullipareous,
amenorrhea, long menstruating period, late pregnancies, use of estrogens (but hardly p-pills), lack of physical activity
• Screening: mammography• Diagnosis: palpation, mammography, biopsy,
ultrasound, CT, chest X-ray, isotope examination• Therapy: surgery, radiation, chemotherapy, adjuvant
therapy
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Breast cancer incidence and mortality by age
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Breast cancer screening – is it
effective?
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Colon cancer
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Urinary tract cancer• Definition: tumor of kidney or lower urinary tract.
Hypernephroma. 2% of all cancers, more often in men
• Causes: smoking• Symptoms: (microscopic) hematuria, pain in the side,
fever, • Diagnosis: CT, MR, biopsy, cytology, cystoscopy,
ultrasound, intravenous urography• Treatment: surgery, chemotherapy, radiation• Prognosis: kidney – not so good; bladder:
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Male reproductive system
• Penis, three erectile tissue/bodies• Testes: two functions: producing
sperm/semen and testosterone• Priapism – what is it
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Benign Prostatic Hyperplasia
• Definition: Benign growth of the prostate gland
• Cause: age, unknown• Diagnosis: hesitation, frequent urination,
nocturia, less urination force, dribble at end of urination, infections, rectal examination, cystoscopy, biopsy
• Treatment: expectation, drugs, transurethral surgery, abdominal surgery
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Prostatic Cancer• Definition: malignant tumor of the prostate
gland (found in 50% of men aged 70 and all men aged 90)
• Diagnosis: symptoms largely as for BPH, back pain (metastases), rectal examination, urinary retention, cystoscopy, biopsy, PSA
• Treatment: watchful waiting, brachytherapy, external beam radiation, radical surgery, orchidectomy, estrogen, other drugs
• Prognosis: fewer than 3% die from it
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Female genital cancer
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Cancer of the female genital organs
• Uterus: age 50+, abnormal bleeding• Cervix: caused by sexual activity/virus,
abnormal bleeding• Ovaries: 40+, no symptoms, abdominal swell, • Diagnostics: colposcopy, curettage,
ultrasound• Treatment: conization, surgery,
chemotherapy, radiation
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Immunology
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The immune system
• Cells• Soluble substances (immunoglobulins,
antibodies)
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Antibodies
• Produced by T-lymphocytes• igM: the initial substance• igG: the most prevalent• igA: surface antigen• igE: causes immidiate allergic reactions
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Terms
• Antigen• Antibody (immunglobulin)• Complement• Cytokines• HLA antigens• Leucocytes (neutrophile, lymphocyte,
eosonophilic
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Allergy• Allergic reactions –hypersensitivity reactions
(atopic diseases)• Immune reactions in which normal body
tissue is damaged• Types: sesonal rhinitis/conjunctivitis, food
allergy, (asthma), anaphylaxis, urticaria(hives, elveblest)
• Diagnosis: history, blood tests (igE), skintests