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VOL. 186 | NO. 9 | May 1, 2011 | Pages 5017–5524

IN THIS ISSUE5017

LETTERS TO THE EDITOR5019 Comment on “Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial Airway Infection”

Samithamby Jeyaseelan

5019 Response to Comment on “Nonhematopoietic Cells Are Key Players in Innate Control of Bacterial AirwayInfection”Salom�e LeibundGut-Landmann and Annette Oxenius

PILLARS OF IMMUNOLOGY5021 ICAM-1: Getting a Grip on Leukocyte Adhesion

Eric O. Long

5024 Pillars Article: Induction By IL 1 and Interferon-g: Tissue Distribution, Biochemistry, and Function of aNatural Adherence Molecule (ICAM-1). J. Immunol. 1986. 137: 245–254Michael L. Dustin, Robert Rothlein, Atul K. Bhan, Charles A. Dinarello, and Timothy A. Springer

5034 Pillars Article: A Human Intercellular Adhesion Molecule (ICAM-1) Distinct from LFA-1. J. Immunol.1986. 137: 1270–1274Robert Rothlein, Michael L. Dustin, Steven D. Marlin, and Timothy A. Springer

Brief Reviews5039 Strength of TCR–Peptide/MHC Interactions and In Vivo T Cell Responses

Emily Corse, Rachel A. Gottschalk, and James P. Allison

On the cover: Histopathological analysis of Pseudomonas aeruginosa-induced chronic pneumonia. The bronchial involvement

was characterized by massive granulocytic infiltration or by macrophagic infiltration, bronchial wall disruption andparenchyma invasion by bacteria. The parenchyma was infiltrated by leukocytes. Finally, hyperplasia of the bronchus-associated lymphoid tissue was observed in most bronchi of involved lobes. Moalli, F., M. Paroni, T. Veliz Rodriguez,

F. Riva, N. Polentarutti, B. Bottazzi, S. Valentino, S. Mantero, M. Nebuloni, A. Mantovani, A. Bragonzi, and C. Garlanda.2011. The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused byPseudomonas aeruginosa. J. Immunol. 186: 5425–5434.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists,Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: Newsubscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and

details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issuescan be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf).

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Copyright � 2011 by The American Association of Immunologists, Inc.

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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION5047 Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic

Thymic StromaYasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Fumiko Hirota, Yumiko Nishikawa, Takuro Nii,

Hiroshi Kiyonari, Takaya Abe, Hisanori Uehara, Keisuke Izumi, Koji Tamada, Lieping Chen, Josef M. Penninger,

Jun-ichiro Inoue, Taishin Akiyama, and Mitsuru Matsumoto

5058 Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+

Conventional Dendritic Cells through IL-6Jun Diao, Jun Zhao, Erin Winter, and Mark S. Cattral

5068 Enhanced Sensitivity to IL-2 Signaling Regulates the Clinical Responsiveness of IL-12–Primed CD8+

T Cells in a Melanoma ModelDominique N. Lisiero, Horacio Soto, Linda M. Liau, and Robert M. Prins

5078 Endogenous Opioid-Mediated Analgesia Is Dependent on Adaptive T Cell Response in MiceJ�erome Bou�e, Catherine Blanpied, Pierre Brousset, Nathalie Vergnolle, and Gilles Dietrich

5085 IFN-a Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing ImmuneComplexes Is Promoted by NK Cells via MIP-1b and LFA-1Niklas Hagberg, Olof Berggren, Dag Leonard, Gert Weber, Yenan T. Bryceson, Gunnar V. Alm, Maija-Leena Eloranta,

and Lars Ronnblom

5095 p66Shc Is a Negative Regulator of Fc«RI-Dependent Signaling in Mast CellsCristina Ulivieri, Daniela Fanigliulo, Giulia Masi, Maria Teresa Savino, Alessandra Gamberucci, Pier Giuseppe Pelicci,

and Cosima T. Baldari

5107 Heterologous T Cells Can Help Restore Function in Dysfunctional Hepatitis C Virus Nonstructural3/4A-Specific T Cells during Therapeutic VaccinationAntony Chen, Gustaf Ahl�en, Erwin D. Brenndorfer, Anette Brass, Fredrik Holmstrom, Margaret Chen, Jonas Soderholm,

David R. Milich, Lars Frelin, and Matti Sallberg

5119 Mice with Disrupted Type I Protein Kinase A Anchoring in T Cells Resist Retrovirus-InducedImmunodeficiencyRandi Mosenden, Pratibha Singh, Isabelle Cornez, Mikael Heglind, Anja Ruppelt, Michel Moutschen, Sven Enerback,

Souad Rahmouni, and Kjetil Task�en

5131 Exposure to IL-15 and IL-21 Enables Autoreactive CD8 T Cells To Respond to Weak Antigens and CauseDisease in a Mouse Model of Autoimmune DiabetesSheela Ramanathan, Stephanie Dubois, Xi-Lin Chen, Chantal Leblanc, Pamela S. Ohashi, and Subburaj Ilangumaran

5142 Type I IFNs Control Antigen Retention and Survival of CD8a+ Dendritic Cells after Uptake of TumorApoptotic Cells Leading to Cross-PrimingSilvia Lorenzi, Fabrizio Mattei, Antonella Sistigu, Laura Bracci, Francesca Spadaro, Massimo Sanchez, Massimo Spada,

Filippo Belardelli, Lucia Gabriele, and Giovanna Schiavoni

5151 Early Induction of Polyfunctional Simian Immunodeficiency Virus (SIV)-Specific T Lymphocytes andRapid Disappearance of SIV from Lymph Nodes of Sooty Mangabeys during Primary InfectionMareike Meythaler, Zichun Wang, Amanda Martinot, Sarah Pryputniewicz, Melissa Kasheta, Harold M. McClure,

Shawn P. O’Neil, and Amitinder Kaur

5162 Testosterone Replacement Effectively Inhibits the Development of Experimental Autoimmune Orchitis inRats: Evidence for a Direct Role of Testosterone on Regulatory T Cell ExpansionMonika Fijak, Eva Schneider, Jorg Klug, Sudhanshu Bhushan, Holger Hackstein, Gerhard Schuler, Malgorzata Wygrecka,

Jorg Gromoll, and Andreas Meinhardt

5173 MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance toApoptosisPatrice Hemon, Francette Jean-Louis, Kiran Ramgolam, Chrystelle Brignone, Manuelle Viguier, Herv�e Bachelez,

Fr�ed�eric Triebel, Dominique Charron, Fawzi Aoudjit, Reem Al-Daccak, and Laurence Michel

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5184 The Acquisition of Antigen Cross-Presentation Function by Newly Formed Dendritic CellsPriyanka Sathe, Joanne Pooley, David Vremec, Justine Mintern, Jun-O Jin, Li Wu, Jong-Young Kwak, Jose A. Villadangos,

and Ken Shortman

5193 Opposite Effects of Endogenous Peptide–MHC Class I on T Cell Activity in the Presence and Absence ofCD8Jennifer D. Stone, David H. Aggen, Adam S. Chervin, Samanthi Narayanan, Thomas M. Schmitt, Philip D. Greenberg,

and David M. Kranz

5201 Control of TNF-Induced Dendritic Cell Maturation by Hybrid-Type N-GlycansStephan Schlickeiser, Svetlana Stanojlovic, Christine Appelt, Katrin Vogt, Simone Vogel, Stefanie Haase, Thomas Ritter,

Hans-Dieter Volk, Uwe Pleyer, and Birgit Sawitzki

5212 The Adaptor Protein TRADD Is Essential for TNF-Like Ligand 1A/Death Receptor 3 SignalingYelena L. Pobezinskaya, Swati Choksi, Michael J. Morgan, Xiumei Cao, and Zheng-gang Liu

5217 Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase3-b–Signaling Pathways Regulates the Innate Inflammatory ResponseHuizhi Wang, Jonathan Brown, Zhen Gu, Carlos A. Garcia, Ruqiang Liang, Pascale Alard, El�eonore Beurel,

Richard S. Jope, Terrance Greenway, and Michael Martin

5227 Clonal Analysis Reveals Uniformity in the Molecular Profile and Lineage Potential of CCR9+ and CCR92

Thymus-Settling ProgenitorsGuillaume E. Desanti, William E. Jenkinson, Sonia M. Parnell, Amine Boudil, Laetitia Gautreau-Rolland, Bertus Eksteen,

Sophie Ezine, Peter J. L. Lane, Eric J. Jenkinson, and Graham Anderson

5236 Anthrax Lethal Factor Activates K+ Channels To Induce IL-1b Secretion in MacrophagesJohnson Thomas, Yulia Epshtein, Arun Chopra, Balazs Ordog, Mahmood Ghassemi, John W. Christman, Stanley Nattel,

James L. Cook, and Irena Levitan

5244 Analysis of the Role of IL-21 in Development of Murine B Cell Progenitors in the Bone MarrowNathalie Simard, Danijela Konforte, Anne H. Tran, Jessica Esufali, Warren J. Leonard, and Christopher J. Paige

5254 Leptin Enhances Survival and Induces Migration, Degranulation, and Cytokine Synthesis of HumanBasophilsMaho Suzukawa, Hiroyuki Nagase, Ikuko Ogahara, Kaiyu Han, Hiroyuki Tashimo, Akiko Shibui, Rikiya Koketsu,

Susumu Nakae, Masao Yamaguchi, and Ken Ohta

5261 CD1d and CD1c Expression in Human B Cells Is Regulated by Activation and Retinoic Acid ReceptorSignalingLenka L. Allan, Annelein M. Stax, Dong-Jun Zheng, Brian K. Chung, Fred K. Kozak, Rusung Tan, and Peter van den Elzen

5273 A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- andNonintegrin-Related Defects in Different Steps of Leukocyte AdhesionPhilippe Robert, Matthias Canault, Catherine Farnarier, Alan Nurden, Charlotte Grosdidier, Vincent Barlogis,

Pierre Bongrand, Anne Pierres, Herv�e Chambost, and Marie-Christine Alessi

5284 CXCR3 Deficiency Exacerbates Liver Disease and Abrogates Tolerance in a Mouse Model ofImmune-Mediated HepatitisAnnette Erhardt, Claudia Wegscheid, Benjamin Claass, Antonella Carambia, Johannes Herkel, Hans-Willi Mittrucker,

Ulf Panzer, and Gisa Tiegs

5294 B Cell-Specific Expression of B7-2 Is Required for Follicular Th Cell Function in Response to Vaccinia VirusSamira Salek-Ardakani, Youn Soo Choi, Mohammed Rafii-El-Idrissi Benhnia, Rachel Flynn, Ramon Arens,

Stephen Shoenberger, Shane Crotty, Michael Croft, and Shahram Salek-Ardakani

5304 Antigen Is Required for Maturation and Activation of Pathogenic Anti-DNA Antibodies and SystemicInflammationJeganathan Venkatesh, Hajime Yoshifuji, Daisuke Kawabata, Prameladevi Chinnasamy, Anfisa Stanevsky,

Christine M. Grimaldi, Joel Cohen-Solal, and Betty Diamond

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MOLECULAR AND STRUCTURAL IMMUNOLOGY5313 Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

Wei Jia and You-Wen He

5323 The Novel Neutrophil Differentiation Marker Phosphatidylglucoside Mediates Neutrophil ApoptosisKatsunari Kina, Hiromi Masuda, Hitoshi Nakayama, Yasuko Nagatsuka, Takuji Nabetani, Yoshio Hirabayashi,

Yasue Takahashi, Kazunori Shimada, Hiroyuki Daida, Hideoki Ogawa, Kenji Takamori, and Kazuhisa Iwabuchi

5333 Mapping of Conformational IgE Epitopes with Peptide-Specific Monoclonal Antibodies RevealsSimultaneous Binding of Different IgE Antibodies to a Surface Patch on the Major Birch Pollen Allergen,Bet v 1Anna Gieras, Petra Cejka, Katharina Blatt, Margarete Focke-Tejkl, Birgit Linhart, Sabine Flicker, Angelika Stoecklinger,

Katharina Marth, Anja Drescher, Josef Thalhamer, Peter Valent, Otto Majdic, and Rudolf Valenta

5345 Sphingosine 1-Phosphate–Induced Motility and Endocytosis of Dendritic Cells Is Regulated by SWAP-70through RhoACarlos Ocan~a-Morgner, Peter Reichardt, Micha€el Chopin, Sarah Braungart, Christine Wahren, Matthias Gunzer,

and Rolf Jessberger

5356 A Multifunctional Element in the Mouse Igk Locus That Specifies Repertoire and Ig Loci SubnuclearLocationYougui Xiang, Xiaorong Zhou, Susannah L. Hewitt, Jane A. Skok, and William T. Garrard

IMMUNOGENETICS5367 Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

Brandt L. Esplin, Tomoyuki Shimazu, Robert S. Welner, Karla P. Garrett, Lei Nie, Qingzhao Zhang, Mary Beth Humphrey,

Qi Yang, Lisa A. Borghesi, and Paul W. Kincade

HOST DEFENSE5376 P2Y6 Agonist Uridine 59-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte

Chemoattractant Protein-1–Mediated Monocytes/Macrophages RecruitmentZhi Zhang, Ziqiang Wang, Hua Ren, Miaomiao Yue, Kan Huang, Hongjie Gu, Mingyao Liu, Bing Du, and Min Qian

5388 Attenuated Bordetella pertussis Vaccine Candidate BPZE1 Promotes Human Dendritic CellCCL21-Induced Migration and Drives a Th1/Th17 ResponseGiorgio Fedele, Manuela Bianco, Anne-Sophie Debrie, Camille Locht, and Clara Maria Ausiello

5397 Characterization of Chicken Mda5 Activity: Regulation of IFN-b in the Absence of RIG-I FunctionalityAdam J. Karpala, Cameron Stewart, Jim McKay, John W. Lowenthal, and Andrew G. D. Bean

5406 TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T CellResponses to a Flagellated PathogenShirdi E. Letran, Seung-Joo Lee, Shaikh M. Atif, Adriana Flores-Langarica, Satoshi Uematsu, Shizuo Akira,

Adam F. Cunningham, and Stephen J. McSorley

5413 The PPE18 Protein ofMycobacterium tuberculosis Inhibits NF-kB/rel–Mediated Proinflammatory CytokineProduction by Upregulating and Phosphorylating Suppressor of Cytokine Signaling 3 ProteinShiny Nair, Akhilesh Datt Pandey, and Sangita Mukhopadhyay

5425 The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung InfectionCaused by Pseudomonas aeruginosaFederica Moalli, Moira Paroni, Tania V�eliz Rodriguez, Federica Riva, Nadia Polentarutti, Barbara Bottazzi,

Sonia Valentino, Stefano Mantero, Manuela Nebuloni, Alberto Mantovani, Alessandra Bragonzi, and Cecilia Garlanda

INFLAMMATION5435 IL-21 Promotes Skin Recruitment of CD4+ Cells and Drives IFN-g–Dependent Epidermal Hyperplasia

Massimiliano Sarra, Roberta Caruso, Maria Laura Cupi, IvanMonteleone, Carmine Stolfi, Elena Campione, Laura Diluvio,

Annamaria Mazzotta, Elisabetta Botti, Sergio Chimenti, Antonio Costanzo, Thomas T. MacDonald, Francesco Pallone,

and Giovanni Monteleone

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5443 IL-6 Production Is Positively Regulated by Two Distinct Src Homology Domain 2-Containing TyrosinePhosphatase-1 (SHP-1)–Dependent CCAAT/Enhancer-Binding Protein b and NF-kB Pathways and anSHP-1–Independent NF-kB Pathway in Lipopolysaccharide-Stimulated Bone Marrow-DerivedMacrophagesDorothy Rego, Ashok Kumar, Ladan Nilchi, Kathryn Wright, Stephen Huang, and Maya Kozlowski

5457 The Role of ChemR23 in the Induction and Resolution of Cigarette Smoke-Induced InflammationTine Demoor, Ken R. Bracke, Lisa L. Dupont, Maud Plantinga, Benjamin Bondue, Marie-Odile Roy, Vincent Lannoy,

Bart N. Lambrecht, Guy G. Brusselle, and Guy F. Joos

5468 Differentiation of Inflammatory Dendritic Cells Is Mediated by NF-kB1–Dependent GM-CSF Productionin CD4 T CellsIan K. Campbell, Annemarie van Nieuwenhuijze, Elodie Segura, Kristy O’Donnell, Elise Coghill, Mirja Hommel,

Steve Gerondakis, Jos�e A. Villadangos, and Ian P. Wicks

5478 Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast CellsSimone Keck, Ines Muller, Gyorgy Fejer, Iva Savic, Sandrine Tchaptchet, Peter J. Nielsen, Chris Galanos, Michael Huber,

and Marina A. Freudenberg

5489 Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding ofProinflammatory IL-1b–Rich MicroparticlesG. Thomas Brown and Thomas M. McIntyre

5497 Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage ResponsesKelly L. Brown, Grace F. T. Poon, Darlene Birkenhead, Olga M. Pena, Reza Falsafi, Claes Dahlgren, Anna Karlsson,

Johan Bylund, Robert E. W. Hancock, and Pauline Johnson

5506 An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-MediatedMurine ColitisShehzad Z. Sheikh, Refaat A. Hegazi, Taku Kobayashi, Joseph C. Onyiah, Steven M. Russo, Katsuyoshi Matsuoka,

Antonia R. Sepulveda, Fengling Li, Leo E. Otterbein, and Scott E. Plevy

CLINICAL IMMUNOLOGY5514 Circulating Human Antibody-Secreting Cells during Vaccinations and Respiratory Viral Infections Are

Characterized by High Specificity and Lack of Bystander EffectF. Eun-Hyung Lee, Jessica L. Halliley, Edward E. Walsh, Andrew P. Moscatiello, Brittany L. Kmush, Ann R. Falsey,

Troy D. Randall, Denise A. Kaminiski, Richard K. Miller, and In~aki Sanz

5522 AUTHOR INDEX

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