implementation science...oct 07, 2018 · [email protected] @angieingrahammd implementation...
TRANSCRIPT
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Association for Academic Surgery
29th Annual Fundamentals of Surgical Research Course
October 20, 2018
Angela M. Ingraham, MD, MS
University of Wisconsin
@AngieIngrahamMD
Implementation Science
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Disclosures
• No financial disclosures
• Acknowledgement:
– Heather Neuman, MD, MS, FACS
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Overview
• Definitions/context
• Impact
• Conceptual model of Implementation Research
• Couple important concepts
• Models for Implementation Research
• Additional Resources
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Definitions • Dissemination Research
– Study of targeted distribution of information and
intervention materials to a specific public health or
clinical practice audience
– Understand how best to spread and sustain
knowledge and the associated evidence-based
interventions
• Implementation Research
– Study of the use of strategies to adopt and
integrate evidence-based health interventions into
clinical and community settings
Adapted from “A Brief Introduction to Implementation Science” by D. Chambers, DPhil
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Putting it in context
-“What is Implementation Science? Implications for Conducting Antimicrobial Stewardship Research” by H.
Reisinger, PhD and D. Livorsi, MD
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The big picture
Adapted from “A Brief Introduction to Implementation Science” by D. Chambers, DPhil
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Overview
• Definitions/context
• Impact
• Conceptual model of Implementation Research
• Couple important concepts
• Models for Implementation Research
• Additional Resources
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Importance
• Evidence-based health intervention…
– Is only so good as how and whether…
• It is adopted?
• Providers are trained to deliver it?
• Trained providers choose to deliver it?
• Eligible patients receive it?
• Degree to which access/engagement/quality/sustainability exist?
Adapted from “A Brief Introduction to Implementation Science” by D. Chambers, DPhil
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Impact
On average, it takes 17 years for evidence based
practices to be incorporated into routine care.
Efficacy and
effectiveness trials
Sustained application
in routine care
Lack of awareness
Competing demands
Limited resources and
skills
Misalignment of priorities
Balas EA, Boren SA, Yearb Med Inform 2000, 1: 65‐70; Bauer MS, et al. BMC Psychology 2015, 3:3 2
“What is Implementation Science? Implications for Conducting Antimicrobial Stewardship Research” by
Heather Schacht Reisinger, PhD Dan Livorsi, MD
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Implementation Scientists
• Want to know:
– Why evidence‐based practices are adopted
– How they’re adapted to fit a specific context
– How the pace of adoption can be
accelerated
-“What is Implementation Science? Implications for Conducting Antimicrobial Stewardship Research” by H.
Reisinger, PhD and D. Livorsi, MD
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Overview
• Definitions/context
• Impact
• Conceptual model of Implementation Research
• Couple important concepts
• Models for Implementation Research
• Additional Resources
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Conceptual model of
implementation research
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• Frames core elements of implementation research
• Distinguishes two required strategies:
– Evidence-based intervention strategies
– Separate strategies for implementing interventions in usual care
• Implementation strategies are key component to be manipulated
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• Differential effects on three outcomes
– Ultimate goal - improve clinical outcomes
• ‘‘Intermediate outcomes’’ - important, particularly in relation to
implementation strategies
– Improving acceptability of interventions may be a worthy goal itself
• Call for multilevel implementation strategies
– Explicitly mentions levels of implementation context
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Overview
• Definitions/context
• Impact
• Conceptual model of Implementation Research
• Couple important concepts
• Models for Implementation Research
• Additional Resources
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Program Drift
• Expected effect of an intervention is
presumed to decrease over time as
practitioners adapt the delivery of
the intervention
Program Drift
Expected
Effect
Optimal
Effect
Chambers
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Voltage Drop
• Effect of an intervention is
presumed to decrease as
testing moves from Efficacy
to Effectiveness to
Dissemination and
Implementation
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Overview
• Definitions/context
• Impact
• Conceptual model of Implementation Research
• Couple important concepts
• Models for Implementation Research
• Additional Resources
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• Identified 109 models 61 included in review
Tabak, Khoong, Chambers, Brownson, AJPM, 2012
Chambers
Brownson
Tabak
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Finding the Right Implementation Models
http://dissemination-implementation.org
Adapted from “A Brief Introduction to Implementation Science” by D. Chambers, DPhil
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More than Efficacy/Effectiveness
Glascow, Volt, and Boles (1999)
Ross Glascow, MS, PhD
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RE-AIM
RE-AIM Dimension Research Questions
Reach
Absolute number, proportion, and
representativeness of individuals who
participate.
What proportion of states have statewide protocols or triage
guidelines?
Effectiveness
The impact of an intervention on outcomes
(including potential negative effects)
Have there been any unexpected outcomes or negative
effects associated with existing protocols?
If so, what implementation factors may be related to
negative effects and how can negative effects be avoided?
• Increase the number of states with statewide protocols or triage
guidelines for EMS personnel during mass casualty situations
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RE-AIM
RE-AIM Dimension Research Questions
Adoption
The absolute number, proportion, and
representativeness of those who carry out the
intervention
What states have adopted protocols and how do they
compare to others that have not?
What factors influence the decision to adopt protocols?
Implementation
Consistency of delivery, time and cost of
program, and what adaptations to the program
are made in various settings
What challenges had to be overcome when adopting
protocols?
How and why do protocols vary across states?
Maintenance
Extent to which a program or policy becomes
institutionalized
Do protocols or guidelines require government approval
for renewal?
• Increase the number of states with statewide protocols or triage
guidelines for EMS personnel during mass casualty situations
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Overview
• Definitions/context
• Impact
• Conceptual model of Implementation Research
• Couple important concepts
• Models for Implementation Research
• Additional Resources
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Other Resources
• https://cancercontrol.cancer.gov/IS/
sample-grant-applications.html
• https://www.academyhealth.
org/events/site/11th-annual-
conference-science-
dissemination-and-
implementation-health
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Thank you
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