IMMUNIZATION OF INFECTION IMMUNIZATION OF INFECTION DISIASESDISIASES

ACTUALITY OF LECTUREACTUALITY OF LECTURE Immunization one of most cost-Immunization one of most cost-

effective means of preventing effective means of preventing infectious diseaseinfectious disease

The epidemiologically appropriate The epidemiologically appropriate use of vaccines has resulted in the use of vaccines has resulted in the global eradication of smallpox and in global eradication of smallpox and in the potential eradication of the potential eradication of poliomyelitis in the next few years poliomyelitis in the next few years and measles by 2020.and measles by 2020.

THE AIM OF THE LECTURETHE AIM OF THE LECTURE

TU STUDY OF IMMUNIZATIONTU STUDY OF IMMUNIZATIONTU STUDY OF ACTIVE AND PASSIVE TU STUDY OF ACTIVE AND PASSIVE

IMMUNIZATIONIMMUNIZATIONTU STUDY TIPES OF VACCINES TU STUDY TIPES OF VACCINES TU STUDY IMMUNIZATION CHEDULETU STUDY IMMUNIZATION CHEDULE

Natural smallpoxNatural smallpox

VACCINEVACCINE – A SUSPENSION – A SUSPENSION OF ATTENUATED LIVE OR KILLED OF ATTENUATED LIVE OR KILLED MICROORGANISMS OR MICROORGANISMS OR ANTIGENIC PORTIONS OF THESE ANTIGENIC PORTIONS OF THESE AGENYS PRESENTED TO A AGENYS PRESENTED TO A POTENTIAL HOST TO INDUCE POTENTIAL HOST TO INDUCE IMMUNITY AND PREVENT IMMUNITY AND PREVENT DISEASEDISEASE

TETANUSTETANUS

MeaslesMeasles

TOXOIDTOXOID – A MODIFIED – A MODIFIED BACTERIAL TOXIN THAT HAS BACTERIAL TOXIN THAT HAS BEEN MADE NONTOXIC BUT BEEN MADE NONTOXIC BUT RETAINS THE CAPACITY TO RETAINS THE CAPACITY TO SIMULATE THE FORMATION SIMULATE THE FORMATION OF ANTITOXIN OF ANTITOXIN

IMMUNE GLOBULINIMMUNE GLOBULIN – AN – AN ANTIBODY-CONTAINING SOLUTION ANTIBODY-CONTAINING SOLUTION DERIVED FROM HUMAN BLOOD BY DERIVED FROM HUMAN BLOOD BY COLD ETHANOL FRACTIONATION OF COLD ETHANOL FRACTIONATION OF LARGE POOLS OF PLASMA AND LARGE POOLS OF PLASMA AND USED PROMARILY FOR USED PROMARILY FOR MAINTENANCE OF THE IMMUNITY OF MAINTENANCE OF THE IMMUNITY OF IMMUNODEFICIENT PERSONS OR IMMUNODEFICIENT PERSONS OR FOR PASSIVE IMMUNIZATION; FOR PASSIVE IMMUNIZATION; INTRAMUSCULAR AND INTRAMUSCULAR AND INTRAVENOUS PREPARATIONS INTRAVENOUS PREPARATIONS AVAILABLEAVAILABLE

ANTITOXINANTITOXIN – AN – AN ANTIBODY DERIVED FROM ANTIBODY DERIVED FROM THE SERUM OF ANIMALS THE SERUM OF ANIMALS AFTER STIMULATION WITH AFTER STIMULATION WITH SPECIFIC ANTIGENS AND SPECIFIC ANTIGENS AND USED TO PROVIDE PASSIVE USED TO PROVIDE PASSIVE IMMUNITY IMMUNITY

TIPES OF IMMUNIZATIONTIPES OF IMMUNIZATION

ACTIVE ACTIVE IMMUNIZATION – IMMUNIZATION – INJECTED INJECTED ANTIGENS AND ANTIGENS AND ORGANIZM ORGANIZM PRODUSED PRODUSED ANTIBODIESANTIBODIES

PASIVE PASIVE IMMUNIZATION – IMMUNIZATION – INJECTED READY INJECTED READY ANTIBODIESANTIBODIES

INDICATION FOR IMMUNIZATION INDICATION FOR IMMUNIZATION

ACCORDING TO PLAN ACCORDING TO PLAN INDICATION:INDICATION:

-CHILDRENS-CHILDRENS-SERVICEMANS-SERVICEMANS-THE PEOPLES WHO HAS -THE PEOPLES WHO HAS

CONTACT WITH CONTACT WITH INFECTION DISEASESINFECTION DISEASES

- THE POPULATION IN - THE POPULATION IN NATURAL FOCUS OF NATURAL FOCUS OF INFECTIONINFECTION

ACCORDING TO ACCORDING TO EPIDEMIC INDICATION:EPIDEMIC INDICATION:

- THREAT SPREADING OF THREAT SPREADING OF INFECTION DISEASES IN INFECTION DISEASES IN CONCRETE TERRITORY CONCRETE TERRITORY

- EMERGENCY EMERGENCY PROPHYLACTIC THE PROPHYLACTIC THE PEOPLES IN PEOPLES IN INCUBATION PERIODINCUBATION PERIOD

- FORTHCOMING FORTHCOMING JOURNEY IN JOURNEY IN UNFAVOURABLE UNFAVOURABLE REGIONREGION

IMMUNIZATION ACCORDING TO IMMUNIZATION ACCORDING TO PLAN INDICATION PLAN INDICATION

CHILDRENS (TUBERCULOSIS, CHILDRENS (TUBERCULOSIS, PERTUSIS, DIPHTERIA, RUBEOLLA, PERTUSIS, DIPHTERIA, RUBEOLLA, MEASLES,MUMPS, POLIOMIOLITIS, MEASLES,MUMPS, POLIOMIOLITIS, TETANUS, HAEMOPHYLIA INFECTION)TETANUS, HAEMOPHYLIA INFECTION)

SERVICEMANS (TUBERCULOSIS, SERVICEMANS (TUBERCULOSIS, TETANUS, GAS GANGRENA, TETANUS, GAS GANGRENA, BOTULISM)BOTULISM)

IN NATURAL FOCUS OF INFECTION IN NATURAL FOCUS OF INFECTION (TULAREMIA, TICK ENSEPHALITIS)(TULAREMIA, TICK ENSEPHALITIS)

IMMUNIZATION ACCORDING TO IMMUNIZATION ACCORDING TO EPIDEMIC INDICATIONEPIDEMIC INDICATION

- THREAT SPREADING OF INFECTION THREAT SPREADING OF INFECTION DISEASES IN CONCRETE TERRITORY DISEASES IN CONCRETE TERRITORY (INFLUENZA, TIPHUS ABDOMINALIS, (INFLUENZA, TIPHUS ABDOMINALIS, CHOLERA)CHOLERA)

- EMERGENCY PROPHYLACTIC THE PEOPLES EMERGENCY PROPHYLACTIC THE PEOPLES IN INCUBATION PERIOD (RUBEOLLA, IN INCUBATION PERIOD (RUBEOLLA, MUMPS, DIPHTERIA, MEMINGOCOCCAL MUMPS, DIPHTERIA, MEMINGOCOCCAL INF., POLIOMIOLITIS, TETANUS)INF., POLIOMIOLITIS, TETANUS)

- FORTHCOMING JOURNEY IN FORTHCOMING JOURNEY IN UNFAVOURABLE REGION (TULAREMIA, UNFAVOURABLE REGION (TULAREMIA, TICK ENSEPHALITIS, YELLOW FEVER)TICK ENSEPHALITIS, YELLOW FEVER)

TIPES OF VACCINES

LIVE KILLED CHEMICALNEW VACCINE

LIVE VACCINESLIVE VACCINESTUBERCULOSISTUBERCULOSISPOLIOMIOLITISPOLIOMIOLITISMUMPSMUMPSMEASLESMEASLES INFLUENZAINFLUENZATICK TICK

ENSEPHALITISENSEPHALITIS

BRUSELLOSISBRUSELLOSISTULAREMIATULAREMIAANTHRAXANTHRAXPLAGUAPLAGUAYELLOW FEVERYELLOW FEVERQ FEVERQ FEVER

KILLED VACCINES

PERTUSISPERTUSISTIPHUS ABDOMINALISTIPHUS ABDOMINALISRABIESRABIESLEPTOSPIROSISLEPTOSPIROSISINFLUENZAINFLUENZAHERPESHERPES

CHEMICAL VACCINES

TIPHUS ABDOMINALISTIPHUS ABDOMINALISBRUSELOSISBRUSELOSISCHOLERACHOLERA INFLUENZAINFLUENZAPLAGUAPLAGUAMENINGOCOCCAL INFECTIONMENINGOCOCCAL INFECTION

NEW VACCINE

HEPATITIS BHEPATITIS BSALMONELLOSISSALMONELLOSISPHEUMONIA (Streptococcus PHEUMONIA (Streptococcus

pneumonia)pneumonia)

CONTRAINDICATION OF CONTRAINDICATION OF VACCINATIONVACCINATION

VACCINEVACCINE CONTRAINDICATIONCONTRAINDICATION

ALL VACCINESALL VACCINES Reaction on foregoing Reaction on foregoing dosedose

ALL LIVE VACCINESALL LIVE VACCINES Immuno-deficiency, Immuno-deficiency, cancer,pregnancycancer,pregnancy

BCGBCG Weight less 1500kg,Weight less 1500kg,

Keloid cicatrix after Keloid cicatrix after foregoing doseforegoing dose

OPVOPV Absolute Absolute contraindication is contraindication is absentabsent

CONTRAINDICATION OF CONTRAINDICATION OF VACCINATIONVACCINATION

VACCINEVACCINE CONTRAINDICATIOCONTRAINDICATIONN

ADTP vaccineADTP vaccine The diseases of The diseases of nervous system, nervous system, convulsionsconvulsions

ADT, ADT-MADT, ADT-M Absolute Absolute contraindication is contraindication is absentabsent

CONTRAINDICATION OF CONTRAINDICATION OF VACCINATIONVACCINATION

VACCINEVACCINE CONTRAINDICATIONCONTRAINDICATION

Measles, mumps Measles, mumps vaccinevaccine

Reaction on amino Reaction on amino glycosideglycoside

Measles, rubella, Measles, rubella, mump vaccinemump vaccine

Anaphylaxis reaction Anaphylaxis reaction on egg protein on egg protein

IMMUNIZATION CHEDULEIMMUNIZATION CHEDULEBCGBCG OPVOPV HepatHepat

BBADTPADTP HibHib ADTADT AD-MAD-M ADT-MADT-M RMMRMM miaslesmiasles

0-40-4++ ++

2 m2 m++ ++ ++ ++

3 m3 m++ ++ ++

4 m4 m++ ++ ++ ++

12-15 m12-15 m++ ++

18m18m++ ++

6 year6 year++ ++

12 year12 year++

BCGBCG OPVOPV HepatHepat

BBADTPADTP HibHib ADTADT AD-MAD-M ADT-MADT-M RMMRMM miaslesmiasles

15 15 YEARSYEARS ++

16 16 YEARSYEARS ++

evryevry10 10 yearsyears ++

THENK YOU!THENK YOU!