identify biomarkers for susceptibility to both type 1 diabetes and mental disorders
TRANSCRIPT
Agata Jurczyk, Ph.D.
• The way beta cells store and release insulin in response to stimuli mimics the way neurons store and release neurotransmitters
Brain
neurotransmitter release
Neuron
Pancreas
Islet ofLangerhan
Beta cell
Insulin release
≈
• Similar genes and proteins expression
DISC1
GAD1
GAD2
IA2
Associate with risk to type 1 diabetes and mental disorders
depressiontype 1 diabetes
bipolar disordersschizophrenia
Blood
GeneSignature Type 1 diabetes + mental illness
Type 1 diabetes
vs
Experimental Approach
Biorepository of blood samplesHealthy ControlsType 1 diabetes
Type 1 diabetes with schizophreniaType 1 diabetes with bipolar disorder
Type 1 diabetes with depression
Blood RNA DNA
Healthy
Gene Signature
Type 1 diabetics
Type 1 diabeticswith mental illness
Identify Novel Molecules and/or Pathways to Improve Therapies to Alleviate Suffering
Caused by Both illnesses
Outcome
Type 1 diabetes and mental disorders alone are very devastating diseases, now imagine what patients have to go through when faced with both?
Your support will fund a project that is trying to help these people to take preventive measures or to find better treatment