immune system
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Immune system
Histophysiology
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Innate Immunity
The innate immunity system is what we are born with
It is nonspecific
All antigens are attacked equally.
It is genetically based
We pass it on to our offspring.
Surface Barriers or Mucosal Immunity1.The first the most important barrier is the skin and mucosa. 2. Secretion on surface of skin and mucosa3. Epithelial barrier4. Macrophages, mast cells5. Blood cells: platelets, Nph, Eo, NK
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Cells mediating immunity
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Antigen presenting cells
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Antigen processing and presentation
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Diversity of dendritic cells
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Organs of immune system
Central organs:
-Red bone marrow
- Thymus
Peripheral
-Spleen
- Lymph nodes
- MALT
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Red bone marrow
Myeloid tissue-Hematopoietic cells-Microenvironment
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Key morphological features
1. Sinusoidal capillaries
2. Megakaryocytes
3. Adipocytes
4. Many immature and
maturing cells
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Cells maturation and kinetics in RBM
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Thymus
1. Type of structure is parenchymal lobulated
2. Parenchyme is lymphoid tissue.
3. Each lobule consists of cortex and medulla.
4. In medulla there are Hassal`s bodies
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Selection of lymphocytes in thymus
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Types of T-lymphocytes
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Regulatory T cells: friend or foe in immunity to infection?
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Spleen
1. Type of structure is parenchymal
2. Stroma is composed by capsule and trabecules (DCT +SM + ElF)
3. Parenchyme includes red and white pulp.
3. White pulp is lymphoid tissue, forms LSh and LF.
4. Red pulp includes sinusoids and cords.
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Spleen
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Spleen
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Lymph nodes
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Lymph node
1. Type of structure is parenchymal
2. Stroma is composed by capsule and trabecules (DCT)
3. Parenchyme includes cortex and medulla.
4. Cortex includes LFs and paracortical zone.
5. Medulla includes sinuses and medullary cords.
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Lymph node
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Funny humoral immunity