Immuno Chemistry

Immunology Immunobiology Hyun Ho Park Ph.D.

Introduction

• Immunology : Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system

• Immune System : A collection of bone marrow-derived cells and plasma proteins that work together to fight against microbe world (Pathogen)

Pathogens

4 types of pathogen 1. Bacteria 2. Virus 3. Fungi 4. Parasites

From this lecture

• Be confident

• Have a great fun with immune system

• Be aggressive for the knowledge

• Feel that biology is not difficult at all

You guys can absolutely enjoy it and worth for living with it!!

Suggestion

1. Study immunology with a text book written in English

2. Cell phone

3. 2 Quizzes

4. All exam questions are from the lectures

Text book

Main text : Immunobiology, A short course (5th) Richard Coico Supportive text:Immunobiology Charles a Janeway

Evaluation

Mid-term exam: 30% Final exam: 30% Quiz 2 times: 10% Report:10% Attendence:10%

1주 Introduction of Immunology History of Immunology

2주 Elements of the immune system and their roles (I) Elements of the immune system and their roles (II)

3주 Innate Immunity (I) Innate Immunity (II) (1st Quiz)

4주 Brief introduction of Adaptive Immunity Immunogens and antigens

5주 Antibody structure and function (I) Antibody structure and function (II)

6주 Generation of antibody diversity (I) Generation of antibody diversity (II)

7주 Mid-term exam

8주 Role of MHC in the immune response Biology of the T lymphocyte (I)

9주 Biology of the T lymphocyte (II) Biology of the B lymphocyte

10주 Activation and function of T and B cells (I) Activation and function of T and B cells (II) (2nd Quiz)

11주 Apoptosis and immune system Cytokine (I)

12주 Cytokine (II) Failure of Immune system: Tolerance, autoimmunity and autoimmune disease

13주 Failure of Immune system: Hypersensitivity reactions Failure of Immune system: Immunodeficiency disorders

14주 Tumor Immunology (I) Tumor Immunology (II)

15주 Final exam

Introduction

• Immunology : Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system

• Immune System : A collection of bone marrow-derived cells and plasma proteins that work together to fight against microbe world (Pathogen)

Pathogens

4 types of pathogen 1. Bacteria 2. Virus 3. Fungi 4. Parasites

1st defense

The basic System… Skin Mucous membranes

provides a physical barrier preventing microbial access

Physiological variables • pH of our environment • temperature of our environment

chemical defenses

nitric oxide, enzymes, proteins

2nd defense

• Immune system

1) The Innate Immune system (~4hours)

defense mechanisms that are used by the host

immediately of encountering pathogen.

a general response to anything other than recognized “self cells”

2) The Adaptive Immune System =

a specific counter-assault against a “known foreign” invader (previously recognized)

It is not simple

History

The first formal explanation of vaccination was provided by Edward Jenner’s reinfection studies (1780’s)

1. the “Father of immunology” 2. Large scale vaccination(hospital) 3. developed "pasteurization,"

Edward Jenner(1749~1823) Louis Pasteur (1822-1895)

Robert Koch (1843-1910) Father of bacteriology German physician; also started to work on Anthrax in 1870's. First time the causative agent of an infectious disease was identified. • Identified bacteria causing Tuberculosis Awarded 1905 Nobel Prize.

Elie Metchnikoff (1845-1916) · Embryologist studying starfish development. · Found phagocytosis. Formed the basis of leukocyte phagocytosis. · Birth of cellular immunology Shared Nobel Prize with Ehrlich in 1908

Gerald M. Edelman 1929-

Rodney R. Porter 1917-1985

1972 Nobel Prize for their discoveries concerning the chemical structure of antibodies.

BARUJ BENACERRAF JEAN DAUSSET GEORGE D. SNELL

Discovered genes that regulate immune responses, Now known as the major histocompatibility antigens 1980 Noble prize

Susumu Tonegawa (b. 1939) Cloning of the Immunoglobulin gene 1987 Nobel prize for his discovery of "the genetic principle for generation of antibody diversity".

Peter C. Doherty and Rolf M. Zinkernagel 1996 Nobel Prize for their discoveries concerning "the specificity of the cell-mediated immune defense".

2011 Bruce Beutler(1957-), Jules A. Hoffmann (1941-) " for their discoveries concerning the activation of innate immunity" and Ralph Marvin Steinman (1943-2011)"for his discovery of the dendritic cell and its role in adaptive immunity"