immunology stack slackers facts by mike ori. disclaimer the information represents my understanding...
Post on 19-Dec-2015
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![Page 1: Immunology Stack Slackers Facts by Mike Ori. Disclaimer The information represents my understanding only so errors and omissions are probably rampant](https://reader035.vdocument.in/reader035/viewer/2022062516/56649d2e5503460f94a05560/html5/thumbnails/1.jpg)
Immunology Stack
Slackers Facts by Mike Ori
![Page 2: Immunology Stack Slackers Facts by Mike Ori. Disclaimer The information represents my understanding only so errors and omissions are probably rampant](https://reader035.vdocument.in/reader035/viewer/2022062516/56649d2e5503460f94a05560/html5/thumbnails/2.jpg)
Disclaimer
The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes.
The document can mostly be used forward and backward. I tried to mark questionable stuff with (?).
If you want it to look pretty, steal some crayons and go to town.
Finally…
If you’re a gunner, buck up and do your own work.
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SLE antibodies
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Anti-phospholipidAnti-smith
Anti-dsDNA
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SLE mortality factors
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Short term: active disease (renal) and infectionLong term: chronic renal failure, heart failure,
malignancies, infection
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SLE treatment
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Immune suppression with cyclophosphamide and corticosteroids
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Rheumatoid arthritis antibodies
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RF
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What is Rheumatoid Factor?
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IgM antibodies directed against an immunoglobin such as IgG
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RA description
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Autoimmune attack on synovium leads to synovial overgrowth (fronding) onto articular cartilage causing irreversible joint destruction
and malformation.
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Other RA affected areas
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Nodules in soft tissue, inflammation of the eye, vasculitis.
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RA Immune cell involvement
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CD4+ T and B cell infiltrates into joins with lymphoid follicle formation
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Sjogren syndrome antibodies
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Anti-SS-A/RoAnti-SS-B/La
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Sjogren description
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Autoimmune destruction of exocrine gland epithelium particularly that of the salivary and
lacrimal glands. Formation of germinal centers is possible.
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Sjogren cells
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CD4+ cells. NOTE: Although ab are present, they do not
appear to be the principle cause of the damage. (Robbins)
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Sjogren’s linked disease
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40x increased risk of B cell lymphoma
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Scleroderma Ab
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Anti-scl 70Anti-nucleolar
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Systemic sclerosis (Sceroderma) description
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Progressive fibrosis located throughout the body particularly the skin and to a lesser extent the
GI tract, kidneys, heart, muscles, and lungs.
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Scleroderma cells
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CD4+ T cells activate fibroblasts through unknown mechanisms.
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Systemic Vasculitis Antibodies
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Anti-neutrophil cytoplasmic antigen (ANCA)
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Systemic vasculitis description
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Immune response that results in either the deposition of Ab/Ag complexes or the binding of Ab in situ to elements of the endothelium. This results in a range of diseases involving the vasculature including wegener granulomatosis
and churg-strauss. The reaction may range from mild to fatal.
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Systemic vasculitis causes
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Drugs and viruses