immunityimmunity ch 37 vaccination vaccination –pathogen- disease causing organism w/ antigens....
TRANSCRIPT
Immunity Ch 37vaccination
– Pathogen- disease causing organism w/ antigens. Ex: virus, bacteria, protozoan, fungi (any foreign protein).
– 1st line of defense: (Non-specific)
• skin, mucus, tears, cilia, ear wax.– 2nd line of defense– Temperature, WBC types, Inflammation– Phagocytes, dead cells, pathogens = PUS
Our Immune System
Tears dehydrate bacteria
– Salty Tears are Hypertonic to the Bacteria and cause water to flow out of them.
Mucus protects
Sweat protects
Ear wax
Nonspecific Immune response
• Macrophages engulf foreign invaders
• Mast cells release histamines--Inflammation
3rd Line of Defensespecific
– Lymphocytes = Macrophages & phagocytes engulf foreign proteins (pathogens)
– Antigens vs Antibodies interactions– (foreign protein :’Y’ shaped protein produced
by “B” cells.)– Immune Response: ‘T’ cells command and
attack protein invaders.
Specific response involves the ‘T’ and ‘Plasma B’ cells with
their antibodies
The complement System alerts Macrophages
Macrophages
• The “Big Eaters” patrol the body devouring old dead cells and pathogens.
Antigen presentation
T cell/ B cell interactions
T-cells- cell mediated response
How T-cells work
Suppressor T Cells function
B Cell Clonal Selection
Antibody types
Immune response
Lymph Nodes in the Head & Neck Regions
Lymph Nodes Around the Body Store many WBC’s
Tonsils
• The Thymus Gland is where some ‘B’ cells develop into mature ‘T’ cells and “learn” to recognize foreign antigens. (This is where they go to school)
Inflammation
• Viral infection
vaccination• Measles-according to Dr. OZ-2/12/2015• The measles virus can stay air born between
60-90 minutes 100-200nm• 10-9
• It is one of the most infectious viruses.• It is the worst for young children and older
adults and people with compromised immune systems.
• 1person will infect 18 people• 1 measles vaccination-93% effective (they give
you two)
Immune responses 1st & 2nd
Retroviruses
• Viruses that contain RNA which is both replicated and transcribed. Uses reverse transcriptase that makes cDNA from RNA , contains no introns.
• Vaccine : A dead or weakened form of a pathogen (antigen) injected into the body that stimulates a primary immune response.
• Retrovirus (RNA virus) mutates quickly-(ex: Influenza, common cold-Rhinovirus)
• Fever is your friend-caused by the release of interleukin I-inhibits pathogens; stimulates Macrophages (Pyrokins-fever inducers)
Immune Overreaction
• Mast cells (another type of WBC) release Histamines which cause swelling and more mucus production. More antibodies that are needed bind to mast cells and cause and allergic reaction.
• How do Antihistamines work?
• Arthritis
Tissue healing
• Mag therapy
• Mag bum-leg
Auto immune diseases• Your body creates antibodies against “self”
proteins. Ex: Multiple Sclerosis –antibodies destroy myelin on nerves.
Rheumatoid Arthritis
• Allergies
• Anaphylactic shock
Blood types & factors
Blood types
RH Factor
• What is the Rh Factor?• Red blood cells carry
proteins on their surfaces. The Rhesus factor, or Rh, is a protein carried by some individuals. If a person's red blood cells carry Rh, they are considered to be "Rh Positive." If not, they are "Rh Negative."
• A person with A+ blood contains _____ antibodies and _____ Rh antigens.
• A person with O- blood contains _____ antibodies and _____ Rh antigens.
• Why is _____ blood the universal donor?
Erythroblastosis fetalis (RH disease)
Attack invaders
Antibodies
Tapeworm
• heartworm
DNA Virus shapes
RNA Virus
Human infectious fungi
Sporotrichosis
Oral Thrush (Fungal infection)
Prions
Bacteria
• Prokaryotic-no nucleus• Use external enzymes then absorb
materials• Can form an endospore –’indestructible
stage’• Benefit: good decomposers, nitrogen
fixers, used in foods (yogurt flavor cheeses…)
• Harmful- can cause rotting and disease
Bacterial structuresPlasmid
Bacteria can do this to a mouth.
Bacteria
Shapes of Bacteria
• Cocci = round
• Bacilli = rod shaped
• Spirillia = spiral shaped
Strep throat
More strep throat
Viruses - non-living -not a cellMost enter the body through the nose
or the mouth
strands of DNA or RNA encased in protein coats• Possess only one form of nucleic acid, either DNA or RNA
depending on the virus type• Cannot grow or replicate without a host• Replicate only utilizing host cell`s machinery• Specific to host cell for site of attachment
Chicken Pox Virus
HPV Virus
Tree man Viral Warts
Defense against Bacteria/Viruses
• T-cells (WBC’s)• Phagocytes • Antibodies• Temperature-slows bacterial growth rate
• Bacteria only- Antibiotics-stops the growth of cell walls so that they can’t multiply, however they “develop” resistance to the antibiotic over time.
• A) Viruses B) Bacteria C) Both D) Neither• 1-Which can be pathogens?• 2-Which contain either DNA or RNA ?• 3-Which take over the host while reproducing?• 4-Which can not be viewed w/ a light microscope?• 5-Which have a cell wall & a cell membrane?• 6-Which can carry on metabolism?• 7-Can cause disease?• 8-Are unicellular w/ a nucleus?• 9-Some species are parasitic; others species are not?
Cancer + other Tumors Uncontrolled growth of your own
cellsBenign-
Spreads very little
Forms a tissue mass
Usually not fatal
• Malignant-• Spreads rapidly• Causes tissue
damage• Usually fatal
Activity Passive immunity packet pg 27
Elephantiasis
Use the chart below (Note oxacillin is an antibiotic.) Dashes indicate that no data was available or that the data was incomplete. The “No. isolates” column indicates the total number bacteria colonies counted that year.
Hookworm
Ch 37 & 18 Immunity /pathogen test