imaging of extracellular nanovesicle …imaging of extracellular nanovesicle exosome in mental...
TRANSCRIPT
![Page 1: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/1.jpg)
IMAGING OF EXTRACELLULAR NANOVESICLE
EXOSOME IN MENTAL HEALTH
ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY AND MOLECULAR MEDICINE UNIVERSITY OF OULU, FINLAND
1
![Page 2: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/2.jpg)
2
![Page 3: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/3.jpg)
3
![Page 4: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/4.jpg)
DEPRESSION
BIPOLAR MOOD DISORDER
SCHIZOPHRENIA
![Page 5: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/5.jpg)
DIAGNOSTIC ROLE
THERAPEUTIC ROLE
PROGNOSTIC ROLE
![Page 6: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/6.jpg)
DIAGNOSTIC ROLEPSYCHIATRIC DISORDERS INCREASED miRs DECREASED miRs
SCHIZOPHRENIAmiR-497, miR-34a, miR-449a, miR-548d,
miR-564, miR-572, miR-652, let-7g, miR-181b, miR-219-2-3p, miR-1308
miR-195, miR-432, miR-31, miR-99b, miR-107, miR-134, miR-431, miR-433,
miR-487b
BIPOLAR MOOD DISORDER miR-29c -
DEPRESSION miR-132, miR-182, miR-107, miR-133a,
miR-148a, miR-425-3p, miR-494, miR-579, miR-589, miR-652, miR-941,
miR-200c, miR-381, miR-517b, miR-636,
miR-1243
![Page 7: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/7.jpg)
DIAGNOSTIC ROLEPSYCHIATRIC DISORDERS INCREASED miRs DECREASED miRs
SCHIZOPHRENIAmiR-497, miR-34a, miR-449a, miR-548d,
miR-564, miR-572, miR-652, let-7g, miR-181b, miR-219-2-3p, miR-1308
miR-195, miR-432, miR-31, miR-99b, miR-107, miR-134, miR-431, miR-433,
miR-487b
BIPOLAR MOOD DISORDER miR-29c -
DEPRESSION miR-132, miR-182, miR-107, miR-133a,
miR-148a, miR-425-3p, miR-494, miR-579, miR-589, miR-652, miR-941,
miR-200c, miR-381, miR-517b, miR-636,
miR-1243
![Page 8: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/8.jpg)
DIAGNOSTIC ROLEPSYCHIATRIC DISORDERS INCREASED miRs DECREASED miRs
SCHIZOPHRENIAmiR-497, miR-34a, miR-449a, miR-548d,
miR-564, miR-572, miR-652, let-7g, miR-181b, miR-219-2-3p, miR-1308
miR-195, miR-432, miR-31, miR-99b, miR-107, miR-134, miR-431, miR-433,
miR-487b
BIPOLAR MOOD DISORDER miR-29c -
DEPRESSION miR-132, miR-182, miR-107, miR-133a,
miR-148a, miR-425-3p, miR-494, miR-579, miR-589, miR-652, miR-941,
miR-200c, miR-381, miR-517b, miR-636,
miR-1243
![Page 9: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/9.jpg)
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
![Page 10: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/10.jpg)
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
![Page 11: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/11.jpg)
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
![Page 12: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/12.jpg)
PROGNOSTIC ROLE
SCHIZOPHRENIA Decreased miR-365 and miR-520c-3p after a 1-year treatment with risperidone
DEPRESSION 30 miRNAs differentially expressed after a 12-weeks treatment with escitalopram
DEPRESSION Increased miR-20b-3p, miR-133a, miR-145, miR-409-3p, miR-410,
miR-433, miR-485-3p decreased miR-331-5p after an 8-weeks treatment with different classes of drugs
BIPOLAR MOOD DISORDER Increased miR-134 from baseline after a 4-weeks treatment
![Page 13: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/13.jpg)
NFBC 1986
471
50% MATERNAL SMOKING
![Page 14: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/14.jpg)
ANALYSIS OF EXOSOME CONTENTS
& MATCHING WITH NEUROPSYCHIATRIC
DISORDERS AND ADDICTION
IMAGING OF EXOSOMES WITH HYPER-SPRECTAL
CAMERAS
IMAGING OF EXOSOMES BY MRI AND PET
![Page 15: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/15.jpg)
PURIFICATION OF EXOSOMES
ELECTRON
MICROSCOPY
12 SAMPLES
PROTEIN ANALYSIS
12 SAMPLES
12 PILOT SAMPLES 6 SMOKING MOTHERS,
6 NON SMOKING MOTHERS
![Page 16: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/16.jpg)
![Page 17: IMAGING OF EXTRACELLULAR NANOVESICLE …IMAGING OF EXTRACELLULAR NANOVESICLE EXOSOME IN MENTAL HEALTH ATIQUL HAQ MAZUMDER, MD DOCTORAL STUDENT SEPPO VAINIO GROUP FACULTY OF BIOCHEMISTRY](https://reader034.vdocument.in/reader034/viewer/2022050223/5f681755db83ce0a2078e487/html5/thumbnails/17.jpg)
THANK YOU