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Prof. Dr. P. Pauwels (UZA, UA) Houston, we have a problem....

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Page 1: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726

Prof. Dr. P. Pauwels(UZA, UA)

Houston, we have a problem....

Page 2: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 3: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 4: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 5: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 6: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 7: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 8: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 9: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 10: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 11: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 12: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 13: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 14: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 15: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726

Patiënt: NSCLC ‐ EGFR exon19 deletie + T790M mutatie

11/02/2015• Geen behandeling• Ex19 del: 70% ‐T790M: 3.59%

12/03/2015• Behandeling AZD9291 

(start 06/03/2015)• Ex19 del: 26.2% ‐ T790M: 1.96%

T790M

Ex19 deletie

Ex19 WT

Page 16: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726

Patient with EGFR exon 19 del – T790M

T790M

Ex19 deletieBackground

Ex19 WT

Ex19 deletion

Treatment with AZD9291

Page 17: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 18: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 19: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 20: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 21: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 22: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 23: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 24: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 25: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726
Page 26: Houston, we have a problem - · PDF fileData Sources.—The review is based on peer-reviewed ... PLC P13K Caspase-3 BLTA CD137 TCR 87.1 B7.2 ... .551 Chl.Ch2 1000 O ChiCtO.O ChlChE17726