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Page 1: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

http:// www.metu.edu.tr

Page 2: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

METU NCCMETU NCC

HORIZON2020 INFO DAYHORIZON2020 INFO DAY

PROF. DR. IREM DIKMEN TOKERASSISTANT TO THE PRESIDENT

RESEARCH COORDINATOR

DR. AYSU ÖZENCOORDINATOR OF KNOWLEDGE TRANSFER OFFICE

JANUARY, 2015

Page 3: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

HORIZON 2020The EU Framework Programme for Research and Innovation

13:30 Session One: METU in EU ProjectsPast PerformanceStrengths and WeaknessesEU project management system at METUFuture plansParticipation of METU NCC faculty in EU projectsQ/A

14:30 Coffee Break14:45 Session Two: Horizon 2020

General InformationCritical success factors for participationSupport schemesQ/A

15:45 Coffee Break16:00 Session Three: Current Calls of Horizon 2020

Examples related with different subjectsRecommendations for METU NCC facultyQ/A

Page 4: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

National scientific research funds Largest share of research funds from The Scientific and Technological Research Council of Turkey (TÜBİTAK) and ministries.International research funds Largest share in EU Framework Programs: –Highest number of projects administrated in FP7 –Highest number of partners in FP7–11% of all EU research funds brought to Turkey–REGPOT sponsored centers (METU-MEMS largest single REGPOT partner budget in Turkey - 2,7 million €)–Major EU funding for marine sciences, earthquake studies and ICT (Institute of Marine Sciences carried out more than 20 projects amounting to around 4 million Euros)

RESEARCH@METU

Page 5: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

MOST SUCCESSFUL TURKISH UNIVERSITY IN FP7 ACCORDING TO NUMBER OF PARTNERSHIP

UNIVERSITY NUMBER OF PARTNERSHIP

METU 53

Sabancı University 40

Bilkent University 32

Bogazici University 30

Koç University 29

Istanbul Technical University

24

Ege University 13

Hacettepe University 13

Dokuz Eylul University 10

Ozyegin University 10

Page 6: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

At any time, ~ 400 R&D projects sponsored by TUBITAK and Ministries~ 60 international R&D projects (mainly EU)~ 1,000 projects sponsored by the industry

Research revenues: Research funds comprising 30-35% of annual budget of METU (incl. payroll)

Page 7: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Completed International Projects

Project Type Number Total budget METU Share

5th FP 2 2.842.000 € 79.000 €

6th FP 58 159.347.985 € 12.104.904 €

7th FP 46 241.649.803 € 9.104.590 €

Life Long Learning (LLP) 50 13.883.277 € 1.758.201 €

Other 53 25.987.347 € 3.263.386 €

Total 209 443.710.412 € 26.301.081 €

Page 8: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Ongoing International Projects

Project Type Number Total Budget METU Share Horizon 2020

4

10.250.035 €

405.305 €

7th FP 43 151.878.174 € 8.372.922 €Life Long Learning (LLP)

4 2.041.515 €

98.086 €

Other 8 535.000 € 429.393 €Total 59 164.704.724 € 9.305.706 €

Page 9: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Number of International Project Applications (since January 2014)

Project Type Number

Horizon 2020 42

Other(Erasmus +, M-ERA-NET, LIFE, NATO, TÜBİTAK Bilateral Cooperations)

25

Total 67

Page 10: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Distribution of FP Projects Among Departments and Institutes

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Page 11: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Societal challenges - Areas of Excellence in the EU Framework Projects

Page 12: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Distribution of the EU Framework Projects according to LEIT Areas

Page 13: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

METU’s Areas of Excellence in Nationally Funded Projects

Page 14: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Current TÜBİTAK Projects

* Categorization according to H2020 Societal Challenges

Page 15: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Current Industry-Led Projects

* Categorization according to H2020 Societal Challenges

Page 16: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

Current National Projects – Overall Look

* Categorization according to H2020 Societal Challenges

Page 17: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Health, Demographic Change and Wellbeing

BIOMATEN – CENTER OF EXCELLENCE IN BIOMATERIALS AND TISSUE ENGINEERING EXCELLENCE IN REGENERATIVE MEDICINE

•The only center in Turkey focusing on Biomaterials and Tissue Engineering and is both a site for experimental analysis/testing and scientific and industrial guidance.•The Center has an interdisciplinary group of researchers from Biological Sciences, Biomedical Engineering, Chemistry, Engineering Sciences, Metallurgical and Materials Engineering, Biotechnology, and Mechanical Engineering Departments.•Biodegradable implants, tissue engineering of various tissues and regeneration, controlled release systems and drug delivery, synthetic biology, biosensors, cell imaging and trafficking, biological applications of nanoparticles, bioceramics are among the center’s areas of expertise.

Page 18: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Food Security, Sustainable Agriculture and Forestry, Marine and Maritime and Inland Water Research, and the Bioeconomy METU -LEVENT BAYINDIRLI FOOD ANALYSIS LABORATORY DEPARTMENT OF FOOD ENGINEERING

•Generating new knowledge and innovation in order to enable consumers’ access to safe, healthy, high quality and affordable food•The main objective of laboratory is to generate new knowledge and innovation for the access of consumers to safe, healthy, high quality and affordable food. Our research on safe foods focuses on chemical and biological hazards throughout the total food material.•Areas of expertise: Basic food analyses , sample preparation, nutritional value analyses , microbiological analyses , GMO analyses, advanced analyses, accelerated shelf-life storage analyses•Besides the analyses, trainings on laboratory accreditation and food safety management are also organized upon demand.

Page 19: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Secure, Clean and Efficient Energy RÜZGEM - CENTRE FOR WIND ENERGY

“Providing new aerodynamic data that could help improve the performance of current wind turbine systems” •The Large Scale Multi-Purpose Wind Tunnel is one of the largest and unique test facilities both in Turkey as well as in Europe•Its core competency is its test facilities and research infrastructure that are also essential for the aeronautical and civil engineering sectors. The two major research test facilities are the Large Scale Multi-Purpose Wind Tunnel and the Structures and Materials Laboratory.•Variable test sections provide a unique testing capability for both research and contract work related to turbine aerodynamics. •It can also be used for research on various rotary and fixed wing aeronautical systems as well as testing many civil engineering structures.

Page 20: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Smart, Green and Integrated Transport

“TRAFFIC PSYCHOLOGY FOR SAFE TRAVELS” Measurement of road safety signals and evaluation and reporting of after intervention in Turkey: •METU is a partner of “Road Safety in 10 Countries” (RS- 10) initiative‐ , initiated and coordinated by The International Injury Research Unit (IIRU) at the Johns Hopkins University Bloomberg School of Public Health, USA •METU provides the technical assistance in understanding the impact of road traffic injuries in Turkey.•Activities involve:

• Observational studies of seatbelt use and excessive speeding in 2 sites in Turkey,

• Roadside interviews of drivers and passengers on seatbelt use and speeding in 2 sites in Turkey.

Page 21: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Climate Action, Environment, Resource Efficiency and Raw Materials “REFRESH: Contributing To Refreshing Adaptive Strategies To The Mitigation Of The Impacts Of Climate Change" •REFRESH is concerned with climate change, land use (e.g. agriculture), eutrophication and water demand, all of which affect freshwater ecosystems. •REFRESH has the two main goals of:

• Increasing our understanding of how freshwater ecosystems will respond to the environmental changes driven by climate, land use, water use and pollution over the next 50-60 years,

• Translating this knowledge into a form that can be used by water managers.

•This can then feed into the design of cost-effective restoration and management programmes that will account for the projected future impacts and will support efforts to achieve and maintain compliance with the Water Framework Directive and Habitats Directive.

Page 22: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

METU – I-REES: Initiative for Renewable Energy, Ecosystems and Sustainability

•The field of ‘’Renewable Energy and Sustainability’’ was selected as the first priority area to be supported and a research network was established with the heading ‘’ Initiative for Renewable Energy, Ecosystems and Sustainability (YESAP).’’ •YESAP is a platform aiming at bringing the studies carried out in the fields of renewable energy, ecosystems and sustainability in different departments and units within METU under the same roof. •It endeavours to this end to provide the grounds for cooperation between groups working in the fields of renewable energy, ecosystems and sustainability. •There are different specific fields such as Renewable Energy, Sustainable Environment Management and Technologies, National and International Sustainability Governance under the roof of METU-YESAP. •Researchers from several departments of METU are carrying interdisciplinary studies in these work groups. •Six projects have been supported from 2010 to 2013 in this concept and three of them have already been completed.

Climate Action, Environment, Resource Efficiency and Raw Materials

Page 23: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

SUSTAINABILITY AND ENERGY RESEARCH @ METU

• On average, 125 publications/year• A total of 4000 citations worldwide• 12 % of all papers published in METU are related to Energy and

Environment• 70 + nationally and internationally funded projects (mainly EU)

completed amounting to 45 million USD (since 2008)• Centers of excellence collaborating with the industry : Solar, Wind,

Marine Sciences, Built Environment• 12 firms at METU Teknopark directly involved in energy R&D with a

total turnover of ~7 million $• Integrated Research and Inovation teams : Basic Science,

Technology, Design, Socio-Economics ...

Page 24: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Climate Action, Environment, Resource Efficiency and Raw Materials

Page 25: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Secure Societies

Developing New Generation Seismic Codes: “LARGEST BUILDING MODELS TESTED IN TURKEY!”

•The project aimed at exploring the applicability of different performance assessment procedures to the existing and new buildings in Turkey, their consistency with each other and their conformance with the analytical procedures in the 2007 Seismic Code. •In the first phase of the experimental studies, data from the experiments on reinforced concrete components under simulated earthquake loads were compiled. •The performance of structures which represent the Turkish building stock was investigated experimentally in the second phase with laboratory testing. •The third phase was devoted to developing the most effective and economically feasible retrofitting techniques for school and residential buildings, and testing the seismic performances of retrofitted buildings with laboratory experiments.

Page 26: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

QUING actively brings together and construct the knowledge needed for inclusive gender+ equality policies, by conceptualizing how technocratic tendencies can be counteracted and how attention for intersectionality can be integrated.

•QUING assess the current content, quality and problems of gender+ equality policies and produce recommendations and standards for gender+ training so that policy making fits active gender equal citizenship in a multicultural Europe through 5 integrated activities:

• LARG and WHY generate and bring together new concepts, knowledge and understanding on current practices across the whole of Europe on gender equality policies.

• FRAGEN provides knowledge both on the origins of gender equality policies, and their current materialization.

• STRIQ provides the necessary knowledge to address gender inequality in policy making without contributing to other inequalities.

• Finally, OPERA is an innovative contribution to provide standards, materials and training for gender+ equality.

Europe in a changing world - Inclusive, innovative and reflective societies

Page 27: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Dr. Bilge DEMİRKÖZ“FROM DARK MATTER TO THE POSSIBILITY OF ANTIGALAXIES: TRYING TO UNDERSTAND WHAT WE - AND THE UNIVERSE - ARE MADE OF” Dr. Demirköz got her B.Sc. in the fields of Physics and Mathematics at MIT, USA and continued her studies in the same university for three years at Ph.D. level. She received her doctoral degree from Oxford University, UK and conducted research at CERN. Dr. Demirköz, who took part in the ATLAS Experiment, is currently a faculty member of the Physics Department at METU. Research: AMS is a multi-purpose particle physics experiment that was carried to the International Space Station with the launch of Space Shuttle Endeavour flight STS-134 on the 16th of May, 2011. AMS-02 was installed to its final position on the 19th of May, 2011 and has been taking cosmic-ray data since then. AMS has already collected billions of particles in low earth orbit and is now under a calibration and data validation period. AMS will measure cosmic-ray spectrum for photons and charged particles, as well as for primary elements upto Fe with unprecedented accuracy. Specifically, the energy spectra of photons, electrons, positrons and anti-protons can contain signatures of dark-matter annihilation in the galactic halo and the METU team will concentrate its efforts on understanding these spectra.

Page 28: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KONU ADI BENTON SANS REGULAR 12 PUNTO

Dr. Haluk KülahDr. Haluk KÜLAH“INNOVATIVE AND INTERDISCIPLINARY RESEARCH, FOCUSING ON REAL PRODUCTS” Dr. Haluk Külah received his B.Sc. and M.Sc. degrees in Electrical Engineering from METU. He received a Ph.D. degree in Electrical Engineering from the University of Michigan, Ann Arbor. From 2003 to 2004, he was employed as a Research Fellow at the Department of Electrical Engineering and Computer Science, University of Michigan. In 2004, he joined the Electrical and Electronics Engineering Department of METU. His research is focused on MEMS sensors, mixed-signal interface electronics design for MEMS sensors, BioMEMS, and MEMSbased energy scavenging. Dr. Külah is the Deputy Director of the METU-MEMS Centre. Dr. Külah’s interdisciplinary research group includes collaborators from different disciplines ranging from METU Biology Department Cancer Research Laboratory; Hacettepe University Medical School; Gazi University Medical School; Gazi University Faculty of Pharmacy; METU Mechanical Engineering Department; and METU Chemical Engineering Department.

Dr. Külah’s research is funded by various national and international agencies and companies, including Intel Inc., IBM, European Union 7th Framework Programme, Turkcell, The Scientific and Technological Research Council of Turkey (TÜBİTAK), and The Ministry of Science, Industry and Technology.

Page 29: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR
Page 30: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

RESEARCH RESEARCH ADMINISTRATION SYSTEM ADMINISTRATION SYSTEM

AT METUAT METU

Page 31: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

RESEARCH ADMINISTRATION SYSTEM AT METU

METU Research Coordination and Industrial Liasion Offices work in cooperation with METU Technopark offices

Page 32: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

METU Research Coordination Office

• Coordination of research centers (25 centers of excellence)

• Development of research-related initiatives (centers, programmes etc.)

• Management of projects administered by Rectorate (ÖYP, DOSAP, Science in Society etc.)

• Coordination of national and internally funded research projects

Page 33: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

PROJECT DEVELOPMENT OFFICE (PGO)• Developing programs for training of researchers, university-

industry collaborations, etc.• Designing programs according to the areas needed to be

developed and priorities set by Research Policies Commission and METU Strategic Plan

• Forming collaborations among METU researcher groups by creating field-specific platforms – e.g., Initiative for Renewable Energy, Ecosystems and Sustainability yesap.metu.edu.tr

Page 34: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

PROJECT MANAGEMENT OFFICES (PYO)• Coordination and implemention of programs developed by

Project Development Office– Student Development Programme (OYP)– Post-Doctorate Research Program (DOSAP)– Society and Science– The Researcher Development Programme for the Industry (SAYP)– The Collaboration Development Programme for Centers (MIGEP)

• Management of administrative work for researchers benefiting from programs– e.g., keeping accounts and budget records, providing financial

consultancy, payments, purchases

Page 35: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

OFFICE OF SPONSERED PROJECTS (PDO)• Providing information about national and international R&D

funding and support opportunities• Announcements of open and forthcoming calls and events of

R&D support programs• Organizing information days to bring together METU

researchers with experts from funding organizations or experienced researchers

• Assisting researchers in writing project proposals by organizing workshops, providing pre-evaluations, etc.

• Support to researchers for administrative work (documentation, signatures, etc.) during proposal submission process

Page 36: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

OFFICE OF SPONSERED PROJECTS (PDO)

Page 37: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

OFFICE OF SPONSERED PROJECTS (PDO)• Composed of 2 units; national and international• Unit for International Projects:

– Activities for international R&D funding programs– Mainly focused on H2020-related activities

• Unit for National Projects:– Activities for national R&D funding programs– Mainly focused on TUBITAK programs-related activities– Personnel Subunit (formerly TUBITAK-EU Project Office) for employment

and payment formalities of the personnel working in projects

• Contact Info: Phone: 0312 210 38 34, Email: [email protected], web: pdo.metu.edu.tr

Page 38: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

TECHNOPARK PROJECT OFFICE (TPO)• Services for proposal writing:

– Preparing project budget– Establishing an effective project management structure – Preparing work plans and establishing work breakdown structures – Preparing sections not directly related with research– Networking for potential partners, collecting and organizing information about the

selected consortium partners– Organizing timings of project deliverables or providing support to the researcher to

prepare relevant sections – Providing feedback regarding general integrity of the proposal– Determining points need to be emphasized in the proposal– Formatting the project documents– Preparing dissemination and exploitation strategies for the project– Ensuring the compliance of the proposal with EU policies– Preparing IPR sections of the proposal– Completing necessary tasks dictated by EU during application period, filling out A1,

A2, A3 forms – Formatting the project file to be submitted via EPSS and submitting the proposal

Page 39: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

TECHNOPARK PROJECT OFFICE (TPO)• Services for project management:

– Controlling consortium and grant agreements – Preparing contracts to be signed among project members – Support for negotiation, filling out necessary forms– Recording expenditures according to Turkish and EU legislations, tracking expenditure

documents– Planning and tracking expenditures according to project budget, limiting when necessary– Ensuring costs’ fulfillment of the eligibility criteria in terms of EU and Turkish legislations– Preparing periodic financial reports– VAT exemption certificate applications– Preparing 3 monthly VAT exemption statements – Preparing project personnel time sheets – Pre-audits– Preparing for project audits to present required documents to authorities– Proceeding with “project closure” procedure at the end of the project period– Storing and archiving project documents for the period defined by Turkish and EU

legislations

Page 40: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

TECHNOPARK PROJECT OFFICE (TPO)• Established in 2010 to offer services for researchers and

Teknopark companies for EU-funded projects • Implemented ~50 FP7 projects and assisted ~70 projects so far• Assisting researchers/companies in proposal writing, project

management, reporting, and pre-audit services focusing mainly on administrative duties

• Consultancy services for development and implementation of large scale and multi partnered national and international projects

• Contact Info Phone: 0312 987 35 00, Email: [email protected], web: odtuteknokent.com.tr

Page 41: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KNOWLEDGE TRANSFER OFFICE (BTO)• Established in 2013 with a

funding from TUBITAK 1513 Support Program for Technology Transfer Offices

• METU and METU Technopark joint application to program’s first year call

• METU one of the first 10 universities in Turkey to secure this fund

• Support for a period of 10 years with a total budget of 10 M TL

Page 42: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KNOWLEDGE TRANSFER OFFICE (BTO)

Page 43: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

KNOWLEDGE TRANSFER OFFICE (BTO)• Responsibilities include:

– Implementation of the 1513 project in line with the priorities of the university– Increasing awareness about national and international funding programs– Guiding academicians and industry to the proper support program for R&D

activities– Managing intellectual assets of the university and regulating knowledge transfer

processes– Coordinating collaboration activities between university and the industry – Disseminating intellectual assets, research capabilities and infrastructures of the

university– Matching activities in line with demands of researchers and industry – Support to industry and researchers in sharing intellectual and industrial property

rights, for patent protection applications and commercialization processes– Legal consultancy services for R&D project contracts for academicians and

negotiation processes concerning the contract terms

• Contact Info Phone: 0312 210 70 41-42, Email: [email protected], web: bto.metu.edu.tr

Page 44: Http:// . METU NCC HORIZON2020 INFO DAY PROF. DR. IREM DIKMEN TOKER ASSISTANT TO THE PRESIDENT RESEARCH COORDINATOR DR. AYSU ÖZEN COORDINATOR

TECHNOPARK TECHNOLOGY TRANSFER OFFICE (TTO)• Established in 2007 • To provide support to academicians and Technopark companies

for commercialization of research outcomes, and thus financially contributing to both researcher and the university

• IPR protection• Legal consultancy services and financial support for patenting

process • Licensing agreements• Contact Info Phone: 0312 987 35 00, Email: [email protected], web: odtuteknokent.com.tr

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PREPARATIONS AT METU PREPARATIONS AT METU FOR H2020FOR H2020

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H2020 PREPARATION ACTIVITIES AT METU

• Membership of Vision2020: The Horizon Network – H2020 networking platform to contribute contents of calls

• Membership of Enterprise Europe Network (˃600 member organizations) to search for/consortium partners

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H2020 PREPARATION ACTIVITIES AT METU

• H2020 info days specific to faculty /department /center by METU offices

• H2020 information presentations organized jointly with TUBITAK

• University-industry collaboration activities to promote joint H2020 project applications

• Innovation management support to SME’s for H2020 SME Instrument calls through H2020 project, BSNinnoSMEs

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H2020 PREPARATION ACTIVITIES AT METU• Specific trainings and supports (e.g. pre-evaluation,

travel support) for ERC-applicants • One-to-one supports for METU academicians, centers,

and Teknopark companies preparing H2020 proposals for searching for calls and consortiums, pre-evaluation, travel support, etc.

• Academician-specific H2020 announcement system (in preparation)

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H2020 PREPARATION

ACTIVITIES AT METU

https://h2020.metu.edu.tr

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H2020H2020AT A GLANCEAT A GLANCE

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EUROPEAN COMMISSION FRAMEWORK PROGRAMMES

2002-2006(5 years)

17,5 Billion Euro

6th FP

2007-2013(7 years)

53,2 Billion Euro

7th FP

2014-2020(7 years)

80 Billion Euro

H2020

Horizon 2020 is EC’s new Research and Innovation Framework Programme

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HORIZON 2020 AT A GLANCE• Biggest EU Research and Innovation program• Flagship initiative of Europe 2020, Innovation Union & European

Research Area: Responding to the economic crisis to invest in future jobs and

growth Addressing people’s concerns about their livelihoods, safety and

environment Strengthening the EU’s global position in research, innovation and

technology • A financial instrument implementing Innovation Union • Great ideas from lab to market

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NOVELTIES IN H2020• A single programme bringing together 3 separate

programmes/initiatives*• Coupling research to innovation – from research to

retail, all forms of innovation• Focus on societal challenges facing EU society, e.g.

health, clean energy and transport• Simplified access, for all companies, universities,

institutes in all EU countries and beyond

� The 7th Research Framework Programme (FP7), innovation aspects of Competitiveness and Innovation Framework Programme (CIP), EU contribution to the European Institute of Innovation and Technology (EIT)

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SIMPLIFICATION IN H2020• A single set of rules:

Adapted for the whole research and innovation cycle Covering all research programmes and funding bodies Aligned to the Financial Regulation, coherent with other new EU

Programmes• One project – one funding rate

Max 100% of the total eligible costs (except for innovation actions, where a 70% max for profit making entities)

Indirect eligible costs: a flat rate of 25% of direct eligible costs• Simple evaluation criteria

Excellence – Impact – Implementation (Excellence only, for the ERC)

• Successful applicants to get working more quickly time-to-grant of 8 months; exceptions for the ERC and in duly

justified cases

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H2020 WORK PROGRAMMES• Funding opportunities in multiannual work

programmes

• Prepared by EC taking into account H2020 legislation EU policy objectives

• Prepared by H2020 Advisory Groups in consultation with Enterprise Policy Group European Innovation Partnerships European Technology Platforms

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H2020 3 PILLARS18 THEMATIC SECTIONS

• World-class science

• Removing barriers to innovation

• Public and private sectors together in delivering innovation

• Simple structure reducing red tape and time

H2020 STRUCTURE

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RATIONALE FOR 3 PILLARSExcellent Science

• Concerns of citizens and society/EU policy objectives

• Multi-disciplinary collaborations, including social sciences & humanities

• To test, demonstrate and scale up solutions

• World class science• To develop, attract and retain

research talent• To provide access for researchers

to the best infrastructures

Science with and for SocietyWidening Participation and Dissemination

European Institute of Innovation & Technology (EIT)Joint Research Centre (JRC)-not including EURATOM

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BREAKDOWN OF BUDGET

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ERC PRINCIPLES• 1 researcher; 1 host institution; 1 project; 1 selection criterion:

scientific excellence• No consortia, no networks, no co-financing• Applications in any field of research, inc. social sciences and

humanities• Independent researchers from anywhere in the world, of any age and

career stage • Conditions for the researcher to direct the research and manage its

funding provided by host institution• "Portable" grant to another host institution, if grantholder wishes so• Research in one of the 28 EU member states or associated countries

22.04.23

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ERC Starting Grant for young, early-career top researchers 2-7 years after PhD up to 2 million euro for 5 years

ERC Consolidator Grant for already independent excellent researchers 7-12 years after PhD up to 2.75 million euro for 5 years

ERC Advanced Grant for senior research leaders significant research achievements in the last 10 years up to 3.5 million euro for 5 years

ERC GRANTS

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ERC STARTING GRANT TRACK RECORD• Publications in major international peer-reviewed multi-disciplinary

scientific journals and/or in the leading international peer-reviewed journals, peer-reviewed conferences proceedings and/or monographs of their respective research fields, highlighting five representative publications, those without the presence as co-author of their PhD supervisor, and the number of citations (excluding self-citations) they have attracted (if applicable).

• Granted patent(s) (if applicable). • Invited presentations to peer-reviewed, internationally established

conferences and/or international advanced schools (if applicable). • Prizes and Awards (if applicable).

22.04.23

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ERC CONSOLIDATOR GRANT TRACK RECORD• Publications in major international peer-reviewed multi-disciplinary

scientific journals and/or in the leading international peer-reviewed journals, peer-reviewed conferences proceedings and/or monographs of their respective research fields, highlighting ten representative publications, those without the presence as co-author of their PhD supervisor, and the number of citations (excluding self-citations) they have attracted (if applicable).

• Granted patent(s) (if applicable). • Invited presentations to peer-reviewed, internationally established

conferences and/or international advanced schools (if applicable). • Prizes and Awards (if applicable).

22.04.23

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ERC ADVANCED GRANT (TEN-YEAR TRACK RECORD) • Highlight ten representative publications, as senior author (or in those fields where

alphabetic order of authorship is the norm, joint author) in major international peer-reviewed multi-disciplinary scientific journals and/or in the leading international peer-reviewed journals and peer-reviewed conferences proceedings of their respective research fields, also indicating the number of citations (excluding self-citations) they have attracted (if applicable).

• Research monographs and any translations thereof (if applicable). • Granted patents (if applicable). • Invited presentations to peer-reviewed, internationally established conferences

and/or international advanced schools (if applicable). • Research expeditions that the applicant Principal Investigator has led (if applicable). • Organisation of international conferences in the field of the applicant (membership in

the steering and/or organising committee) (if applicable). • International Prizes/ Awards/ Academy memberships (if applicable). • Major contributions to the early careers of excellent researchers (if applicable). • Examples of leadership in industrial innovation or design (if applicable).

22.04.23

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MARIE SKŁODOWSKA-CURIE ACTIONS (MSCA) To support the career development and training of researchers All scientific disciplines through worldwide All career stages from PhD candidates to highly experienced researchers Transnational, intersectoral and interdisciplinary mobility "Bottom-up" approach, i.e. individuals and organisations working in any

area of research eligible

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Detaylı TÜBİTAK Marie Cruie Bilgilendirme Günü Sunumuna http://www.fp7.org.tr/home.do?ot=5&rt=&sid=0&pid=0&cid=27770 Linkinden Ulaşabilirsiniz

FP7 Marie Cruie Project

Types

HORIZON2020 Marie Cruie

Project Types

Description of Project Types

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FUTURE AND EMERGING TECHNOLOGIES (FETS)• High risk, long term, multidisciplinary, collaborative

frontier research • Unexplored collaborations between advanced

multidisciplinary science and cutting-edge engineering

• 3 complementary schemes to initiate radically new, next generation technologies

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2nd PILLAR: INDUSTRIAL LEADERSHIPII. Industrial Leadership 22.09%

(breakdown)17.016 (Million €)

Leadership in enabling and industrial technologies (LEITs) i. ICT ii. Nanotechnologies, adv. materials, adv. materials, adv. Manufacturing & processing, biotechnology iii. Space

17.60 13.557

6. Access to risk financeLeveraging private finance and venturecapital for research and innovation

3.69 2.842

7. Innovation in SMEsFostering all forms of innovation in alltypes of SMEs

0.80 616

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EmphasisEmphasis Technology Readiness Level (TRL)Technology Readiness Level (TRL)

• Objective: to achieve the EU Industrial Policy goals

• R&I to strengthen Europe's industrial capacities and business perspectives

• Involvement of industrial participants, and of SMEs in particular, strongly encouraged

• 3-4 < TRL < 7-8

TRL 1 - basic principles observed TRL 2 - technology concept formulated TRL 3 - experimental proof of concept TRL 4 - technology validated in lab TRL 5 - technology validated in relevant environment TRL 6 - technology demonstrated in relevant environment TRL 7 - system prototype demonstration in operational environment TRL 8 - system complete and qualified TRL 9 - actual system proven in operational environment

LEADERSHIP IN ENABLING AND INDUSTRİAL TECHNOLOGIES (LEITS)

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3rd PILLAR: SOCIETAL CHALLENGESIII. Societal Challenges 38.53%

(breakdown) 29.679 (Million €)

Health, demographic change and wellbeing 9.70 7.472

Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy 5.00 3.851

Secure, clean and efficient energy 7.70 5.931

Smart, green and integrated transport 8.23 6.339

Climate action, environment, resource efficiency and raw materials 4.00 3.081

Europe in a changing world - inclusive, innovative and reflective societies 1.70 1.309

Secure societies - protecting freedom and security of Europe and its citizens 2.20 1.695

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H2020 WORK PROGRAMME THEMATIC SECTIONS

Each thematic section describes• objectives• calls for proposals• topics within each call

http://ec.europa.eu/programmes/horizon2020/

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Research and Innovation Actions: Main activity type: Research and DevelopmentBasic and applied research, technology development and integration, testing and validation on a small-scale prototype in a laboratory or simulated environmentMinimum 3 legal entities established in a different Member State or associated country

Innovation Actions: Main activity type: Innovation activities - activities close to the market Prototyping, testing, demonstrating, piloting, large-scale product validation and market replicationMinimum 3 legal entities established in a different Member State or associated country

Coordination and Support Actions: Main activity type: Standardisation, dissemination, awareness-raising and communication, networking, coordination or support services, policy dialogues and mutual learning exercises and studiesDesign studies for new infrastructure and complementary activities of strategic planning, networking and coordination between programmes in different countriesMinimum 1 legal entity established in a different Member State or associated country

TYPES OF ACTIONS

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CROSS-CUTTING OBJECTIVES IN H2020

22.04.23

• Strong participation by SMEs• International cooperation (i.e. cooperation with non-EU

member states and non associated countries) • Socio-economic sciences and humanities (SSH) as an

essential element of pillar 2 and pillar 3 activities• Contribution to sustainable development and combating

climate change• Sustainability of impact• Discoveries from lab to market to commercialize ideas• Gender, ethical issues, and open access to results

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22.04.23

SMART, GREEN AND INTEGRATED TRANSPORTHorizon 2020 will provide funding for a resource efficient transport that respects the environment by making aircraft, vehicles and vessels cleaner and quieter to minimise transport’s systems’s impact on climate and the environment, by developing smart equipment, infrastructures and services and by improving transport and mobility in urban areas.Horizon 2020 also aims at a better mobility, less congestion, more safety and security with a substantial reduction of traffic congestion; with a substantial improvement in the mobility of people and freight; by developing  new concepts of freight transport and logistics and by reducing accident rates, fatalities and casualties and improving security.Horizon 2020 supports a global leadership for the European transport industry by reinforcing the competitiveness and performance of European transport manufacturing industries and related services including logistic processes and retain areas of European leadership (e.g. such as aeronautics).Horizon 2020 targets a socio-economic and behavioural research and forward looking activities for policy making. The aim is to support improved policy making which is necessary to promote innovation and meet the challenges raised by transport and the societal needs related to it.These activities are addressed in this Work Programme by three Calls for proposals:Mobility for GrowthGreen VehiclesSmall Business and Fast Track Innovation for Transport

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HOW TO PARTICIPATE IN HOW TO PARTICIPATE IN H2020H2020

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As a Project CoordinatorAs a Project Coordinator As a Project PartnerAs a Project Partner• Project idea• Previous FP project experience and

scientific expertise in related area• Find a suitable call• Find project partners• Plan the project via consortium

meetings• Write the proposal with inputs from

partners• *Average time spent by

coordinator: 45-60 working days (full time)

• Project idea• Contribution in related scientific

area• Find a suitable call• Find a consortium• Participate in consortium

meetings• Write a work package• *Average time spent by work

package leader: 9-14 working days (full time)

HOW TO PARTICIPATE IN H2020

*Deloitte (2011 monitoring report) http://ec.europa.eu/research/evaluations/pdf/archive/other_reports_studies_and_documents/rtd_annual_report_evaluation_activities_2011.pdf

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EU H2020 Official Web Pagehttp://ec.europa.eu/programmes/horizon2020/

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http://ec.europa.eu/programmes/horizon2020/en/how-get-funding

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EU Participant Portalhttp://ec.europa.eu/research/participants/portal/desktop/en/home.html

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http://ec.europa.eu/research/participants/portal/desktop/en/opportunities/index.html

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22.04.23

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http://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/search/search_topics.html

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ICT AND SSH IN H2020ICT AND SSH IN H2020& EXAMPLES FOR& EXAMPLES FOR

H2020 CALLSH2020 CALLS

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ICT IN H2020

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ICT IN EXCELLENT SCIENCE

• Under FET: covered in Open, Proactive, and Flagship

• Under Research Infrastructures: development,deployment and operation of ICT-based e-infrastructures with main priorities;– development and integration of ICT infrastructure

resources and services for research– access to and management of research data– implementation of the e-infrastructure part of the EU

strategy on high-performance computing

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ICT IN LEIT• Covers technological areas;

– A new generation of components and system: • engineering of advanced embedded and resource efficient components and

systems

– Advanced Computing: • advanced and secure computing systems and technologies, inc. cloud computing

– Future Internet: • software, hardware, infrastructures, technologies and services

– Content technologies and information management: • for digital content, cultural and creative industries

– Robotics: • advanced interfaces and robots

– Micro- and nano-electronic technologies, Photonics: • Generic technology developments focused on advanced research and lower TRLs

(MEMS)• full innovation and value chain in markets sectors (Photonics)

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ICT IN LEIT• Also included in;

– Factories of the Future• ICT components of innovative production systems in all sectors

– Cross-Cutting Activities• Internet of Things and platforms for Connected Smart Objects• Human-centric Digital Age• Cyber-security, Trustworthy ICT

– Horizontal Innovation Actions (supports specific to SMEs)

– International Cooperation Actions (e.g. Brazil, Japan)

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ICT IN SOCIETAL CHALLENGES

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SOCIAL SCIENCES AND HUMANITIES IN H2020

• EC supported SSH research over the last 4 FPs

• A specific theme dedicated to SSH under FP7

• SSH in H2020 as a separate call• Societal Challenges

– Europe in a changing world – Innovative, inclusive and reflective societies

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SOCIAL SCIENCES AND HUMANITIES IN H2020• Specific areas under Europe in a changing world –

Innovative, inclusive and reflective societies:• Overcoming the crisis: new ideas, strategies and governance

structures for Europe • The young generation in an innovative, inclusive and

sustainable Europe (job insecurity, youth mobility, adult education, social and political engagement of young people)

• Europe as a global actor (R&I with third countries, new geopolitical order in the Mediterranean, EU eastern partnership)

• Reflective societies (understanding of Europe's intellectual basis, its past, creative capacity, cultural identity and history)

• New forms of innovation (in public sector and business models, social innovation, open government)

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SSH IN H2020• Also SSH integrated across H2020 as a cross-cutting

issue to enhance industrial leadership and to tackle each societal challenge

• Examples of SSH embedding across H2020:– economic and social analysis for reforming public health

systems or food security– cultural and human dimension analysis of European

policies in transport, climate change, energy or agriculture– analyses of cultural, behavioural, psychological, social and

institutional change transforming Europe and its global environment

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Big Data – ResearchCall: ICT-16-2015Deadline: 14-04-2015 17:00:00 (Brussels local time)Main Pillar: Industrial LeadershipTypes of action:a. Research & Innovation Actions – A mix of proposals requesting Small and Large contributions are expectedb. Coordination and Support Actions

• The activities supported within LEIT under this topic contribute to the Big Data challenge by addressing the fundamental research problems related to the scalability and responsiveness of analytics capabilities (such as privacy-aware machine learning, language understanding, data mining and visualization). Special focus is on industry-validated, user-defined challenges like predictions, and rigorous processes for monitoring and measurement.

ICT CALL EXAMPLE

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The European Union, Turkey and its wider neighbourhood: challenges and opportunitiesCall: INT-09-2015Deadline: 28-05-2015 17:00:00 (Brussels local time)Main Pillar: Societal ChallengesType of Action: Research and innovation actions

• Following the decades of close cooperation, Turkey is already well integrated with the European Union in particular in the socio-economic themes, including cooperation on research and innovation, and in cultural matters. In recent years however, due to the economic and financial crisis as well as continuing tensions in the Middle East and the South and East Mediterranean region, the challenges facing both Turkey and the EU have grown. In this context, the different options for further EU-Turkey cooperation in the next decade should be fully explored, taking into account the rising global importance of Turkey as an independent regional power.

• Research should analyse the economic, social, political and geostrategic challenges and opportunities - for Turkey itself and for the EU - of further integration of Turkey with the EU, taking into account the different forms this collaboration could take as well as its historical, socio-economic and cultural dimensions.

• Broad participation of partners from Turkey and its wider neighbourhood countries in proposals submitted to this call is strongly encouraged.

• Research is expected to advance theoretical and practical debates on the different scenarios, and their implications, of the potential further integration of Turkey with the EU and to provide the analysis of the challenges and opportunities associated with this process. It will make a critical assessment of the evolution of EU relations with Turkey in the last decades as well as how they were affected by the shifting global order and the rise of Turkey as a regional power

SSH CALL EXAMPLE

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Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Call: MSCA-RISE-2015Deadline: 28-04-2015 17:00:00 (Brussels local time)Main Pillar: Excellent ScienceType of action: Marie Skłodowska-Curie Action

• The RISE scheme will promote international and inter-sector collaboration through research and innovation staff exchanges, and sharing of knowledge and ideas from research to market (and vice-versa) for the advancement of science and the development of innovation.

• RISE involves organisations from the academic and non-academic sectors (in particular SMEs), based in Europe (EU Member States and Associated Countries) and outside Europe (third countries).

• Support is provided for the development of partnerships in the form of joint research and innovation activities between the participants. This is aimed at knowledge sharing via international as well as inter-sectoral mobility, based on two-way secondments of research and innovation staff (exchanges) with an in-built return mechanism.

• Exchanges can be for both early-stage and experienced researchers' levels and can also include administrative, managerial and technical staff supporting the research and innovation activities of the proposal.

• Research and innovation activities under RISE are expected to build or enhance new and existing networks of international and inter-sectoral cooperation. They will significantly strengthen the interaction between organisations in the academic and non-academic sectors, and between Europe and third countries.

• In terms of knowledge sharing and broad skills development, they will better align different cultures and expectations, with a view to a more effective contribution of research and innovation to Europe's knowledge economy and society.

A CALL FOR MOBILITY

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KONU ADI BENTON SANS REGULAR 12 PUNTO

ERC – Starting GrantProject: Bioengineering prediction of three-dimensional vascular growth and remodeling in embryonic great-vessel developmentProject acronym: VASCULARGROWTHResearcher (PI): Kerem PekkanHost institution (HI): KOC UNIVERSITY, TURKEYCall details: ERC-2012-StG, PE8 Max ERC funding: 2 million EurosWebsite (HI): http://www.ku.edu.trDuration: 60 months

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KONU ADI BENTON SANS REGULAR 12 PUNTO

ERC – Starting GrantSummary: Globally 1 in 100 children are born with significant congenital heart defects (CHD), representing either new genetic mutations or epigenetic insults that alter cardiac morphogenesis in utero. Embryonic CV systems dynamically regulate structure and function over very short time periods throughout morphogenesis and that biomechanical loading conditions within the heart and great-vessels alter morphogenesis and gene expression. This proposal has structured around a common goal of developing a comprehensive and predictive understanding of the biomechanics and regulation of great-vessel development and its plasticity in response to clinically relevant epigenetic changes in loading conditions. Biomechanical regulation of vascular morphogenesis, including potential aortic arch (AA) reversibility or plasticity after epigenetic events relevant to human CHD are investigated using multimodal experiments in the chick embryo that investigate normal AA growth and remodelling, microsurgical instrumentation that alter ventricular and vascular blood flow loading during critical periods in AA morphogenesis. WP 1 establishes our novel optimization framework, incorporates basic input/output in vivo data sets, and validates. In WP 2 and 3 the numerical models for perturbed biomechanical environment and incorporate new objective functions that have in vivo structural data inputs and predict changes in structure and function. WP 4 incorporates candidate genes and pathways during normal and experimentally altered AA morphogenesis. This proposal develops and validates the first in vivo morphomechanics-integrated three-dimensional mathematical models of AA growth and remodelling that can predict normal growth patterns and abnormal vascular adaptations common in CHD. Multidisciplinary application of bioengineering principles to CHD is likely to provide novel insights and paradigms towards our long-term goal of optimizing CHD interventions, outcomes, and the potential for preventive strategies.

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