human papillomavirus (hpv) and cancer cancer education project university of rochester
TRANSCRIPT
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Human Papillomavirus (HPV) and Cancer
Cancer Education ProjectUniversity of Rochester
http://lifesciences.envmed.rochester.edu/curriculum/cancer/HPV_and_Cancer_PPT.ppt
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Human Papillomavirus (HPV)
http://healthlawblog.blogspot.com/uploaded_images/hpv_380-743858.jpg
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Overview of HPV Activities
Part Title Strategy
1 “One Less” and “Tell Someone” Short PBL
2 HPV Vaccine & Immune System Making Notes
3 HPV Vaccine & Cervical Cancer Jigsaw
4 The Pap Test Reading for Understanding
5 Cancer Detection: A Laboratory Simulation
Hands-on Lab
6 Why Not the Boys? Decision-Making
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Part 1:
“One Less” and “Tell Someone”
http://www.healthline.com/blogs/teen_health/uploaded_images/hpv-743477.jpg
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Part 1:“One Less” and “Tell Someone”
• A “hook” for HPV lesson series• TV commercials
http://www.gardasil.com/tv-commercial-for-gardasil
http://www.youtube.com/watch?v=hJ8x3KR75fA
• PBL teams of 3-4 students• “Facts” and “Questions” charts
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After watching the video, students write one question about:
• Human Papillomavirus (HPV)?
• The Gardasil vaccine?
• An ELSI* implication?(*ethical, legal, or social issue )
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Part 2:HPV Vaccine
and The Immune System
http://www.signonsandiego.com/news/health/images/060816cervical_cancer.gif
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Part 2:HPV Vaccine & the Immune System
Students will:
• View Gardasil TV commercial
http://www.stronghealth.com/services/cancer/hpvMedia.cfm
• See National Cancer Institute (NCI) PowerPoint:
“HPV Vaccine to Prevent Cervical Cancer”
http://cancer.gov/cancertopics/understandingcancer/HPV-vaccine
• Make Notes from the NCI PowerPoint
• Complete a 3-2-1 Refection Sheet
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Part 2:HPV Vaccine and Immune System
“Making Notes” pages from the HPV PowerPoint
Name ____ ___ ___ ___ ___ _____ ___ ___ ___ ___ Period ____ ___ _
Title / N otes / Question Notes, Comments, Drawings
HPV Vaccine to Prevent Cervical CancerTitle Page (no questions)
Common Infection:Two facts about HPV: 1. 2.
I nfection is Sexually Transmitted:What might “the virus is silent” mean?
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Understanding Cancer and Related Topics
HPV Vaccine To Prevent Cervical Cancer
This PowerPoint presentation from the National Cancer Institute explains the science behind the development of a new vaccine against high-risk types of human papillomaviruses, which can lead to cervical cancer over time.
These PowerPoint slides are not locked files. You can mix and match slides. In the Notes section, you will find explanations of the graphics.
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Infection Is Sexually Transmitted
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Common Infection
Infected with HPV
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Many Types of HPVs
Different HPVs–Different Infections
Harmless
No warts or cancer
Warts-Linked
Genital warts
Cancer-Linked
Most clear up
Some persist, but no abnormalities in cervix
Some persist, some abnormalities in cervix
A few persist and progress to cervical cancer
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Virus Penetrates Cervix
Uterus
HPVinfection
Vagina
Cervix
Layers of epithelial cells
Papillomavirus
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Virus Uncoats
Virus “uncoats”
Nucleus
Epithelial cell interior
mRNAs for viral proteins E6 and E7
Viral DNA enters nucleus
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Virus Disables Suppressors
Cancerous epithelial cells
Suppressor protein 2
E7 viral protein
Degraded suppressors
Healthy cellsMucus
E6 viral protein
Suppressor protein 1
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Virus-Like Particles
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The Vaccination
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Antibodies Prevent Infection
Papillomavirus
No DNA strands can escape the capsid= Antibodies
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Pap Test Still Necessary
Normal Pap test
Abnormal Pap test
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More Work Ahead
4 years later
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Part 3:
HPV Vaccine and Cervical Cancer
http://msnbcmedia4.msn.com/i/msnbc/Components/Art/HEALTH/060828/AP_CERVICAL.gif
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Part 3:HPV Vaccine and Cervical Cancer
Students will:
• In Jigsaw “home groups,” get one of four readings and decide on Top 5 facts.
• In reading “specialty groups,” brainstorm top facts and decide on Top 3.
• Discuss Top 3 with “home group” members.
• Complete Personal Reflection sheet as Ticket-to-Leave.
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Part 4:The Pap Test
http://www.steadyhealth.com/articles/user_files/4540/Image/HPV_pic2.jpg
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Part 4:The Pap Test
Students will:
• Receive directions about “Save the Last Word for Me” reading strategy.
• Read Mayo Clinic handout and complete “significant passage” task.
• Meet in groups of 3 to complete the “listening & reacting” protocol.
• Complete The Pap Test review sheet
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Part 5:Cancer Detection:
A Laboratory Simulation
Students will:
• Perform visual, radiation, and chemical testing on images of simulated biopsy samples to test for the presence of “abnormal” cells
• Estimate the chances of a biopsy sample being cancerous
• Write a lab report
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Question?
What are two science laboratory skills that are critical to the work of a crime scene
investigator (CSI)?
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Answer!
Observation (accurate and detailed)
Analysis of Data
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Goal of The Pap Test Lab:
…. to understand medical professionals use three different kinds of observation and data
analysis techniques to detect cancer cells when given a biopsy (tissue sample) from a
person suspected of having cancer.
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Introduction to the Lab:Student Version
1. Form into teams of 2-3 students.
2. Obtain 1 copy of the lab per team.
3. Read the first 4 paragraphs.
4. Be able to name the 3 procedures.
5. Be able to identify 3 medical careers involved in cancer detection.
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Pre-lab
For each student, obtain:
1 Cancer Detection Lab Report Form
2 biopsy images
1 cotton swab
For each lab group, obtain:
1 UV light source
1 bottle of “antibody”
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Visual Detection
• Study the two images carefully to identify what you believe are differences between “normal” and “abnormal cells.
• Use a pencil to mark suspected abnormal cells with an “Ab.”
• Be ready to state your hypothesis (Q-1).
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Visual Detection
Brainstorm a list of different hypotheses that might be used to visually detect differences between “normal” and
“abnormal” epithelial cells.
(Q-2)
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Radiation Detection(Safety Warning: UV light)
• Shine a UV light on your biopsy samples.
• Use a pencil to mark suspected abnormal cells with “UV.”
• Discuss differences between normal & abnormal cells (Q-3).
• Accept or reject hypotheses (Q-4).
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Chemical Detection
• Use the swab to add a very light coating of “antibody” to cell membranes of “UV” cells, and describe observations (Q-5).
• Coat all the cell membranes in both images.
• Count your team’s biopsies (not cells) that show abnormal cells (Q-6).
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Estimating Odds
• What is the class’s “operation definition” of an “abnormal” biopsy sample (Q-7)?
• What data have to be collected to estimate the odds that a biopsy sample will be cancerous? (Q-8)?
• Calculate the odds and show your work (Q-9).
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Summary (“a” or “b”)
“a”: Write one sentence (or group of sentences) that summarize the main idea(s) behind this simulated cancer detection lab.
“b”: Choose one vocabulary word (or main idea) from this lab and write a Cinquain (a 5-line poem) to summarize this lab.
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Rules of Writing a Cinquain
A word and it’s root or derivatives can be used only once! (e.g., life, living, alive)
Line 1 1 word Title
Line 2 2 words Nouns or adjectives that describe Line 1
Line 3 3 words “-ing” words that tell what Line 1 does
Line 4 4 words Your personal, emotional reaction to Line 1
Line 5 1 word Synonym for Line 1 (foreign words are OK)
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Cinquain Example
Cancer
Abnormal Growth
Hiding, Dividing, Metastasizing
Should’ve Worn Enough Sunblock!
Tumor
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Part 6:Why Not the Boys?
http://www.plannedparenthood.org/ppaustin/images/Texas%20Capital
%20Region/hpv_vaccine.jpg
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Part 6:Why Not the Boys?
Students will:
• Read a Board of Education press release about mandating Gardasil vaccine for all middle school students
• Complete 8-step decision-making model to formulate position statements for BOE
• Steps 1-3 as whole class
• Steps 4-6 in teams
• Steps 7-8 individually