imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)
TRANSCRIPT
![Page 1: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/1.jpg)
Imaging in Neuro-Ophthalmology & Revisiting Orbital Imaging
Dr Himadri Sikhor Das Matrix http//:www.radiozen.wordpress.com
![Page 2: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/2.jpg)
Optic nerve from posterior globe to the Optic Chiasm . After the characteristic crossing, fibers of optic nerve travel as Optic Tracts to the Lateral Geniculate Body.
The optic nerve has 2 sets of fibres:
1. Visual going to lateral geniculate body.2. afferent fibres of the pupillary reflex going to tectum of midbrain
Motor system( Extraocular nerves)
THE VISUAL PATHWAY
![Page 3: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/3.jpg)
Outer layer:
constitutes sclera & transparent cornea anteriorly fibrous protective layer
Middle layer (uveal tract)
choroid, ciliary body and iris
vascular and nutritive functions contains blood vessels, numerous nerves, connective tissue, and pigmented melanocytes.
vascular supply of the uveal tract is important to the Neuroradiologists, because of the "blood-ocular barrier", analogous to the BBB, present at several points.
Inner layer (retina):
consists of a thin, outer retinal pigment epithelium layer and an innermost sensory retina contains neural elements for visual perception
Normal Orbital Anatomy (Globe)
THE GLOBE :
![Page 4: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/4.jpg)
Normal Orbital Anatomy (EOM)
6 skeletal EOM insert on the sclera and control motion of the globe
4 rectus muscles (superior, inferior, lateral, & medial) arise from a common tendinous ring, the annulus of Zinn, and form a muscle cone that inserts onto the front of the sclera
![Page 5: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/5.jpg)
Ophthalmic artery
Chief artery of the orbit
Arises medial to the anterior clinoid process from the supraclinoid internal carotid artery
Superior and inferior ophthalmic veins drain the orbital structures
Normal Orbital Anatomy (Vessels)
![Page 6: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/6.jpg)
Normal Orbital Anatomy (Nerves)
● oculomotor (3rd cranial nerve) is the major motor supply for movements, supplying extraocular muscles except the superior oblique and lateral rectus muscles.
● trochlear (4th cranial nerve), supplies only the superior oblique
● abducens (6th cranial nerve) supplies only the lateral rectus muscle.
![Page 7: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/7.jpg)
optic nerve (2nd cranial nerve)
interconnects retina to brain and extends approximately 3.5 to 5 cm between posterior globe and optic chiasm
approximately 90% of its fibers are afferent
ophthalmic nerve (first division of the 5th cranial nerve)
sensory nerve that receives input from the globe and its conjunctivae, the lacrimal gland, the nose and nasal mucosa, the upper lid, frontal sinus, scalp, and forehead
Normal Orbital Anatomy (Nerve)
![Page 8: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/8.jpg)
Disturbances of the visual pathway
![Page 9: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/9.jpg)
Imaging modalities
●Plain Radiographs
●USG
●CT:● :Axial● :Coronal,● :Reformats● :3D-VRT●MRI:● : DWI ● : MRS● : MRV
●Carotid angiography (CT,MRI,DSA)
●Orbital Phlebography
![Page 10: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/10.jpg)
THE VISUAL PATHWAY
Optic Nerve
Optic ChiasmOptic Tracts
Optic Radiation
![Page 11: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/11.jpg)
THE VISUAL PATHWAY
Lateral Geniculate Body
![Page 12: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/12.jpg)
THE VISUAL PATHWAY
Primary Visual (Calcarine) Cortex
![Page 13: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/13.jpg)
Optic Nerve is divided to 4 parts:
A-Intraocular
B-Intra-orbital
C-Intra canalicular
D-Intracranial
THE VISUAL PATHWAY
![Page 14: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/14.jpg)
Division of Optic Nerves
● All the retinal nerve fibers merge to the optic nerve here
● Central retinal vessels enter and leave the eye here
● Absence of photoreceptors at this site creates a gap in the visual field known as the blind spot.
● Visible on ophthalmoscopy as the optic disc
1. The Intraocular portion:
![Page 15: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/15.jpg)
It is particularly important to document the size of the optic cup. This is specified as the horizontal and vertical ratios of cup to disc diameter (cup – disc ratio).
Optic cup:
Cavitation of the optic nerve & brightest part of the optic disc, no nerve fibers exit from it and there is acorrelation between the size of it and the size of the optic disc.
The intraorbital portion begins after the nerve passes through a sieve-like plate of scleral connective tissue, the lamina cribrosa
Intraorbital portion:
![Page 16: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/16.jpg)
After the optic nerve passes through the optic canal, the short intracranialportion begins and extends as far as the optic chiasm.
Like the brain, the intraorbital and intracranial portions of the optic nerve are surrounded by sheaths of dura mater, pia mater, and arachnoid. The nerve receives its blood supply through the vascular pia mater sheath.
4. Intracranial Portion of the Optic Nerve:
![Page 17: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/17.jpg)
3rd nerve (Oculomotor)
4th nerve (Trigeminal)
6th nerve (Abducens)
Extraocular Cranial Nerves
![Page 18: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/18.jpg)
Nuclear part
Cisternal part
Cavernous portion
Superior orbital fissure (SOF)
Possible sites of involvement
![Page 19: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/19.jpg)
Common lesions:
InfarctionHaemorrhageDemyelinationTumours Infection
![Page 20: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/20.jpg)
Nucleus :Nuclear involvement
Nuclear Lesions
●Infarction
●Haemorrhage
●Tumours
●Demyelination
![Page 21: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/21.jpg)
Nuclear involvement: Demyelination
![Page 22: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/22.jpg)
Demyelination 3rd nerve nucleus
![Page 23: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/23.jpg)
Aneurysm
Trauma
Vasculitis
Adjacent masses
Meningeal Infections
Lesions of Cisternal Part
![Page 24: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/24.jpg)
(PCoA) aneurysm in pt with left pupil-involving third nerve palsy
MIP image from Circle of Willis MR angiography
CT Angio with 3D-VRT images of same patient optimally demonstrates aneurysm sac (dot) & aneurysm neck (arrow)
![Page 25: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/25.jpg)
Acute right occipital lobe infarction ( patient with complete left homonymous hemianopsia) .
DWI- right occipital lobe restricted diffusion ADC map : decreased signal (arrow) confirming acute ischemic stroke.
![Page 26: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/26.jpg)
T2 FLAIR image - hyper intense signal in both occipital lobes (arrow).
Hypertensive patient (PRES)
Corresponding DWI : iso & hypointense signal (arrow) consistent with vasogenic edema.
![Page 27: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/27.jpg)
SOF
![Page 28: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/28.jpg)
Cavernous part
Cavernous Sinus Cavernous parts ( 3rd, 4th & 6th nerve )
![Page 29: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/29.jpg)
Cavernous Sinus thrombosis
![Page 30: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/30.jpg)
Parasellar Aneurysm compressing 3rd,4th & 6th Nerve
MRA
MIP
![Page 31: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/31.jpg)
Lesions common to Cavernous Sinus & Superior orbital fissure
● Idiopathic Orbital Pseudotumour (Tolosa Hunt Syndrome)
● Lymphoma (Lymphoma Pseudotumor complex)
● Extension from adjacent SOL’s
● Primary nerve sheath tumor
● CCF
![Page 32: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/32.jpg)
Hypertrophic Pachymeningitis
![Page 33: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/33.jpg)
Hypertrophic Pachymeningitis
![Page 34: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/34.jpg)
![Page 35: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/35.jpg)
Nasopharyngeal carcinoma
![Page 36: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/36.jpg)
Diseases of Optic Disc
- Optic Nerve Drusen- Papilledema
- Papillitis
![Page 37: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/37.jpg)
Papilloedema vs optic disc swelling
Papilloedema ●Pseudo papilloedema
●Drusen of the optic disc●Raised intra orbital pressure.●Optic nerve tumors
![Page 38: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/38.jpg)
Pathophysiology
The disc swelling in papilledema is the result of axoplasmic flow stasis with intra-axonal edema in the area of the optic disc. The subarachnoid space of the brain is continuous with the optic nerve sheath.
Hence, as the cerebrospinal fluid (CSF) pressure increases, the pressure is transmitted to the optic nerve, and the optic nerve sheath acts as a tourniquet to impede axoplasmic transport. This leads to a buildup of material at the level of the lamina cribrosa, resulting in the characteristic swelling of the nerve head. Papilledema may be absent in cases of prior optic atrophy. In these cases, the absence of papilledema is most likely secondary to a decrease in the number of physiologically active nerve fibers.
![Page 39: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/39.jpg)
normal optic nerve head :distinct margins, central pinkish disk.
Papilloedema :showing blurred disc margins and dilated tortuous vessels
![Page 40: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/40.jpg)
Causes:
Any tumors or space-occupying lesions of the CNS( hematoma abscess,…..)
Decreased CSF resorption (e.g., venous sinus thrombosis, meningitis, subarachnoid hemorrhage)
Craniosynostosis (rare) Idiopathic intracranial hypertension(aka pseudo tumor cerebri)
Cerebral edema/encephalitis Medications, for example, tetracycline, minocycline, lithium, nalidixic acid, and corticosteroids (both use and withdrawal)
Obstruction of the ventricular system Increased CSF production (tumors)
Intracranial tumors occupies 60% of the causes
![Page 41: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/41.jpg)
- Optic Neuritis- Optic Nerve Sheath Tumor
Optic Neuritis
Causes
- MS - Viral Infection - SLE - ADEM - Neurosarcoidosis - Radiation
Retrobulbar Optic Nerve Lesions
![Page 42: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/42.jpg)
Optic Neuritis
MS
![Page 43: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/43.jpg)
Optic Neuritis
MS
![Page 44: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/44.jpg)
Optic Neuritis
MS
![Page 45: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/45.jpg)
Value of fat suppression & fluid attenuation inversion recovery (FLAIR)
![Page 46: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/46.jpg)
Post traumatic optic neuritis
![Page 47: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/47.jpg)
- Meningioma
- Glioma
Optic Nerve / Sheath Tumour
![Page 48: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/48.jpg)
Meningioma
![Page 49: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/49.jpg)
Glioma
![Page 50: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/50.jpg)
Glioma
![Page 51: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/51.jpg)
Sellar / Supra & Parasellar sellar Anatomy
![Page 52: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/52.jpg)
● Craniopharyngioma
● Pituitary adenoma
● Meningioma
● Aneurysm
● Hydrocephalus
Sellar / Suprasellar Masses
![Page 53: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/53.jpg)
Hydrocephalus
Cisternal herniation
![Page 54: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/54.jpg)
Craniopharyngioma
![Page 55: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/55.jpg)
Pitutiary Macro-adenoma
![Page 56: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/56.jpg)
Pitutiary Macro-adenoma
![Page 57: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/57.jpg)
Pituitary apoplexy
![Page 58: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/58.jpg)
Haemorrhagic Pitutiary Macro-adenoma
![Page 59: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/59.jpg)
Visual Cortex, Optic radiation &Lateral Geniculate Body
- Infarction- Haemorrhage- Demyelination- Tumours - Infection
![Page 60: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/60.jpg)
Acute ICH
Axial gradient recall echo image showing marked hypointensity around the acute ICH
![Page 61: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/61.jpg)
Anterior compartment: consists of eye lids, lacrimal apparatus and anterior soft tissues
Posterior compartment (Retrobulbar space): divided into intraconal and extraconal spaces
The cone: consists of extraocular muscles and an envelope of fascia
optic nerve is located within the intraconal space
Normal Orbital Anatomy (Compartments)
![Page 62: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/62.jpg)
![Page 63: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/63.jpg)
Thyroid eye disease
![Page 64: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/64.jpg)
Idiopathic orbital inflammation ( Pseudo tumor )
![Page 65: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/65.jpg)
Classification of tumours of orbit
Intraocular
In paediatric age group
Retinoblastoma
D/D : PHPV Coat disease
In Adults
Malignant melanoma
Choroidal haemangioma
Metastasis
![Page 66: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/66.jpg)
Orbital tumours
In paediatric age group
●Haemangioma●Rhabdomyosarcoma●Metastasis from Neuroblastoma
In Adults
●Haemangioma●Lacrimal gland tumour●Optic nerve glioma●Meningioma●Lymphoma●Orbital Metastasis from lung, breast, prostate
![Page 67: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/67.jpg)
Retinoblastoma
● Most common tumour (commonly 1-3 yrs of age)
● Leukokoria in 60% (white pupil)
● Causes leukocoria in other causes include PHPV, congenital cataract, trauma, retrolental fibroplasia etc)
● Approx 30% bilateral
● ( 90% )associated with inherited forms)
![Page 68: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/68.jpg)
●commonly : posterolateral globe wall ●solid, retrolental hyperdense mass (endophytic type)●most common cause of orbital calcifications (90%; fav prog sign)●retinal detachment invariably present●usually enhances with contrast (poor prog sign)●extraocular extension in 25%: optic nerve enlargement, intracranial extension, abnormal soft tissue in orbit
Retinoblastoma
![Page 69: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/69.jpg)
Retinoblastoma
![Page 70: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/70.jpg)
D/D of pineal region masses includes germinoma,teratoma, and pineocytoma/blastoma
Trilateral Retinoblastoma
30% multifocal in one eye; also may occur “trilaterally”
![Page 71: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/71.jpg)
PHPV
●Results due to failure of regression of embryonic hyaloid vascular system.●Persistence of primary vitreous●usually unilateral.
Imaging: Triangular retrolental band of soft tissue extending along Cloquet’s canal from posterior surface of lens to posterior pole of the globe.
Layering of fluid in sub-retinal space
NO CALCIFICATION
clinical: blindness, leukocoria, microphthalmia (small hypoplastic globe)
![Page 72: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/72.jpg)
Coats’ disease
●Primary retina vasular telangiectasis with accumulation of lipoproteinaceous exudates in retina and subretinal space●Almost always unilateral●Boys older than those who have retinoblastoma●In advanced cases total R.D. may be seen●Absence of calcification.
![Page 73: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/73.jpg)
●cellular accretions of hyaline-like material in the optic disk , often familial
●bilateral in 75% , frequently calcify●many are asymptomatic, arcuate visual field defects may be present●CT scan shows discrete rounded high densities confined to the optic
disk surface
Optic Nerve Drusen
![Page 74: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/74.jpg)
●deficient closure of embryonic choroidal fissure ●ocular contents herniate posteriorly to retrobulbar space at site of ON attachment●may be associated with encephalocele and/or agenesis of the corpus callosum●bilateral in 60%
Coloboma
![Page 75: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/75.jpg)
● MC - adult ocular malignancy● 6Th-7th decades of life● almost always uniocular and single● aggressive malignant tumor of uveal tract; most arise from preexisting choroidal nevi ● invades along choroid, into vitreous & through sclera into ON and RB Space
Imaging : CDFI - Mass very vascular : CT – high density; do not calcify; enhances : MRI – compared to the vitreous, high signal on T1 and low on T2WI (secondary to paramagnetic properties of melanin)
●thickening/irregularity of choroid/urea or exophytic/biconcave mass●sub retinal effusion and retinal detachment very common
●Primary D/D: choroidal metastasis (esp. breast and lung Ca) : moderate signal on T1 and high signal on T2
Melanoma:
![Page 76: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/76.jpg)
Melanoma:
![Page 77: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/77.jpg)
Intraocular Metastasis
●Sub retinal masses located in posterior part of fundus.●flattened or placoid masses and may be multiple.●Common primary tumors : Lungs, breast, prostate etc.
![Page 78: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/78.jpg)
Intraocular Metastasis
![Page 79: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/79.jpg)
Orbital Tumours:
Capillary Haemangioma:●MC vascular tumor of orbit in children●10% of all pediatric orbital tumors●first year of life , spontaneously involutes >1 year●no fibrous capsule (unlike cavernous haemangioma)●can infiltrate both intraconal/extraconal spaces●90% associated with cutaneous angiomas
Cavernous Haemangioma: ●Commonest intraorbital tumour in adults●Commonly intraconal may be extraconal .●Well encapsulated round, oval or lobulated●Histologically – large dilated vascular channels (sinusoid like spaces) lined by endothelial cells. ●These contain relatively stagnant blood.
Haemangioma
![Page 80: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/80.jpg)
Haemangioma
● vascular nature not apparent on MR because they are not high flow lesions ● most found in intraconal space, lateral to optic nerve
![Page 81: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/81.jpg)
Osseous Haemangioma
![Page 82: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/82.jpg)
Cavernous Hemangioma
A.chemical-shift artefact on T2 sequence (indicating the presence
of fat)
B-D. characteristic pattern of progressive enhancement from periphery to center with gad
![Page 83: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/83.jpg)
Lymphangioma
●Most lymphangiomas present during childhood.●Benign tumours containing lymphatic channels ( lymph fluid alone / lymph / blood products) separated by septae.
Imaging: Undulating or irregular margins consisting of septae which separate it into lobules and cysts of varying size and echo/density/intensity.The ability to characterise the various stages of evaluation of the haemorrhage makes MR on ideal diagnostic modality for studying these lesions.
![Page 84: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/84.jpg)
Lacrimal gland tumours
● Benign mixed tumours (Pleomorphic adenoma)-MC benign tumour ● Most often involves the orbital part of the lacrimal gland.● Well defined mass with posterior rounded configuration.● Fossa formation in superolateral part of bony orbit.● Presence of calcification, necrosis and bone destruction, all suggestive of malignancy.
![Page 85: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/85.jpg)
Lacrimal gland tumours
![Page 86: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/86.jpg)
Orbital Dermoids and Epidermoids
MC benign paediatric orbital tumour
congenital developmental tumours arising from embryonic epidermis that gets trapped in developing sutures of the orbital bones.
Most frequently located in superolateral quadrant.
Dermoid tumours contain hair and sebaceous glands containing keratinaceous debris and fatty substances. Bone changes by expansion and pressure erosion leading to thinning and scalloping of adjacent bone.
Imaging oval, lobulated, dumb bell, shaped with cystic or solid components. Orbital bone changes may be seen.
A specific diagnosis can be made if fat fluid level is demonstrated
![Page 87: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/87.jpg)
Orbital Dermoids and Epidermoids
![Page 88: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/88.jpg)
OPTIC NERVE GLIOMA
●Common childhood tumour with a female preponderance.●High association with neurofibromatosis (over 50%).
Plain radiography
●Enlargement of optic foramen may be seen. ●Tubular, fusiform or saccular enlargement of the optic nerve. ●Tortuous course of the nerve goes in favour of optic nerve glioma. ●Contrast enhancement less intense.●Calcification rarely.●MRI better evaluates intra canalicular and intracranial parts.
![Page 89: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/89.jpg)
Optic Nerve Glioma
![Page 90: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/90.jpg)
Optic Nerve Glioma
![Page 91: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/91.jpg)
Bilateral Optic Nerve Gliomas
![Page 92: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/92.jpg)
Neurofibromatosis
![Page 93: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/93.jpg)
Neurofibromatosis with Meningiomas
![Page 94: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/94.jpg)
MENINGIOMA OF THE ORBIT
More common in womenoccurs most frequently in middle age
Meningiomas of the orbit are of 3 types :I Sphenoid wing meningioma with extension to the orbitII Optic nerve sheath meningioma III Meningioma arising de novo from arachnoid cells in the orbit.
![Page 95: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/95.jpg)
Type I : Sphenoid Wing Meningioma
● Results in hyperostosis and expansion of the bone●● The osseous tumour as well as soft tissue component
may extend into the orbit, anterior or middle cranial fossa or extracranially to temporal fossa.
Sphenoid Wing Meningioma
![Page 96: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/96.jpg)
Sphenoid Wing Meningioma
![Page 97: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/97.jpg)
Sphenoid Wing Meningioma
![Page 98: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/98.jpg)
OPTIC NERVE SHEATH MENINGIOMA
Type II : Optic Nerve Sheath Meningioma
● Arises from archnoid cells of the dural sheath covering the optic nerve.
● Diffuse enlargement of the optic nerve sheath complex results in a tubular, fusiform or saccular appearance
● Rather straight course.Sheath shows marked enhancement following IV contrast.
● Calcification is a common feature and may appear diffuse, coarse, punctate, or tubular shaped along the O.N. sheath.
![Page 99: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/99.jpg)
Optic Nerve Sheath Meningioma
![Page 100: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/100.jpg)
MENINGIOMA ARISING DE NOVO
Type III :
● Meningioma arising from rests of archnoid cells inside the orbit.
● Very rare, variety.● No characteristic features. ● Seen as an orbital mass located in any part of
the orbit.
![Page 101: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/101.jpg)
RHABDOMYOSARCOMA
Most common primary orbital malignancy of childhood.
●Mean age of onset 6 yrs.
●Rapidly progressive proptosis
●Tumour arises from extraocular muscles
●Superonasal quadrant most common
●Mass may be associated with bone destruction.
![Page 102: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/102.jpg)
Rhabdomyosarcoma
![Page 103: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/103.jpg)
LYMPHOMA
More often seen in anterior part of orbit or retrobulbar area
Generally lesions mould themselves to pre-existing structures such as globe, optic nerve and bony orbit without eroding the bone
![Page 104: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/104.jpg)
Lymphoma
![Page 105: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/105.jpg)
Leukemia
Squa. Cell Ca. Lower Eyelid
![Page 106: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/106.jpg)
ORBITAL METASTASES
Relatively rare
In children
●Neuroblastoma●Ewing’s sarcoma●Leukemia
In adults
●Breast●Lung ●Prostate etc.
![Page 107: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/107.jpg)
ORBITAL METASTASES IMAGING
Infiltrative, poorly defined or well defined masses.
![Page 108: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/108.jpg)
Neuroblastoma Metastases
![Page 109: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/109.jpg)
Mets. from Ca Lung
![Page 110: Imaging in neuro ophthalmology & revisting orbital imaging.2012 (1) (1)](https://reader033.vdocument.in/reader033/viewer/2022042700/556390c6d8b42acc128b51b8/html5/thumbnails/110.jpg)
CONCLUSIONS
Ocular Tumours●US has an edge over CT●CT has a definite complimentary role.Orbital Tumours●CT has an edge over US●CT & MR comparable in general●CT being cheaper and easily available has wider acceptance.