Hydrogen Sulfide as a Novel Cardiovascular Therapeutic

Muhammad Mobeen Zafar

12-arid-1337

Contents

• Introduction• History• H2S

– Metabolism– Functions

• Recent Advances• Future prospects• Refernences

Gasotransmitters

• Gaseous signaling molecules that possess a unique ability to freely diffuse through cell membranes and regulate cellular signaling

• NO, CO and H2S

• 1981 discovery• 2002

Conditions

• Small molecule of gas• Permeable to membranes• Endogenously and enzymatically

generated and its production is regulated• Well defined and specific functions at

relevant concentrations• Should have specific cellular and

molecular targets

History

• 1987 NO (vasodilator in mammals)• 1991 CO (cardiovascular mediator that

upregulates protective mechanisms)• 2002 H2S (cytoprotective)

• European Network on Gasotransmitters (ENOG) in 2011

H2S

• Discovered in 2002• Unstable molecule• Endogeneously produce

H2S Functions

• Neuroprotective• Cytoprotective• Treatment for atherosclerosis• Antioxident activity• Cardioprotective

ADVANCES IN THERAPEUTICS

Complications

• Suitable Compound• Optimum concentration• Delivery mechanism

H2S Donors

• NaHS (Tablet)• Na2S Salts (Tablet)

• Diallyl trisulfide • SG-1002 • GYY4137 ( Water Soluble)

Future prospects

• H2S could act as a biomarker enabling the severity of coronary artery disease progression

• Delivery mechanism• Molecular insights

References

• Discoveries of Hydrogen Sulfide as a Novel Cardiovascular Therapeutic. Larry A. Barr, PhD; John W. Calvert, PhD (Circ J 2014; 78: 2111 – 2118

• Regulation of cardiovascular cell function by hydrogen sulfide (h2s). David j elsey 1, robert c fowkes 2 and gary f baxter cell biochem funct 2012; 28: 95–106.