IACUC Protocol FormComparison of the eSirius vs. 3G protocol application form

March 2015

Comparison of eSirius vs. 3G protocol application form 2

IACUC Protocol Form

• The University of Kentucky IACUC is migrating to a new protocol application and animal management system in March 2015, eSirius3G.• The protocol application has been updated and

streamlined• The following slides compare the design and content

of the eSirius (old) and 3G (updated) protocol forms

Comparison of eSirius vs. 3G protocol application form 3

IACUC Protocol Application Form

eSirius: Protocol PI Contact Page 3G: Page Removed

PI information shown only on the Protocol Personnel page

Comparison of eSirius vs. 3G protocol application form 4

IACUC Protocol Application Form

eSirius: Title, Lay Summary, and Background are separate pages

Comparison of eSirius vs. 3G protocol application form 5

IACUC Protocol Application Form3G: Title, Lay Summary, and Objectives/Aims* are sections (tabs)

on the new Protocol Overview page

* Formerly Background

Comparison of eSirius vs. 3G protocol application form 6

IACUC Protocol Application Form

eSirius: Private/Commercial Funding Allowed space for only one funding source

3G: Private/Commercial/Foundation FundingAllows multiple funding sources

Comparison of eSirius vs. 3G protocol application form 7

IACUC Protocol Application FormeSirius: Literature Search 3G: Databases Searched

Moved to the end of the protocolSearch for Animal Alternatives group is removed

Located near the top of the protocol

Comparison of eSirius vs. 3G protocol application form 8

IACUC Protocol Application FormeSirius: Experimental Design

Located on protocol level: describes all species procedures

3G: Methodology*Moved to species level: describes single species procedures **

* Formerly Experimental Design** For protocols with multiple species, the entire Experimental Design is copied into each Species Methodology page at conversion. PI will resolve redundancy at 3-year rewrite.

Comparison of eSirius vs. 3G protocol application form 9

IACUC Protocol Application Form

eSirius: Species Information page 3G: Species Information pageTotal number of animals requested question removed.Gender question removed. Identification question reformatted. Animal disposition question displays only if Species Euthanasia = No.Species activities questions moved to the Setup page.

Comparison of eSirius vs. 3G protocol application form 10

IACUC Protocol Application Form

eSirius: Non-Surgical Procedures 3G: Page Removed

Non-Surgical Procedures are described in the Species Methodology.

Comparison of eSirius vs. 3G protocol application form 11

IACUC Protocol Application Form

eSirius: Drugs 3G: Page Removed

Neuromuscular blocker and non-USP grade drug questions moved to Species Methodology page. All drugs administered are described in the Species Methodology.

Comparison of eSirius vs. 3G protocol application form 12

IACUC Protocol Application Form

eSirius: Housing Location Request 3G: Housing/Use Locations

eSirius: Animal Usage Location

Pages are combined

Comparison of eSirius vs. 3G protocol application form 13

IACUC Protocol Application FormeSirius: Justification for Number Requested

and Humane Use Animal Categories pages are separate

Comparison of eSirius vs. 3G protocol application form 14

IACUC Protocol Application Form3G: Justification for Number Requested and Humane Use Animal Categories pages are combined

Humane Use Categories / Justification for Number Used

New question added: Scientific justification for unalleviated Pain (Level E).

Comparison of eSirius vs. 3G protocol application form 15

IACUC Protocol Application FormeSirius: Surgery

One continuous page3G: Surgery

Divided into sections (tabs): Info, Pre-op, Post-op, and Surgery Locations

Comparison of eSirius vs. 3G protocol application form 16

IACUC Protocol Application FormeSirius: Adverse Consequences

One continuous page3G: Adverse Consequences

Divided into sections (tabs)New Humane Endpoints question

Comparison of eSirius vs. 3G protocol application form 17

IACUC Protocol Application FormeSirius: Personnel

Ugly and slow3G: Personnel

Divided into sections (tabs): Personnel Info, Personnel Activities, and Training ProfileSignificantly pared down / streamlined

Comparison of eSirius vs. 3G protocol application form 18

And finally….

Comparison of eSirius vs. 3G protocol application form 19

IACUC Protocol Application FormeSirius: Protocol-wide pages/questions condensed and merged…

Comparison of eSirius vs. 3G protocol application form 20

IACUC Protocol Application Form3G: …to the Setup page (new)

Comparison of eSirius vs. 3G protocol application form 21

IACUC Protocol Form

See the 3G ‘how-to’ videos on the ORI website: http://www.research.uky.edu/ori/univet/training/video.html