hplc methods on drug analysis || miscibility of solvents

2
Table 3. Miscibility of Solvents Acetic acid ,-- Acetone I-- - Acetonitrile Benzene Butyl alcohol Carbon tetrachloride Chloroform Cyclohexane - EI Cyc\opentane - Dichloroethane I-- Dichloromethane Dimethylforma Dimethyl Sl Dioxam Eth) I - - mide(DMF) foxide (DMSO) acetate hyl alcohol I Diethyl ether D miscible I immiscible Vl --J 0-- -l P> 0- ir M. K. Ghosh, HPLC Methods on Drug Analysis © Springer-Verlag Berlin Heidelberg 1992

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Page 1: HPLC Methods on Drug Analysis || Miscibility of Solvents

Tab

le 3

. M

isci

bili

ty o

f S

olve

nts

Ace

tic a

cid

,--

Ace

tone

I--

-A

ceto

nitr

ile

Ben

zene

But

yl a

lcoh

ol

Car

bon

tetr

achl

orid

e

Chl

orof

orm

Cyc

lohe

xane

-

EI C

yc\o

pent

ane

-D

ichl

oroe

than

e

I--

Dic

hlor

omet

hane

Dim

ethy

lfor

ma

Dim

ethy

l Sl

Dio

xam

Eth

) I

--

mid

e(D

MF

)

foxi

de (

DM

SO

)

acet

ate

hyl

alco

hol

I

Die

thyl

eth

er

D misci

ble

I im

mis

cibl

e

Vl

--J

0--

-l

P>

0- ir

M. K. Ghosh, HPLC Methods on Drug Analysis© Springer-Verlag Berlin Heidelberg 1992

Page 2: HPLC Methods on Drug Analysis || Miscibility of Solvents

n-H

epta

ne

Fro

m:

God

frey

NB

(19

72):

Che

rn.

Tec

hno!

. 2:

359

Hil

debr

and

JH a

nd S

cott

RL

(19

50):

The

Sol

ubil

ity

of

Non

elec

trol

ytes

. R

einh

old

Pub!

. C

orp.

new

Yor

k, N

.Y.

Met

hyl

ethy

l ke

tone

Iso-

octa

ne

n-P

enta

ne

Iso-

prop

yl a

lcoh

ol

Di-

prop

yl e

ther

Tet

rach

loro

etha

ne

Tet

rahy

drof

uran

(T

HF

)

Tol

uene

Tri

chlo

roet

hane

;l

r::r

r;- oo

U>

..., ...,