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Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway James C. Lee, Marion Espéli, Carl A. Anderson, Michelle A. Linterman, Joanna M. Pocock, Naomi J. Williams, Rebecca Roberts, Sebastien Viatte, Bo Fu, Norbert Peshu, Tran Tinh Hien, Nguyen Hoan Phu, Emma Wesley, Cathryn Edwards, Tariq Ahmad, John C. Mansfield, Richard Gearry, Sarah Dunstan, Thomas N. Williams, Anne Barton, Carola G. Vinuesa Anne Phillips, Craig Mowat, Hazel Drummond, Nick Kennedy, Charlie W. Lees, Jack Satsangi, Kirstin Taylor, Natalie J. Prescott, Christopher G. Mathew, Peter Simpson, Alison Simmons, Mohammed Khan, William G. Newman, Christopher Hawkey, Ailsa Hart, David C. Wilson, Paul Henderson, Jeffrey C. Barrett, Miles Parkes, Paul A. Lyons, Kenneth G.C. Smith James C. Lee, Marion Espéli, Carl A. Anderson, Michelle A. Linterman, Joanna M. Pocock, Naomi J. Williams, Rebecca Roberts, Sebastien Viatte, Bo Fu, Norbert Peshu, Tran Tinh Hien, Nguyen Hoan Phu, Emma Wesley, Cathryn Edwards, Tariq Ahmad, John C. Mansfield, Richard Gearry, Sarah Dunstan, Thomas N. Williams, Anne Barton, Carola G. Vinuesa Anne Phillips, Craig Mowat, Hazel Drummond, Nick Kennedy, Charlie W. Lees, Jack Satsangi, Kirstin Taylor, Natalie J. Prescott, Christopher G. Mathew, Peter Simpson, Alison Simmons, Mohammed Khan, William G. Newman, Christopher Hawkey, Ailsa Hart, David C. Wilson, Paul Henderson, Jeffrey C. Barrett, Miles Parkes, Paul A. Lyons, Kenneth G.C. Smith Cell Volume 155, Issue 1, Pages 57-69 (September 2013) DOI: 10.1016/j.cell.2013.08.034 Copyright © 2013 The Authors Terms and Conditions

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Page 1: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway 

James C. Lee, Marion Espéli, Carl A. Anderson, Michelle A. Linterman, Joanna M. Pocock, Naomi J. Williams, Rebecca Roberts, Sebastien Viatte, Bo Fu, Norbert Peshu, Tran Tinh Hien, Nguyen Hoan Phu, Emma Wesley, Cathryn Edwards, Tariq Ahmad, John C. Mansfield, Richard Gearry, Sarah Dunstan, Thomas N. Williams, Anne Barton, Carola G. Vinuesa Anne Phillips, Craig Mowat, Hazel

Drummond, Nick Kennedy, Charlie W. Lees, Jack Satsangi, Kirstin Taylor, Natalie J. Prescott, Christopher G. Mathew, Peter Simpson, Alison Simmons, Mohammed Khan, William G. Newman, Christopher Hawkey, Ailsa Hart, David C. Wilson, Paul Henderson, Jeffrey C.

Barrett, Miles Parkes, Paul A. Lyons, Kenneth G.C. Smith James C. Lee, Marion Espéli, Carl A. Anderson, Michelle A. Linterman, Joanna M. Pocock, Naomi J. Williams, Rebecca Roberts, Sebastien Viatte, Bo Fu, Norbert Peshu, Tran Tinh Hien, Nguyen Hoan Phu,

Emma Wesley, Cathryn Edwards, Tariq Ahmad, John C. Mansfield, Richard Gearry, Sarah Dunstan, Thomas N. Williams, Anne Barton, Carola G. Vinuesa Anne Phillips, Craig Mowat, Hazel Drummond, Nick Kennedy, Charlie W. Lees, Jack Satsangi, Kirstin Taylor,

Natalie J. Prescott, Christopher G. Mathew, Peter Simpson, Alison Simmons, Mohammed Khan, William G. Newman, Christopher Hawkey, Ailsa Hart, David C. Wilson, Paul Henderson, Jeffrey C. Barrett, Miles Parkes, Paul A. Lyons, Kenneth G.C. Smith 

Cell Volume 155, Issue 1, Pages 57-69 (September 2013)

DOI: 10.1016/j.cell.2013.08.034

Copyright © 2013 The Authors Terms and Conditions

Page 2: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure 1

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 3: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure 2

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 4: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure 3

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 5: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure 4

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 6: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure 5

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 7: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S1

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 8: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S2

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 9: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S3

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 10: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S4

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 11: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S5

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 12: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S6

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 13: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Figure S7

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions

Page 14: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway…

Cell 2013 155, 57-69DOI: (10.1016/j.cell.2013.08.034) Copyright © 2013 The Authors Terms and Conditions